{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T22:25:59Z","timestamp":1770071159930,"version":"3.49.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2016,4,13]],"date-time":"2016-04-13T00:00:00Z","timestamp":1460505600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1007\/s12020-016-0951-4","type":"journal-article","created":{"date-parts":[[2016,4,14]],"date-time":"2016-04-14T11:33:46Z","timestamp":1460633626000},"page":"573-581","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["One-year GH replacement therapy reduces early cardiac target organ damage (TOD) in adult GHD patients"],"prefix":"10.1007","volume":"55","author":[{"given":"Mara","family":"Boschetti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Agosti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Albanese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Casalino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Teti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gian Paolo","family":"Bezante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Brunelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Albertelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Ferone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,4,13]]},"reference":[{"key":"951_CR1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0140-6736(90)91812-O","volume":"336","author":"TBB Rosen","year":"1990","unstructured":"T.B.B. Rosen, Premature mortality due to cardiovascular disease in hypopituitarism. Lancet 336, 285\u2013288 (1990)","journal-title":"Lancet"},{"key":"951_CR2","first-page":"1169","volume":"81","author":"AS Bates","year":"1996","unstructured":"A.S. Bates, W. Vant\u2019Hoff, P.J. Jones, R.N. Clayton, The effect of hypopituitarism on life expectancy. J Clin. Endocrinol. Metab. 81, 1169\u20131172 (1996)","journal-title":"J Clin. Endocrinol. Metab."},{"key":"951_CR3","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1046\/j.1365-2265.1997.d01-1749.x","volume":"46","author":"B B\u00fclow","year":"1997","unstructured":"B. B\u00fclow, L. Hagmar, Z. Mikoczy, C.H. Nordstr\u00f6m, E.M. Erfurth, Increased cerebrovascular mortality in patients with hypopituitarism. Clin. Endocrinol. 46, 75\u201381 (1997)","journal-title":"Clin. Endocrinol."},{"key":"951_CR4","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0140-6736(00)04006-X","volume":"357","author":"JW Tomlinson","year":"2001","unstructured":"J.W. Tomlinson, N. Holden, R.K. Hills, K. Wheatley, R.N. Clayton, A.S. Bates, M.C. Sheppard, P.M. Stewart, Association between premature mortality and hypopituitarism. West Midlands Prospective Hypopituitary Study Group. Lancet 357, 425\u2013431 (2001)","journal-title":"Lancet"},{"key":"951_CR5","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1210\/jcem.87.6.8542","volume":"87","author":"S Ezzat","year":"2002","unstructured":"S. Ezzat, S. Fear, R.C. Gaillard, C. Gayle, H. Landy, S. Marcovitz, T. Mattioni, S. Nussey, A. Rees, E. Svanberg, Gender-specific responses of lean body composition and non-gender-specific cardiac function improvement after GH replacement in GH-deficient adults. J. Clin. Endocrinol. Metab. 87, 2725\u20132733 (2002)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"951_CR6","first-page":"2373","volume":"84","author":"J Maaten Ter","year":"1999","unstructured":"J. Ter Maaten, H. De Boer, O. Kamp, L. Stuurman, E. Van der Veen, Long-term effects of growth hormone (GH) replacement in men with childhood-onset GH deficiency. J. Clin. Endocrinol. Metab. 84, 2373\u20132380 (1999)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"951_CR7","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1210\/jcem.84.8.5916","volume":"84","author":"J Gibney","year":"1999","unstructured":"J. Gibney, J.D. Wallace, T. Spinks, L. Schnorr, A. Ranicar, R.C. Cuneo, S. Lockhart, K.G. Burnand, F. Salomon, P.H. Sonksen, D. Russell-Jones, The effects of 10\u00a0years of recombinant human growth hormone (GH) in adult GH-deficient patients. J. Clin. Endocrinol. Metab. 84, 2596\u20132602 (1999)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"951_CR8","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1161\/01.CIR.0000100720.01867.1D","volume":"108","author":"P Maison","year":"2003","unstructured":"P. Maison, P. Chanson, Cardiac effects of growth hormone in adults with growth hormone deficiency: a meta-analysis. Circulation 108, 2648\u20132652 (2003)","journal-title":"Circulation"},{"issue":"9 Suppl","key":"951_CR9","first-page":"85","volume":"31","author":"M Boschetti","year":"2008","unstructured":"M. Boschetti, U. Goglia, C. Teti, D. Esposito, M. Giusti, F. Minuto, D. Ferone, Replacement therapy and cardiovascular diseases. J. Endocrinol. Invest. 31(9 Suppl), 85\u201390 (2008)","journal-title":"J. Endocrinol. Invest."},{"key":"951_CR10","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1056\/NEJM199910143411607","volume":"341","author":"ML Vance","year":"1999","unstructured":"M.L. Vance, N. Mauras, Growth hormone therapy in adults and children. N. Engl. J. Med. 341, 1206\u20131216 (1999)","journal-title":"N. Engl. J. Med."},{"key":"951_CR11","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1046\/j.1365-2265.2001.01218.x","volume":"54","author":"A Colao","year":"2001","unstructured":"A. Colao, C. Di Somma, P. Marzullo, G. Lombardi, Growth hormone and the heart. Clin. Endocrinol. 54, 137\u2013154 (2001)","journal-title":"Clin. Endocrinol."},{"key":"951_CR12","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/S0140-6736(89)92328-3","volume":"1","author":"JO Jorgensen","year":"1989","unstructured":"J.O. Jorgensen, S.A. Pedersen, L. Thuesen, J. Jorgensen, T. Ingemann-Hansen, N.E. Skakkebaek, J.S. Christiansen, Beneficial effects of growth hormone treatment in GH-deficient adults. Lancet 1, 1221\u20131225 (1989)","journal-title":"Lancet"},{"issue":"6","key":"951_CR13","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1210\/jc.2005-2566","volume":"91","author":"A Colao","year":"2006","unstructured":"A. Colao, C. Di Somma, S. Spiezia, F. Rota, R. Pivonello, S. Savastano, G. Lombardi, Partial GH deficiency in adults and cardiovascular risk. J. Clin. Endocrinol. Metab. 91(6), 2191\u20132200 (2006)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"951_CR14","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1056\/NEJM198912283212605","volume":"321","author":"F Salomon","year":"1989","unstructured":"F. Salomon, R.C. Cuneo, R. Hesp, P.H. S\u00f6nksen, The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. N. Engl. J. Med. 321, 1797\u20131803 (1989)","journal-title":"N. Engl. J. Med."},{"key":"951_CR15","first-page":"1874","volume":"86","author":"A Colao","year":"2001","unstructured":"A. Colao, C. Di Somma, A. Cuocolo, L. Spinelli, N. Tedesco, R. Pivonello, D. Bonaduce, M. Salvatore, G. Lombardi, Improved cardiovascular risk factors and cardiac performance after 12\u00a0months of growth hormone (GH) replacement in young adult patients with GH deficiency. J. Clin. Endocrinol. Metab. 86, 1874\u20131881 (2001)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"951_CR16","first-page":"1671","volume":"77","author":"G Amato","year":"1993","unstructured":"G. Amato, C. Carella, S. Fazio, G. La Montagna, A. Cittadini, D. Sabatini, C. Marciano-Mone, L. Sacc\u00e0, A. Bellastella, Body composition, bone metabolism, and heart structure and function in growth hormone (GH)-deficient adults before and after GH replacement therapy at low doses. J Clin. Endocrinol. Metab. 77, 1671\u20131676 (1993)","journal-title":"J Clin. Endocrinol. Metab."},{"issue":"6","key":"951_CR17","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1210\/jc.2011-0179","volume":"96","author":"ME Molitch","year":"2011","unstructured":"M.E. Molitch, D.R. Clemmons, S. Malozowski, G.R. Merriam, M.L. Vance, Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab. 96(6), 1587\u20131609 (2011)","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"3","key":"951_CR18","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1365-2265.2004.02109.x","volume":"61","author":"TA Abdu","year":"2004","unstructured":"T.A. Abdu, T.A. Elhadd, H. Buch, D. Barton, R. Neary, R.N. Clayton, Recombinant GH replacement in hypopituitary adults improves endothelial cell function and reduces calculated absolute and relative coronary risk. Clin. Endocrinol. 61(3), 387\u2013393 (2004)","journal-title":"Clin. Endocrinol."},{"issue":"2","key":"951_CR19","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1161\/01.ATV.0000051384.43104.FC","volume":"23","author":"PO Bonetti","year":"2003","unstructured":"P.O. Bonetti, L.O. Lerman, A. Lerman, Endothelial dysfunction: a marker of atherosclerotic risk. Arterioscler. Thromb. Vasc. Biol. 23(2), 168\u2013175 (2003)","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"951_CR20","first-page":"3","volume":"25","author":"F Rigo","year":"2005","unstructured":"F. Rigo, Coronary flow reserve in stress-echo lab: from pathophysiologic toy to diagnostic tool. Cardiovasc Ultrasound 25, 3\u20138 (2005)","journal-title":"Cardiovasc Ultrasound"},{"issue":"1","key":"951_CR21","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/0002-9149(74)90092-7","volume":"34","author":"KL Gould","year":"1974","unstructured":"K.L. Gould, K. Lipscomb, Effects of coronary stenoses on coronary flow reserve and resistance. Am. J. Cardiol. 34(1), 48\u201355 (1974)","journal-title":"Am. J. Cardiol."},{"issue":"6","key":"951_CR22","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","volume":"18","author":"WT Friedewald","year":"1972","unstructured":"W.T. Friedewald, R.I. Levy, D.S. Fredrickson, Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 18(6), 499\u2013502 (1972)","journal-title":"Clin. Chem."},{"issue":"8","key":"951_CR23","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.echo.2012.04.022","volume":"25","author":"M Ruscazio","year":"2012","unstructured":"M. Ruscazio, R. Montisci, G. Bezante, C. Caiati, M. Balbi, F. Tona, G. Lai, M. Cadeddu, R. Pirisi, C. Brunelli, S. Iliceto, L. Meloni, Early noninvasive evaluation of coronary flow reserve after angioplasty in the left anterior descending coronary artery identifies patients at high risk of restenosis at follow-up. J. Am. Soc. Echocardiogr. 25(8), 902\u2013910 (2012)","journal-title":"J. Am. Soc. Echocardiogr."},{"issue":"5","key":"951_CR24","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1161\/01.CIR.89.5.2150","volume":"89","author":"DD Miller","year":"1994","unstructured":"D.D. Miller, T.J. Donohue, L.T. Younis, R.G. Bach, F.V. Aguirre, M.D. Wittry, H.M. Goodgold, B.R. Chaitman, M.J. Kern, Correlation of pharmacological 99mTc-sestamibi myocardial perfusion imaging with poststenotic coronary flow reserve in patients with angiographically intermediate coronary artery stenoses. Circulation 89(5), 2150\u20132160 (1994)","journal-title":"Circulation"},{"issue":"5","key":"951_CR25","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/0735-1097(95)00569-2","volume":"27","author":"V Voudris","year":"1996","unstructured":"V. Voudris, A. Manginas, V. Vassilikos, M. Koutelou, J. Kantzis, D.V. Cokkinos, Coronary flow velocity changes after intravenous dipyridamole infusion: measurements using intravascular Doppler guide wire. A documentation of flow inhomogeneity. J Am. Coll. Cardiol. 27(5), 1148\u20131155 (1996)","journal-title":"J Am. Coll. Cardiol."},{"issue":"1","key":"951_CR26","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ijcard.2014.06.076","volume":"176","author":"I Haraldsson","year":"2014","unstructured":"I. Haraldsson, L.M. Gan, S. Svedlund, A. Wittfeldt, T. R\u00e5munddal, O. Anger\u00e5s, P. Albertsson, G. Matejka, E. Omerovic, Non-invasive evaluation of coronary flow reserve with transthoracic Doppler echocardiography predicts the presence of significant stenosis in coronary arteries. Int. J. Cardiol. 176(1), 294\u2013297 (2014)","journal-title":"Int. J. Cardiol."},{"issue":"1","key":"951_CR27","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.echo.2014.09.009","volume":"28","author":"TR Porter","year":"2015","unstructured":"T.R. Porter, S.K. Shillcutt, M.S. Adams, G. Desjardins, K.E. Glas, J.J. Olson, R.W. Troughton, Guidelines for the use of echocardiography as a monitor for therapeutic intervention in adults: a report from the american society of echocardiography. J. Am. Soc. Echocardiogr. 28(1), 40\u201356 (2015)","journal-title":"J. Am. Soc. Echocardiogr."},{"issue":"3","key":"951_CR28","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3122\/jabfm.18.3.189","volume":"18","author":"S Haney","year":"2005","unstructured":"S. Haney, D. Sur, Z. Xu, Diastolic heart failure: a review and primary care perspective. J. Am. Board Fam. Pract. 18(3), 189\u2013198 (2005)","journal-title":"J. Am. Board Fam. Pract."},{"issue":"5","key":"951_CR29","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/BF03346389","volume":"31","author":"G Aimaretti","year":"2008","unstructured":"G. Aimaretti, M. Boschetti, G. Corneli, V. Gasco, D. Valle, M. Borsotti, A. Rossi, A. Barreca, L. Fazzuoli, D. Ferone, E. Ghigo, F. Minuto, Normal age-dependent values of serum insulin growth factor-I: results from a healthy Italian population. J. Endocrinol. Invest. 31(5), 445\u2013449 (2008)","journal-title":"J. Endocrinol. Invest."},{"issue":"2","key":"951_CR30","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1046\/j.1365-2265.2001.01218.x","volume":"54","author":"A Colao","year":"2001","unstructured":"A. Colao, P. Marzullo, C. Di Somma, G. Lombardi, Growth hormone and the heart. Clin. Endocrinol. 54(2), 137\u2013154 (2001)","journal-title":"Clin. Endocrinol."},{"issue":"1","key":"951_CR31","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1210\/jc.2013-2394","volume":"99","author":"C Gazzaruso","year":"2014","unstructured":"C. Gazzaruso, M. Gola, I. Karamouzis, R. Giubbini, A. Giustina, Cardiovascular risk in adult patients with growth hormone (GH) deficiency and following substitution with GH\u2013an update. J. Clin. Endocrinol. Metab. 99(1), 18\u201329 (2014)","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"951_CR32","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1046\/j.1365-2265.1998.00589.x","volume":"49","author":"EM Erfurth","year":"1998","unstructured":"E.M. Erfurth, L. Hagmar, Cardiovascular mortality among pituitary insufficient patients. Clin. Endocrinol. 49(2), 271\u2013272 (1998)","journal-title":"Clin. Endocrinol."},{"issue":"6","key":"951_CR33","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/S0002-8703(99)70359-5","volume":"137","author":"A Giustina","year":"1999","unstructured":"A. Giustina, M. Volterrani, F. Manelli, P. Desenzani, C. Poiesi, R. Lorusso, A. Giordano, Endocrine predictors of acute hemodynamic effects of growth hormone in congestive heart failure. Am. Heart J. 137(6), 1035\u20131043 (1999)","journal-title":"Am. Heart J."},{"issue":"11","key":"951_CR34","doi-asserted-by":"crossref","first-page":"4219","DOI":"10.1210\/jc.2013-2415","volume":"98","author":"EM Erfurth","year":"2013","unstructured":"E.M. Erfurth, Update in mortality in GH-treated patients. J. Clin. Endocrinol. Metab. 98(11), 4219\u20134226 (2013)","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"951_CR35","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/oby.20856","volume":"23","author":"M Balaz","year":"2014","unstructured":"M. Balaz, B. Ukropcova, T. Kurdiova, L. Gajdosechova, M. Vlcek, Z. Janakova, J. Fedeles, M. Pura, D. Gasperikova, S.R. Smith, R. Tkacova, I. Klimes, J. Payer, C. Wolfrum, J. Ukropec, Growth hormone regulates zinc-\u03b12-glycoprotein, adipokine linked to insulin sensitivity. Obesity 23(2), 322\u2013328 (2014)","journal-title":"Obesity"},{"issue":"4","key":"951_CR36","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1111\/j.1365-2265.2007.02767.x","volume":"66","author":"H Oflaz","year":"2007","unstructured":"H. Oflaz, F. Sen, A. Elitok, A.O. Cimen, I. Onur, E. Kasikcioglu, S. Korkmaz, M. Demirturk, F. Kutluturk, B. Pamukcu, N. Ozbey, Coronary flow reserve is impaired in patients with adult growth hormone (GH) deficiency. Clin. Endocrinol. 66(4), 524\u2013529 (2007)","journal-title":"Clin. Endocrinol."},{"issue":"3","key":"951_CR37","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s12020-008-9037-2","volume":"32","author":"H Oflaz","year":"2007","unstructured":"H. Oflaz, R. Kurt, F. Sen, I. Onur, A.O. Cimen, A. Elitok, K. Turkmen, B. Pamukcu, E. Kasikcioglu, Z. Bugra, F. Mercanoglu, N. Ozbey, Coronary flow reserve after l-thyroxine therapy in Hashimoto\u2019s thyroiditis patients with subclinical and overt hypothyroidism. Endocrine 32(3), 264\u2013270 (2007)","journal-title":"Endocrine"},{"issue":"2","key":"951_CR38","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/ajh.2008.351","volume":"22","author":"GP Bezante","year":"2009","unstructured":"G.P. Bezante, F. Viazzi, G. Leoncini, E. Ratto, N. Conti, M. Balbi, S. Agosti, L. Deferrari, G. Deferrari, R. Pontremoli, Coronary flow reserve is impaired in hypertensive patients with subclinical renal damage. Am. J. Hypertens. 22(2), 191\u2013196 (2009)","journal-title":"Am. J. Hypertens."},{"issue":"9","key":"951_CR39","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1080\/08860220802353819","volume":"30","author":"H Oflaz","year":"2008","unstructured":"H. Oflaz, F. Sen, S.K. Bayrakli, A. Elitok, A.O. Cimen, E. Golcuk, E. Kasikcioglu, M. Tukenmez, H. Yazici, A. Turkmen, Reduced coronary flow reserve and early diastolic filling abnormalities in patients with nephrotic syndrome. Ren. Fail. 30(9), 914\u2013920 (2008)","journal-title":"Ren. Fail."},{"issue":"6","key":"951_CR40","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1111\/j.1399-0012.2008.00879.x","volume":"22","author":"Y Caliskan","year":"2008","unstructured":"Y. Caliskan, H. Oflaz, M. Demirturk, H. Yazici, A. Turkmen, A. Cimen, A. Elitok, A. Yildiz, Coronary flow reserve dysfunction in hemodialysis and kidney transplant patients. Clin. Transpl. 22(6), 785\u2013793 (2008)","journal-title":"Clin. Transpl."},{"issue":"1","key":"951_CR41","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.atherosclerosis.2010.01.049","volume":"211","author":"Y Yilmaz","year":"2010","unstructured":"Y. Yilmaz, R. Kurt, O. Yonal, N. Polat, C.A. Celikel, A. Gurdal, H. Oflaz, O. Ozdogan, N. Imeryuz, C. Kalayci, E. Avsar, Coronary flow reserve is impaired in patients with nonalcoholic fatty liver disease: association with liver fibrosis. Atherosclerosis 211(1), 182\u2013186 (2010)","journal-title":"Atherosclerosis"},{"issue":"4","key":"951_CR42","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1093\/rheumatology\/keh087","volume":"43","author":"A Sulli","year":"2004","unstructured":"A. Sulli, M. Ghio, G.P. Bezante, L. Deferrari, C. Craviotto, V. Sebastiani, M. Setti, A. Barsotti, M. Cutolo, F. Indiveri, Blunted coronary flow reserve in systemic sclerosis. Rheumatology 43(4), 505\u2013509 (2004)","journal-title":"Rheumatology"},{"issue":"3","key":"951_CR43","first-page":"775","volume":"18","author":"F Sen","year":"2013","unstructured":"F. Sen, I. Yildiz, M. Basaran, M. Ekenel, F. Oz, L. Kilic, B. Toz, A. Gurdal, H. Camlica, S. Bavbek, H. Oflaz, Impaired coronary flow reserve in metastatic cancer patients treated with sunitinib. J Buon 18(3), 775\u2013781 (2013)","journal-title":"J Buon"},{"issue":"16","key":"951_CR44","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1161\/01.CIR.101.16.1899","volume":"101","author":"V Sch\u00e4chinger","year":"2000","unstructured":"V. Sch\u00e4chinger, M.B. Britten, A.M. Zeiher, Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation 101(16), 1899\u20131906 (2000)","journal-title":"Circulation"},{"issue":"5","key":"951_CR45","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/01.mca.0000134590.99841.81","volume":"15","author":"MB Britten","year":"2004","unstructured":"M.B. Britten, A.M. Zeiher, V. Sch\u00e4chinger, Microvascular dysfunction in angiographically normal or mildly diseased coronary arteries predicts adverse cardiovascular long-term outcome. Coron. Artery Dis. 15(5), 259\u2013264 (2004)","journal-title":"Coron. Artery Dis."},{"issue":"5","key":"951_CR46","doi-asserted-by":"crossref","first-page":"H1882","DOI":"10.1152\/ajpheart.412.2008","volume":"295","author":"A Csiszar","year":"2008","unstructured":"A. Csiszar, N. Labinskyy, V. Perez, F.A. Recchia, A. Podlutsky, P. Mukhopadhyay, G. Losonczy, P. Pacher, S.N. Austad, A. Bartke, Z. Ungvari, Endothelial function and vascular oxidative stress in long-lived GH\/IGF-deficient Ames dwarf mice. Am. J. Physiol. Heart Circ. Physiol. 295(5), H1882\u2013H1894 (2008)","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"3","key":"951_CR47","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1530\/eje.0.1420254","volume":"142","author":"LM Evans","year":"2000","unstructured":"L.M. Evans, J.S. Davies, R.A. Anderson, G.R. Ellis, S.K. Jackson, M.J. Lewis, M.P. Frenneaux, A. Rees, M.F. Scanlon, The effect of GH replacement therapy on endothelial function and oxidative stress in adult growth hormone deficiency. Eur. J. Endocrinol. 142(3), 254\u2013262 (2000)","journal-title":"Eur. J. Endocrinol."},{"key":"951_CR48","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1210\/jc.2004-0545","volume":"90","author":"M Gola","year":"2005","unstructured":"M. Gola, S. Bonadonna, M. Doga, A. Giustina, Growth hormone and cardiovascular risk factors. J. Clin. Endocrinol. Metab. 90, 1864\u20131870 (2005)","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"4","key":"951_CR49","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1530\/eje.1.02125","volume":"154","author":"J Bollerslev","year":"2006","unstructured":"J. Bollerslev, T. Ueland, A.P. J\u00f8rgensen, K.J. Fougner, R. Wergeland, T. Schreiner, P. Burman, Positive effects of a physiological dose of GH on markers of atherogenesis: a placebo-controlled study in patients with adult-onset GH deficiency. Eur. J. Endocrinol. 154(4), 537\u2013543 (2006)","journal-title":"Eur. J. Endocrinol."},{"issue":"7","key":"951_CR50","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1007\/BF03345081","volume":"25","author":"N Ozbey","year":"2002","unstructured":"N. Ozbey, A. Sezgil, H. Oflaz, B. Umman, Y. Orhan, E. Sencer, S. Molvalilar, Left ventricular diastolic function abnormalities in hypopituitary patients with GH deficiency: evidence for a subclinical cardiomyopathy. J. Endocrinol. Invest. 25(7), 590\u2013597 (2002)","journal-title":"J. Endocrinol. Invest."},{"issue":"Suppl 1","key":"951_CR51","doi-asserted-by":"crossref","first-page":"S93","DOI":"10.1530\/eje.0.151S093","volume":"151","author":"A Colao","year":"2004","unstructured":"A. Colao, G. Vitale, R. Pivonello, A. Ciccarelli, C. Di Somma, G. Lombardi, The heart: an end-organ of GH action. Eur. J. Endocrinol. 151(Suppl 1), S93\u2013S101 (2004)","journal-title":"Eur. J. Endocrinol."},{"issue":"15","key":"951_CR52","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1161\/01.CIR.0000144309.87183.FB","volume":"110","author":"E Conti","year":"2004","unstructured":"E. Conti, C. Carrozza, E. Capoluongo, M. Volpe, F. Crea, C. Zuppi, F. Andreotti, Insulin-like growth factor-1 as a vascular protective factor. Circulation 110(15), 2260\u20132265 (2004)","journal-title":"Circulation"},{"issue":"2","key":"951_CR53","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ghir.2007.01.009","volume":"17","author":"M Shechter","year":"2007","unstructured":"M. Shechter, S. Ginsberg, M. Scheinowitz, M.S. Feinberg, Z. Laron, Obese adults with primary growth hormone resistance (Laron Syndrome) have normal endothelial function. Growth Horm IGF Res 17(2), 165\u2013170 (2007)","journal-title":"Growth Horm IGF Res"},{"issue":"6","key":"951_CR54","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1210\/jc.2003-030144","volume":"88","author":"R Napoli","year":"2003","unstructured":"R. Napoli, V. Guardasole, V. Angelini, F. D\u2019Amico, E. Zarra, M. Matarazzo, L. Sacc\u00e0, Acute effects of growth hormone on vascular function in human subjects. J. Clin. Endocrinol. Metab. 88(6), 2817\u20132820 (2003)","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"8","key":"951_CR55","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.amjcard.2014.07.046","volume":"114","author":"BJ Sun","year":"2014","unstructured":"B.J. Sun, E. Hwang, J.Y. Jang, D.H. Kim, J.M. Song, D.H. Kang, Effect of rosuvastatin on coronary flow reserve in patients with systemic hypertension. Am. J. Cardiol. 114(8), 1234\u20131237 (2014)","journal-title":"Am. J. Cardiol."}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-016-0951-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12020-016-0951-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-016-0951-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-016-0951-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T19:17:39Z","timestamp":1718479059000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12020-016-0951-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,13]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["951"],"URL":"https:\/\/doi.org\/10.1007\/s12020-016-0951-4","relation":{},"ISSN":["1355-008X","1559-0100"],"issn-type":[{"value":"1355-008X","type":"print"},{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,13]]}}}