{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:11:49Z","timestamp":1785773509254,"version":"3.56.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,5,6]],"date-time":"2016-05-06T00:00:00Z","timestamp":1462492800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Ministero della Salute (IT)","award":["Ricerca Corrente 2012"],"award-info":[{"award-number":["Ricerca Corrente 2012"]}]},{"name":"Ministero della Salute (IT)","award":["RF-2010-2320098"],"award-info":[{"award-number":["RF-2010-2320098"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1007\/s12020-016-0974-x","type":"journal-article","created":{"date-parts":[[2016,5,6]],"date-time":"2016-05-06T06:30:19Z","timestamp":1462516219000},"page":"266-272","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Vitamin D status in primary hyperparathyroidism: effect of genetic background"],"prefix":"10.1007","volume":"55","author":[{"given":"Claudia","family":"Battista","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"Guarnieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Carnevale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filomena","family":"Baorda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Pileri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Garrubba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio S.","family":"Salcuni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iacopo","family":"Chiodini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Minisola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Romagnoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Eller-Vainicher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano A.","family":"Santini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Parisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Frusciante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Fontana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Copetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey N.","family":"Hendy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Scillitani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E. C.","family":"Cole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,5,6]]},"reference":[{"key":"974_CR1","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.mayocp.2013.05.011","volume":"88","author":"A Hossein-Nezhad","year":"2013","unstructured":"A. Hossein-Nezhad, M.F. Holick, Vitamin D for health: a global perspective. Mayo Clin. Proc. 88, 720\u2013755 (2013)","journal-title":"Mayo Clin. Proc."},{"key":"974_CR2","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1210\/jc.2011-2601","volume":"97","author":"MF Holick","year":"2012","unstructured":"M.F. Holick, N.C. Binkley, H.A. Bischoff-Ferrari, C.M. Gordon, D.A. Hanley, R.P. Heaney, M.H. Murad, C.M. Weaver, Guidelines for preventing and treating vitamin D deficiency and insufficiency revisited. J. Clin. Endocrinol. Metab. 97, 1153\u20131158 (2012)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"974_CR3","unstructured":"Institute of Medicine, Committee to Review Dietary Reference Intakes for Calcium and Vitamin D. Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: National Academies Press (2011)"},{"key":"974_CR4","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1093\/hmg\/ddq155","volume":"19","author":"J Ahn","year":"2010","unstructured":"J. Ahn, K. Yu, R. Stolzenberg-Solomon, K.C. Simon, M.L. McCullough, L. Gallicchio, E.J. Jacobs, A. Ascherio, K. Helzlsouer, K.B. Jacobs, Q. Li, S.J. Weinstein, M. Purdue, J. Virtamo, R. Horst, W. Wheeler, S. Chanock, D.J. Hunter, R.B. Hayes, P. Kraft, D. Albanes, Genome-wide association study of circulating vitamin D levels. Hum. Mol. Genet. 19, 2739\u20132745 (2010)","journal-title":"Hum. Mol. Genet."},{"key":"974_CR5","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1007\/s001980170012","volume":"12","author":"V Carnevale","year":"2001","unstructured":"V. Carnevale, S. Modoni, M.Di Pileri, A. Giorgio, I. Chiodini, S. Minisola, R. Vieth, A. Scillitani, Longitudinal evaluation of vitamin D status in healthy subjects from southern Italy: seasonal and gender differences. Osteoporos. Int. 12, 1026\u20131030 (2001)","journal-title":"Osteoporos. Int."},{"key":"974_CR6","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/sj.ejcn.1602959","volume":"63","author":"MK Shea","year":"2009","unstructured":"M.K. Shea, E.J. Benjamin, J. Dupuis, J.M. Massaro, P.F. Jacques, R.B. D\u2019Agostino Sr., J.M. Ordovas, C.J. O\u2019Donnell, B. Dawson-Hughes, R.S. Vasan, S.L. Booth, Genetic and non-genetic correlates of vitamins K and D. Eur. J. Clin. Nutr. 63, 458\u2013464 (2009)","journal-title":"Eur. J. Clin. Nutr."},{"key":"974_CR7","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1046\/j.1469-1809.1999.6350429.x","volume":"63","author":"G Livshits","year":"1999","unstructured":"G. Livshits, D. Karasik, M.J. Seibel, Statistical genetic analysis of plasma levels of vitamin D: familial study. Ann. Hum. Genet. 63, 429\u2013439 (1999)","journal-title":"Ann. Hum. Genet."},{"key":"974_CR8","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1056\/NEJMoa1306357","volume":"369","author":"CE Powe","year":"2013","unstructured":"C.E. Powe, M.K. Evans, J. Wenger, A.B. Zonderman, A.H. Berh, M. Nalls, H. Tarnez, D. Zhang, I. Bhan, S.A. Karumanchi, N.R. Powe, R. Thadhani, Vitamin D\u2013binding protein and vitamin D status of black Americans and white Americans. N. Engl. J. Med. 369, 1991\u20132000 (2013)","journal-title":"N. Engl. J. Med."},{"key":"974_CR9","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1359\/jbmr.2001.16.2.371","volume":"16","author":"D De Hunter","year":"2001","unstructured":"D.De Hunter, M. Lange, H. Snieder, A.J. MacGregor, R. Swaminathan, R.V. Thakker, T.D. Spector, Genetic contribution to bone metabolism, calcium excretion, and vitamin D and parathyroid hormone regulation. J. Bone Miner. Res. 16, 371\u2013378 (2001)","journal-title":"J. Bone Miner. Res."},{"key":"974_CR10","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1210\/jcem-61-5-969","volume":"61","author":"DD Bikle","year":"1985","unstructured":"D.D. Bikle, P.K. Siiteri, E. Ryzen, J.G. Haddad, Serum protein binding of 1,25-dihydroxyvitamin D: a reevaluation by direct measurement of free metabolite levels. J. Clin. Endocrinol. Metab. 61, 969\u2013975 (1985)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"974_CR11","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1172\/JCI112636","volume":"78","author":"DD Bikle","year":"1986","unstructured":"D.D. Bikle, B.P. Halloran, E. Gee, E. Ryzen, J.G. Haddad, Free 25-hydroxyvitamin D levels are normal in subjects with liver disease and reduced total 25-hydroxyvitamin D levels. J. Clin. Invest. 78, 748\u2013752 (1986)","journal-title":"J. Clin. Invest."},{"key":"974_CR12","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/561214","author":"I Bhan","year":"2014","unstructured":"I. Bhan, Vitamin D binding protein and bone health. Int. J. Endocrinol. (2014). doi: 10.1155\/2014\/561214","journal-title":"Int. J. Endocrinol."},{"key":"974_CR13","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1478-3231.2011.02638.x","volume":"32","author":"PP Reese","year":"2012","unstructured":"P.P. Reese, R.D. Bloom, H.I. Feldman, A. Huverserian, A. Thomasson, J. Shults, T. Harnano, S. Goral, A. Shaked, K. Olthoff, M.R. Rickets, M. Bleicher, M.B. Leonard, Changes in vitamin D binding protein and vitamin D concentrations associated with liver transplantation. Liver Int. 32, 287\u2013296 (2012)","journal-title":"Liver Int."},{"key":"974_CR14","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1159\/000183672","volume":"42","author":"J De Auwerx","year":"1986","unstructured":"J.De Auwerx, L. Keyser, R. Bouillon, P. De Moor, Decreased free 1,25-dihydroxycholecalciferol index in patients with the nephrotic syndrome. Nephron. 42, 231\u2013235 (1986)","journal-title":"Nephron."},{"key":"974_CR15","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1172\/JCI111617","volume":"74","author":"DD Bikle","year":"1984","unstructured":"D.D. Bikle, E. Gee, B. Halloran, J.G. Haddad, Free 1,25-dihydroxyvitamin D levels in serum from normal subjects, pregnant subjects, and subjects with liver disease. J. Clin. Invest. 74, 1966\u20131971 (1984)","journal-title":"J. Clin. Invest."},{"key":"974_CR16","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/BF00219689","volume":"92","author":"J Arnaud","year":"1993","unstructured":"J. Arnaud, J. Constans, Affinity differences for vitamin D metabolites associated with the genetic isoforms of the human serum carrier protein (DBP). Hum. Genet. 92, 183\u2013188 (1993)","journal-title":"Hum. Genet."},{"key":"974_CR17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00223-004-0227-5","volume":"77","author":"AL Lauridsen","year":"2005","unstructured":"A.L. Lauridsen, P. Vestergaard, A.P. Hermann, C. Brot, L. Heickendorff, L. Mosekilde, E. Nexo, Plasma concentrations of 25-hydroxy-vitamin D and 1,25-dihydroxy-vitamin D are related to the phenotype of Gc (vitamin D-binding protein): a cross-sectional study on 595 early postmenopausal women. Calcif. Tissue Int. 77, 15\u201322 (2005)","journal-title":"Calcif. Tissue Int."},{"key":"974_CR18","doi-asserted-by":"crossref","first-page":"634","DOI":"10.3945\/ajcn.2008.26445","volume":"89","author":"M Sinotte","year":"2009","unstructured":"M. Sinotte, C. Diorio, S. B\u00e9rub\u00e9, M. Pollak, J. Brisson, Genetic polymorphisms of the vitamin D binding protein and plasma concentrations of 25-hydroxyvitamin D in premenopausal women. Am. J. Clin. Nutr. 89, 634\u2013640 (2009)","journal-title":"Am. J. Clin. Nutr."},{"key":"974_CR19","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.clinbiochem.2009.03.008","volume":"42","author":"L Fu","year":"2009","unstructured":"L. Fu, F. Yun, M. Oczak, B.Y. Wong, R. Vieth, D.E. Cole, Common genetic variants of the vitamin D binding protein (DBP) predict differences in response of serum 25-hydroxyvitamin D [25(OH)D] to vitamin D supplementation. Clin. Biochem. 42, 1174\u20131177 (2009)","journal-title":"Clin. Biochem."},{"key":"974_CR20","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1111\/cen.12210","volume":"79","author":"F Tassone","year":"2013","unstructured":"F. Tassone, L. Gianotti, C. Baffoni, G. Visconti, M. Pellegrino, S. Cassibba, C.G. Croce, G. Magro, F. Cesario, R. Attanasio, G. Borretta, Vitamin D status in primary hyperparathyroidism: a Southern European perspective. Clin. Endocrinol. 79, 784\u2013790 (2013)","journal-title":"Clin. Endocrinol."},{"key":"974_CR21","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jsbmb.2010.03.077","volume":"121","author":"JC Souberbielle","year":"2010","unstructured":"J.C. Souberbielle, E. Maury, G. Friedlander, C. Cormier, Vitamin D and primary hyperparathyroidism (PHPT). J. Steroid Biochem. Mol. Biol. 121, 199\u2013203 (2010)","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"974_CR22","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/j.1365-2265.2005.02371.x","volume":"63","author":"B Moosgaard","year":"2005","unstructured":"B. Moosgaard, P. Vestergaard, L. Heickendorff, F. Melsen, P. Christiansen, L. Mosekilde, Vitamin D status, seasonal variations, parathyroid adenoma weight and bone mineral density in primary hyperparathyroidism. Clin. Endocrinol. 63, 506\u2013513 (2005)","journal-title":"Clin. Endocrinol."},{"key":"974_CR23","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1365-2265.2004.01946.x","volume":"60","author":"V Carnevale","year":"2004","unstructured":"V. Carnevale, G. Manfredi, E. Romagnoli, S. De Geronimo, F. Paglia, J. Pepe, A. Scillitani, E. D\u2019Erasmo, S. Minisola, Vitamin D status in female patients with primary hyperparathyroidism: does it play a role in skeletal damage? Clin. Endocrinol. 60, 81\u201386 (2004)","journal-title":"Clin. Endocrinol."},{"key":"974_CR24","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0002-9343(99)00294-6","volume":"107","author":"SJ Silverberg","year":"1999","unstructured":"S.J. Silverberg, E. Shane, D.W. Dempster, J.P. Bilezikian, The effects of vitamin D insufficiency in patients with primary hyperparathyroidism. Am. J. Med. 107, 561\u2013567 (1999)","journal-title":"Am. J. Med."},{"key":"974_CR25","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3109\/00365513.2013.869701","volume":"74","author":"MS Johnsen","year":"2014","unstructured":"M.S. Johnsen, G. Grimnes, Y. Figenschau, P.A. Torjesen, B. Alm\u00e5s, R. Jorde, Serum free and bio-available 25-hydroxyvitamin D correlate better with bone density than serum total 25-hydroxyvitamin D. Scand. J. Clin. Lab. Invest. 74, 177\u2013183 (2014)","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"974_CR26","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1210\/jcem.84.10.6079","volume":"84","author":"A Vermeulen","year":"1999","unstructured":"A. Vermeulen, L. Verdonck, J.M. Kaufman, A critical evaluation of simple methods for the estimation of free testosterone in serum. J. Clin. Endocrinol. Metab. 84, 3666\u20133672 (1999)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"974_CR27","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1002\/jbmr.387","volume":"26","author":"CE Powe","year":"2011","unstructured":"C.E. Powe, C. Ricciardi, A.H. Berg, D. Erdenesanaa, G. Collerone, E. Ankers, J. Wenger, S.A. Karumanchi, R. Thadhani, I. Bhan, Vitamin D-binding protein modifies the vitamin D-bone mineral density relationship. J. Bone Miner. Res. 26, 1609\u20131616 (2011)","journal-title":"J. Bone Miner. Res."},{"key":"974_CR28","unstructured":"A. Scillitani, Vitamin D status in primary hyperparathyroidism. ASBMR San Diego (CA) 16\u201320 September 2011, Ab SA0174"},{"key":"974_CR29","doi-asserted-by":"crossref","first-page":"609","DOI":"10.4158\/EP12371.OR","volume":"19","author":"X Wang","year":"2013","unstructured":"X. Wang, S.A. Shapses, S. Wei, D. Sukumar, J. Ghosh, Vitamin D binding protein levels in female patients with primary hyperparathyroidism. Endocr. Pract. 19, 609\u2013613 (2013)","journal-title":"Endocr. Pract."},{"key":"974_CR30","doi-asserted-by":"crossref","first-page":"30773","DOI":"10.1371\/journal.pone.0030773","volume":"7","author":"RF Chun","year":"2012","unstructured":"R.F. Chun, B.E. Peercy, J.S. Adams, M. Hewison, Vitamin D binding protein and monocyte response to 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D: analysis by mathematical modeling. PLoS One 7, 30773 (2012)","journal-title":"PLoS One"},{"key":"974_CR31","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1749-6632.1988.tb48851.x","volume":"538","author":"JF Dunn","year":"1988","unstructured":"J.F. Dunn, Computer simulation of vitamin D transport. Ann. N. Y. Acad. Sci. 538, 69\u201376 (1988)","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"974_CR32","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0140-6736(10)60588-0","volume":"376","author":"TJ Wang","year":"2010","unstructured":"T.J. Wang, F. Zhang, J.B. Richards, B. van Kestenbaum, J.B. Meurs, D. Berry, D.P. Kiel, E.A. Streeten, C. Ohlsson, D.L. Koller, L. Peltonen et al., Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet 376, 180\u2013188 (2010)","journal-title":"Lancet"},{"key":"974_CR33","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1056\/NEJMc1502602","volume":"373","author":"AN Hoofnagle","year":"2015","unstructured":"A.N. Hoofnagle, J.H. Eckfeldt, P.L. Lutsey, Vitamin D-binding protein concentrations quantified by mass spectrometry. N. Engl. J. Med. 373, 1480\u20131482 (2015)","journal-title":"N. Engl. J. Med."},{"key":"974_CR34","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1210\/edrv-10-3-294","volume":"10","author":"NE Cooke","year":"1989","unstructured":"N.E. Cooke, J.G. Haddad, Vitamin D binding protein (Gc-globulin). Endocr. Rev. 10, 294\u2013307 (1989)","journal-title":"Endocr. Rev."}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-016-0974-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12020-016-0974-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-016-0974-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-016-0974-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T01:57:18Z","timestamp":1559440638000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12020-016-0974-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,6]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["974"],"URL":"https:\/\/doi.org\/10.1007\/s12020-016-0974-x","relation":{},"ISSN":["1355-008X","1559-0100"],"issn-type":[{"value":"1355-008X","type":"print"},{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,6]]}}}