{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:40:33Z","timestamp":1791020433923,"version":"4.1.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T00:00:00Z","timestamp":1514937600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"National Natural Science Foundation of China (CN)","award":["31471188"],"award-info":[{"award-number":["31471188"]}]},{"name":"National Natural Science Foundation of China (CN)","award":["81573241"],"award-info":[{"award-number":["81573241"]}]},{"name":"National Natural Science Foundation of China (CN)","award":["31771399"],"award-info":[{"award-number":["31771399"]}]},{"name":"China Postdoctoral Science Foundation (CN)","award":["2016M602797"],"award-info":[{"award-number":["2016M602797"]}]},{"name":"Natural Science Basic Research Program Shaanxi Province","award":["2016JQ3026"],"award-info":[{"award-number":["2016JQ3026"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1007\/s12020-017-1507-y","type":"journal-article","created":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T17:13:11Z","timestamp":1514999591000},"page":"296-303","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Association between fibroblast growth factor 21 and bone mineral density in adults"],"prefix":"10.1007","volume":"59","author":[{"given":"Ruo-Han","family":"Hao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Ling","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Li","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hlaing Nwe","family":"Thynn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan-Shan","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,1,3]]},"reference":[{"issue":"11","key":"1507_CR1","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1002\/jbmr.2269","volume":"29","author":"NC Wright","year":"2014","unstructured":"N.C. Wright, A.C. Looker, K.G. Saag, J.R. Curtis, E.S. Delzell, S. Randall, B. Dawson-Hughes, The recent prevalence of osteoporosis and low bone mass in the United States based on bone mineral density at the femoral neck or lumbar spine. J. Bone Miner. Res. 29(11), 2520\u20132526 (2014)","journal-title":"J. Bone Miner. Res."},{"issue":"6937","key":"1507_CR2","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nature01660","volume":"423","author":"S Harada","year":"2003","unstructured":"S. Harada, G.A. Rodan, Control of osteoblast function and regulation of bone mass. Nature 423(6937), 349\u2013355 (2003)","journal-title":"Nature"},{"issue":"2","key":"1507_CR3","first-page":"115","volume":"21","author":"SC Manolagas","year":"2000","unstructured":"S.C. Manolagas, Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr. Rev. 21(2), 115\u2013137 (2000)","journal-title":"Endocr. Rev."},{"issue":"12","key":"1507_CR4","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1016\/j.febslet.2008.04.038","volume":"582","author":"P Arner","year":"2008","unstructured":"P. Arner, A. Pettersson, P.J. Mitchell, J.D. Dunbar, A. Kharitonenkov, M. Ryden, FGF21 attenuates lipolysis in human adipocytes\u2014a possible link to improved insulin sensitivity. FEBS Lett. 582(12), 1725\u20131730 (2008)","journal-title":"FEBS Lett."},{"issue":"19","key":"1507_CR5","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1016\/j.febslet.2009.09.012","volume":"583","author":"XF Li","year":"2009","unstructured":"X.F. Li, H.F. Ge, J. Weiszmann, R. Hecht, Y.S. Li, M.M. Veniant, J. Xu, X.L. Wu, R. Lindberg, Y. Li, Inhibition of lipolysis may contribute to the acute regulation of plasma FFA and glucose by FGF21 in ob\/ob mice. FEBS Lett. 583(19), 3230\u20133234 (2009)","journal-title":"FEBS Lett."},{"issue":"6","key":"1507_CR6","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.cmet.2007.05.002","volume":"5","author":"MK Badman","year":"2007","unstructured":"M.K. Badman, P. Pissios, A.R. Kennedy, G. Koukos, J.S. Flier, E. Maratos-Flier, Hepatic fibroblast growth factor 21 is regulated by PPAR alpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab. 5(6), 426\u2013437 (2007).","journal-title":"Cell Metab."},{"issue":"5","key":"1507_CR7","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.cmet.2015.09.010","volume":"22","author":"X Wang","year":"2015","unstructured":"X. Wang, W. Wei, J.Y. Krzeszinski, Y. Wang, Y. Wan, A liver-bone endocrine relay by IGFBP1 promotes osteoclastogenesis and mediates FGF21-induced bone resorption. Cell. Metab. 22(5), 811\u2013824 (2015)","journal-title":"Cell. Metab."},{"issue":"8","key":"1507_CR8","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1073\/pnas.1200797109","volume":"109","author":"W Wei","year":"2012","unstructured":"W. Wei, P.A. Dutchak, X.D. Wang, X.S. Ding, X.Q. Wang, A.L. Bookout, R. Goetz, M. Mohammadi, R.D. Gerard, P.C. Dechow, D.J. Mangelsdorf, S.A. Kliewer, Y.H. Wan, Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor gamma. Proc. Natl. Acad. Sci. USA 109(8), 3143\u20133148 (2012)","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"12","key":"1507_CR9","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1007\/s00198-013-2464-9","volume":"24","author":"P Lee","year":"2013","unstructured":"P. Lee, J. Linderman, S. Smith, R.J. Brychta, R. Perron, C. Idelson, C.D. Werner, K.Y. Chen, F.S. Celi, Fibroblast growth factor 21 (FGF21) and bone: is there a relationship in humans? Osteoporos. Int. 24(12), 3053\u20133057 (2013)","journal-title":"Osteoporos. Int."},{"issue":"5","key":"1507_CR10","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1210\/er.2009-0044","volume":"31","author":"SH Ralston","year":"2010","unstructured":"S.H. Ralston, A.G. Uitterlinden, Genetics of osteoporosis. Endocr. Rev. 31(5), 629\u2013662 (2010)","journal-title":"Endocr. Rev."},{"issue":"11","key":"1507_CR11","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/ng.446","volume":"41","author":"F Rivadeneira","year":"2009","unstructured":"F. Rivadeneira, U. Styrkarsdottir, K. Estrada, B.V. Halldorsson, Y.H. Hsu, J.B. Richards, M.C. Zillikens, F.K. Kavvoura, N. Amin, Y.S. Aulchenko, L.A. Cupples, P. Deloukas, S. Demissie, E. Grundberg, A. Hofman, A. Kong, D. Karasik, J.B. van Meurs, B. Oostra, T. Pastinen, H.A. Pols, G. Sigurdsson, N. Soranzo, G. Thorleifsson, U. Thorsteinsdottir, F.M. Williams, S.G. Wilson, Y. Zhou, S.H. Ralston, C.M. van Duijn, T. Spector, D.P. Kiel, K. Stefansson, J.P. Ioannidis, A.G. Uitterlinden, Genetic factors for osteoporosis, C.: twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. Nat. Genet. 41(11), 1199\u20131206 (2009)","journal-title":"Nat. Genet."},{"issue":"9623","key":"1507_CR12","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/S0140-6736(08)60599-1","volume":"371","author":"JB Richards","year":"2008","unstructured":"J.B. Richards, F. Rivadeneira, M. Inouye, T.M. Pastinen, N. Soranzo, S.G. Wilson, T. Andrew, M. Falchi, R. Gwilliam, K.R. Ahmadi, A.M. Valdes, P. Arp, P. Whittaker, D.J. Verlaan, M. Jhamai, V. Kumanduri, M. Moorhouse, J.B. van Meurs, A. Hofman, H.A. Pols, D. Hart, G. Zhai, B.S. Kato, B.H. Mullin, F. Zhang, P. Deloukas, A.G. Uitterlinden, T.D. Spector, Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study. Lancet 371(9623), 1505\u20131512 (2008)","journal-title":"Lancet"},{"issue":"1","key":"1507_CR13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/ng.284","volume":"41","author":"U Styrkarsdottir","year":"2009","unstructured":"U. Styrkarsdottir, B.V. Halldorsson, S. Gretarsdottir, D.F. Gudbjartsson, G.B. Walters, T. Ingvarsson, T. Jonsdottir, J. Saemundsdottir, S. Snorradottir, J.R. Center, T.V. Nguyen, P. Alexandersen, J.R. Gulcher, J.A. Eisman, C. Christiansen, G. Sigurdsson, A. Kong, U. Thorsteinsdottir, K. Stefansson, New sequence variants associated with bone mineral density. Nat. Genet. 41(1), 15\u201317 (2009)","journal-title":"Nat. Genet."},{"issue":"22","key":"1507_CR14","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1056\/NEJMoa0801197","volume":"358","author":"U Styrkarsdottir","year":"2008","unstructured":"U. Styrkarsdottir, B.V. Halldorsson, S. Gretarsdottir, D.F. Gudbjartsson, G.B. Walters, T. Ingvarsson, T. Jonsdottir, J. Saemundsdottir, J.R. Center, T.V. Nguyen, Y. Bagger, J.R. Gulcher, J.A. Eisman, C. Christiansen, G. Sigurdsson, A. Kong, U. Thorsteinsdottir, K. Stefansson, Multiple genetic loci for bone mineral density and fractures. N. Engl. J. Med. 358(22), 2355\u20132365 (2008)","journal-title":"N. Engl. J. Med."},{"key":"1507_CR15","unstructured":"Q.D.R Hologic. 4500 X-ray Bone Densitometer User\u2019s Guide. (Hologic, Bedford, MA, 1996)"},{"issue":"4","key":"1507_CR16","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00198-004-1779-y","volume":"16","author":"KG Faulkner","year":"2005","unstructured":"K.G. Faulkner, The tale of the T-score: review and perspective. Osteoporos. Int. 16(4), 347\u2013352 (2005)","journal-title":"Osteoporos. Int."},{"issue":"3","key":"1507_CR17","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","volume":"81","author":"S Purcell","year":"2007","unstructured":"S. Purcell, B. Neale, K. Todd-Brown, L. Thomas, M.A. Ferreira, D. Bender, J. Maller, P. Sklar, P.I. de Bakker, M.J. Daly, P.C. Sham, PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81(3), 559\u2013575 (2007)","journal-title":"Am. J. Hum. Genet."},{"issue":"6235","key":"1507_CR18","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1126\/science.1262110","volume":"348","author":"GT Consortium","year":"2015","unstructured":"G.T. Consortium, Human genomics. The genotype-tissue expression (GTEx) pilot analysis: multitissue gene regulation in humans. Science 348(6235), 648\u2013660 (2015)","journal-title":"Science"},{"key":"1507_CR19","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.bone.2015.04.001","volume":"77","author":"PK Fazeli","year":"2015","unstructured":"P.K. Fazeli, A.T. Faje, E.J. Cross, H. Lee, C.J. Rosen, M.L. Bouxsein, A. Klibanski, Serum FGF-21 levels are associated with worsened radial trabecular bone microarchitecture and decreased radial bone strength in women with anorexia nervosa. Bone 77, 6\u201311 (2015)","journal-title":"Bone"},{"issue":"1","key":"1507_CR20","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1210\/jc.2013-3190","volume":"99","author":"LT Ho-Pham","year":"2014","unstructured":"L.T. Ho-Pham, U.D. Nguyen, T.V. Nguyen, Association between lean mass, fat mass, and bone mineral density: a meta-analysis. J. Clin. Endocrinol. Metab. 99(1), 30\u201338 (2014)","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"5","key":"1507_CR21","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.2337\/db07-1476","volume":"57","author":"X Zhang","year":"2008","unstructured":"X. Zhang, D.C. Yeung, M. Karpisek, D. Stejskal, Z.G. Zhou, F. Liu, R.L. Wong, W.S. Chow, A.W. Tso, K.S. Lam, A. Xu, Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes 57(5), 1246\u20131253 (2008)","journal-title":"Diabetes"},{"issue":"2","key":"1507_CR22","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1053\/j.gastro.2010.04.054","volume":"139","author":"J Dushay","year":"2010","unstructured":"J. Dushay, P.C. Chui, G.S. Gopalakrishnan, M. Varela-Rey, M. Crawley, F.M. Fisher, M.K. Badman, M.L. Martinez-Chantar, E. Maratos-Flier, Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease. Gastroenterology 139(2), 456\u2013463 (2010)","journal-title":"Gastroenterology"}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12020-017-1507-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-017-1507-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-017-1507-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T20:21:53Z","timestamp":1589833313000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12020-017-1507-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,3]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["1507"],"URL":"https:\/\/doi.org\/10.1007\/s12020-017-1507-y","relation":{},"ISSN":["1355-008X","1559-0100"],"issn-type":[{"value":"1355-008X","type":"print"},{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,3]]}}}