{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:32:11Z","timestamp":1783654331010,"version":"3.55.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T00:00:00Z","timestamp":1454976000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370680"],"award-info":[{"award-number":["81370680"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The specialized research fund for the doctoral program of Chinese Ministry of Education","award":["20130171130009"],"award-info":[{"award-number":["20130171130009"]}]},{"name":"The Natural Science Foundation of Key Research Project of Guangdong Province","award":["2013020012660"],"award-info":[{"award-number":["2013020012660"]}]},{"name":"2010 Key project of research of National Ministry of Health","award":["WGCH [2010]439<\/"],"award-info":[{"award-number":["WGCH [2010]439<\/"]}]},{"name":"Fund of Natural Science Foundation of Guangdong Province, China","award":["2014A030310069"],"award-info":[{"award-number":["2014A030310069"]}]},{"name":"Naional Natural Science Foundation of China","award":["81402168"],"award-info":[{"award-number":["81402168"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1007\/s12020-016-0878-9","type":"journal-article","created":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T09:45:27Z","timestamp":1455011127000},"page":"280-290","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Identification of several circulating microRNAs from a genome-wide circulating microRNA expression profile as potential biomarkers for impaired glucose metabolism in polycystic ovarian syndrome"],"prefix":"10.1007","volume":"53","author":[{"given":"Linlin","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yabo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongzi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,2,9]]},"reference":[{"issue":"5","key":"878_CR1","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1016\/j.fertnstert.2004.11.070","volume":"83","author":"CM DeUgarte","year":"2005","unstructured":"C.M. DeUgarte, A.A. Bartolucci, R. Azziz, Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment. Fertil. Steril. 83(5), 1454\u20131460 (2005). doi: 10.1016\/j.fertnstert.2004.11.070","journal-title":"Fertil. Steril."},{"issue":"8","key":"878_CR2","doi-asserted-by":"publisher","first-page":"2027","DOI":"10.1093\/humrep\/del142","volume":"21","author":"X Chen","year":"2006","unstructured":"X. Chen, D. Yang, L. Li, S. Feng, L. Wang, Abnormal glucose tolerance in Chinese women with polycystic ovary syndrome. Hum. Reprod. 21(8), 2027\u20132032 (2006). doi: 10.1093\/humrep\/del142","journal-title":"Hum. Reprod."},{"issue":"3","key":"878_CR3","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1530\/EJE-09-0298","volume":"161","author":"RM Ni","year":"2009","unstructured":"R.M. Ni, Y. Mo, X. Chen, J. Zhong, W. Liu, D. Yang, Low prevalence of the metabolic syndrome but high occurrence of various metabolic disorders in Chinese women with polycystic ovary syndrome. Eur. J. Endocrinol. 161(3), 411\u2013418 (2009)","journal-title":"Eur. J. Endocrinol."},{"key":"878_CR4","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/1477-7827-8-142","volume":"8","author":"J Huang","year":"2010","unstructured":"J. Huang, R. Ni, X. Chen, L. Huang, Y. Mo, D. Yang, Metabolic abnormalities in adolescents with polycystic ovary syndrome in south China. Reprod. Biol. Endocrinol. 8, 142 (2010). doi: 10.1186\/1477-7827-8-142","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"9","key":"878_CR5","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1093\/humrep\/16.9.1995","volume":"16","author":"RJ Norman","year":"2001","unstructured":"R.J. Norman, L. Masters, C.R. Milner, J.X. Wang, M.J. Davies, Relative risk of conversion from normoglycaemia to impaired glucose tolerance or non-insulin dependent diabetes mellitus in polycystic ovarian syndrome. Hum. Reprod. 16(9), 1995\u20131998 (2001)","journal-title":"Hum. Reprod."},{"issue":"7","key":"878_CR6","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.tem.2007.08.001","volume":"18","author":"HJ Teede","year":"2007","unstructured":"H.J. Teede, S.K. Hutchison, S. Zoungas, The management of insulin resistance in polycystic ovary syndrome. Trends Endocrinol. Metab. 18(7), 273\u2013279 (2007)","journal-title":"Trends Endocrinol. Metab."},{"issue":"6","key":"878_CR7","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1210\/jc.2013-1161","volume":"98","author":"D Sarra Di","year":"2013","unstructured":"D. Di Sarra, F. Tosi, C. Bonin, T. Fiers, J.M. Kaufman, C. Signori, F. Zambotti, M. Dall\u2019Alda, B. Caruso, M.E. Zanolin, E. Bonora, P. Moghetti, Metabolic inflexibility is a feature of women with polycystic ovary syndrome and is associated with both insulin resistance and hyperandrogenism. J. Clin. Endocrinol. Metab. 98(6), 2581\u20132588 (2013)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"878_CR8","volume-title":"The microRNA: overview of the RNA gene that modulates gene functions MicroRNA Protocols1-18","author":"S Ying","year":"2006","unstructured":"S. Ying, D.C. Chang, J.D. Miller, S. Lin The microRNA: overview of the RNA gene that modulates gene functions MicroRNA Protocols1-18 (Springer, Berlin, 2006)"},{"key":"878_CR9","volume-title":"Evolution of microRNAs MicroRNA Protocols335-350","author":"A Tanzer","year":"2006","unstructured":"A. Tanzer, P.F. Stadler, Evolution of microRNAs MicroRNA Protocols335-350 (Springer, New York, 2006)"},{"issue":"8","key":"878_CR10","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nrclinonc.2011.76","volume":"8","author":"MA Cortez","year":"2011","unstructured":"M.A. Cortez, C. Bueso-Ramos, J. Ferdin, G. Lopez-Berestein, A.K. Sood, G.A. Calin, MicroRNAs in body fluids\u2014the mix of hormones and biomarkers. Nat. Rev. Clin. Oncol. 8(8), 467\u2013477 (2011)","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"7209","key":"878_CR11","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nature07228","volume":"455","author":"M Selbach","year":"2008","unstructured":"M. Selbach, B. Schwanh\u00e4usser, N. Thierfelder, Z. Fang, R. Khanin, N. Rajewsky, Widespread changes in protein synthesis induced by microRNAs. Nature 455(7209), 58\u201363 (2008)","journal-title":"Nature"},{"issue":"12","key":"878_CR12","doi-asserted-by":"crossref","first-page":"E2271","DOI":"10.1210\/jc.2012-1996","volume":"97","author":"DS Karolina","year":"2012","unstructured":"D.S. Karolina, S. Tavintharan, A. Armugam, S. Sepramaniam, S.L. Pek, M.T. Wong, S.C. Lim, C.F. Sum, K. Jeyaseelan, Circulating miRNA profiles in patients with metabolic syndrome. J. Clin. Endocrinol. Metab. 97(12), E2271\u2013E2276 (2012)","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"878_CR13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jgg.2011.11.007","volume":"39","author":"MAS Dehwah","year":"2012","unstructured":"M.A.S. Dehwah, A. Xu, Q. Huang, MicroRNAs and type 2 diabetes\/obesity. J. Genet. Genomics. 39(1), 11\u201318 (2012)","journal-title":"J. Genet. Genomics."},{"issue":"15","key":"878_CR14","doi-asserted-by":"publisher","first-page":"2474","DOI":"10.1016\/j.febslet.2013.06.023","volume":"587","author":"A Dai","year":"2013","unstructured":"A. Dai, H. Sun, T. Fang, Q. Zhang, S. Wu, Y. Jiang, L. Ding, G. Yan, Y. Hu, MicroRNA-133b stimulates ovarian estradiol synthesis by targeting Foxl2. FEBS Lett. 587(15), 2474\u20132482 (2013). doi: 10.1016\/j.febslet.2013.06.023","journal-title":"FEBS Lett."},{"issue":"2","key":"878_CR15","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1002\/jcp.21689","volume":"219","author":"AV Sirotkin","year":"2009","unstructured":"A.V. Sirotkin, D. Ovcharenko, R. Grossmann, M. Laukova, M. Mlyncek, Identification of microRNAs controlling human ovarian cell steroidogenesis via a genome-scale screen. J. Cell. Physiol. 219(2), 415\u2013420 (2009). doi: 10.1002\/jcp.21689","journal-title":"J. Cell. Physiol."},{"issue":"5","key":"878_CR16","doi-asserted-by":"publisher","first-page":"E729","DOI":"10.1210\/jc.2014-3827","volume":"100","author":"L Jiang","year":"2015","unstructured":"L. Jiang, J. Huang, L. Li, Y. Chen, X. Chen, X. Zhao, D. Yang, MicroRNA-93 promotes ovarian granulosa cells proliferation through targeting CDKN1A in polycystic ovarian syndrome. J. Clin. Endocrinol. Metab. 100(5), E729\u2013E738 (2015). doi: 10.1210\/jc.2014-3827","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"878_CR17","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.pharmthera.2012.08.003","volume":"136","author":"RS Redis","year":"2012","unstructured":"R.S. Redis, S. Calin, Y. Yang, M.J. You, G.A. Calin, Cell-to-cell miRNA transfer: from body homeostasis to therapy. Pharmacol. Ther. 136(2), 169\u2013174 (2012)","journal-title":"Pharmacol. Ther."},{"issue":"10","key":"878_CR18","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1111\/j.1349-7006.2010.01650.x","volume":"101","author":"N Kosaka","year":"2010","unstructured":"N. Kosaka, H. Iguchi, T. Ochiya, Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis. Cancer Sci. 101(10), 2087\u20132092 (2010). doi: 10.1111\/j.1349-7006.2010.01650.x","journal-title":"Cancer Sci."},{"issue":"5","key":"878_CR19","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1159\/000358698","volume":"33","author":"W Long","year":"2014","unstructured":"W. Long, C. Zhao, C. Ji, H. Ding, Y. Cui, X. Guo, R. Shen, J. Liu, Characterization of serum microRNAs profile of PCOS and identification of novel non-invasive biomarkers. Cell. Physiol. Biochem. 33(5), 1304\u20131315 (2014). doi: 10.1159\/000358698","journal-title":"Cell. Physiol. Biochem."},{"issue":"1","key":"878_CR20","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3109\/14647273.2014.956811","volume":"18","author":"CF Ding","year":"2015","unstructured":"C.F. Ding, W.Q. Chen, Y.T. Zhu, Y.L. Bo, H.M. Hu, R.H. Zheng, Circulating microRNAs in patients with polycystic ovary syndrome. Hum. Fertil. (Camb) 18(1), 22\u201329 (2015). doi: 10.3109\/14647273.2014.956811","journal-title":"Hum. Fertil. (Camb)"},{"issue":"11","key":"878_CR21","doi-asserted-by":"publisher","first-page":"4402","DOI":"10.1073\/pnas.0813371106","volume":"106","author":"K Wang","year":"2009","unstructured":"K. Wang, S. Zhang, B. Marzolf, P. Troisch, A. Brightman, Z. Hu, L.E. Hood, D.J. Galas, Circulating microRNAs, potential biomarkers for drug-induced liver injury. Proc. Natl. Acad. Sci. USA 106(11), 4402\u20134407 (2009). doi: 10.1073\/pnas.0813371106","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"878_CR22","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.bbrc.2014.10.064","volume":"454","author":"M Xiang","year":"2014","unstructured":"M. Xiang, Y. Zeng, R. Yang, H. Xu, Z. Chen, J. Zhong, H. Xie, Y. Xu, X. Zeng, U6 is not a suitable endogenous control for the quantification of circulating microRNAs. Biochem. Biophys. Res. Commun. 454(1), 210\u2013214 (2014). doi: 10.1016\/j.bbrc.2014.10.064","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"878_CR23","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1097\/SLA.0b013e3181cc939f","volume":"251","author":"HM Heneghan","year":"2010","unstructured":"H.M. Heneghan, N. Miller, A.J. Lowery, K.J. Sweeney, J. Newell, M.J. Kerin, Circulating microRNAs as novel minimally invasive biomarkers for breast cancer. Ann. Surg. 251(3), 499\u2013505 (2010). doi: 10.1097\/SLA.0b013e3181cc939f","journal-title":"Ann. Surg."},{"issue":"1","key":"878_CR24","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1002\/ijc.25007","volume":"127","author":"Z Huang","year":"2010","unstructured":"Z. Huang, D. Huang, S. Ni, Z. Peng, W. Sheng, X. Du, Plasma microRNAs are promising novel biomarkers for early detection of colorectal cancer. Int. J. Cancer 127(1), 118\u2013126 (2010). doi: 10.1002\/ijc.25007","journal-title":"Int. J. Cancer"},{"issue":"9","key":"878_CR25","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1158\/1940-6207.CAPR-09-0094","volume":"2","author":"J Wang","year":"2009","unstructured":"J. Wang, J. Chen, P. Chang, A. LeBlanc, D. Li, J.L. Abbruzzesse, M.L. Frazier, A.M. Killary, S. Sen, MicroRNAs in plasma of pancreatic ductal adenocarcinoma patients as novel blood-based biomarkers of disease. Cancer Prev. Res. (Phila) 2(9), 807\u2013813 (2009). doi: 10.1158\/1940-6207.CAPR-09-0094","journal-title":"Cancer Prev. Res. (Phila)"},{"issue":"5","key":"878_CR26","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1111\/j.1365-2141.2008.07077.x","volume":"141","author":"CH Lawrie","year":"2008","unstructured":"C.H. Lawrie, S. Gal, H.M. Dunlop, B. Pushkaran, A.P. Liggins, K. Pulford, A.H. Banham, F. Pezzella, J. Boultwood, J.S. Wainscoat, C.S. Hatton, A.L. Harris, Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma. Br. J. Haematol. 141(5), 672\u2013675 (2008). doi: 10.1111\/j.1365-2141.2008.07077.x","journal-title":"Br. J. Haematol."},{"issue":"9","key":"878_CR27","doi-asserted-by":"publisher","first-page":"2588","DOI":"10.1158\/1078-0432.CCR-07-0666","volume":"14","author":"TS Wong","year":"2008","unstructured":"T.S. Wong, X.B. Liu, B.Y. Wong, R.W. Ng, A.P. Yuen, W.I. Wei, Mature miR-184 as potential oncogenic microRNA of squamous cell carcinoma of tongue. Clin. Cancer Res. 14(9), 2588\u20132592 (2008). doi: 10.1158\/1078-0432.CCR-07-0666","journal-title":"Clin. Cancer Res."},{"issue":"Web Server issu","key":"878_CR28","doi-asserted-by":"publisher","first-page":"W498","DOI":"10.1093\/nar\/gks494","volume":"40","author":"IS Vlachos","year":"2012","unstructured":"I.S. Vlachos, N. Kostoulas, T. Vergoulis, G. Georgakilas, M. Reczko, M. Maragkakis, M.D. Paraskevopoulou, K. Prionidis, T. Dalamagas, A.G. Hatzigeorgiou, DIANA miRPath v.2.0: investigating the combinatorial effect of microRNAs in pathways. Nucleic Acids Res 40(Web Server issue), W498\u2013W504 (2012). doi: 10.1093\/nar\/gks494","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"878_CR29","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1530\/EJE-14-0867","volume":"172","author":"R Wang","year":"2015","unstructured":"R. Wang, J. Hong, Y. Cao, J. Shi, W. Gu, G. Ning, Y. Zhang, W. Wang, Elevated circulating microRNA-122 is associated with obesity and insulin resistance in young adults. Eur. J. Endocrinol. 172(3), 291\u2013300 (2015). doi: 10.1530\/EJE-14-0867","journal-title":"Eur. J. Endocrinol."},{"issue":"8","key":"878_CR30","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.2337\/db11-1508","volume":"61","author":"E Arner","year":"2012","unstructured":"E. Arner, N. Mejhert, A. Kulyte, P.J. Balwierz, M. Pachkov, M. Cormont, S. Lorente-Cebrian, A. Ehrlund, J. Laurencikiene, P. Heden, K. Dahlman-Wright, J.F. Tanti, Y. Hayashizaki, M. Ryden, I. Dahlman, E. van Nimwegen, C.O. Daub, P. Arner, Adipose tissue microRNAs as regulators of CCL2 production in human obesity. Diabetes 61(8), 1986\u20131993 (2012). doi: 10.2337\/db11-1508","journal-title":"Diabetes"},{"issue":"6","key":"878_CR31","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1097\/SHK.0000000000000258","volume":"42","author":"Y Yu","year":"2014","unstructured":"Y. Yu, J. Chai, H. Zhang, W. Chu, L. Liu, L. Ma, H. Duan, B. Li, D. Li, miR-194 Promotes burn-induced hyperglycemia via attenuating IGF-IR expression. Shock 42(6), 578\u2013584 (2014). doi: 10.1097\/SHK.0000000000000258","journal-title":"Shock"},{"issue":"7","key":"878_CR32","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1093\/molehr\/gaq017","volume":"16","author":"HW Ahn","year":"2010","unstructured":"H.W. Ahn, R.D. Morin, H. Zhao, R.A. Harris, C. Coarfa, Z.J. Chen, A. Milosavljevic, M.A. Marra, A. Rajkovic, MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing. Mol. Hum. Reprod. 16(7), 463\u2013471 (2010). doi: 10.1093\/molehr\/gaq017","journal-title":"Mol. Hum. Reprod."},{"issue":"1","key":"878_CR33","doi-asserted-by":"publisher","first-page":"e54319","DOI":"10.1371\/journal.pone.0054319","volume":"8","author":"FI Milagro","year":"2013","unstructured":"F.I. Milagro, J. Miranda, M.P. Portillo, A. Fernandez-Quintela, J. Campion, J.A. Martinez, High-throughput sequencing of microRNAs in peripheral blood mononuclear cells: identification of potential weight loss biomarkers. PLoS One 8(1), e54319 (2013). doi: 10.1371\/journal.pone.0054319","journal-title":"PLoS One"},{"issue":"2","key":"878_CR34","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1111\/j.1467-789X.2012.01053.x","volume":"14","author":"SS Lim","year":"2013","unstructured":"S.S. Lim, R.J. Norman, M.J. Davies, L.J. Moran, The effect of obesity on polycystic ovary syndrome: a systematic review and meta-analysis. Obes. Rev. 14(2), 95\u2013109 (2013). doi: 10.1111\/j.1467-789X.2012.01053.x","journal-title":"Obes. Rev."},{"issue":"5","key":"878_CR35","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1007\/s00125-015-3532-9","volume":"58","author":"S Koren","year":"2015","unstructured":"S. Koren, L.M. DiPilato, M.J. Emmett, A.L. Shearin, Q. Chu, B. Monks, M.J. Birnbaum, The role of mouse Akt2 in insulin-dependent suppression of adipocyte lipolysis in vivo. Diabetologia 58(5), 1063\u20131070 (2015). doi: 10.1007\/s00125-015-3532-9","journal-title":"Diabetologia"},{"issue":"4","key":"878_CR36","doi-asserted-by":"crossref","first-page":"935","DOI":"10.2337\/diabetes.52.4.935","volume":"52","author":"JJ Brozinick","year":"2003","unstructured":"J.J. Brozinick, B.R. Roberts, G.L. Dohm, Defective signaling through Akt-2 and -3 but not Akt-1 in insulin-resistant human skeletal muscle: potential role in insulin resistance. Diabetes 52(4), 935\u2013941 (2003)","journal-title":"Diabetes"},{"issue":"3","key":"878_CR37","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.jcte.2015.06.002","volume":"2","author":"N Xu","year":"2015","unstructured":"N. Xu, D.H. Geller, M.R. Jones, V.A. Funari, R. Azziz, M.O. Goodarzi, Comprehensive assessment of expression of insulin signaling pathway components in subcutaneous adipose tissue of women with and without polycystic ovary syndrome. J. Clin. Transl. Endocrinol. 2(3), 99\u2013104 (2015). doi: 10.1016\/j.jcte.2015.06.002","journal-title":"J. Clin. Transl. Endocrinol."},{"key":"878_CR38","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-267856","author":"Y Cheng","year":"2015","unstructured":"Y. Cheng, Y. Feng, L. Jansson, Y. Sato, M. Deguchi, K. Kawamura, A.J. Hsueh, Actin polymerization-enhancing drugs promote ovarian follicle growth mediated by the Hippo signaling effector YAP. FASEB J. (2015). doi: 10.1096\/fj.14-267856","journal-title":"FASEB J."},{"issue":"43","key":"878_CR39","doi-asserted-by":"publisher","first-page":"17474","DOI":"10.1073\/pnas.1312830110","volume":"110","author":"K Kawamura","year":"2013","unstructured":"K. Kawamura, Y. Cheng, N. Suzuki, M. Deguchi, Y. Sato, S. Takae, C.H. Ho, N. Kawamura, M. Tamura, S. Hashimoto, Y. Sugishita, Y. Morimoto, Y. Hosoi, N. Yoshioka, B. Ishizuka, A.J. Hsueh, Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment. Proc. Natl. Acad. Sci. USA 110(43), 17474\u201317479 (2013). doi: 10.1073\/pnas.1312830110","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"3","key":"878_CR40","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1210\/jc.2013-3399","volume":"99","author":"MW O\u2019Reilly","year":"2014","unstructured":"M.W. O\u2019Reilly, A.E. Taylor, N.J. Crabtree, B.A. Hughes, F. Capper, R.K. Crowley, P.M. Stewart, J.W. Tomlinson, W. Arlt, Hyperandrogenemia predicts metabolic phenotype in polycystic ovary syndrome: the utility of serum androstenedione. J. Clin. Endocrinol. Metab. 99(3), 1027\u20131036 (2014)","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"12","key":"878_CR41","doi-asserted-by":"crossref","first-page":"E1967","DOI":"10.1210\/jc.2013-2815","volume":"98","author":"M Brower","year":"2013","unstructured":"M. Brower, K. Brennan, M. Pall, R. Azziz, The severity of menstrual dysfunction as a predictor of insulin resistance in PCOS. J. Clin. Endocrinol. Metab. 98(12), E1967\u2013E1971 (2013)","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"878_CR42","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","volume":"136","author":"DP Bartel","year":"2009","unstructured":"D.P. Bartel, MicroRNAs: target recognition and regulatory functions. Cell 136(2), 215\u2013233 (2009). doi: 10.1016\/j.cell.2009.01.002","journal-title":"Cell"},{"issue":"7","key":"878_CR43","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1210\/jc.2013-1715","volume":"98","author":"Q Sang","year":"2013","unstructured":"Q. Sang, Z. Yao, H. Wang, R. Feng, H. Wang, X. Zhao, Q. Xing, L. Jin, L. He, L. Wu, Identification of microRNAs in human follicular fluid: characterization of microRNAs that govern steroidogenesis in vitro and are associated with polycystic ovary syndrome in vivo. J. Clin. Endocrinol. Metab. 98(7), 3068\u20133079 (2013)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"878_CR44","doi-asserted-by":"crossref","unstructured":"M. Murri, M.\u00ec.A. Insenser, E. Fern \u00ec ndez-Dur \u00ec n, L. Jos \u00ec, , Escobar-Morreale, H.\u00ec.C.F. Effects of polycystic ovary syndrome (PCOS), sex hormones, and obesity on circulating miRNA-21, miRNA-27b, miRNA-103 and miRNA-155 expression. J. Clin. Endocr. Metab. 2013\u20132218 (2013)","DOI":"10.1210\/jc.2013-2218"},{"issue":"5","key":"878_CR45","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s13238-012-2036-3","volume":"3","author":"J Hu","year":"2012","unstructured":"J. Hu, Y. Xu, J. Hao, S. Wang, C. Li, S. Meng, MiR-122 in hepatic function and liver diseases. Protein Cell 3(5), 364\u2013371 (2012)","journal-title":"Protein Cell"},{"issue":"3","key":"878_CR46","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1016\/j.tvjl.2013.03.027","volume":"197","author":"SN Fleischhacker","year":"2013","unstructured":"S.N. Fleischhacker, S. Bauersachs, A. Wehner, K. Hartmann, K. Weber, Differential expression of circulating microRNAs in diabetic and healthy lean cats. Vet. J. 197(3), 688\u2013693 (2013). doi: 10.1016\/j.tvjl.2013.03.027","journal-title":"Vet. J."},{"issue":"4","key":"878_CR47","doi-asserted-by":"crossref","first-page":"944","DOI":"10.18632\/oncotarget.1458","volume":"5","author":"MX Liu","year":"2014","unstructured":"M.X. Liu, M.K. Siu, S.S. Liu, J.W. Yam, H.Y. Ngan, D.W. Chan, Epigenetic silencing of microRNA-199b-5p is associated with acquired chemoresistance via activation of JAG1-Notch1 signaling in ovarian cancer. Oncotarget 5(4), 944\u2013958 (2014)","journal-title":"Oncotarget"},{"issue":"5","key":"878_CR48","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.2337\/dc13-1847","volume":"37","author":"FJ Ortega","year":"2014","unstructured":"F.J. Ortega, J.M. Mercader, J.M. Moreno-Navarrete, O. Rovira, E. Guerra, E. Esteve, G. Xifra, C. Martinez, W. Ricart, J. Rieusset, S. Rome, M. Karczewska-Kupczewska, M. Straczkowski, J.M. Fernandez-Real, Profiling of circulating microRNAs reveals common microRNAs linked to type 2 diabetes that change with insulin sensitization. Diabetes Care 37(5), 1375\u20131383 (2014). doi: 10.2337\/dc13-1847","journal-title":"Diabetes Care"}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-016-0878-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12020-016-0878-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-016-0878-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T07:29:15Z","timestamp":1567582155000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12020-016-0878-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,9]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["878"],"URL":"https:\/\/doi.org\/10.1007\/s12020-016-0878-9","relation":{},"ISSN":["1355-008X","1559-0100"],"issn-type":[{"value":"1355-008X","type":"print"},{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,9]]}}}