{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:44:19Z","timestamp":1792640659128,"version":"4.5.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T00:00:00Z","timestamp":1489536000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1007\/s12020-017-1281-x","type":"journal-article","created":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T01:49:32Z","timestamp":1489542572000},"page":"203-208","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["MKRN3 levels in girls with central precocious puberty and correlation with sexual hormone levels: a pilot study"],"prefix":"10.1007","volume":"59","author":[{"given":"Anna","family":"Grandone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazia","family":"Cirillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcella","family":"Sasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Capristo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Tornese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4682-0170","authenticated-orcid":false,"given":"Pierluigi","family":"Marzuillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Luongo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Rosaria Umano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adalgisa","family":"Festa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruggero","family":"Coppola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Miraglia del Giudice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Perrone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,3,15]]},"reference":[{"key":"1281_CR1","first-page":"111","volume":"22","author":"E Terasawa","year":"2001","unstructured":"E. Terasawa, D.L. Fernandez, Neurobiological mechanisms of the onset of puberty in primates. Endocr. Rev. 22, 111\u2013151 (2001)","journal-title":"Endocr. Rev."},{"key":"1281_CR2","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1210\/jc.2003-030361","volume":"89","author":"L Vries de","year":"2004","unstructured":"L. de Vries, A. Kauschansky, M. Shohat, M. Phillip, Familial central precocious puberty suggests autosomal dominant inheritance. J. Clin. Endocrinol. Metab. 89, 1794\u20131800 (2004)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"1281_CR3","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1097\/MED.0b013e328320253c","volume":"16","author":"ZK Gajdos","year":"2009","unstructured":"Z.K. Gajdos, J.N. Hirschhorn, M.R. Palmert, What controls the timing of puberty? An update on progress from genetic investigation. Curr. Opin. Endocrinol. Diabetes. Obes. 16, 16\u201324 (2009)","journal-title":"Curr. Opin. Endocrinol. Diabetes. Obes."},{"key":"1281_CR4","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJMoa073443","volume":"358","author":"MG Teles","year":"2008","unstructured":"M.G. Teles, S.D. Bianco, V.N. Brito, E.B. Trarbach, W. Kuohung, S. Xu, S.B. Seminara, B.B. Mendonca, U.B. Kaiser, A.C. Latronico, A GPR54-activating mutation in a patient with central precocious puberty. N. Engl. J. Med. 358, 709\u2013715 (2008)","journal-title":"N. Engl. J. Med."},{"key":"1281_CR5","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1210\/jc.2009-2421","volume":"95","author":"LG Silveira","year":"2010","unstructured":"L.G. Silveira, S.D. Noel, A.P. Silveira-Neto, A.P. Abreu, V.N. Brito, M.G. Santos, S.D. Bianco, W. Kuohung, S. Xu, M. Gryngarten, M.E. Escobar, I.J. Arnhold, B.B. Mendonca, U.B. Kaiser, A.C. Latronico, Mutations of the KISS1 gene in disorders of puberty. J. Clin. Endocrinol. Metab. 95, 2276\u20132280 (2010)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"1281_CR6","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1056\/NEJMoa1302160","volume":"368","author":"AP Abreu","year":"2013","unstructured":"A.P. Abreu, A. Dauber, D.B. Macedo, S.D. Noel, V.N. Brito, J.C. Gill, P. Cukier, I.R. Thompson, V.M. Navarro, P.C. Gagliardi, T. Rodrigues, C. Kochi, C.A. Longui, D. Beckers, F. de Zegher, L.R. Montenegro, B.B. Mendonca, R.S. Carroll, J.N. Hirschhorn, A.C. Latronico, U.B. Kaiser, Central precocious puberty caused by mutations in the imprinted gene MKRN3. N. Engl. J. Med. 368, 2467\u20132475 (2013)","journal-title":"N. Engl. J. Med."},{"key":"1281_CR7","doi-asserted-by":"publisher","unstructured":"D.S. Bessa, D.B. Macedo, V.N. Brito, M.M. Fran\u00e7a, L.R. Montenegro, M.C. Silva, L.G. Silveira, T. Hummel, I. Bergad\u00e1, D. Braslavsky, A.P. Abreu, A. Dauber, B.B. Mendonca, U.B. Kaiser, A.C. Latronico High frequency of MKRN3 mutations in male central precocious puberty previously classified as Idiopathic. Neuroendocrinology (2016). doi: 10.1159\/00044693","DOI":"10.1159\/00044693"},{"key":"1281_CR8","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12902-015-0056-8","volume":"15","author":"A Grandone","year":"2015","unstructured":"A. Grandone, G. Cantelmi, G. Cirillo, P. Marzuillo, C. Luongo, E. Miraglia del Giudice, L. Perrone, A case of familial central precocious puberty caused by a novel mutation in the makorin RING finger protein 3 gene. BMC. Endocr. Disord. 15, 60 (2015)","journal-title":"BMC. Endocr. Disord."},{"key":"1281_CR9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/EJE-15-0488","volume":"174","author":"D Simon","year":"2016","unstructured":"D. Simon, I. Ba, N. Mekhail, E. Ecosse, A. Paulsen, D. Zenaty, M. Houang, M. Jesuran Perelroizen, G.P. de Filippo, M. Salerno, G. Simonin, R. Reynaud, J.C. Carel, J. L\u00e9ger, N. de Roux, Mutations in the maternally imprinted gene MKRN3 are common in familial central precocious puberty. Eur. J. Endocrinol. 174, 1\u20138 (2016)","journal-title":"Eur. J. Endocrinol."},{"key":"1281_CR10","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/pr.2015.159","volume":"78","author":"J K\u00e4ns\u00e4koski","year":"2015","unstructured":"J. K\u00e4ns\u00e4koski, T. Raivio, A. Juul, J. Tommiska, A missense mutation in MKRN3 in a Danish girl with central precocious puberty and her brother with early puberty. Pediatr. Res. 78, 709\u2013711 (2015)","journal-title":"Pediatr. Res."},{"key":"1281_CR11","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/cen.12854","volume":"84","author":"V Neocleous","year":"2016","unstructured":"V. Neocleous, C. Shammas, M.M. Phelan, S. Nicolaou, L.A. Phylactou, N. Skordis, In silico analysis of a novel MKRN3 missense mutation in familial central precocious puberty. Clin. Endocrinol. 84, 80\u201384 (2016)","journal-title":"Clin. Endocrinol."},{"key":"1281_CR12","first-page":"118","volume":"48","author":"HS Lee","year":"2016","unstructured":"H.S. Lee, H.S. Jin, Y.S. Shim, H.R. Jeong, E. Kwon, V. Choi, M.C. Kim, I.S. Chung, S.Y. Jeong, J.S. Hwang, Low frequency of MKRN3 mutations in central precocious puberty among Korean girls. Horm. Metab. Res. 48, 118\u2013122 (2016)","journal-title":"Horm. Metab. Res."},{"key":"1281_CR13","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1093\/humrep\/deu256","volume":"29","author":"L Vries de","year":"2014","unstructured":"L. de Vries, G. Gat-Yablonski, N. Dror, A. Singer, M. Phillip, A novel MKRN3 missense mutation causing familial precocious puberty. Hum. Reprod. 29, 2838\u20132843 (2014)","journal-title":"Hum. Reprod."},{"key":"1281_CR14","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1210\/jc.2013-3126","volume":"99","author":"DB Macedo","year":"2014","unstructured":"D.B. Macedo, A.P. Abreu, A.C. Reis, L.R. Montenegro, A. Dauber, D. Beneduzzi, P. Cukier, L.F. Silveira, M.G. Teles, R.S. Carroll, G.G. Junior, G.G. Filho, Z. Gucev, I.J. Arnhold, M. de Castro, A.C. Moreira, C.E. Martinelli Jr., J.N. Hirschhorn, B.B. Mendonca, V.N. Brito, S.R. Antonini, U.B. Kaiser, A.C. Latronico, Central precocious puberty that appears to be sporadic caused by paternally inherited mutations in the imprinted gene makorin ring finger 3. J. Clin. Endocrinol. Metab. 99, 1097\u20131103 (2014)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"1281_CR15","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1210\/jc.2013-4084","volume":"99","author":"N Settas","year":"2014","unstructured":"N. Settas, C. Dacou-Voutetakis, M. Karantza, C. Kanaka-Gantenbein, G.P. Chrousos, A. Voutetakis, Central precocious puberty in a girl and early puberty in her brother caused by a novel mutation in the MKRN3 gene. J. Clin. Endocrinol. Metab. 99, 647\u2013651 (2014)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"1281_CR16","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1093\/hmg\/8.5.783","volume":"8","author":"MT Jong","year":"1999","unstructured":"M.T. Jong, T.A. Gray, Y. Ji, C.C. Glenn, S. Saitoh, D.J. Driscoll, R.D. Nicholls, A novel imprinted gene, encoding a RING zinc-finger protein, and overlapping antisense transcript in the Prader-Willi syndrome critical region. Hum. Mol. Genet. 8, 783\u2013793 (1999)","journal-title":"Hum. Mol. Genet."},{"key":"1281_CR17","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1210\/jc.2014-4462","volume":"100","author":"CP Hagen","year":"2015","unstructured":"C.P. Hagen, K. S\u00f8rensen, M.G. Mieritz, T.H. Johannsen, K. Almstrup, A. Juul, Circulating MKRN3 levels decline prior to pubertal onset and through puberty: a longitudinal study of healthy girls. J. Clin. Endocrinol. Metab. 100, 1920\u20131926 (2015)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"1281_CR18","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1210\/jc.2016-1488","volume":"101","author":"AS Busch","year":"2016","unstructured":"A.S. Busch, C.P. Hagen, K. Almstrup, A. Juul, Circulating MKRN3 levels decline during puberty in healthy boys. J. Clin. Endocrinol. Metab. 101, 2588\u20132593 (2016)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"1281_CR19","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1530\/EJE-15-1193","volume":"174","author":"T Varimo","year":"2016","unstructured":"T. Varimo, L. Dunkel, K. Vaaralahti, P.J. Miettinen, M. Hero, T. Raivio, Circulating makorin ring finger protein 3 levels decline in boys before the clinical onset of puberty. Eur. J. Endocrinol. 174, 785\u2013790 (2016)","journal-title":"Eur. J. Endocrinol."},{"key":"1281_CR20","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1093\/humrep\/der435","volume":"27","author":"CP Hagen","year":"2012","unstructured":"C.P. Hagen, L. Aksglaede, K. S\u00f8rensen, A. Mouritsen, A.M. Andersson, J.H. Petersen, K.M. Main, A. Juul, Individual serum levels of anti-M\u00fcllerian hormone in healthy girls persist through childhood and adolescence: a longitudinal cohort study. Hum. Reprod. 27, 861\u2013866 (2012)","journal-title":"Hum. Reprod."},{"key":"1281_CR21","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1016\/j.fertnstert.2013.01.139","volume":"99","author":"H Lashen","year":"2013","unstructured":"H. Lashen, D.B. Dunger, A. Ness, K.K. Ong, Peripubertal changes in circulating antim\u00fcllerian hormone levels in girls. Fertil. Steril. 99, 2071\u20132075 (2013)","journal-title":"Fertil. Steril."},{"key":"1281_CR22","first-page":"45","volume":"44","author":"TJ Cole","year":"1990","unstructured":"T.J. Cole, The LMS method for constructing normalized growth standards. Eur. J. Clin. Nutr. 44, 45\u201360 (1990)","journal-title":"Eur. J. Clin. Nutr."},{"key":"1281_CR23","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1136\/adc.51.3.170","volume":"51","author":"JM Tanner","year":"1976","unstructured":"J.M. Tanner, R.H. Whitehouse, Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. Arch. Dis. Child. 51, 170\u2013179 (1976)","journal-title":"Arch. Dis. Child."},{"key":"1281_CR24","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1210\/jc.2006-1569","volume":"92","author":"EA Resende","year":"2007","unstructured":"E.A. Resende, B.H. Lara, J.D. Reis, B.P. Ferreira, G.A. Pereira, M.F. Borges, Assessment of basal and gonadotropin-releasing hormone-stimulated gonadotropins by immunochemiluminometric and immunofluorometric assays in normal children. J. Clin. Endocrinol. Metab. 92, 1424\u20131429 (2007)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"1281_CR25","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/B978-0-12-396968-2.00011-7","volume":"105","author":"M Tena-Sempere","year":"2013","unstructured":"M. Tena-Sempere, Keeping puberty on time: novel signals and mechanisms involved. Curr. Top. Dev. Biol. 105, 299\u2013329 (2013)","journal-title":"Curr. Top. Dev. Biol."},{"key":"1281_CR26","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/j.fertnstert.2012.07.1118","volume":"98","author":"CP Hagen","year":"2012","unstructured":"C.P. Hagen, K. S\u00f8rensen, R.A. Anderson, A. Juul, Serum levels of antim\u00fcllerian hormone in early maturing girls before, during, and after suppression with GnRH agonist. Fertil. Steril. 98, 1326\u20131330 (2012)","journal-title":"Fertil. Steril."},{"key":"1281_CR27","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/pr.2015.129","volume":"78","author":"A German","year":"2015","unstructured":"A. German, M. Shmoish, Z. Hochberg, Predicting pubertal development by infantile and childhood height, BMI, and adiposity rebound. Pediatr. Res. 78, 445\u2013450 (2015)","journal-title":"Pediatr. Res."},{"key":"1281_CR28","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s12020-016-1023-5","volume":"54","author":"HS Lee","year":"2016","unstructured":"H.S. Lee, J.S. Yoon, J.K. Roh, J.S. Hwang, Changes in body mass index during gonadotropin-releasing hormone agonist treatment for central precocious puberty and early puberty. Endocrine 54, 497\u2013503 (2016)","journal-title":"Endocrine"},{"key":"1281_CR29","doi-asserted-by":"publisher","unstructured":"A. Christoforidis, N. Skordis, P. Fanis, M. Dimitriadou, M. Sevastidou, M.M. Phelan, V. Neocleous, L A. Phylactou A novel MKRN3 nonsense mutation causing familial central precocious puberty. Endocrine (2017). doi: 10.1007\/s12020-017-1232-6","DOI":"10.1007\/s12020-017-1232-6"}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12020-017-1281-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-017-1281-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-017-1281-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T14:52:09Z","timestamp":1568904729000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12020-017-1281-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,15]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["1281"],"URL":"https:\/\/doi.org\/10.1007\/s12020-017-1281-x","relation":{},"ISSN":["1355-008X","1559-0100"],"issn-type":[{"value":"1355-008X","type":"print"},{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,15]]}}}