{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T09:48:46Z","timestamp":1781257726836,"version":"3.54.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2014,12,27]],"date-time":"2014-12-27T00:00:00Z","timestamp":1419638400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1007\/s12020-014-0513-6","type":"journal-article","created":{"date-parts":[[2014,12,26]],"date-time":"2014-12-26T02:00:46Z","timestamp":1419559246000},"page":"777-782","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["The association with Turner syndrome significantly affects the course of Hashimoto\u2019s thyroiditis in children, irrespective of karyotype"],"prefix":"10.1007","volume":"50","author":[{"given":"Tommaso","family":"Aversa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Francesca","family":"Messina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Mazzanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariacarolina","family":"Salerno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Mussa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Felicia","family":"Faienza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Scarano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"De Luca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Wasniewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,12,27]]},"reference":[{"key":"513_CR1","doi-asserted-by":"crossref","first-page":"A538","DOI":"10.1016\/j.autrev.2011.11.015","volume":"11","author":"A Lleo","year":"2012","unstructured":"A. Lleo, L. Moroni, L. Caliari, P. Invernizzi, Autoimmunity and Turner\u2019s syndrome. Autoimmun. Rev. 11, A538\u2013A543 (2012)","journal-title":"Autoimmun. Rev."},{"key":"513_CR2","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.1210\/jc.2009-0384","volume":"94","author":"VK Bakalov","year":"2009","unstructured":"V.K. Bakalov, C. Cheng, J. Zhou, C.A. Bondy, X-chromosome gene dosage and the risk of diabetes in Turner syndrome. J. Clin. Endocrinol. Metab. 94, 3289\u20133296 (2009)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"513_CR3","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1089\/thy.2005.15.1061","volume":"15","author":"S Livadas","year":"2005","unstructured":"S. Livadas, P. Xekouki, F. Fouka, C. Kanaka-Gantenbein, I. Kaloumenou, A. Mavrou, N. Constantinidou, C. Dacou-Voutetakis, Prevalence of thyroid dysfunction in Turner\u2019s syndrome: a long-term follow-up study and brief literature review. Thyroid 15, 1061\u20131066 (2005)","journal-title":"Thyroid"},{"key":"513_CR4","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1507\/endocrj.K09E-141","volume":"56","author":"I Fukuda","year":"2009","unstructured":"I. Fukuda, N. Hizuka, M. Kurimoto, J. Morita, S. Tanaka, Y. Yamakado, K. Takano, Autoimmune thyroid diseases in 65 Japanese women with Turner syndrome. Endocr. J. 56, 983\u2013986 (2009)","journal-title":"Endocr. J."},{"key":"513_CR5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jaut.2009.03.002","volume":"33","author":"D Larizza","year":"2009","unstructured":"D. Larizza, V. Calcaterra, M. Martinetti, Autoimmune stigmata in Turner syndrome: when lacks an X chromosome. J. Autoimmun. 33, 25\u201330 (2009)","journal-title":"J. Autoimmun."},{"key":"513_CR6","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1824-7288-39-79","volume":"39","author":"A Grossi","year":"2013","unstructured":"A. Grossi, A. Crin\u00f2, R. Luciano, A. Lombardo, M. Cappa, A. Fierabracci, Endocrine autoimmunity in Turner syndrome. Ital. J. Pediatr. 39, 79 (2013)","journal-title":"Ital. J. Pediatr."},{"key":"513_CR7","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/art.27270","volume":"62","author":"KT J\u00f8rgensen","year":"2010","unstructured":"K.T. J\u00f8rgensen, K. Rostgaard, I. Bache, R.J. Biggar, N.M. Nielsen, N. Tommerup, M. Frisch, Autoimmune diseases in women with Turner\u2019s syndrome. Arthritis Rheum. 62, 658\u2013666 (2010)","journal-title":"Arthritis Rheum."},{"key":"513_CR8","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1530\/eje.0.1340568","volume":"134","author":"L Chiovato","year":"1996","unstructured":"L. Chiovato, D. Larizza, G. Bendinelli, M. Tonacchera, M. Marin\u00f3, C. Mammoli, R. Lorini, F. Severi, A. Pinchera, Autoimmune hypothyroidism and hyperthyroidism in patients with Turner\u2019s syndrome. Eur. J. Endocrinol. 134, 568\u2013575 (1996)","journal-title":"Eur. J. Endocrinol."},{"key":"513_CR9","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1111\/j.1651-2227.1995.tb13791.x","volume":"84","author":"G Radetti","year":"1995","unstructured":"G. Radetti, L. Mazzanti, C. Paganini, S. Bernasconi, G. Russo, F. Rigon, E. Cacciari, Frequency, clinical and laboratory features of thyroiditis in girls with Turner\u2019s syndrome. The Italian Study Group for Turner\u2019s Syndrome. Acta Paediatr. 84, 909\u2013912 (1995)","journal-title":"Acta Paediatr."},{"key":"513_CR10","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1046\/j.1365-2265.2001.01296.x","volume":"55","author":"M Elsheikh","year":"2001","unstructured":"M. Elsheikh, J.A. Wass, G.S. Conway, Autoimmune thyroid syndrome in women with Turner\u2019s syndrome\u2014the association with karyotype. Clin. Endocrinol. 55, 223\u2013226 (2001)","journal-title":"Clin. Endocrinol."},{"key":"513_CR11","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1159\/000331050","volume":"76","author":"A Gawlik","year":"2011","unstructured":"A. Gawlik, T. Gawlik, A. Januszek-Trzciakowska, H. Patel, E. Malecka-Tendera, Incidence and dynamics of thyroid dysfunction and thyroid autoimmunity in girls with Turner\u2019s syndrome: a long-term follow-up study. Horm. Res. Paediatr. 76, 314\u2013320 (2011)","journal-title":"Horm. Res. Paediatr."},{"key":"513_CR12","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/BF03346552","volume":"33","author":"M Wasniewska","year":"2010","unstructured":"M. Wasniewska, A. Corrias, M.F. Messina, G. Crisafulli, G. Salzano, M. Valenzise, A. Mussa, F. De Luca, Graves\u2019 disease prevalence in a young population with Turner syndrome. J. Endocrinol. Invest. 33, 69\u201370 (2010)","journal-title":"J. Endocrinol. Invest."},{"key":"513_CR13","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1159\/000357130","volume":"81","author":"M Valenzise","year":"2014","unstructured":"M. Valenzise, T. Aversa, A. Corrias, L. Mazzanti, M. Cappa, G. Ubertini, E. Scarano, A. Mussa, M.F. Messina, F. De Luca, M. Wasniewska, Epidemiology, presentation and long-term evolution of Graves\u2019 disease in children, adolescents and young adults with Turner syndrome. Horm. Res. Paediatr. 81, 245\u2013250 (2014)","journal-title":"Horm. Res. Paediatr."},{"key":"513_CR14","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1159\/000343815","volume":"78","author":"M Wasniewska","year":"2012","unstructured":"M. Wasniewska, A. Corrias, M. Salerno, A. Mussa, D. Capalbo, M.F. Messina, T. Aversa, S. Bombaci, F. De Luca, M. Valenzise, Thyroid function patterns at Hashimoto\u2019s thyroiditis presentation in childhood and adolescence are mainly conditioned by patients\u2019 age. Horm. Res. Paediatr. 78, 232\u2013236 (2012)","journal-title":"Horm. Res. Paediatr."},{"key":"513_CR15","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/BF03346340","volume":"30","author":"M Niedziela","year":"2007","unstructured":"M. Niedziela, Subclinical hypothyroidism: dilemmas in the treatment of children. J. Endocrinol. Invest. 30, 529\u2013531 (2007)","journal-title":"J. Endocrinol. Invest."},{"key":"513_CR16","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1530\/EJE-08-0625","volume":"160","author":"M Wasniewska","year":"2009","unstructured":"M. Wasniewska, M. Salerno, A. Cassio, A. Corrias, T. Aversa, G. Zirilli, D. Capalbo, M. Bal, A. Mussa, F. De Luca, Prospective evaluation of the natural course of idiopathic subclinical hypothyroidism in childhood and adolescence. Eur. J. Endocrinol. 160, 417\u2013421 (2009)","journal-title":"Eur. J. Endocrinol."},{"key":"513_CR17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1824-7288-36-11","volume":"36","author":"F Luca De","year":"2010","unstructured":"F. De Luca, M. Wasniewska, G. Zirilli, T. Aversa, T. Arrigo, At the end of a two-year follow-up elevated TSH levels normalize or remain unchanged in most the children with subclinical hypothyroidism. Ital. J. Pediatr. 36, 11 (2010)","journal-title":"Ital. J. Pediatr."},{"key":"513_CR18","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1530\/EJE-10-0979","volume":"164","author":"M Cerbone","year":"2011","unstructured":"M. Cerbone, C. Bravaccio, D. Capalbo, M. Polizzi, M. Wasniewska, D. Cioffi, N. Improda, M. Valenzise, D. Bruzzese, F. De Luca, M. Salerno, Linear growth and intellectual outcome in children with long-term idiopathic subclinical hypothyroidism. Eur. J. Endocrinol. 164, 591\u2013597 (2011)","journal-title":"Eur. J. Endocrinol."},{"key":"513_CR19","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1159\/000339156","volume":"77","author":"M Wasniewska","year":"2012","unstructured":"M. Wasniewska, A. Corrias, T. Aversa, M. Valenzise, A. Mussa, L. De Martino, F. Lombardo, F. De Luca, M. Salerno, Comparative evaluation of therapy with L-thyroxine versus no treatment in children with idiopathic and mild subclinical hypothyroidism. Horm. Res. Paediatr. 77, 376\u2013381 (2012)","journal-title":"Horm. Res. Paediatr."},{"key":"513_CR20","first-page":"63","volume":"66","author":"F Luca De","year":"2014","unstructured":"F. De Luca, D. Corica, E. Pitrolo, S. Santucci, M. Romeo, Idiopathic and mild subclinical hypothyroidism in childhood: clinical management. Minerva Pediatr. 66, 63\u201368 (2014)","journal-title":"Minerva Pediatr."},{"key":"513_CR21","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1530\/EJE-12-0656","volume":"168","author":"A Monzani","year":"2012","unstructured":"A. Monzani, F. Prodam, A. Rapa, S. Moia, V. Agarla, S. Bellone, G. Bona, Endocrine disorders in childhood and adolescence. Natural history of subclinical hypothyroidism in children and adolescents and potential effects of replacement therapy: a review. Eur. J. Endocrinol. 168, R1\u2013R11 (2012)","journal-title":"Eur. J. Endocrinol."},{"key":"513_CR22","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/j.1365-2265.2011.04251.x","volume":"76","author":"G Radetti","year":"2012","unstructured":"G. Radetti, M. Maselli, F. Buzi, A. Corrias, A. Mussa, P. Cambiaso, M. Salerno, M. Cappa, M. Baiocchi, R. Gastaldi, L. Minerba, S. Loche, The natural history of the normal\/mild elevated TSH serum levels in children and adolescents with Hashimoto\u2019s thyroiditis and isolated hyperthyrotropinaemia: a 3-year follow-up. Clin. Endocrinol. 76, 394\u2013398 (2012)","journal-title":"Clin. Endocrinol."},{"issue":"Suppl. 1","key":"513_CR23","first-page":"23","volume":"5","author":"G Bona","year":"2013","unstructured":"G. Bona, F. Prodam, A. Monzani, Subclinical hypothyroidism in children: natural history and when to treat. J. Clin. Res. Pediatr. Endocrinol. 5(Suppl. 1), 23\u201328 (2013)","journal-title":"J. Clin. Res. Pediatr. Endocrinol."},{"key":"513_CR24","doi-asserted-by":"crossref","unstructured":"T. Aversa, M. Valenzise, A. Corrias, M. Salerno, F. De Luca, A. Mussa, M. Rezzuto, F. Lombardo, M. Wasniewska: Underlying Hashimoto\u2019s thyroiditis negatively affects the evolution of subclinical hypothyroidism in children irrespectively of other concomitant risk factors. Thyroid. (2014 Nov 3) [Epub ahead of print]","DOI":"10.1089\/thy.2014.0235"},{"key":"513_CR25","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1089\/thy.2008.0142","volume":"18","author":"B Champion","year":"2008","unstructured":"B. Champion, B. Gopinath, G. Ma, S. El-Kaissi, J.R. Wall, Conversion to Graves\u2019 hyperthyroidism in a patient with hypothyroidism due to Hashimoto\u2019s thyroiditis documented by real-time thyroid ultrasonography. Thyroid 18, 1135\u20131137 (2008)","journal-title":"Thyroid"},{"key":"513_CR26","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1089\/thy.2008.1551","volume":"18","author":"M Ludgate","year":"2008","unstructured":"M. Ludgate, C.H. Emerson, Metamorphic thyroid autoimmunity. Thyroid 18, 1035\u20131037 (2008)","journal-title":"Thyroid"},{"key":"513_CR27","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1159\/000313395","volume":"73","author":"M Wasniewska","year":"2010","unstructured":"M. Wasniewska, A. Corrias, T. Arrigo, F. Lombardo, M. Salerno, A. Mussa, M.C. Vigone, F. De Luca, Frequency of Hashimoto\u2019s thyroiditis antecedents in the history of children and adolescents with Graves\u2019 disease. Horm. Res. Paediatr. 73, 473\u2013476 (2010)","journal-title":"Horm. Res. Paediatr."},{"key":"513_CR28","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1365-2265.2012.04397.x","volume":"77","author":"C Kamath","year":"2012","unstructured":"C. Kamath, S. Young, K. Kabelis, J. Sanders, M.A. Adlan, J. Furmaniak, B. Rees Smith, L.D. Premawardhana, Thyrotrophin receptor antibody characteristics in a woman with long-standing Hashimoto\u2019s who developed Graves\u2019 disease and pretibial myxoedema. Clin. Endocrinol. 77, 465\u2013470 (2012)","journal-title":"Clin. Endocrinol."},{"key":"513_CR29","first-page":"13","volume":"3","author":"A Troisi","year":"2013","unstructured":"A. Troisi, P. Novati, L. Sali, M. Colzani, G. Monti, C. Cardillo, M. Tesauro, Graves\u2019 thyrotoxicosis following Hashimoto\u2019s thyroiditis. Res. Rep. Endocr. Disord. 3, 13\u201315 (2013)","journal-title":"Res. Rep. Endocr. Disord."},{"key":"513_CR30","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1089\/thy.2013.0452","volume":"24","author":"T Aversa","year":"2014","unstructured":"T. Aversa, F. Lombardo, A. Corrias, M. Salerno, F. De Luca, M. Wasniewska, In young patients with Turner or Down syndrome, Graves\u2019 disease presentation is often preceded by Hashimoto\u2019s thyroiditis. Thyroid 24, 744\u2013747 (2014)","journal-title":"Thyroid"}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-014-0513-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12020-014-0513-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-014-0513-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,18]],"date-time":"2019-08-18T20:54:54Z","timestamp":1566161694000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12020-014-0513-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,27]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["513"],"URL":"https:\/\/doi.org\/10.1007\/s12020-014-0513-6","relation":{},"ISSN":["1355-008X","1559-0100"],"issn-type":[{"value":"1355-008X","type":"print"},{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,27]]}}}