{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:44:42Z","timestamp":1787755482189,"version":"build-2784847793"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T00:00:00Z","timestamp":1527724800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1007\/s12020-018-1637-x","type":"journal-article","created":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T15:59:52Z","timestamp":1527782392000},"page":"308-316","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Is serum TSH a biomarker of thyroid carcinoma in patients residing in a mildly iodine-deficient area?"],"prefix":"10.1007","volume":"61","author":[{"given":"Kristine Z\u00f8ylner","family":"Swan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viveque Egsgaard","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Godballe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Faun\u00f8","family":"Thrane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Riis","family":"Mortensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sten","family":"Schytte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik Baymler","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peer","family":"Christiansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steen Joop","family":"Bonnema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,5,31]]},"reference":[{"issue":"1","key":"1637_CR1","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1210\/er.2002-0016","volume":"24","author":"L Hegedus","year":"2003","unstructured":"L. Hegedus, S.J. Bonnema, F.N. Bennedbaek, Management of simple nodular goiter: current status and future perspectives. Endocr. Rev. 24(1), 102\u2013132 (2003). \n                    https:\/\/doi.org\/10.1210\/er.2002-0016","journal-title":"Endocr. Rev."},{"issue":"9356","key":"1637_CR2","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/S0140-6736(03)12488-9","volume":"361","author":"SI Sherman","year":"2003","unstructured":"S.I. Sherman, Thyroid carcinoma. Lancet 361(9356), 501\u2013511 (2003)","journal-title":"Lancet"},{"issue":"1","key":"1637_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/thy.2015.0020","volume":"26","author":"BR Haugen","year":"2016","unstructured":"B.R. Haugen, E.K. Alexander, K.C. Bible, G.M. Doherty, S.J. Mandel, Y.E. Nikiforov, F. Pacini, G.W. Randolph, A.M. Sawka, M. Schlumberger, K.G. Schuff, S.I. Sherman, J.A. Sosa, D.L. Steward, R.M. Tuttle, L. Wartofsky, 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid 26(1), 1\u2013133 (2016). \n                    https:\/\/doi.org\/10.1089\/thy.2015.0020","journal-title":"Thyroid"},{"issue":"3","key":"1637_CR4","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1111\/j.1365-2265.1993.tb02365.x","volume":"39","author":"Y Shi","year":"1993","unstructured":"Y. Shi, M. Zou, N.R. Farid, Expression of thyrotrophin receptor gene in thyroid carcinoma is associated with a good prognosis. Clin. Endocrinol. (Oxf.) 39(3), 269\u2013274 (1993)","journal-title":"Clin. Endocrinol. (Oxf.)"},{"issue":"11","key":"1637_CR5","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1089\/105072502320908295","volume":"12","author":"H Suzuki","year":"2002","unstructured":"H. Suzuki, M.C. Willingham, S.Y. Cheng, Mice with a mutation in the thyroid hormone receptor beta gene spontaneously develop thyroid carcinoma: a mouse model of thyroid carcinogenesis. Thyroid 12(11), 963\u2013969 (2002). \n                    https:\/\/doi.org\/10.1089\/105072502320908295","journal-title":"Thyroid"},{"issue":"2","key":"1637_CR6","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.ecl.2014.02.012","volume":"43","author":"DS McLeod","year":"2014","unstructured":"D.S. McLeod, Thyrotropin in the development and management of differentiated thyroid cancer. Endocrinol. Metab. Clin. North. Am. 43(2), 367\u2013383 (2014). \n                    https:\/\/doi.org\/10.1016\/j.ecl.2014.02.012","journal-title":"Endocrinol. Metab. Clin. North. Am."},{"issue":"1","key":"1637_CR7","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.endonu.2014.06.002","volume":"62","author":"C Zafon","year":"2015","unstructured":"C. Zafon , G. Obiols , J. Mesa Preoperative TSH level and risk of thyroid cancer in patients with nodular thyroid disease: nodule size contribution. Endocrinol. Nutr. 62(1), 24\u201328 (2015). \n                    https:\/\/doi.org\/10.1016\/j.endonu.2014.06.002","journal-title":"Endocrinol. Nutr."},{"issue":"3","key":"1637_CR8","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1210\/jc.2007-2215","volume":"93","author":"MR Haymart","year":"2008","unstructured":"M.R. Haymart, D.J. Repplinger, G.E. Leverson, D.F. Elson, R.S. Sippel, J.C. Jaume, H. Chen, Higher serum thyroid stimulating hormone level in thyroid nodule patients is associated with greater risks of differentiated thyroid cancer and advanced tumor stage. J. Clin. Endocrinol. Metab. 93(3), 809\u2013814 (2008). \n                    https:\/\/doi.org\/10.1210\/jc.2007-2215","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"3","key":"1637_CR9","doi-asserted-by":"publisher","first-page":"202","DOI":"10.4103\/1450-1147.207277","volume":"16","author":"MA Khan","year":"2017","unstructured":"M.A. Khan, N. Malik, K.H. Khan, M.F. Shahzad, Association of preoperative serum thyroid-stimulating hormone levels with thyroid cancer in patients with nodular thyroid disease. World J. Nucl. Med. 16(3), 202\u2013205 (2017). \n                    https:\/\/doi.org\/10.4103\/1450-1147.207277","journal-title":"World J. Nucl. Med."},{"issue":"8","key":"1637_CR10","doi-asserted-by":"publisher","first-page":"2682","DOI":"10.1210\/jc.2012-1083","volume":"97","author":"DS McLeod","year":"2012","unstructured":"D.S. McLeod, K.F. Watters, A.D. Carpenter, P.W. Ladenson, D.S. Cooper, E.L. Ding, Thyrotropin and thyroid cancer diagnosis: a systematic review and dose-response meta-analysis. J. Clin. Endocrinol. Metab. 97(8), 2682\u20132692 (2012)","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"6","key":"1637_CR11","doi-asserted-by":"publisher","first-page":"dju097","DOI":"10.1093\/jnci\/dju097","volume":"106","author":"S Rinaldi","year":"2014","unstructured":"S. Rinaldi, M. Plummer, C. Biessy, K.K. Tsilidis, J.N. Ostergaard, K. Overvad, A. Tjonneland, J. Halkjaer, M.C. Boutron-Ruault, F. Clavel-Chapelon, L. Dossus, R. Kaaks, A. Lukanova, H. Boeing, A. Trichopoulou, P. Lagiou, D. Trichopoulos, D. Palli, C. Agnoli, R. Tumino, P. Vineis, S. Panico, H.B. Bueno-de-Mesquita, P.H. Peeters, E. Weiderpass, E. Lund, J.R. Quiros, A. Agudo, E. Molina, N. Larranaga, C. Navarro, E. Ardanaz, J. Manjer, M. Almquist, M. Sandstrom, J. Hennings, K.T. Khaw, J. Schmidt, R.C. Travis, G. Byrnes, A. Scalbert, I. Romieu, M. Gunter, E. Riboli, S. Franceschi, Thyroid-stimulating hormone, thyroglobulin, and thyroid hormones and risk of differentiated thyroid carcinoma: the EPIC study. J. Natl. Cancer Inst. 106(6), dju097 (2014). \n                    https:\/\/doi.org\/10.1093\/jnci\/dju097","journal-title":"J. Natl. Cancer Inst."},{"issue":"8","key":"1637_CR12","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1158\/1055-9965.EPI-16-0845","volume":"26","author":"H Huang","year":"2017","unstructured":"H. Huang, J. Rusiecki, N. Zhao, Y. Chen, S. Ma, H. Yu, M.H. Ward, R. Udelsman, Y. Zhang, Thyroid-stimulating hormone, thyroid hormones, and risk of papillary thyroid cancer: A nested case-control study. Cancer Epidemiol. Biomark. Prev. 26(8), 1209\u20131218 (2017). \n                    https:\/\/doi.org\/10.1158\/1055-9965.EPI-16-0845","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"issue":"17","key":"1637_CR13","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1056\/NEJMcp031436","volume":"351","author":"L Hegedus","year":"2004","unstructured":"L. Hegedus , Clinical practice. The Thyroid nodule. N. Engl. J. Med 351(17), 1764\u20131771 (2004).","journal-title":"N. Engl. J. Med"},{"issue":"5","key":"1637_CR14","doi-asserted-by":"publisher","first-page":"325","DOI":"10.7326\/0003-4819-159-5-201309030-00006","volume":"159","author":"ES Cibas","year":"2013","unstructured":"E.S. Cibas, Z.W. Baloch, G. Fellegara, V.A. Livolsi, S.S. Raab, J. Rosai, J. Diggans, L. Friedman, G.C. Kennedy, R.T. Kloos, R.B. Lanman, S.J. Mandel, N. Sindy, D.L. Steward, M.A. Zeiger, B.R. Haugen, E.K. Alexander, A prospective assessment defining the limitations of thyroid nodule pathologic evaluation. Ann. Intern. Med. 159(5), 325\u2013332 (2013)","journal-title":"Ann. Intern. Med."},{"issue":"5","key":"1637_CR15","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1159\/000478927","volume":"6","author":"G Russ","year":"2017","unstructured":"G. Russ, S.J. Bonnema, M.F. Erdogan, C. Durante, R. Ngu, L. Leenhardt, European Thyroid Association Guidelines for ultrasound malignancy risk stratification of thyroid nodules in adults: The EU-TIRADS. Eur. Thyroid J. 6(5), 225\u2013237 (2017)","journal-title":"Eur. Thyroid J."},{"issue":"12","key":"1637_CR16","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1007\/s00405-009-0949-0","volume":"266","author":"C Godballe","year":"2009","unstructured":"C. Godballe, A.R. Madsen, H.B. Pedersen, C.H. Sorensen, U. Pedersen, T. Frisch, J. Helweg-Larsen, L. Barfoed, P. Illum, J.E. Monsted, B. Becker, T. Nielsen, Post-thyroidectomy hemorrhage: a national study of patients treated at the Danish departments of ENT Head and Neck Surgery. Eur. Arch. Otorhinolaryngol. 266(12), 1945\u20131952 (2009). \n                    https:\/\/doi.org\/10.1007\/s00405-009-0949-0","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"1637_CR17","unstructured":"A.V. Egset, C. Holm, S.R. Larsen, S.H. Nielsen, J. Bach, J.P. Helweg-Larsen, L.V. Larsen, J.H. Wanscher, C. Godballe, Risk of malignancy in fine-needle aspiration biopsy in patients with thyroid nodules. Dan. Med. J. 64(2), pii:A5320 (2017)"},{"issue":"4","key":"1637_CR18","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1046\/j.1365-2265.2000.01121.x","volume":"53","author":"N Knudsen","year":"2000","unstructured":"N. Knudsen, I. Bulow, T. Jorgensen, P. Laurberg, L. Ovesen, H. Perrild, Goitre prevalence and thyroid abnormalities at ultrasonography: a comparative epidemiological study in two regions with slightly different iodine status. Clin. Endocrinol. (Oxf.). 53(4), 479\u2013485 (2000)","journal-title":"Clin. Endocrinol. (Oxf.)."},{"issue":"11","key":"1637_CR19","doi-asserted-by":"publisher","first-page":"4022","DOI":"10.1210\/jc.2012-2508","volume":"97","author":"L Bjergved","year":"2012","unstructured":"L. Bjergved, T. Jorgensen, H. Perrild, A. Carle, C. Cerqueira, A. Krejbjerg, P. Laurberg, L. Ovesen, I. Bulow Pedersen, R.L. Banke, N. Knudsen, Predictors of change in serum TSH after iodine fortification: an 11-year follow-up to the DanThyr study. J. Clin. Endocrinol. Metab. 97(11), 4022\u20134029 (2012). \n                    https:\/\/doi.org\/10.1210\/jc.2012-2508","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"12","key":"1637_CR20","doi-asserted-by":"publisher","first-page":"4749","DOI":"10.1210\/jc.2014-2438","volume":"99","author":"A Krejbjerg","year":"2014","unstructured":"A. Krejbjerg, L. Bjergved, I.B. Pedersen, N. Knudsen, T. Jorgensen, H. Perrild, L. Ovesen, L.B. Rasmussen, P. Laurberg, Thyroid nodules in an 11-year DanThyr follow-up study. J. Clin. Endocrinol. Metab. 99(12), 4749\u20134757 (2014). \n                    https:\/\/doi.org\/10.1210\/jc.2014-2438","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"12","key":"1637_CR21","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1017\/S0007114514003225","volume":"112","author":"LB Rasmussen","year":"2014","unstructured":"L.B. Rasmussen, A. Carle, T. Jorgensen, P. Knuthsen, A. Krejbjerg, H. Perrild, L. Bjergved, J.J. Sloth, P. Laurberg, L. Ovesen, Iodine excretion has decreased in Denmark between 2004 and 2010\u2013the importance of iodine content in milk. Br. J. Nutr. 112(12), 1993\u20132001 (2014). \n                    https:\/\/doi.org\/10.1017\/S0007114514003225","journal-title":"Br. J. Nutr."},{"key":"1637_CR22","unstructured":"S.B. Edge, D.R. Byrd, C.C. Compton, A.G. Fritz, F. L. Greene, A. Trotti (eds) AJCC cancer staging manual (7th ed). (Springer, New York, 2010)."},{"key":"1637_CR23","doi-asserted-by":"publisher","first-page":"31969","DOI":"10.3402\/fnr.v60.31969","volume":"60","author":"HF Nystrom","year":"2016","unstructured":"H.F. Nystrom, A.L. Brantsaeter, I. Erlund, I. Gunnarsdottir, L. Hulthen, P. Laurberg, I. Mattisson, L.B. Rasmussen, S. Virtanen, H.M. Meltzer, Iodine status in the Nordic countries-past and present. Food Nutr. Res. 60, 31969 (2016). \n                    https:\/\/doi.org\/10.3402\/fnr.v60.31969","journal-title":"Food Nutr. Res."},{"issue":"9645","key":"1637_CR24","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1016\/S0140-6736(08)61005-3","volume":"372","author":"MB Zimmermann","year":"2008","unstructured":"M.B. Zimmermann, P.L. Jooste, C.S. Pandav, Iodine-deficiency disorders. Lancet 372(9645), 1251\u20131262 (2008). \n                    https:\/\/doi.org\/10.1016\/S0140-6736(08)61005-3","journal-title":"Lancet"},{"issue":"4","key":"1637_CR25","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1111\/j.1365-2265.2008.03241.x","volume":"69","author":"S Fast","year":"2008","unstructured":"S. Fast, S.J. Bonnema, L. Hegedus, The majority of Danish nontoxic goitre patients are ineligible for Levothyroxine suppressive therapy. Clin. Endocrinol. (Oxf.). 69(4), 653\u2013658 (2008). \n                    https:\/\/doi.org\/10.1111\/j.1365-2265.2008.03241.x","journal-title":"Clin. Endocrinol. (Oxf.)."},{"issue":"4","key":"1637_CR26","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1677\/ERC-09-0036","volume":"16","author":"E Fiore","year":"2009","unstructured":"E. Fiore, T. Rago, M.A. Provenzale, M. Scutari, C. Ugolini, F. Basolo, G. Di Coscio, P. Berti, L. Grasso, R. Elisei, A. Pinchera, P. Vitti, Lower levels of TSH are associated with a lower risk of papillary thyroid cancer in patients with thyroid nodular disease: thyroid autonomy may play a protective role. Endocr. Relat. Cancer 16(4), 1251\u20131260 (2009). \n                    https:\/\/doi.org\/10.1677\/ERC-09-0036","journal-title":"Endocr. Relat. Cancer"},{"issue":"6","key":"1637_CR27","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.ando.2011.07.032","volume":"72","author":"A Dorange","year":"2011","unstructured":"A. Dorange, S. Triau, S. Mucci-Hennekinne, A. Bizon, S. Laboureau-Soares, F. Illouz, P. Rodien, V. Rohmer, An elevated level of TSH might be predictive of differentiated thyroid cancer. Ann. Endocrinol. (Paris) 72(6), 513\u2013521 (2011). \n                    https:\/\/doi.org\/10.1016\/j.ando.2011.07.032","journal-title":"Ann. Endocrinol. (Paris)"},{"issue":"1","key":"1637_CR28","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1002\/hed.23252","volume":"36","author":"SY Sohn","year":"2014","unstructured":"S.Y. Sohn, H.J. Kim, H.W. Jang, S.W. Kim, J.H. Chung, Lack of association between high serum thyroid-stimulating hormone level and risk of papillary thyroid microcarcinomas. Head Neck 36(1), 43\u201346 (2014). \n                    https:\/\/doi.org\/10.1002\/hed.23252","journal-title":"Head Neck"},{"issue":"11","key":"1637_CR29","doi-asserted-by":"publisher","first-page":"4295","DOI":"10.1210\/jc.2006-0527","volume":"91","author":"K Boelaert","year":"2006","unstructured":"K. Boelaert, J. Horacek, R.L. Holder, J.C. Watkinson, M.C. Sheppard, J.A. Franklyn, Serum thyrotropin concentration as a novel predictor of malignancy in thyroid nodules investigated by fine-needle aspiration. J. Clin. Endocrinol. Metab. 91(11), 4295\u20134301 (2006). \n                    https:\/\/doi.org\/10.1210\/jc.2006-0527","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"11","key":"1637_CR30","doi-asserted-by":"publisher","first-page":"e0188123","DOI":"10.1371\/journal.pone.0188123","volume":"12","author":"L Golbert","year":"2017","unstructured":"L. Golbert, A.P. de Cristo, C.S. Faccin, M. Farenzena, H. Folgierini, M.S. Graudenz, A.L. Maia, T.S.H. Serum, levels as a predictor of malignancy in thyroid nodules: A prospective study. PLoS ONE 12(11), e0188123 (2017). \n                    https:\/\/doi.org\/10.1371\/journal.pone.0188123","journal-title":"PLoS ONE"},{"issue":"23","key":"1637_CR31","doi-asserted-by":"publisher","first-page":"34918","DOI":"10.18632\/oncotarget.9201","volume":"7","author":"J Zheng","year":"2016","unstructured":"J. Zheng, C. Li, W. Lu, C. Wang, Z. Ai, Quantitative assessment of preoperative serum thyrotropin level and thyroid cancer. Oncotarget 7(23), 34918\u201334929 (2016). \n                    https:\/\/doi.org\/10.18632\/oncotarget.9201","journal-title":"Oncotarget"},{"key":"1637_CR32","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1007\/s12262-014-1084-8","volume":"77","author":"IA Ozemir","year":"2015","unstructured":"I.A. Ozemir, B. Gurbuz, B. Bayraktar, S. Aslan, A. Baskent, H. Yalman, R. Yigitbasi, O. Alimoglu, The effect of thyroid-stimulating hormone on tumor size in differentiated thyroid carcinoma. Indian J. Surg. 77, 967\u2013970 (2015). \n                    https:\/\/doi.org\/10.1007\/s12262-014-1084-8\n                    \n                  . (Suppl 3)","journal-title":"Indian J. Surg."},{"issue":"4","key":"1637_CR33","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.amjoto.2012.12.013","volume":"34","author":"D Ahn","year":"2013","unstructured":"D. Ahn, J.H. Sohn, J.H. Kim, C.M. Shin, J.H. Jeon, J.Y. Park, Preoperative subclinical hypothyroidism in patients with papillary thyroid carcinoma. Am. J. Otolaryngol. 34(4), 312\u2013319 (2013). \n                    https:\/\/doi.org\/10.1016\/j.amjoto.2012.12.013","journal-title":"Am. J. Otolaryngol."},{"issue":"2","key":"1637_CR34","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1210\/jcem.87.2.8182","volume":"87","author":"JG Hollowell","year":"2002","unstructured":"J.G. Hollowell, N.W. Staehling, W.D. Flanders, W.H. Hannon, E.W. Gunter, C.A. Spencer, L.E. Braverman, Serum T.S.H., T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J. Clin. Endocrinol. Metab. 87(2), 489\u2013499 (2002). \n                    https:\/\/doi.org\/10.1210\/jcem.87.2.8182","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"5","key":"1637_CR35","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1210\/edrv.22.5.0444","volume":"22","author":"T Kimura","year":"2001","unstructured":"T. Kimura, A. Van Keymeulen, J. Golstein, A. Fusco, J.E. Dumont, P.P. Roger, Regulation of thyroid cell proliferation by TSH and other factors: a critical evaluation of in vitro models. Endocr. Rev. 22(5), 631\u2013656 (2001). \n                    https:\/\/doi.org\/10.1210\/edrv.22.5.0444","journal-title":"Endocr. Rev."},{"issue":"3","key":"1637_CR36","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1210\/jc.2003-031641","volume":"89","author":"PS Hansen","year":"2004","unstructured":"P.S. Hansen, T.H. Brix, T.I. Sorensen, K.O. Kyvik, L. Hegedus, Major genetic influence on the regulation of the pituitary-thyroid axis: a study of healthy Danish twins. J. Clin. Endocrinol. Metab. 89(3), 1181\u20131187 (2004). \n                    https:\/\/doi.org\/10.1210\/jc.2003-031641","journal-title":"J. Clin. Endocrinol. Metab."}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12020-018-1637-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-018-1637-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-018-1637-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T01:46:22Z","timestamp":1559267182000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12020-018-1637-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,31]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["1637"],"URL":"https:\/\/doi.org\/10.1007\/s12020-018-1637-x","relation":{},"ISSN":["1355-008X","1559-0100"],"issn-type":[{"value":"1355-008X","type":"print"},{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,31]]},"assertion":[{"value":"21 February 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 May 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"For this type of study formal consent is not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}