{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T21:11:14Z","timestamp":1770325874533,"version":"3.49.0"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2013,11,23]],"date-time":"2013-11-23T00:00:00Z","timestamp":1385164800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endocrine"],"DOI":"10.1007\/s12020-013-0118-5","type":"journal-article","created":{"date-parts":[[2013,11,22]],"date-time":"2013-11-22T20:54:14Z","timestamp":1385153654000},"source":"Crossref","is-referenced-by-count":4,"title":["Lifetime, untreated isolated GH deficiency due to a GH-releasing hormone receptor mutation has beneficial consequences on bone status in older individuals, and does not influence their abdominal aorta calcification"],"prefix":"10.1007","author":[{"given":"Anita H. O.","family":"Souza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria I. T.","family":"Farias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Salvatori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella M. F.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o A. M.","family":"Santana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco A.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco J. A.","family":"de Paula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenia H. O.","family":"Valen\u00e7a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enaldo V.","family":"Melo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita A. A.","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossana M. C.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miburge B.","family":"Gois-Junior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel H.","family":"Aguiar-Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,11,23]]},"reference":[{"key":"118_CR1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/00013614-200501000-00003","volume":"21","author":"DJ Vaness","year":"2005","unstructured":"D.J. Vaness, A.N.A. Tosteson, Estimating the opportunity costs of osteoporosis in the United States. Topics Geriatr. Rehab. 21, 4\u201316 (2005)","journal-title":"Topics Geriatr. Rehab."},{"key":"118_CR2","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1377\/hlthaff.26.1.38","volume":"26","author":"GA Mensah","year":"2007","unstructured":"G.A. Mensah, D.W. Brown, An overview of\u00a0cardiovascular\u00a0disease burden in the United States. Health Aff (Millwood) 26, 38\u201348 (2007)","journal-title":"Health Aff (Millwood)"},{"key":"118_CR3","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1007\/s00198-009-1022-y","volume":"21","author":"PC Watanabe","year":"2010","unstructured":"P.C. Watanabe, F.C. Dias, J.P. Issa, S.A. Monteiro, F.J. de Paula, R. Tiossi, Elongated styloid process and atheroma in panoramic radiography and its relationship with systemic osteoporosis and osteopenia. Osteoporos. Int. 21, 831\u2013836 (2010)","journal-title":"Osteoporos. Int."},{"key":"118_CR4","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.1210\/jc.2006-1178","volume":"91","author":"EM Lewiecki","year":"2006","unstructured":"E.M. Lewiecki, A.J. Laster, Clinical review: clinical applications of vertebral fracture assessment by dual-energy X-ray absorptiometry. J. Clin. Endocrinol. Metab. 91, 4215\u20134222 (2006)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"118_CR5","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.maturitas.2008.11.020","volume":"62","author":"A Maghraoui El","year":"2009","unstructured":"A. El Maghraoui, F. Morjane, A. Nouijai, L. Achemlal, A. Bezza, I. Ghozlani, Vertebral fracture assessment in Moroccan women: prevalence and risk factors. Maturitas 62, 171\u2013175 (2009)","journal-title":"Maturitas"},{"key":"118_CR6","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s12020-012-9691-2","volume":"42","author":"JF Griffith","year":"2012","unstructured":"J.F. Griffith, H.K. Genant, New advances in imaging osteoporosis and its complications. Endocrine 42, 39\u201351 (2012)","journal-title":"Endocrine"},{"key":"118_CR7","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s12020-011-9570-2","volume":"41","author":"G Mazziotti","year":"2012","unstructured":"G. Mazziotti, J. Bilezikian, E. Canalis, D. Cocchi, A. Giustina, New understanding and treatments for osteoporosis. Endocrine 41, 58\u201369 (2012)","journal-title":"Endocrine"},{"key":"118_CR8","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1359\/jbmr.071024","volume":"23","author":"JT Schousboe","year":"2008","unstructured":"J.T. Schousboe, B.C. Taylor, D.P. Kiel, K.E. Ensrud, K.E. Wilson, E.V. McCloskey, Abdominal aortic calcification detected on lateral spine images from a bone densitometer predicts incident myocardial infarction or stroke in older women. J. Bone Miner. Res. 23, 409\u2013416 (2008)","journal-title":"J. Bone Miner. Res."},{"key":"118_CR9","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.bone.2005.06.016","volume":"37","author":"MBR Patel","year":"2005","unstructured":"M.B.R. Patel, N.K. Arden, L.M. Masterson, D.I.W. Phillips, R. Swaminathan, H.E. Syddall, C.D. Byrne, P.J. Wood, C. Cooper, R.I. Holt, Hertfordshire Cohort Study Group. Investigating the role of growth hormone\u2013insulin-like growth factor (GH\u2013IGF) axis as a determinant of male bone mineral density (BMD). Bone 37, 833\u2013841 (2005)","journal-title":"Bone"},{"key":"118_CR10","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1210\/endo.131.3.1505451","volume":"131","author":"H Mochizuki","year":"1992","unstructured":"H. Mochizuki, Y. Hakeda, N. Wakatsuki, N. Usui, S. Akashi, T. Sato, K. Tanaka, M. Kumegawa, Insulin-like growth factor-I supports formation and activation of osteoclasts. Endocrinology 131, 1075\u20131080 (1992)","journal-title":"Endocrinology"},{"key":"118_CR11","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s002230020048","volume":"70","author":"P Gillberg","year":"2002","unstructured":"P. Gillberg, H. Olofsson, H. Mallmin, W.F. Blum, S. Ljunghall, A.G. Nilsson, Bone mineral density in femoral neck is positively correlated to circulating insulin-like growth factor (IGF)-I and IGF-binding protein (IGFBP)-3 in Swedish men. Calcif. Tissue Int. 70, 22\u201329 (2002)","journal-title":"Calcif. Tissue Int."},{"key":"118_CR12","first-page":"55","volume":"19","author":"C Ohlsson","year":"1998","unstructured":"C. Ohlsson, B.-A. Bengtsson, O.G.P. Isaksson, T.T. Andreassen, M.C. Slootweg, Growth hormone and bone. Endocr. Rev. 19, 55\u201379 (1998)","journal-title":"Endocr. Rev."},{"key":"118_CR13","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1210\/er.2007-0036","volume":"29","author":"A Giustina","year":"2008","unstructured":"A. Giustina, G. Mazziotti, E. Canalis, Growth hormone, insulin-like growth factors, and the skeleton. Endocr. Rev. 29, 535\u2013539 (2008)","journal-title":"Endocr. Rev."},{"key":"118_CR14","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1161\/01.ATV.0000105902.89459.09","volume":"24","author":"P Delafontaine","year":"2004","unstructured":"P. Delafontaine, Y.H. Song, Y. Li, Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels. Arterioscler. Thromb. Vasc. Biol. 24, 435\u2013444 (2004)","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"118_CR15","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1111\/j.1532-5415.1985.tb04195.x","volume":"33","author":"D Rudman","year":"1985","unstructured":"D. Rudman, Growth hormone, body composition, and aging. J. Am. Geriatr. Soc. 33, 800\u2013807 (1985)","journal-title":"J. Am. Geriatr. Soc."},{"key":"118_CR16","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1093\/gerona\/gls102","volume":"67","author":"Y Higashi","year":"2012","unstructured":"Y. Higashi, S. Sukhanov, A. Anwar, S.Y. Shai, P. Delafontaine, Aging, atherosclerosis and IGF-I. J. Gerontol. A Biol. Sci. Med. Sci. 67, 626\u2013639 (2012)","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"118_CR17","first-page":"327","volume":"16","author":"GI Baroncelli","year":"2003","unstructured":"G.I. Baroncelli, S. Bertelloni, F. Sodini, G. Saggese, Acquisition of bone mass in normal individuals and in patients with growth hormone deficiency. J. Pediatr. Endocrinol. Metab. 16, 327\u2013335 (2003)","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"118_CR18","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1359\/jbmr.2001.16.2.398","volume":"16","author":"C W\u00fcster","year":"2001","unstructured":"C. W\u00fcster, R. Abs, B.A. Bengtsson, H. Bennmarker, U. Feldt-Rasmussen, E. Hernberg-St\u00e5hl, J.P. Monson, B. Westberg, P. Wilton, The influence of growth hormone deficiency, growth hormone replacement therapy, and other aspects of hypopituitarism on fracture rate and bone mineral density. J. Bone Miner. Res. 16, 398\u2013405 (2001)","journal-title":"J. Bone Miner. Res."},{"key":"118_CR19","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0140-6736(90)91812-O","volume":"336","author":"T Ros\u00e9n","year":"1990","unstructured":"T. Ros\u00e9n, B.A. Bengtsson, Premature mortality due to cardiovascular disease in hypopituitarism. Lancet 336, 285\u2013288 (1990)","journal-title":"Lancet"},{"key":"118_CR20","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1210\/jc.2004-0545","volume":"90","author":"M Gola","year":"2005","unstructured":"M. Gola, S. Bonadonna, M. Doga, A. Giustina, Clinical review: growth hormone and cardiovascular risk factors. J. Clin. Endocrinol. Metab. 90, 1864\u20131870 (2005)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"118_CR21","first-page":"917","volume":"84","author":"R Salvatori","year":"1999","unstructured":"R. Salvatori, C.Y. Hayashida, M.H. Aguiar-Oliveira, J.A. Phillips 3rd, A.H. Souza, R.G. Gondo, S.P. Toledo, M.M. Conceic\u00e3o, M. Prince, H.G. Maheshwari, G. Baumann, M.A. Levine, Familial dwarfism due to a novel mutation of the growth hormone-releasing hormone receptor gene. J. Clin. Endocrinol. Metab. 84, 917\u2013923 (1999)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"118_CR22","first-page":"4118","volume":"84","author":"MH Aguiar-Oliveira","year":"1999","unstructured":"M.H. Aguiar-Oliveira, M.S. Gill, E.S. de A Barretto, M.R. Alc\u00e2ntara, F. Miraki-Moud, C.A. Menezes, A.H. Souza, C.E. Martinelli, F.A. Pereira, R. Salvatori, M.A. Levine, S.M. Shalet, C. Camacho-Hubner, P.E. Clayton, Effect of severe growth hormone (GH) deficiency due to a mutation in the GH-releasing hormone receptor on insulin-like growth factors (IGFs), IGF-binding proteins, and ternary complex formation throughout life. J Clin Endocrinol Metab. 84, 4118\u20134126 (1999)","journal-title":"J Clin Endocrinol Metab."},{"key":"118_CR23","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1046\/j.1365-2265.1999.00837.x","volume":"51","author":"ES de A Barretto","year":"1999","unstructured":"E.S. de A Barretto, M.S. Gill, M.E. De Freitas, M.M. Magalh\u00e3es, A.H. Souza, M.H. Aguiar-Oliveira, P.E. Clayton, Serum leptin and body composition in children with familial GH deficiency (GHD) due to a mutation in growth hormone-releasing hormone (GHRH) receptor. Clin. Endocrionl. (Oxf) 51, 559\u2013564 (1999)","journal-title":"Clin. Endocrionl. (Oxf)"},{"key":"118_CR24","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1210\/jcem.87.5.8474","volume":"87","author":"JA Barreto-Filho","year":"2002","unstructured":"J.A. Barreto-Filho, M.R. Alc\u00e2ntara, R. Salvatori, M.A. Barreto, A.C. Sousa, V. Bastos, A.H. Souza, R.M. Pereira, P.E. Clayton, M.S. Gill, M.H. Aguiar-Oliveira, Familial isolated growth hormone deficiency is associated with increased systolic blood pressure, central obesity, and dyslipidemia. J. Clin. Endocrionol. Metab. 87, 2018\u20132023 (2002)","journal-title":"J. Clin. Endocrionol. Metab."},{"key":"118_CR25","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1046\/j.1365-2265.2002.01568.x","volume":"57","author":"HK Gleeson","year":"2002","unstructured":"H.K. Gleeson, A.H. Souza, M.S. Gill, G.E. Wieringa, E.S. Barretto, J.A. Barretto-Filho, S.M. Shalet, M.H. Aguiar-Oliveira, P.E. Clayton, Lipid profiles in untreated severe congenital isolated growth hormone deficiency through the lifespan. Clin. Endocrinol. (Oxf). 57, 89\u201395 (2002)","journal-title":"Clin. Endocrinol. (Oxf)."},{"key":"118_CR26","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1210\/jc.2009-1919","volume":"95","author":"CR Oliveira","year":"2010","unstructured":"C.R. Oliveira, R. Salvatori, R.A. Meneguz-Moreno, M.H. Aguiar-Oliveira, R.M. Pereira, E.H. Valen\u00e7a, V.P. Ara\u00fajo, N.T. Farias, D.C. Silveira, J.G. Vieira, J.A. Barreto-Filho, Adipokine profile and urinary albumin excretion in isolated growth hormone deficiency. J. Clin. Endocrinol. Metab. 95, 693\u2013698 (2010)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"118_CR27","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1210\/jc.2011-2590","volume":"97","author":"CR Oliveira","year":"2012","unstructured":"C.R. Oliveira, R. Salvatori, J.A. Barreto-Filho, I.E. Rocha, A. Mari, R.M. Pereira, V.C. Campos, M. Menezes, E. Gomes, R.A. Meneguz-Moreno, V.P. Ara\u00fajo, N.T. Leite, A.C. Nascimento-Junior, M.I. Farias, T.A. Viscente, R.D. Ara\u00fajo, E.V. Melo, M.H. Aguiar-Oliveira, Insulin sensitivity and \u03b2-cell function in adults with lifetime, untreated isolated growth hormone deficiency. J. Clin. Endocrinol. Metab. 97, 1013\u20131019 (2012)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"118_CR28","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1210\/jc.2005-2571","volume":"91","author":"JL Menezes Oliveira","year":"2006","unstructured":"J.L. Menezes Oliveira, C. Marques-Santos, J.A. Barreto-Filho, R. Ximenes Filho, A.V. de Oliveira Britto, A.H. Oliveira Souza, C.M. Prado, C.R. Pereira Oliveira, R.M. Pereira, A. Ribeiro Vicente Tde, C.T. Farias, M.H. Aguiar-Oliveira, R. Salvatori, Lack of evidence of premature atherosclerosis in untreated severe isolated growth hormone deficiency due to a GHRH receptor mutation. J. Clin. Endocrinol. Metab. 91, 2093\u20132099 (2006)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"118_CR29","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1210\/jc.2009-1879","volume":"95","author":"MH Aguiar-Oliveira","year":"2010","unstructured":"M.H. Aguiar-Oliveira, F.T. Oliveira, R.M. Pereira, C.R. Oliveira, A. Blackford, E.H. Valenca, E.G. Santos, M.B. Gois-Junior, R.A. Meneguz-Moreno, V.P. Araujo, L.A. Oliveira-Neto, R.P. Almeida, M.A. Santos, N.T. Farias, D.C. Silveira, G.W. Cabral, F.R. Calazans, J.D. Seabra, T.F. Lopes, E.O. Rodrigues, L.A. Porto, I.P. Oliveira, E.V. Melo, M. Martari, R. Salvatori, Longevity in untreated congenital growth hormone deficiency due to a homozygous mutation in the GHRH receptor gene. J. Clin. Endocrinol. Metab. 95, 714\u2013721 (2010)","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"11","key":"118_CR30","doi-asserted-by":"crossref","first-page":"E1710","DOI":"10.1210\/jc.2013-2349","volume":"98","author":"CC Epit\u00e1cio-Pereira","year":"2013","unstructured":"C.C. Epit\u00e1cio-Pereira, G.M. Silva, R. Salvatori, J.A. Santana, F.A. Pereira, M.B. Gois-Junior, A.V. Britto, C.R. Oliveira, A.H. Souza, E.G. Santos, V.C. Campos, R.M. Pereira, E.H. Valen\u00e7a, R.A. Barbosa, M.I. Farias, F.J. de Paula, T.V. Ribeiro, M.C. Oliveira, M.H. Aguiar-Oliveira, Isolated GH deficiency due to a GHRH receptor mutation causes hip joint problems and genu valgum, and reduces size, but not density of trabecular and mixed bone. J. Clin. Endocrinol. Metab. 98(11), E1710\u2013E1715 (2013). doi: 10.1210\/jc.2013-2349","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"118_CR31","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0895-7061(00)01229-2","volume":"14","author":"MC Lansang","year":"2001","unstructured":"M.C. Lansang, G.H. Williams, J.S. Carroll, Correlation between the glucose clamp technique and the homeostasis model assessment in hypertension. Am. J. Hypertens. 14, 51\u201353 (2001)","journal-title":"Am. J. Hypertens."},{"key":"118_CR32","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/jbmr.5650070204","volume":"7","author":"DR Carter","year":"1992","unstructured":"D.R. Carter, M.L. Bouxsein, R. Marcus, New approaches for interpreting projected bone densitometry data. J. Bone Miner. Res. 7, 137\u2013245 (1992)","journal-title":"J. Bone Miner. Res."},{"key":"118_CR33","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1210\/jcem-73-6-1332","volume":"73","author":"DK Katzman","year":"1991","unstructured":"D.K. Katzman, L.K. Bachrach, D.R. Carter, R. Marcus, Clinical and anthropometric correlates of bone mineral acquisition in healthy adolescent girls. J. Clin. Endocrinol. Metab. 73, 1332\u20131339 (1991)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"118_CR34","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1210\/jc.2002-021120","volume":"88","author":"HG Maheshwari","year":"2003","unstructured":"H.G. Maheshwari, R. Bouillon, J. Nijs, V.S. Oganov, A.V. Bakulin, G. Baumann, The impact of congenital, severe, untreated growth hormone (GH) deficiency on bone size and density in young adults: insights from genetic GH-releasing hormone receptor deficiency. J. Clin. Endocrinol. Metab. 88, 2614\u20132618 (2003)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"118_CR35","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1007\/s11547-012-0835-5","volume":"117","author":"D Diacinti","year":"2012","unstructured":"D. Diacinti, G. Guglielmi, D. Pisani, D. Diacinti, R. Argir\u00f2, C. Serafini, E. Romagnoli, S. Minisola, C. Catalano, V. David, Vertebral morphometry by dual-energy X-ray absorptiometry (DXA) for osteoporotic vertebral fractures assessment (VFA). Radiol. Med. 117, 1374\u20131385 (2012)","journal-title":"Radiol. Med."},{"key":"118_CR36","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/jbmr.5650080915","volume":"8","author":"HK Genant","year":"1993","unstructured":"H.K. Genant, C.Y. Wu, C. van Kuijk, M.C. Nevitt, Vertebral fracture assessment using a semiquantitative technique. J. Bone Miner. Res. 8, 1137\u20131148 (1993)","journal-title":"J. Bone Miner. Res."},{"key":"118_CR37","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1359\/jbmr.1998.13.3.415","volume":"13","author":"LK Bachrach","year":"1998","unstructured":"L.K. Bachrach, R. Marcus, S.M. Ott, A.L. Rosenbloom, O. Vasconez, V. Martinez, A.L. Martinez, R.G. Rosenfeld, J. Guevara-Aguirre, Bone\u00a0mineral, histomorphometry, and body composition in\u00a0adults\u00a0with\u00a0growth\u00a0hormone\u00a0receptor\u00a0deficiency. J. Bone Miner. Res. 13, 415\u2013421 (1998)","journal-title":"J. Bone Miner. Res."},{"key":"118_CR38","doi-asserted-by":"crossref","first-page":"4586","DOI":"10.1210\/jc.2003-030623","volume":"88","author":"CA Benbassat","year":"2003","unstructured":"C.A. Benbassat, V. Eshed, M. Kamjin, Z. Laron, Are adult patients with Laron syndrome osteopenic? A comparison between dual-energy X-ray absorptiometry and volumetric bone densities. J. Clin. Endocrinol. Metab. 88, 4586\u20134589 (2003)","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"5","key":"118_CR39","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1210\/jcem-73-5-1081","volume":"73","author":"A Iranmanesh","year":"1991","unstructured":"A. Iranmanesh, G. Lizarralde, J.D. Veldhuis, Age and relative obesity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men. J. Clin. Endocrinol. Metab. 73(5), 1081\u20131088 (1991)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"118_CR40","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1159\/000184241","volume":"43","author":"JL W\u00e9meau","year":"1995","unstructured":"J.L. W\u00e9meau, Calciotropic hormones and ageing. Horm. Res. 43, 76\u201379 (1995)","journal-title":"Horm. Res."},{"key":"118_CR41","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1677\/JOE-09-0431","volume":"205","author":"S Perrini","year":"2010","unstructured":"S. Perrini, L. Laviola, M.C. Carreira, A. Cignarelli, A. Natalicchio, F. Giorgino, The GH\/IGF-I axis and signaling pathways in the muscle and bone: mechanisms underlying age-related skeletal muscle wasting and osteoporosis. J. Endocrinol. 205, 201\u2013210 (2010)","journal-title":"J. Endocrinol."},{"key":"118_CR42","first-page":"232","volume":"5","author":"E Schoenau","year":"2007","unstructured":"E. Schoenau, From mechanostat theory to development of the \u201cFunctional Muscle-Bone-Unit\u201d. J. Musculoskelet. Neuronal. Interact. 5, 232\u2013238 (2007)","journal-title":"J. Musculoskelet. Neuronal. Interact."},{"key":"118_CR43","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1172\/JCI10753","volume":"106","author":"NA Sims","year":"2000","unstructured":"N.A. Sims, P. Cl\u00e9ment-Lacroix, F. Da Ponte, Y. Bouali, N. Binart, R. Moriggl, V. Goffin, K. Coschigano, M. Gaillard-Kelly, J. Kopchick, R. Baron, P.A. Kelly, Bone homeostasis in growth hormone receptor null mice is restored by IGF-I but independent of Stat5. J. Clin. Invest. 106, 1095\u20131103 (2000)","journal-title":"J. Clin. Invest."},{"key":"118_CR44","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1677\/joe.0.0710037","volume":"71","author":"WH Beamer","year":"1976","unstructured":"W.H. Beamer, E.M. Eicher, Stimulation of growth in the little mouse. J. Endocrinol. 71, 37\u201345 (1976)","journal-title":"J. Endocrinol."},{"key":"118_CR45","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1359\/JBMR.050314","volume":"20","author":"HA Fink","year":"2005","unstructured":"H.A. Fink, D.L. Milavetz, L. Palermo, M.C. Nevitt, J.A. Cauley, H.K. Genant, D.M. Black, K.E. Ensrud, What proportional of incident radiographic vertebral deformities is clinically diagnosed and vice versa? J. Bone Miner. Res. 20, 1216\u20131222 (2005)","journal-title":"J. Bone Miner. Res."},{"key":"118_CR46","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s11657-012-0086-z","volume":"7","author":"N Oliveira Ferreira de","year":"2012","unstructured":"N. de Oliveira Ferreira, R.B. da Silva, M. Arthuso, A.M. Pinto-Neto, N. Caserta, L. Costa-Paiva, Prevalence of vertebral fractures and quality of life in a sample of postmenopausal Brazilian women with osteoporosis. Arch. Osteoporos. 7, 101\u2013106 (2012)","journal-title":"Arch. Osteoporos."},{"key":"118_CR47","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.psyneuen.2009.01.001","volume":"34","author":"JA Barbosa","year":"2009","unstructured":"J.A. Barbosa, R. Salvatori, C.R. Oliveira, R.M. Pereira, C.T. Farias, A.V. Britto, N.T. Farias, A. Blackford, M.H. Aguiar-Oliveira, Quality of life in congenital, untreated, lifetime isolated growth hormone deficiency. Psychoneuroendocrinology 34, 894\u2013900 (2009)","journal-title":"Psychoneuroendocrinology"},{"key":"118_CR48","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.critrevonc.2013.01.005","volume":"87","author":"VN Anisimov","year":"2013","unstructured":"V.N. Anisimov, A. Bartke, The key role of growth hormone\u2013insulin\u2013IGF-1 signaling in aging and cancer. Crit. Rev. Oncol. Hemat. 87, 201\u2013223 (2013)","journal-title":"Crit. Rev. Oncol. Hemat."},{"key":"118_CR49","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1007\/s00198-012-2101-z","volume":"24","author":"P Szulc","year":"2013","unstructured":"P. Szulc, E.J. Samelson, E. Sornay-Rendu, R. Chapurlat, D.P. Kiel, Severity of aortic calcification is positively associated with vertebral fracture in older men\u2014a densitometry study in the STRAMBO cohort. Osteoporos. Int. 24, 1177\u20131848 (2013)","journal-title":"Osteoporos. Int."},{"key":"118_CR50","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1365-2796.2004.01430.x","volume":"257","author":"G Rajzbaum","year":"2005","unstructured":"G. Rajzbaum, V.L. Roger, Y. B\u00e9zie, M. Chauffert, P. Br\u00e9ville, F. Roux, M.E. Safar, J. Blacher, French women, fractures and aortic calcifications. J. Intern. Med. 257, 117\u2013119 (2005)","journal-title":"J. Intern. Med."},{"key":"118_CR51","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1359\/jbmr.070903","volume":"23","author":"P Szulc","year":"2008","unstructured":"P. Szulc, D.P. Kiel, P.D. Delmas, Calcifications in the abdominal aorta predict fractures in men: MINOS study. J. Bone Miner. Res. 23, 95\u2013102 (2008)","journal-title":"J. Bone Miner. Res."},{"key":"118_CR52","author":"J Iwamoto","year":"2010","unstructured":"J. Iwamoto, H. Matsumoto, T. Takeda, Y. Sato, M. Uzawa, A radiographic study on the associations of age and prevalence of vertebral fractures with abdominal aortic calcification in Japanese postmenopausal women and men. J. Osteoporos. (2010). doi: 10.4061\/2010\/748380","journal-title":"J. Osteoporos."},{"key":"118_CR53","author":"GS Tajeu","year":"2013","unstructured":"G.S. Tajeu, E. Delzell, W. Smith, T. Arora, J.R. Curtis, K.G. Saag, M.A. Morrisey, H. Yun, M.L. Kilgore, Death, Debility, and Destitution Following\u00a0Hip\u00a0Fracture. J. Gerontol. A Biol. Sci. Med. Sci. (2013). doi: 10.1093\/gerona\/glt105","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"118_CR54","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1359\/jbmr.1997.12.1.24","volume":"12","author":"NF Ray","year":"1997","unstructured":"N.F. Ray, J.K. Chan, M. Thamer, L.J. Melton 3rd, Medical expenditures for the treatment of osteoporotic fractures in the United States in 1995: report from the National Osteoporosis Foundation. J. Bone Miner. Res. 12, 24\u201335 (1997)","journal-title":"J. Bone Miner. Res."},{"key":"118_CR55","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00198-004-1596-3","volume":"15","author":"J Morales-Torres","year":"2004","unstructured":"J. Morales-Torres, S. Guti\u00e9rrez-Ure\u00f1a, The burden of osteoporosis in Latin America. Osteoporos. Int. 15, 625\u2013632 (2004)","journal-title":"Osteoporos. Int."},{"key":"118_CR56","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1007\/s00330-010-1845-0","volume":"20","author":"J Damilakis","year":"2010","unstructured":"J. Damilakis, J.E. Adams, G. Guglielmi, T.M. Link, Radiation exposure in X-ray-based imaging techniques used in osteoporosis. Eur. Radiol. 20, 2707\u20132714 (2010)","journal-title":"Eur. Radiol."},{"key":"118_CR57","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00198-006-0211-1","volume":"18","author":"SJ Gallacher","year":"2007","unstructured":"S.J. Gallacher, A.P. Gallagher, C. McQuillian, P.J. Mitchell, T. Dixon, The prevalence of vertebral fracture amongst patients presenting with non-vertebral fractures. Osteoporos. Int. 18, 185\u2013192 (2007)","journal-title":"Osteoporos. Int."},{"key":"118_CR58","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00198-005-2010-5","volume":"17","author":"JT Schousboe","year":"2006","unstructured":"J.T. Schousboe, C.R. Debold, Reliability and accuracy of vertebral fracture assessment with densitometry compared to radiography in clinical practice. Osteoporos. Int. 17, 281\u2013289 (2006)","journal-title":"Osteoporos. Int."},{"key":"118_CR59","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev-med-041709-133809","volume":"62","author":"DR Owen","year":"2011","unstructured":"D.R. Owen, A.C. Lindsay, R.P. Choudhury, Z.A. Fayad, Imaging of atherosclerosis. Ann. Rev. Med. 62, 25\u201340 (2011)","journal-title":"Ann. Rev. Med."},{"key":"118_CR60","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1161\/hy1001.096358","volume":"38","author":"J Blacher","year":"2001","unstructured":"J. Blacher, A.P. Guerin, B. Pannier, S.J. Marchais, G.M. London, Arterial calcifications, arterial stiffness, and cardiovascular risk in end-stage renal disease. Hypertension 38, 938\u2013942 (2001)","journal-title":"Hypertension"},{"key":"118_CR61","doi-asserted-by":"crossref","first-page":"S305","DOI":"10.1097\/01.ASN.0000081664.65772.EB","volume":"14","author":"GM London","year":"2003","unstructured":"G.M. London, Cardiovascular calcifications in uremic patients: clinical impact on cardiovascular function. J. Am. Soc. Nephrol. 14, S305\u2013S309 (2003)","journal-title":"J. Am. Soc. Nephrol."},{"key":"118_CR62","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s00223-013-9704-z","volume":"92","author":"M Cecelja","year":"2013","unstructured":"M. Cecelja, M.L. Frost, T.D. Spector, P. Chowienczyk, Abdominal aortic calcification detection using dual-energy X-ray absorptiometry: validation study in healthy women compared to computed tomography. Calcif. Tissue Int. 92, 495\u2013500 (2013)","journal-title":"Calcif. Tissue Int."},{"key":"118_CR63","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1530\/EC-13-0014","volume":"2","author":"TA Vicente","year":"2013","unstructured":"T.A. Vicente, I.E. Rocha, R. Salvatori, C.R. Oliveira, R.M. Pereira, A.H. Souza, V.C. Campos, E.G. Santos, R.D. Diniz, E.H. Valen\u00e7a, C.C. Epit\u00e1cio-Pereira, M.C. Oliveira, A. Mari, M.H. Aguiar-Oliveira, Lifetime congenital isolated GH deficiency does not protect from the development of diabetes. Endocr. Connect. 2, 112\u2013117 (2013)","journal-title":"Endocr. Connect."}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-013-0118-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12020-013-0118-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-013-0118-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,4]],"date-time":"2019-08-04T00:22:44Z","timestamp":1564878164000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12020-013-0118-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,23]]},"references-count":63,"alternative-id":["118"],"URL":"https:\/\/doi.org\/10.1007\/s12020-013-0118-5","relation":{},"ISSN":["1355-008X","1559-0100"],"issn-type":[{"value":"1355-008X","type":"print"},{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,23]]}}}