{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T14:08:15Z","timestamp":1781014095240,"version":"3.54.1"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T00:00:00Z","timestamp":1538092800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"National Science Centre, Poland","award":["2017\/01\/X\/NZ4\/00466 MINIATURA grant"],"award-info":[{"award-number":["2017\/01\/X\/NZ4\/00466 MINIATURA grant"]}]},{"name":"National Science Centre, Poland","award":["2015\/19\/N\/NZ4\/00572 PRELUDIUM grant"],"award-info":[{"award-number":["2015\/19\/N\/NZ4\/00572 PRELUDIUM grant"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1007\/s12020-018-1766-2","type":"journal-article","created":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T06:59:45Z","timestamp":1538117985000},"page":"513-519","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Spexin in the physiology of pancreatic islets\u2014mutual interactions with insulin"],"prefix":"10.1007","volume":"63","author":[{"given":"Maciej","family":"Sassek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawel A.","family":"Kolodziejski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawid","family":"Szczepankiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Pruszynska-Oszmalek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,9,28]]},"reference":[{"key":"1766_CR1","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1101\/gr.5755407","volume":"17","author":"O Mirabeau","year":"2007","unstructured":"O. Mirabeau, E. Perlas, C. Severini, E. Audero, O. Gascuel, R. Possenti, E. Birney, N. Rosenthal, C. Gross, Identification of novel peptide hormones in the human proteome by hidden Markov model screening. Genome Res. 17, 320\u2013327 (2007). \n                    https:\/\/doi.org\/10.1101\/gr.5755407.320","journal-title":"Genome Res."},{"key":"1766_CR2","doi-asserted-by":"publisher","first-page":"2931","DOI":"10.1210\/jc.2016-1177","volume":"101","author":"S Kumar","year":"2016","unstructured":"S. Kumar, J. Hossain, N. Nader, R. Aguirre, S. Sriram, P.B. Balagopal, Decreased circulating levels of spexin in obese children. J. Clin. Endocrinol. Metab. 101, 2931\u20132936 (2016)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"1766_CR3","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1210\/en.2013-2106","volume":"155","author":"D Kim","year":"2014","unstructured":"D. Kim, S. Yun, G.H. Son, J. Hwang, C.R. Park, J. Il Kim, K. Kim, H. Vaudry, J.Y. Seong, Coevolution of the spexin\/galanin\/kisspeptin family: spexin activates galanin receptor type II and III. Endocrinology 155, 1864\u20131873 (2014)","journal-title":"Endocrinology"},{"key":"1766_CR4","doi-asserted-by":"publisher","first-page":"12095","DOI":"10.1038\/srep12095","volume":"5","author":"CY Lin","year":"2015","unstructured":"C.Y. Lin, M. Zhang, T. Huang, L.L. Yang, H.B. Fu, L. Zhao, L.L. Zhong, H.X. Mu, X.K. Shi, C.F. Leung, B.M. Fan, M. Jiang, A.P. Lu, L.X. Zhu, Z.X. Bian, Spexin enhances bowel movement through activating L-type voltage-dependent calcium channel via galanin receptor 2 in mice. Scientific reports 5, 12095 (2015)","journal-title":"Scientific reports"},{"key":"1766_CR5","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.mce.2013.04.008","volume":"374","author":"Y Liu","year":"2013","unstructured":"Y. Liu, S. Li, X. Qi, W. Zhou, X. Liu, H. Lin, Y. Zhang, C.H.K. Cheng, A novel neuropeptide in suppressing luteinizing hormone release in goldfish, Carassius auratus. Mol. Cell. Endocrinol. 374, 65\u201372 (2013)","journal-title":"Mol. Cell. Endocrinol."},{"key":"1766_CR6","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/j.peptides.2009.12.025","volume":"31","author":"M Rucinski","year":"2010","unstructured":"M. Rucinski, A. Porzionato, A. Ziolkowska, M. Szyszka, V. Macchi, R. De Caro, L.K. Malendowicz, Peptides expression of the spexin gene in the rat adrenal gland and evidences suggesting that spexin inhibits adrenocortical cell proliferation. Peptides 31, 676\u2013682 (2010)","journal-title":"Peptides"},{"key":"1766_CR7","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1152\/ajpendo.00141.2013","volume":"305","author":"MKH Wong","year":"2013","unstructured":"M.K.H. Wong, K.H. Sze, T. Chen, C.K. Cho, H.C.H. Law, I.K. Chu, A.O.L. Wong, Goldfish spexin: solution structure and novel function as a satiety factor in feeding control. Am. J. Physiol. Endocrinol. Metab. 305, 348\u2013366 (2013)","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"1766_CR8","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1096\/fj.11-192831","volume":"26","author":"L Toll","year":"2012","unstructured":"L. Toll, T.V. Khroyan, K. Sonmez, A. Ozawa, I. Lindberg, J.P. Mclaughlin, S.O. Eans, A.A. Shahien, D.R. Kapusta, Peptides derived from the prohormone proNPQ\/spexin are potent central modulators of cardiovascular and renal function and nociception. FASEB J. 26, 947\u2013954 (2012)","journal-title":"FASEB J."},{"key":"1766_CR9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110384","volume":"9","author":"DT Hoang","year":"2014","unstructured":"D.T. Hoang, H. Matsunari, M. Nagaya, H. Nagashima, J.M. Millis, P. Witkowski, V. Periwal, M. Hara, J. Jo, , A conserved rule for pancreatic islet organization. PLoS ONE 9, e110384 2014).","journal-title":"PLoS ONE"},{"key":"1766_CR10","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1080\/19382014.2016.1251538","volume":"8","author":"M Sassek","year":"2016","unstructured":"M. Sassek, E. Pruszynska-Oszmalek, P.A. Ko\u0142odziejski, D. Szczepankiewicz, P. Kaczmarek, M. Wieloch, K. Kurto, L. Nogowski, K.W. Nowak, M.Z. Strowski, P. Mackowiak, Resistin is produced by rat pancreatic islets and regulates insulin and glucagon in vitro secretion. Islets 8, 177\u2013185 (2016)","journal-title":"Islets"},{"key":"1766_CR11","first-page":"815","volume":"68","author":"M Sassek","year":"2017","unstructured":"M. Sassek, E. Pruszynska-Oszmalek, K.W. Nowak, Orexin a modulates endocrine function and viability of porcine pancreatic islets. J. Physiol. Pharmacol. 68, 815\u2013821 (2017)","journal-title":"J. Physiol. Pharmacol."},{"key":"1766_CR12","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.peptides.2015.07.018","volume":"71","author":"L Gu","year":"2015","unstructured":"L. Gu, Y. Ma, M. Gu, Y. Zhang, S. Yan, N. Li, Y. Wang, X. Ding, J. Yin, N. Fan, Y. Peng, Spexin peptide is expressed in human endocrine and epithelial tissues and reduced after glucose load in type 2 diabetes. Peptides 71, 232\u2013239 (2015)","journal-title":"Peptides"},{"key":"1766_CR13","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1369\/jhc.2010.956300","volume":"58","author":"A Porzionato","year":"2010","unstructured":"A. Porzionato, M. Rucinski, V. Macchi, C. Stecco, L. Malendowicz, R. De Caro, Spexin expression in normal rat tissues. J. Histochem. Cytochem. 58, 825\u2013837 (2010)","journal-title":"J. Histochem. Cytochem."},{"key":"1766_CR14","first-page":"560","volume":"158","author":"A Ma","year":"2017","unstructured":"A. Ma, M. He, J. Bai, M.K.H. Wong, W.K.W. Ko, A.O.L. Wong, Dual role of insulin in spexin regulation: functional link between food intake and spexin expression in a fish model. Endocrinology 158, 560\u2013577 (2017)","journal-title":"Endocrinology"},{"key":"1766_CR15","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1055\/s-0036-1597248","volume":"36","author":"JF Ge","year":"2016","unstructured":"J.F. Ge, J.L. Walewski, D. Anglade, P.D. Berk, Regulation of hepatocellular fatty acid uptake in mouse models of fatty liver disease with and without functional leptin signaling: roles of NfKB and SREBP-1C and the effects of spexin. Semin. Liver Dis. 36, 360\u2013372 (2016)","journal-title":"Semin. Liver Dis."},{"issue":"2","key":"1766_CR16","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1111\/pedi.12549","volume":"19","author":"SK Hodges","year":"2018","unstructured":"S.K. Hodges, A.M. Teague, P.S. Dasari, K.R. Short, Effect of obesity and type 2 diabetes, and glucose ingestion on circulating spexin concentration in adolescents. Pediatr. Diabetes 19(2), 212\u2013216 (2018)","journal-title":"Pediatr. Diabetes"}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-018-1766-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12020-018-1766-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-018-1766-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T05:05:47Z","timestamp":1589951147000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12020-018-1766-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,28]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["1766"],"URL":"https:\/\/doi.org\/10.1007\/s12020-018-1766-2","relation":{},"ISSN":["1355-008X","1559-0100"],"issn-type":[{"value":"1355-008X","type":"print"},{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,28]]},"assertion":[{"value":"20 June 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 September 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 September 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}