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He has previously received grant support from Abbott Pharmaceuticals for investigator-initiated studies unrelated to this study and has previously consulted for AbbVie, Eli Lilly, Inc and Regeneron Pharmaceuticals. The other authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The BLSA study protocol was reviewed by the National Institute of Environmental Health Sciences Institutional Review Board and the study with participants not from the BLSA cohort was approved by the Intramural Research Program of the National Institute on Aging and the institutional review board of the National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in both studies.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}