{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T17:39:50Z","timestamp":1762623590858},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,10,10]],"date-time":"2014-10-10T00:00:00Z","timestamp":1412899200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1007\/s12020-014-0445-1","type":"journal-article","created":{"date-parts":[[2014,10,9]],"date-time":"2014-10-09T11:02:31Z","timestamp":1412852551000},"page":"250-257","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Aromatase enzyme expression in acromegaly and its possible relationship with disease prognosis"],"prefix":"10.1007","volume":"49","author":[{"given":"Alev","family":"Selek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berrin","family":"Cetinarslan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yesim","family":"Gurbuz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilhan","family":"Tarkun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeynep","family":"Canturk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burak","family":"Cabuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,10,10]]},"reference":[{"key":"445_CR1","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1210\/mend-5-12-2005","volume":"5","author":"GD Means","year":"1991","unstructured":"G.D. Means, M.W. Kilgore, M.S. Mahendroo, C.R. Mendelson, E.R. Simpson, Tissue-specific promo- ters regulate aromatase cytochrome P450 gene expression in human ovary and fetal tissues. Mol. Endocrinol. 5, 2005\u20132013 (1991)","journal-title":"Mol. Endocrinol."},{"key":"445_CR2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0960-0760(95)00031-T","volume":"53","author":"H Nawata","year":"1995","unstructured":"H. Nawata, S. Tanaka, S. Tanaka et al., Aromatase in bone cells: association with osteoporosis in postmenopausal women. J. Steroid Biochem. Mol. Biol. 53, 165\u2013174 (1995)","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"445_CR3","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1046\/j.1365-2265.1998.00390.x","volume":"48","author":"H Sasano","year":"1998","unstructured":"H. Sasano, K. Takahashi, F. Satoh, H. Nagura, N. Harada, Aromatase in the human central nervous system. Clin. Endocrinol. 48, 325\u2013332 (1998)","journal-title":"Clin. Endocrinol."},{"key":"445_CR4","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1007\/s11102-012-0436-2","volume":"16","author":"H Akinci","year":"2013","unstructured":"H. Akinci, A. Kapucu, K.A. Dar et al., Aromatase cytochrome P450 enzyme expression in prolactinomas and its relationship to tumor behavior. Pituitary 16, 386\u2013392 (2013)","journal-title":"Pituitary"},{"key":"445_CR5","first-page":"53","volume":"86","author":"FJ Hayes","year":"2001","unstructured":"F.J. Hayes, S. DeCruz, S.B. Seminara et al., Differential regulation of gonadotropin secretion by testosterone in the human male: absence of a negative feedback effectof testosterone on follicle-stimulating hormone secretion. J. Clin. Endocrinol. Metab. 86, 53\u201358 (2001)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"445_CR6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yhbeh.2004.02.003","volume":"46","author":"J Bakker","year":"2004","unstructured":"J. Bakker, S. Honda, N. Harada, J. Balthazart, Restoration of male sexual behavior by adultexogenous estrogens in male aromatase knockout mice. Horm. Behav. 46, 1\u201310 (2004)","journal-title":"Horm. Behav."},{"key":"445_CR7","first-page":"61","volume":"31","author":"M Hiltunen","year":"2006","unstructured":"M. Hiltunen, S. Iivonen, H. Soininen, Aromatase enzyme and Alzheimer\u2019s disease. Minerva Endocrinol. 31, 61\u201373 (2006)","journal-title":"Minerva Endocrinol."},{"key":"445_CR8","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s004410051248","volume":"295","author":"J Carretero","year":"1999","unstructured":"J. Carretero, G. V\u00e1zquez, E. Blanco, Immunohistochemical evidence of the presence of aromatase P450 in the rat hypophysis. Cell Tissue Res. 295, 419\u2013423 (1999)","journal-title":"Cell Tissue Res."},{"key":"445_CR9","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s11102-007-0065-3","volume":"11","author":"P Kadioglu","year":"2008","unstructured":"P. Kadioglu, G. Oral, M. Sayitoglu et al., Aromatase cytochrome P450 enzyme expression in human pituitary. Pituitary 11, 29\u201335 (2008)","journal-title":"Pituitary"},{"key":"445_CR10","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0304-3835(97)00455-2","volume":"124","author":"TJ Spady","year":"1998","unstructured":"T.J. Spady, D.M.E. Harvell, M.C. Snyder et al., Estrogen-induced tumorigenesis in the Copenhagen rat: disparate susceptibilies to development of prolactin-producing pituitary tumors and mammary carcinomas. Cancer Lett. 124, 95\u2013103 (1998)","journal-title":"Cancer Lett."},{"issue":"1097","key":"445_CR11","first-page":"e13","volume":"94","author":"K Garc\u00eda-Malpartida","year":"2010","unstructured":"K. Garc\u00eda-Malpartida, A. Mart\u00edn-Gorgojo, M. Rocha et al., Prolactinoma induced by estrogen and cyproterone acetate in a male-to-female transsexual. Fertil. Steril. 94(1097), e13\u2013e15 (2010)","journal-title":"Fertil. Steril."},{"key":"445_CR12","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1258\/0004563053492784","volume":"42","author":"R Sodi","year":"2005","unstructured":"R. Sodi, R. Fikri, M. Diver et al., Testosterone replacement-induced hyperprolactinaemia: case report and review of the literature. Ann. Clin. Biochem. 42, 153\u2013159 (2005)","journal-title":"Ann. Clin. Biochem."},{"issue":"6","key":"445_CR13","doi-asserted-by":"crossref","first-page":"e101403","DOI":"10.1371\/journal.pone.0101403","volume":"9","author":"MJ Garc\u00eda Barrado","year":"2014","unstructured":"M.J. Garc\u00eda Barrado, E.J. Blanco, M. Carretero Hern\u00e1ndez et al., Local transformations of androgens into estradiol by aromatase p450 is involved in the regulation of prolactin and the proliferation of pituitary prolactin-positive cells. PLoS ONE 9(6), e101403 (2014)","journal-title":"PLoS ONE"},{"issue":"4","key":"445_CR14","doi-asserted-by":"crossref","first-page":"E521","DOI":"10.1210\/jc.2011-3347","volume":"97","author":"V Birzniece","year":"2012","unstructured":"V. Birzniece, S. Sutanto, K.K. Ho, Gender difference in the neuroendocrine regulation of growth hormone axis by selective estrogen receptor modulators. J. Clin. Endocrinol. Metab. 97(4), E521\u2013E527 (2012)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"445_CR15","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1210\/jc.2011-2837","volume":"97","author":"V Birzniece","year":"2012","unstructured":"V. Birzniece, U.J. Meinhardt, J. Gibney et al., Differential effects of raloxifene and estrogen on body composition in growth hormone-replaced hypopituitary women. J. Clin. Endocrinol. Metab. 97, 1005\u20131012 (2012)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"445_CR16","first-page":"1407","volume":"76","author":"AJ Weissberger","year":"1993","unstructured":"A.J. Weissberger, K.K. Ho, Activation of the somatotropic axis by testosterone in adult males: evidence for the role of aromatization. J. Clin. Endocrinol. Metab. 76, 1407\u20131412 (1993)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"445_CR17","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1210\/jc.2008-2108","volume":"94","author":"JD Veldhuis","year":"2009","unstructured":"J.D. Veldhuis, K.L. Mielke, M. Cosma et al., Aromatase and 5alpha-reductase inhibition during an exogenous testosterone clamp unveils selective sex steroid modulation of somatostatin and growth hormone secretagogue actions in healthy older men. J. Clin. Endocrinol. Metab. 94, 973\u2013978 (2009)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"445_CR18","first-page":"3414","volume":"82","author":"JD Veldhuis","year":"1997","unstructured":"J.D. Veldhuis, D.L. Metzger, P.M. Martha et al., Estrogen and testosterone, but not a nonaromatizable androgen, direct network integration of the hypothalamo-somatotrope (growth hormone)-insulin-like growth factor I axis in the human: evidence from pubertal pathophysiology and sex-steroid hormone replacement. J. Clin. Endocrinol. Metab. 82, 3414\u20133420 (1997)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"445_CR19","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1530\/eje.0.1500481","volume":"150","author":"EV Dimaraki","year":"2004","unstructured":"E.V. Dimaraki, K.V. Symons, A.L. Barkan, Raloxifene decreases serum IGF-I in male patients with active acromegaly. Eur. J. Endocrinol. 150, 481\u2013487 (2004)","journal-title":"Eur. J. Endocrinol."},{"key":"445_CR20","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1136\/jcp.48.9.876","volume":"48","author":"S Detre","year":"1995","unstructured":"S. Detre, G. Saccani Jotti, M. Dowsett, A \u201cquickscore\u201d method for immunohistochemical semiquantitation: validation for oestrogen receptor in breast carcinomas. J. Clin. Pathol. 48, 876\u2013878 (1995)","journal-title":"J. Clin. Pathol."},{"issue":"7","key":"445_CR21","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1210\/jc.2009-2670","volume":"95","author":"A Giustina","year":"2010","unstructured":"A. Giustina, P. Chanson, M.D. Bronstein et al., A consensus on criteria for cure of acromegaly. J. Clin. Endocrinol. Metab. 95(7), 3141\u20133148 (2010)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"445_CR22","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1677\/joe.1.06508","volume":"188","author":"LA Nolan","year":"2006","unstructured":"L.A. Nolan, A. Levy, The effects of testosterone and oestrogen on gonadectomised and intact male rat anterior pituitary mitotic andapoptotic activity. J. Endocrinol. 188, 387\u2013396 (2006)","journal-title":"J. Endocrinol."},{"key":"445_CR23","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1210\/jcem-64-2-391","volume":"64","author":"JC Prior","year":"1987","unstructured":"J.C. Prior, T.A. Cox, D. Fairholm et al., Testosterone-related exacerbation of a prolactin-producing macroadenoma: possible role for estrogen. J. Clin. Endocrinol. Metab. 64, 391\u2013394 (1987)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"445_CR24","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1210\/jcem-62-1-159","volume":"62","author":"K Link","year":"1986","unstructured":"K. Link, R.M. Blizzard, W.S. Evans et al., The effect of androgens on the pulsatile release and the twenty-four-hour mean concentration of growth hormone in peripubertal males. J. Clin. Endocrinol. Metab. 62, 159\u2013164 (1986)","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"4","key":"445_CR25","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1210\/jc.2009-1743","volume":"95","author":"V Rochira","year":"2010","unstructured":"V. Rochira, L. Zirilli, L. Maffei et al., Tall stature without growth hormone: four male patients with aromatase deficiency. J. Clin. Endocrinol. Metab. 95(4), 1626\u20131633 (2010)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"445_CR26","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.aanat.2013.01.009","volume":"195","author":"J Carretero","year":"2013","unstructured":"J. Carretero, E.J. Blanco, M. Carretero et al., The expression of AIB1 correlates with cellular proliferation in human prolactinomas. Ann Anat. 195, 253\u2013259 (2013)","journal-title":"Ann Anat."},{"key":"445_CR27","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1677\/joe.1.06508","volume":"188","author":"LA Nolan","year":"2006","unstructured":"L.A. Nolan, A. Levy, The effects of testosterone and oestrogen on gonadectomised and intact male rat anterior pituitary mitotic and apoptotic activity. J. Endocrinol. 188, 387\u2013396 (2006)","journal-title":"J. Endocrinol."},{"issue":"3","key":"445_CR28","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1159\/000077269","volume":"79","author":"JF Pereira-Lima","year":"2004","unstructured":"J.F. Pereira-Lima, C.P. Marroni, C.B. Pizarro et al., Immunohistochemical detection of ER-alpha in pituitary adenomas and its correlation with cellular replication. Neuroendocrinology 79(3), 119\u2013124 (2004)","journal-title":"Neuroendocrinology"},{"issue":"11","key":"445_CR29","doi-asserted-by":"crossref","first-page":"4196","DOI":"10.1210\/en.2002-220353","volume":"143","author":"DA Schreihofer","year":"2002","unstructured":"D.A. Schreihofer, D.F. Rowe, E.F. Rissman et al., Estrogen receptor-alpha (ERalpha), but not ERbeta, modulates estrogen stimulation of the ERalpha-truncated variant, TERP-1. Endocrinology 143(11), 4196\u20134202 (2002)","journal-title":"Endocrinology"},{"key":"445_CR30","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1046\/j.0007-1331.2001.00744.x","volume":"14","author":"MA Shupnik","year":"2002","unstructured":"M.A. Shupnik, Oestrogen receptors, receptor variants and oestrogen actions in the hypothalamic-pituitary axis. J. Neuroendocrinol. 14, 85\u201394 (2002)","journal-title":"J. Neuroendocrinol."},{"issue":"6","key":"445_CR31","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1159\/000071310","volume":"77","author":"M Bondanelli","year":"2003","unstructured":"M. Bondanelli, M.R. Ambrosio, A. Margutti et al., Activation of the somatotropic axis by testosterone in adult men: evidence for a role of hypothalamic growth hormone-releasing hormone. Neuroendocrinology 77(6), 380\u2013387 (2003)","journal-title":"Neuroendocrinology"},{"issue":"4","key":"445_CR32","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1210\/en.2004-1111","volume":"146","author":"GV Childs","year":"2005","unstructured":"G.V. Childs, M. Iruthayanathan, N. Akhter et al., Bipotential effects of estrogen on growth hormone synthesis and storage in vitro. Endocrinology 146(4), 1780\u20131788 (2005)","journal-title":"Endocrinology"},{"key":"445_CR33","doi-asserted-by":"crossref","unstructured":"I. Balili, A. Barkan, Tamoxifen as a therapeutic agent in acromegaly. Pituitary (2013).\u00a0doi: 10.1007\/s11102-013-0534-9","DOI":"10.1007\/s11102-013-0534-9"},{"issue":"3","key":"445_CR34","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/s11102-013-0504-2","volume":"17","author":"JC Stone","year":"2014","unstructured":"J.C. Stone, J. Clark, R. Cuneo, A.W. Russell, S.A. Doi, Estrogen and selective estrogen receptor modulators (SERMs) for the treatment of acromegaly: a meta-analysis of published observational studies. Pituitary 17(3), 284\u2013295 (2014)","journal-title":"Pituitary"}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-014-0445-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12020-014-0445-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-014-0445-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T01:43:07Z","timestamp":1565919787000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12020-014-0445-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,10]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["445"],"URL":"https:\/\/doi.org\/10.1007\/s12020-014-0445-1","relation":{},"ISSN":["1355-008X","1559-0100"],"issn-type":[{"value":"1355-008X","type":"print"},{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,10]]}}}