{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T12:37:41Z","timestamp":1772109461026,"version":"3.50.1"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2016,12,22]],"date-time":"2016-12-22T00:00:00Z","timestamp":1482364800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1007\/s12020-016-1214-0","type":"journal-article","created":{"date-parts":[[2016,12,22]],"date-time":"2016-12-22T17:13:28Z","timestamp":1482426808000},"page":"303-311","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Safety of transsphenoidal microsurgical approach in patients with an ACTH-secreting pituitary adenoma"],"prefix":"10.1007","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9123-8158","authenticated-orcid":false,"given":"Carmine Antonio","family":"Donofrio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Losa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Gemma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lodoviga","family":"Giudice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina Raffaella","family":"Barzaghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Mortini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,12,22]]},"reference":[{"issue":"Suppl 1","key":"1214_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000314297","volume":"92","author":"C Steffensen","year":"2010","unstructured":"C. Steffensen, A.M. Bak, K.Z. Rubeck, J.O. Jorgensen, Epidemiology of cushing\u2019s syndrome. Neuroendocrinology 92(Suppl 1), 1\u20135 (2010). doi: 10.1159\/000314297","journal-title":"Neuroendocrinology"},{"issue":"1","key":"1214_CR2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1046\/j.1365-2265.2001.01324.x","volume":"55","author":"M Losa","year":"2001","unstructured":"M. Losa, P. Mortini, S. Dylgjeri, R. Barzaghi, A. Franzin, C. Mandelli, M. Giovanelli, Desmopressin stimulation test before and after pituitary surgery in patients with cushing\u2019s disease. Clin. Endocrinol. 55(1), 61\u201368 (2001)","journal-title":"Clin. Endocrinol."},{"issue":"6","key":"1214_CR3","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1227\/01.neu.0000159647.64275.9d","volume":"56","author":"P Mortini","year":"2005","unstructured":"P. Mortini, M. Losa, R. Barzaghi, N. Boari, M. Giovanelli, Results of transsphenoidal surgery in a large series of patients with pituitary Adenoma. Neurosurgery 56(6), 1222\u20131233 (2005). doi: 10.1227\/01.neu.0000159647.64275.9d","journal-title":"Neurosurgery"},{"issue":"7","key":"1214_CR4","doi-asserted-by":"publisher","first-page":"2454","DOI":"10.1210\/jc.2007-2734","volume":"93","author":"BM Biller","year":"2008","unstructured":"B.M. Biller, A.B. Grossman, P.M. Stewart, S. Melmed, X. Bertagna, J. Bertherat, M. Buchfelder, A. Colao, A.R. Hermus, L.J. Hofland, A. Klibanski, A. Lacroix, J.R. Lindsay, J. Newell-Price, L.K. Nieman, S. Petersenn, N. Sonino, G.K. Stalla, B. Swearingen, M.L. Vance, J.A. Wass, M. Boscaro, Treatment of adrenocorticotropin-dependent Cushing\u2019s syndrome: a consensus statement. J. Clin Endocrinol. Metab. 93(7), 2454\u20132462 (2008). doi: 10.1210\/jc.2007-2734","journal-title":"J. Clin Endocrinol. Metab."},{"issue":"5","key":"1214_CR5","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/nrendo.2011.12","volume":"7","author":"NA Tritos","year":"2011","unstructured":"N.A. Tritos, B.M. Biller, B. Swearingen, Management of cushing disease. Nat. Rev. Endocrinol. 7(5), 279\u2013289 (2011). doi: 10.1038\/nrendo.2011.12","journal-title":"Nat. Rev. Endocrinol."},{"issue":"4","key":"1214_CR6","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1210\/er.2013-1048","volume":"36","author":"R Pivonello","year":"2015","unstructured":"R. Pivonello, M. De Leo, A. Cozzolino, A. Colao, The treatment of cushing\u2019s disease. Endocr. Rev. 36(4), 385\u2013486 (2015). doi: 10.1210\/er.2013-1048","journal-title":"Endocr. Rev."},{"key":"1214_CR7","doi-asserted-by":"publisher","unstructured":"R.R. Lonser, L. Nieman, E.H. Oldfield, Cushing\u2019s disease: pathobiology, diagnosis, and management. J. Neurosurg. 1\u201314 (2016). 10.3171\/2016.1.JNS152119","DOI":"10.3171\/2016.1.JNS152119"},{"issue":"10","key":"1214_CR8","doi-asserted-by":"publisher","first-page":"4709","DOI":"10.1210\/jc.2003-030461","volume":"88","author":"FG Barker 2nd","year":"2003","unstructured":"F.G. Barker 2nd, A. Klibanski, B. Swearingen, Transsphenoidal surgery for pituitary tumors in the United States, 1996\u20132000: mortality, morbidity, and the effects of hospital and surgeon volume. J. Clin. Endocrinol. Metab. 88(10), 4709\u20134719 (2003). doi: 10.1210\/jc.2003-030461","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"9","key":"1214_CR9","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1007\/s00701-007-1244-8","volume":"149","author":"LR Barzaghi","year":"2007","unstructured":"L.R. Barzaghi, M. Losa, M. Giovanelli, P. Mortini, Complications of transsphenoidal surgery in patients with pituitary adenoma: experience at a single centre. Acta. Neurochir. 149(9), 877\u2013886 (2007). doi: 10.1007\/s00701-007-1244-8","journal-title":"Acta. Neurochir."},{"issue":"2","key":"1214_CR10","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/00006123-199702000-00001","volume":"40","author":"I Ciric","year":"1997","unstructured":"I. Ciric, A. Ragin, C. Baumgartner, D. Pierce, Complications of transsphenoidal surgery: results of a national survey, review of the literature, and personal experience. Neurosurgery 40(2), 225\u2013237 (1997)","journal-title":"Neurosurgery"},{"issue":"2","key":"1214_CR11","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1007\/s12020-014-0294-y","volume":"47","author":"AN Mamelak","year":"2014","unstructured":"A.N. Mamelak, Pro: endoscopic endonasal transsphenoidal pituitary surgery is superior to microscope-based transsphenoidal surgery. Endocrine 47(2), 409\u2013414 (2014). doi: 10.1007\/s12020-014-0294-y","journal-title":"Endocrine"},{"issue":"2","key":"1214_CR12","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1007\/s12020-014-0365-0","volume":"47","author":"P Mortini","year":"2014","unstructured":"P. Mortini, Cons: endoscopic endonasal transsphenoidal pituitary surgery is not superior to microscopic transsphenoidal surgery for pituitary adenomas. Endocrine 47(2), 415\u2013420 (2014). doi: 10.1007\/s12020-014-0365-0","journal-title":"Endocrine"},{"issue":"2","key":"1214_CR13","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.ecl.2005.01.007","volume":"34","author":"AL Utz","year":"2005","unstructured":"A.L. Utz, B. Swearingen, B.M. Biller, Pituitary surgery and postoperative management in Cushing\u2019s disease. Endocrinol. Metab. Clin. North. Am. 34(2), 459\u2013478 (2005). doi: 10.1016\/j.ecl.2005.01.007 . xi","journal-title":"Endocrinol. Metab. Clin. North. Am."},{"issue":"Suppl 4","key":"1214_CR14","doi-asserted-by":"publisher","first-page":"S322","DOI":"10.4103\/2230-8210.86975","volume":"15","author":"R Domi","year":"2011","unstructured":"R. Domi, Cushing\u2019s surgery: role of the anesthesiologist. Indian. J. Endocrinol. Metab. 15(Suppl 4), S322\u2013328 (2011). doi: 10.4103\/2230-8210.86975","journal-title":"Indian. J. Endocrinol. Metab."},{"issue":"3","key":"1214_CR15","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1007\/s12020-015-0601-2","volume":"52","author":"S Cannavo","year":"2016","unstructured":"S. Cannavo, E. Messina, A. Albani, F. Ferrau, V. Barresi, S. Priola, F. Esposito, F. Angileri, Clinical management of critically ill patients with cushing\u2019s disease due to ACTH-secreting pituitary macroadenomas: effectiveness of presurgical treatment with pasireotide. Endocrine 52(3), 481\u2013487 (2016). doi: 10.1007\/s12020-015-0601-2","journal-title":"Endocrine"},{"issue":"1","key":"1214_CR16","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1530\/EJE-07-0514","volume":"158","author":"F Castinetti","year":"2008","unstructured":"F. Castinetti, I. Morange, P. Jaquet, B. Conte-Devolx, T. Brue, Ketoconazole revisited: a preoperative or postoperative treatment in cushing\u2019s disease. Eur. J. Endocrinol. 158(1), 91\u201399 (2008). doi: 10.1530\/EJE-07-0514","journal-title":"Eur. J. Endocrinol."},{"issue":"2","key":"1214_CR17","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1530\/EJE-12-0274","volume":"167","author":"VA Preda","year":"2012","unstructured":"V.A. Preda, J. Sen, N. Karavitaki, A.B. Grossman, Etomidate in the management of hypercortisolaemia in cushing\u2019s syndrome: a review. Eur. J. Endocrinol. 167(2), 137\u2013143 (2012). doi: 10.1530\/EJE-12-0274","journal-title":"Eur. J. Endocrinol."},{"issue":"9","key":"1214_CR18","doi-asserted-by":"publisher","first-page":"2796","DOI":"10.1210\/jc.2011-0536","volume":"96","author":"P Kamenicky","year":"2011","unstructured":"P. Kamenicky, C. Droumaguet, S. Salenave, A. Blanchard, C. Jublanc, J.F. Gautier, S. Brailly-Tabard, S. Leboulleux, M. Schlumberger, E. Baudin, P. Chanson, J. Young, Mitotane, metyrapone, and ketoconazole combination therapy as an alternative to rescue adrenalectomy for severe ACTH-dependent cushing\u2019s syndrome. J. Clin. Endocrinol. Metab. 96(9), 2796\u20132804 (2011). doi: 10.1210\/jc.2011-0536","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"6","key":"1214_CR19","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1007\/s40265-013-0052-0","volume":"73","author":"K McKeage","year":"2013","unstructured":"K. McKeage, Pasireotide: a review of its use in cushing\u2019s disease. Drugs 73(6), 563\u2013574 (2013). doi: 10.1007\/s40265-013-0052-0","journal-title":"Drugs"},{"issue":"1","key":"1214_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/cen.12345","volume":"80","author":"MR Gadelha","year":"2014","unstructured":"M.R. Gadelha, L. Vieira Neto, Efficacy of medical treatment in cushing\u2019s disease: a systematic review. Clin. Endocrinol. 80(1), 1\u201312 (2014). doi: 10.1111\/cen.12345","journal-title":"Clin. Endocrinol."},{"issue":"2","key":"1214_CR21","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1111\/cen.12286","volume":"80","author":"OF Bosch van den","year":"2014","unstructured":"O.F. van den Bosch, A.M. Stades, P.M. Zelissen, Increased long-term remission after adequate medical cortisol suppression therapy as presurgical treatment in cushing\u2019s disease. Clin. Endocrinol. 80(2), 184\u2013190 (2014). doi: 10.1111\/cen.12286","journal-title":"Clin. Endocrinol."},{"issue":"6","key":"1214_CR22","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1530\/EJE-13-0515","volume":"169","author":"M Losa","year":"2013","unstructured":"M. Losa, C.A. Donofrio, R. Barzaghi, P. Mortini, Presentation and surgical results of incidentally discovered nonfunctioning pituitary adenomas: evidence for a better outcome independently of other patients\u2019 characteristics. Eur. J. Endocrinol. 169(6), 735\u2013742 (2013). doi: 10.1530\/EJE-13-0515","journal-title":"Eur. J. Endocrinol."},{"issue":"1","key":"1214_CR23","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1213\/00000539-200201000-00031","volume":"94","author":"M Gemma","year":"2002","unstructured":"M. Gemma, C. Tommasino, S. Cozzi, S. Narcisi, P. Mortini, M. Losa, A. Soldarini, Remifentanil provides hemodynamic stability and faster awakening time in transsphenoidal surgery. Anesth. Analg. 94(1), 163\u2013168 (2002)","journal-title":"Anesth. Analg."},{"issue":"6","key":"1214_CR24","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1227\/01.NEU.0000255459.14764.BA","volume":"60","author":"P Mortini","year":"2007","unstructured":"P. Mortini, R. Barzaghi, M. Losa, N. Boari, M. Giovanelli, Surgical treatment of giant pituitary adenomas: strategies and results in a series of 95 consecutive patients. Neurosurgery 60(6), 993\u20131004 (2007). doi: 10.1227\/01.NEU.0000255459.14764.BA","journal-title":"Neurosurgery"},{"issue":"8","key":"1214_CR25","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1136\/jnnp-2012-303194","volume":"84","author":"M Ammirati","year":"2013","unstructured":"M. Ammirati, L. Wei, I. Ciric, Short-term outcome of endoscopic versus microscopic pituitary adenoma surgery: a systematic review and meta-analysis. J. Neurol. Neurosurg. Psychiatry. 84(8), 843\u2013849 (2013). doi: 10.1136\/jnnp-2012-303194","journal-title":"J. Neurol. Neurosurg. Psychiatry."},{"issue":"6","key":"1214_CR26","doi-asserted-by":"crossref","first-page":"487","DOI":"10.7326\/0003-4819-109-6-487","volume":"109","author":"TJ Mampalam","year":"1988","unstructured":"T.J. Mampalam, J.B. Tyrrell, C.B. Wilson, Transsphenoidal microsurgery for cushing disease. A report of 216 cases. Ann. Intern. Med. 109(6), 487\u2013493 (1988)","journal-title":"Ann. Intern. Med."},{"issue":"11","key":"1214_CR27","doi-asserted-by":"publisher","first-page":"3114","DOI":"10.1210\/jcem.80.11.7593411","volume":"80","author":"D Bochicchio","year":"1995","unstructured":"D. Bochicchio, M. Losa, M. Buchfelder, Factors influencing the immediate and late outcome of cushing\u2019s disease treated by transsphenoidal surgery: a retrospective study by the European cushing\u2019s disease survey group. J. Clin. Endocrinol. Metab. 80(11), 3114\u20133120 (1995). doi: 10.1210\/jcem.80.11.7593411","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"1214_CR28","first-page":"31","volume":"65","author":"UJ Knappe","year":"1996","unstructured":"U.J. Knappe, D.K. Ludecke, Persistent and recurrent hypercortisolism after transsphenoidal surgery for cushing\u2019s disease. Acta. Neurochir. Suppl. 65, 31\u201334 (1996)","journal-title":"Acta. Neurochir. Suppl."},{"issue":"2","key":"1214_CR29","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1210\/jcem.84.2.5465","volume":"84","author":"C Invitti","year":"1999","unstructured":"C. Invitti, F. Pecori Giraldi, M. de Martin, F. Cavagnini, Diagnosis and management of Cushing\u2019s syndrome: results of an Italian multicentre study. Study group of the Italian society of endocrinology on the pathophysiology of the hypothalamic-pituitary-adrenal axis. J. Clin. Endocrinol. Metab. 84(2), 440\u2013448 (1999). doi: 10.1210\/jcem.84.2.5465","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"12","key":"1214_CR30","doi-asserted-by":"publisher","first-page":"6348","DOI":"10.1210\/jc.2003-032180","volume":"89","author":"GD Hammer","year":"2004","unstructured":"G.D. Hammer, J.B. Tyrrell, K.R. Lamborn, C.B. Applebury, E.T. Hannegan, S. Bell, R. Rahl, A. Lu, C.B. Wilson, Transsphenoidal microsurgery for cushing\u2019s disease: initial outcome and long-term results. J. Clin. Endocrinol. Metab. 89(12), 6348\u20136357 (2004). doi: 10.1210\/jc.2003-032180","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"1214_CR31","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1210\/jc.2007-2013","volume":"93","author":"CG Patil","year":"2008","unstructured":"C.G. Patil, D.M. Prevedello, S.P. Lad, M.L. Vance, M.O. Thorner, L. Katznelson, E.R. Laws Jr., Late recurrences of Cushing\u2019s disease after initial successful transsphenoidal surgery. J. Clin. Endocrinol. Metab. 93(2), 358\u2013362 (2008). doi: 10.1210\/jc.2007-2013","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"1214_CR32","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3171\/JNS\/2008\/108\/01\/0009","volume":"108","author":"BM Hofmann","year":"2008","unstructured":"B.M. Hofmann, M. Hlavac, R. Martinez, M. Buchfelder, O.A. Muller, R. Fahlbusch, Long-term results after microsurgery for cushing disease: experience with 426 primary operations over 35 years. J. Neurosurg. 108(1), 9\u201318 (2008). doi: 10.3171\/JNS\/2008\/108\/01\/0009","journal-title":"J. Neurosurg."},{"issue":"3","key":"1214_CR33","doi-asserted-by":"publisher","first-page":"531","DOI":"10.3171\/2008.8.JNS08339","volume":"111","author":"J Jagannathan","year":"2009","unstructured":"J. Jagannathan, R. Smith, H.L. DeVroom, A.O. Vortmeyer, C.A. Stratakis, L.K. Nieman, E.H. Oldfield, Outcome of using the histological pseudocapsule as a surgical capsule in Cushing disease. J. Neurosurg. 111(3), 531\u2013539 (2009). doi: 10.3171\/2008.8.JNS08339","journal-title":"J. Neurosurg."},{"issue":"7","key":"1214_CR34","doi-asserted-by":"publisher","first-page":"2057","DOI":"10.1210\/jc.2011-0456","volume":"96","author":"JR Lindsay","year":"2011","unstructured":"J.R. Lindsay, E.H. Oldfield, C.A. Stratakis, L.K. Nieman, The postoperative basal cortisol and CRH tests for prediction of long-term remission from Cushing\u2019s disease after transsphenoidal surgery. J. Clin. Endocrinol. Metab. 96(7), 2057\u20132064 (2011). doi: 10.1210\/jc.2011-0456","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"3","key":"1214_CR35","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1210\/jc.2012-2893","volume":"98","author":"JK Lambert","year":"2013","unstructured":"J.K. Lambert, L. Goldberg, S. Fayngold, J. Kostadinov, K.D. Post, E.B. Geer, Predictors of mortality and long-term outcomes in treated cushing\u2019s disease: a study of 346 patients. J. Clin. Endocrinol. Metab. 98(3), 1022\u20131030 (2013). doi: 10.1210\/jc.2012-2893","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"1214_CR36","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1227\/NEU.0000000000001011","volume":"78","author":"WF Chandler","year":"2016","unstructured":"W.F. Chandler, A.L. Barkan, T. Hollon, A. Sakharova, J. Sack, B. Brahma, D.E. Schteingart, Outcome of transsphenoidal surgery for cushing disease: a single-center experience over 32 years. Neurosurgery 78(2), 216\u2013223 (2016). doi: 10.1227\/NEU.0000000000001011","journal-title":"Neurosurgery"},{"issue":"Suppl 1","key":"1214_CR37","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1159\/000314292","volume":"92","author":"RA Feelders","year":"2010","unstructured":"R.A. Feelders, L.J. Hofland, W.W. de Herder, Medical treatment of cushing\u2019s syndrome: adrenal-blocking drugs and ketaconazole. Neuroendocrinology 92(Suppl 1), 111\u2013115 (2010). doi: 10.1159\/000314292","journal-title":"Neuroendocrinology"},{"issue":"2","key":"1214_CR38","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3171\/jns.1999.91.2.0175","volume":"91","author":"PL Semple","year":"1999","unstructured":"P.L. Semple, E.R. Laws Jr., Complications in a contemporary series of patients who underwent transsphenoidal surgery for cushing\u2019s disease. J. Neurosurg. 91(2), 175\u2013179 (1999). doi: 10.3171\/jns.1999.91.2.0175","journal-title":"J. Neurosurg."},{"issue":"1","key":"1214_CR39","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1177\/0003489415595424","volume":"125","author":"PF Svider","year":"2016","unstructured":"P.F. Svider, M.D. Raikundalia, M.J. Pines, S. Baredes, A.J. Folbe, J.K. Liu, J.A. Eloy, Inpatient complications after transsphenoidal surgery in cushing\u2019s versus non-cushing\u2019s disease patients. Ann. Otol. Rhinol. Laryngol. 125(1), 5\u201311 (2016). doi: 10.1177\/0003489415595424","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"issue":"3","key":"1214_CR40","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1530\/EJE-11-1095","volume":"167","author":"RA Feelders","year":"2012","unstructured":"R.A. Feelders, S.J. Pulgar, A. Kempel, A.M. Pereira, The burden of cushing\u2019s disease: clinical and health-related quality of life aspects. Eur. J. Endocrinol. 167(3), 311\u2013326 (2012). doi: 10.1530\/EJE-11-1095","journal-title":"Eur. J. Endocrinol."},{"issue":"3","key":"1214_CR41","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1210\/jc.2010-1942","volume":"96","author":"RN Clayton","year":"2011","unstructured":"R.N. Clayton, D. Raskauskiene, R.C. Reulen, P.W. Jones, Mortality and morbidity in cushing\u2019s disease over 50 years in stoke-on-trent, UK: audit and meta-analysis of literature. J. Clin. Endocrinol. Metab. 96(3), 632\u2013642 (2011). doi: 10.1210\/jc.2010-1942","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"1214_CR42","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1007\/s11102-015-0645-6","volume":"18","author":"ST Sharma","year":"2015","unstructured":"S.T. Sharma, L.K. Nieman, R.A. Feelders, Comorbidities in cushing\u2019s disease. Pituitary 18(2), 188\u2013194 (2015). doi: 10.1007\/s11102-015-0645-6","journal-title":"Pituitary"},{"issue":"3","key":"1214_CR43","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1530\/EJE-11-0272","volume":"165","author":"E Valassi","year":"2011","unstructured":"E. Valassi, A. Santos, M. Yaneva, M. Toth, C.J. Strasburger, P. Chanson, J.A. Wass, O. Chabre, M. Pfeifer, R.A. Feelders, S. Tsagarakis, P.J. Trainer, H. Franz, K. Zopf, S. Zacharieva, S.W. Lamberts, A. Tabarin, S.M. Webb, E.S. Group, The European registry on cushing\u2019s syndrome: 2-year experience. Baseline demographic and clinical characteristics. Eur. J. Endocrinol. 165(3), 383\u2013392 (2011). doi: 10.1530\/EJE-11-0272","journal-title":"Eur. J. Endocrinol."},{"issue":"Suppl 1","key":"1214_CR44","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1159\/000314349","volume":"92","author":"L Trementino","year":"2010","unstructured":"L. Trementino, G. Arnaldi, G. Appolloni, V. Daidone, C. Scaroni, A. Casonato, M. Boscaro, Coagulopathy in cushing\u2019s syndrome. Neuroendocrinology 92(Suppl 1), 55\u201359 (2010). doi: 10.1159\/000314349","journal-title":"Neuroendocrinology"},{"issue":"8","key":"1214_CR45","doi-asserted-by":"publisher","first-page":"3662","DOI":"10.1210\/jcem.87.8.8703","volume":"87","author":"M Boscaro","year":"2002","unstructured":"M. Boscaro, N. Sonino, A. Scarda, L. Barzon, F. Fallo, M.T. Sartori, G.M. Patrassi, A. Girolami, Anticoagulant prophylaxis markedly reduces thromboembolic complications in cushing\u2019s syndrome. J. Clin. Endocrinol. Metab. 87(8), 3662\u20133666 (2002). doi: 10.1210\/jcem.87.8.8703","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"4","key":"1214_CR46","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1111\/cen.12094","volume":"78","author":"R Pas van der","year":"2013","unstructured":"R. van der Pas, F.W. Leebeek, L.J. Hofland, W.W. de Herder, R.A. Feelders, Hypercoagulability in cushing\u2019s syndrome: prevalence, pathogenesis and treatment. Clin. Endocrinol. 78(4), 481\u2013488 (2013). doi: 10.1111\/cen.12094","journal-title":"Clin. Endocrinol."},{"issue":"5","key":"1214_CR47","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1177\/014107688607900504","volume":"79","author":"R Fahlbusch","year":"1986","unstructured":"R. Fahlbusch, M. Buchfelder, O.A. Muller, Transsphenoidal surgery for Cushing\u2019s disease. J. R. Soc. Med. 79(5), 262\u2013269 (1986)","journal-title":"J. R. Soc. Med."},{"issue":"1","key":"1214_CR48","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1227\/NEU.0b013e31822dda2c","volume":"70","author":"I Ciric","year":"2012","unstructured":"I. Ciric, J.C. Zhao, H. Du, J.W. Findling, M.E. Molitch, R.E. Weiss, S. Refetoff, W.D. Kerr, J. Meyer, Transsphenoidal surgery for cushing disease: experience with 136 patients. Neurosurgery 70(1), 70\u201381 (2012). doi: 10.1227\/NEU.0b013e31822dda2c","journal-title":"Neurosurgery"},{"issue":"2","key":"1214_CR49","doi-asserted-by":"publisher","first-page":"E12","DOI":"10.3171\/2014.10.FOCUS14705","volume":"38","author":"TR Smith","year":"2015","unstructured":"T.R. Smith, M.M. Hulou, K.T. Huang, B. Nery, S.M. de Moura, D.J. Cote, E.R. Laws, Complications after transsphenoidal surgery for patients with cushing\u2019s disease and silent corticotroph adenomas. Neurosurg. Focus. 38(2), E12 (2015). doi: 10.3171\/2014.10.FOCUS14705","journal-title":"Neurosurg. Focus."},{"issue":"2","key":"1214_CR50","doi-asserted-by":"publisher","first-page":"E2","DOI":"10.3171\/2014.11.FOCUS14694","volume":"38","author":"D Wilson","year":"2015","unstructured":"D. Wilson, D.L. Jin, T. Wen, J.D. Carmichael, S. Cen, W.J. Mack, G. Zada, Demographic factors, outcomes, and patient access to transsphenoidal surgery for cushing\u2019s disease: analysis of the nationwide inpatient sample from 2002 to 2010. Neurosurg. Focus. 38(2), E2 (2015). doi: 10.3171\/2014.11.FOCUS14694","journal-title":"Neurosurg. Focus."},{"issue":"1","key":"1214_CR51","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1210\/jcem.80.1.7829644","volume":"80","author":"BR Olson","year":"1995","unstructured":"B.R. Olson, D. Rubino, J. Gumowski, E.H. Oldfield, Isolated hyponatremia after transsphenoidal pituitary surgery. J. Clin. Endocrinol. Metab. 80(1), 85\u201391 (1995). doi: 10.1210\/jcem.80.1.7829644","journal-title":"J. Clin. Endocrinol. Metab."}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12020-016-1214-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-016-1214-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-016-1214-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T19:56:06Z","timestamp":1658260566000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12020-016-1214-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,22]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["1214"],"URL":"https:\/\/doi.org\/10.1007\/s12020-016-1214-0","relation":{},"ISSN":["1355-008X","1559-0100"],"issn-type":[{"value":"1355-008X","type":"print"},{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,22]]}}}