{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:10:18Z","timestamp":1781277018831,"version":"3.54.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2015,11,17]],"date-time":"2015-11-17T00:00:00Z","timestamp":1447718400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1007\/s12020-015-0783-7","type":"journal-article","created":{"date-parts":[[2015,11,17]],"date-time":"2015-11-17T06:31:29Z","timestamp":1447741889000},"page":"344-351","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Copeptin under glucagon stimulation"],"prefix":"10.1007","volume":"52","author":[{"given":"Krzysztof C.","family":"Lewandowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Lewi\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u017cbieta","family":"Skowro\u0144ska-J\u00f3\u017awiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Stasiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Horzelski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Brabant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,11,17]]},"reference":[{"key":"783_CR1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/295299a0","volume":"295","author":"H Land","year":"1982","unstructured":"H. Land, G. Schutz, H. Schmale, D. Richter, Nucleotide sequence of cloned cDNA encoding bovine arginine vasopressin-neurophysin II precursor. Nature 295, 299\u2013303 (1982)","journal-title":"Nature"},{"key":"783_CR2","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1373\/clinchem.2005.060038","volume":"52","author":"NG Morgenthaler","year":"2006","unstructured":"N.G. Morgenthaler, J. Struck, C. Alonso, A. Bergmann, Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin. Clin. Chem. 52, 112\u2013119 (2006)","journal-title":"Clin. Chem."},{"key":"783_CR3","doi-asserted-by":"crossref","first-page":"4656","DOI":"10.1210\/jc.2014-2295","volume":"99","author":"R Roussel","year":"2014","unstructured":"R. Roussel, L. Fezeu, M. Marre et al., Comparison between copeptin and vasopressin in a population from the community and in people with chronic kidney disease. J. Clin. Endocrinol. Metab. 99, 4656\u20134663 (2014)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"783_CR4","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1210\/jc.2006-2046","volume":"92","author":"M Katan","year":"2007","unstructured":"M. Katan, N.G. Morgenthaler, K.C.S. Dixit, J. Rutishauser, G.E. Brabant, B. M\u00fcller, M. Christ-Crain, Anterior and posterior pituitary function testing with simultaneous insulin tolerance test and a novel copeptin assay. J. Clin. Endocrinol. Metab. 92, 2640\u20132643 (2007)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"783_CR5","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/299355a0","volume":"299","author":"GE Gillies","year":"1982","unstructured":"G.E. Gillies, E.A. Linton, P.J. Lowry, Corticotropin releasing activity of the new CRF is potentiated several times by vasopressin. Nature 299, 355\u2013357 (1982)","journal-title":"Nature"},{"key":"783_CR6","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/305325a0","volume":"305","author":"C Rivier","year":"1983","unstructured":"C. Rivier, W. Vale, Modulation of stress-induced ACTH release by corticotropin-releasing factor, catecholamines and vasopressin. Nature 305, 325\u2013327 (1983)","journal-title":"Nature"},{"key":"783_CR7","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1741-7015-10-7","volume":"10","author":"CH Nickel","year":"2012","unstructured":"C.H. Nickel, R. Bingisser, N.G. Morgenthaler, The role of copeptin as a diagnostic and prognostic biomarker for risk stratification in the emergency department. BMC Med. 10, 7\u201313 (2012)","journal-title":"BMC Med."},{"key":"783_CR8","doi-asserted-by":"crossref","first-page":"172","DOI":"10.11613\/BM.2013.021","volume":"23","author":"L Dobsa","year":"2013","unstructured":"L. Dobsa, K.C. Edozien, Copeptin and its potential role in diagnosis and prognosis of various diseases. Biochem. Med. 23, 172\u2013190 (2013)","journal-title":"Biochem. Med."},{"key":"783_CR9","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1046\/j.1365-2265.2002.01472.x","volume":"56","author":"JM G\u00f3mez","year":"2002","unstructured":"J.M. G\u00f3mez, R.M. Espadero, F. Escobar-Jim\u00e9nez, F. Hawkins, P. Antonio, H.-P. Jos Luis, V. Enric, D. Alejandra, M. Jordi, F. Eduardo, S. Anna, Growth hormone release after glucagon as a reliable test of growth hormone assessment in adults. Clin. Endocrinol. 56, 329\u2013334 (2002)","journal-title":"Clin. Endocrinol."},{"key":"783_CR10","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1515\/JPEM.2005.18.5.433","volume":"18","author":"A B\u00f6ttner","year":"2005","unstructured":"A. B\u00f6ttner, J. Kratzsch, S. Liebermann, K. Alexandra, W.P. Roland, K. Wieland, K. Eberhard, Comparison of adrenal function tests in children\u2014the glucagon stimulation test allows the simultaneous assessment of adrenal function and growth hormone response in children. J. Pediatr. Endocrinol. Metab. 18, 433\u2013442 (2005)","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"783_CR11","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1046\/j.1365-2265.1996.d01-1562.x","volume":"45","author":"SM Orme","year":"1996","unstructured":"S.M. Orme, S.R. Peacey, J.H. Bath, P.E. Belchetz, Comparison of tests of stress-released cortisol secretion in pituitary disease. Clin. Endocrinol. (Oxford) 45, 135\u2013140 (1996)","journal-title":"Clin. Endocrinol. (Oxford)"},{"key":"783_CR12","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1016\/j.peptides.2005.04.019","volume":"26","author":"J Struck","year":"2005","unstructured":"J. Struck, N.G. Morgenthaler, A. Bergmann, Copeptin, a stable peptide derived from the vasopressin precursor, is elevated in serum of sepsis patients. Peptides 26, 2500\u20132504 (2005)","journal-title":"Peptides"},{"key":"783_CR13","doi-asserted-by":"crossref","first-page":"325","DOI":"10.4158\/EP11146.OR","volume":"18","author":"A Toogood","year":"2012","unstructured":"A. Toogood, G. Brabant, D. Maiter, B. Jonsson, U. Feldt-Rasmussen, M. Koltowska-Haggstrom, A.K. Rasmussen, M. Buchfelder, B. Saller, B.M. Biller, Similar clinical features among patients with severe adult growth hormone deficiency diagnosed with insulin tolerance test or arginine or glucagon stimulation test. Endocr. Pract. 18, 325\u2013334 (2012)","journal-title":"Endocr. Pract."},{"key":"783_CR14","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1530\/EJE-09-0824","volume":"162","author":"C Berg","year":"2010","unstructured":"C. Berg, T. Meinel, H. Lahner, A. Yuece, K. Mann, S. Petersenn, Diagnostic utility of the glucagon stimulation test in comparison with the insulin tolerance test in patients following pituitary surgery. Eur. J. Endocrinol. 162, 477\u2013482 (2010)","journal-title":"Eur. J. Endocrinol."},{"key":"783_CR15","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/cen.12397","volume":"81","author":"HY Cho","year":"2014","unstructured":"H.Y. Cho, J.H. Kim, S.W. Kim, C.S. Shin, K.S. Park, S.W. Kim, H.C. Jang, S.Y. Kim, Different cut-off values of the insulin tolerance test, the high-dose short Synacthen test (250\u00a0\u00b5g) and the low-dose short Synacthen test (1\u00a0\u00b5g) in assessing central adrenal insufficiency. Clin. Endocrinol. (Oxford) 81, 77\u201384 (2014)","journal-title":"Clin. Endocrinol. (Oxford)"},{"key":"783_CR16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/cen.12528","volume":"82","author":"Y Simsek","year":"2015","unstructured":"Y. Simsek, Z. Karaca, F. Tanriverdi, K. Unluhizarci, A. Selcuklu, F. Kelestimur, A comparison of low-dose ACTH, glucagon stimulation and insulin tolerance test in patients with pituitary disorders. Clin. Endocrinol. (Oxford) 82, 45\u201352 (2015)","journal-title":"Clin. Endocrinol. (Oxford)"},{"key":"783_CR17","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/cen.12608","volume":"82","author":"S Kacheva","year":"2015","unstructured":"S. Kacheva, K. Kolk, N.G. Morgenthaler, G. Brabant, W. Karges, Gender-specific co-activation of arginine vasopressin and the hypothalamic-pituitary-adrenal axis during stress. Clin. Endocrinol. (Oxford) 82, 570\u2013576 (2015)","journal-title":"Clin. Endocrinol. (Oxford)"},{"key":"783_CR18","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1161\/CIRCULATIONAHA.109.909663","volume":"121","author":"S Enhorning","year":"2010","unstructured":"S. Enhorning, T.J. Wang, P.M. Nilsson, P. Almgren, B. Hedblad, G. Berglund, J. Struck, N.G. Morgenthaler, A. Bergmann, E. Lindholm, L. Groop, V. Lyssenko, M. Orho-Melander, C. Newton-Cheh, O. Melander, Plasma copeptin and the risk of diabetes mellitus. Circulation 121, 2102\u20132108 (2010)","journal-title":"Circulation"},{"key":"783_CR19","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1172\/JCI200419656","volume":"113","author":"A Tanoue","year":"2004","unstructured":"A. Tanoue, S. Ito, K. Honda, S. Oshikawa, Y. Kitagawa, T. Koshimizu, T. Mori, G. Tsujimoto, The vasopressin V1b receptor critically regulates hypothalamic-pituitary-adrenal axis activity under both stress and resting conditions. J. Clin. Investig. 113, 302\u2013309 (2004)","journal-title":"J. Clin. Investig."},{"key":"783_CR20","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0079-6123(08)00403-2","volume":"170","author":"G Aguilera","year":"2008","unstructured":"G. Aguilera, S. Subburaju, S. Young, J. Chen, The parvocellular vasopressinergic system and responsiveness of the hypothalamic pituitary axis adrenal axis during chronic stress. Prog. Brain Res. 170, 29\u201339 (2008)","journal-title":"Prog. Brain Res."},{"key":"783_CR21","first-page":"341","volume":"29","author":"M Katan","year":"2008","unstructured":"M. Katan, N. Morgenthaler, I. Widmer, J.J. Puder, C. Koning, B. Muller, M. Christ-Crain et al., Copeptin, a stable peptide derived from the vasopressin precursor, correlates with the individual stress level. Neuroendocrinol. Lett. 29, 341\u2013346 (2008)","journal-title":"Neuroendocrinol. Lett."},{"key":"783_CR22","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1530\/eje.0.1430099","volume":"143","author":"E Arvat","year":"2000","unstructured":"E. Arvat, B. Maccagno, J. Ramunni, M. Maccario, R. Giordano, F. Broglio, F. Cammanni, E. Ghigo, Interaction between glucagon and human corticotropin-releasing hormone or vasopressin on ACTH and cortisol secretion in humans. Eur. J. Endocrinol. 143, 99\u2013104 (2000)","journal-title":"Eur. J. Endocrinol."},{"key":"783_CR23","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1159\/000284355","volume":"73","author":"I Kreitschmann-Andermahr","year":"2010","unstructured":"I. Kreitschmann-Andermahr, P. Suarez, R. Jennings, N. Evers, G. Brabant, GH\/IGF-I regulation in obesity\u2013mechanisms and practical consequences in children and adults. Hormon. Res. Paediatr. 73, 153\u2013160 (2010)","journal-title":"Hormon. Res. Paediatr."},{"key":"783_CR24","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.ghir.2014.09.002","volume":"24","author":"S Savastano","year":"2014","unstructured":"S. Savastano, C. Di Somma, L. Barrea et al., The complex relationship between obesity and the somatropic axis: the long and winding road. Growth Hormon. IGF Res. 24, 221\u2013226 (2014)","journal-title":"Growth Hormon. IGF Res."},{"key":"783_CR25","doi-asserted-by":"crossref","first-page":"4712","DOI":"10.1210\/jc.2014-2830","volume":"99","author":"LE Dichtel","year":"2014","unstructured":"L.E. Dichtel, K.C. Yuen, M.A. Bredella, A.V. Gerweck, B.M. Russell, A.D. Riccio, M.H. Gurel, P.M. Sluss, B.M. Biller, K.K. Miller, Overweight\/obese adults with pituitary disorders require lower peak growth hormone cutoff values on glucagon stimulation testing to avoid overdiagnosis of growth hormone deficiency. J. Clin. Endocrinol. Metab. 99, 4712\u20134719 (2014)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"783_CR26","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1210\/jcem.87.2.8193","volume":"87","author":"C Sch\u00f6fl","year":"2002","unstructured":"C. Sch\u00f6fl, A. Schleth, D. Berger, C. Terkamp, A. von zur M\u00fchlen, G. Brabant, Sympathoadrenal counterregulation in patients with hypothalamic craniopharyngioma. J. Clin. Endocrinol. Metab. 87, 624\u2013629 (2002)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"783_CR27","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1530\/eje.0.1430601","volume":"143","author":"E Arvat","year":"2000","unstructured":"E. Arvat, B. Maccagno, J. Ramunni, R. Giordano, F. Broglio, L. Gianotti, M. Maccario, F. Camanni, E. Ghigo, Interaction between glucagon and hexarelin, a peptidyl GH secretagogue, on somatotroph and corticotroph secretion in humans. Eur. J. Endocrinol. 143, 601\u2013606 (2000)","journal-title":"Eur. J. Endocrinol."},{"key":"783_CR28","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1046\/j.1365-2265.2001.01169.x","volume":"54","author":"KS Leong","year":"2001","unstructured":"K.S. Leong, A.B. Walker, I. Martin, D. Wile, J. Wilding, I.A. MacFarlane, An audit of 500 subcutaneous glucagon stimulation tests to assess growth hormone and ACTH secretion in patients with hypothalamo-pituitary disease. Clin. Endocrinol. (Oxford) 54, 463\u2013468 (2001)","journal-title":"Clin. Endocrinol. (Oxford)"},{"issue":"1","key":"783_CR29","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3109\/10253890.2014.993966","volume":"18","author":"SA Urwyler","year":"2015","unstructured":"S.A. Urwyler, P. Schuetz, C. Sailer, M. Christ-Crain, Copeptin\u00a0as a\u00a0stress\u00a0marker prior and after a written examination\u2014the CoEXAM study. Stress 18(1), 134\u2013137 (2015)","journal-title":"Stress"},{"key":"783_CR30","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1530\/EJE-14-0405","volume":"171","author":"J Siegenthaler","year":"2014","unstructured":"J. Siegenthaler, C. Walti, S.A. Urwyler, P. Schuetz, M. Christ-Crain, Copeptin\u00a0concentrations during psychological\u00a0stress: the PsyCo study. Eur. J. Endocrinol. 171, 737\u2013742 (2014)","journal-title":"Eur. J. Endocrinol."},{"key":"783_CR31","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.psychres.2014.11.078","volume":"226","author":"O Geisel","year":"2015","unstructured":"O. Geisel, P. Panneck, R. Hellweg, K. Wiedermann, C.A. M\u00fcller, Hypothalamic-pituitary-adrenal axis activity in patients with pathological gambling and internet use disorder. Psychiatry Res. 226, 97\u2013102 (2015)","journal-title":"Psychiatry Res."},{"key":"783_CR32","doi-asserted-by":"crossref","first-page":"R115","DOI":"10.1530\/EJE-14-0824","volume":"172","author":"B Allolio","year":"2015","unstructured":"B. Allolio, Extensive expertise in endocrinology. Adrenal crisis. Eur. J. Endocrinol. 172, R115\u2013R2434 (2015)","journal-title":"Eur. J. Endocrinol."},{"key":"783_CR33","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1007\/s12020-013-9919-9","volume":"44","author":"A Wuttke","year":"2013","unstructured":"A. Wuttke, K.C. Dixit, G. Szinnai, S.C. Werth, U. Haagen, M. Christ-Crain, N. Morgenthaler, G. Brabant, Copeptin\u00a0as a marker for arginine-vasopressin\/antidiuretic hormone secretion in the diagnosis of paraneoplastic syndrome of inappropriate ADH secretion. Endocrine 44, 744\u2013749 (2013)","journal-title":"Endocrine"}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-015-0783-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12020-015-0783-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-015-0783-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T15:06:44Z","timestamp":1553612804000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12020-015-0783-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,17]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["783"],"URL":"https:\/\/doi.org\/10.1007\/s12020-015-0783-7","relation":{},"ISSN":["1355-008X","1559-0100"],"issn-type":[{"value":"1355-008X","type":"print"},{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,17]]}}}