{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T11:20:52Z","timestamp":1793013652622,"version":"4.5.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T00:00:00Z","timestamp":1543881600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No. 81500606"],"award-info":[{"award-number":["No. 81500606"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1007\/s12020-018-1820-0","type":"journal-article","created":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T05:21:07Z","timestamp":1543900867000},"page":"265-270","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Glycemic variation in uncontrolled Graves\u2019 disease patients with normal glucose metabolism: Assessment by continuous glucose monitoring"],"prefix":"10.1007","volume":"64","author":[{"given":"Gu","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-fei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reng-na","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing-li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-mei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-fei","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-hua","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,12,4]]},"reference":[{"issue":"1","key":"1820_CR1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/j.0954-6820.1986.tb02724.x","volume":"220","author":"B Ahr\u00e9n","year":"2010","unstructured":"B. Ahr\u00e9n, Hyperthyroidism and glucose intolerance. Acta Med. Scand. 220(1), 5\u201314 (2010)","journal-title":"Acta Med. Scand."},{"issue":"9","key":"1820_CR2","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1016\/S0024-3205(02)01791-5","volume":"71","author":"M Fukuchi","year":"2002","unstructured":"M. Fukuchi, M. Shimabukuro, Y. Shimajiri, Y. Oshiro, M. Higa, H. Akamine, I. Komiya, N. Takasu, Evidence for a deficient pancreatic beta-cell response in a rat model of hyperthyroidism. Life. Sci. 71(9), 1059\u20131070 (2002)","journal-title":"Life. Sci."},{"issue":"8","key":"1820_CR3","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1113\/EP085627","volume":"101","author":"N Karbalaei","year":"2016","unstructured":"N. Karbalaei, A. Noorafshan, E. Hoshmandi, Impaired glucose\u2010stimulated insulin secretion and reduced \u03b2\u2010cell mass in pancreatic islets of hyperthyroid rats. Exp. Physiol. 101(8), 1114\u20131127 (2016)","journal-title":"Exp. Physiol."},{"issue":"4","key":"1820_CR4","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.4274\/Tjem.2238","volume":"17","author":"D Ozdemir","year":"2013","unstructured":"D. Ozdemir, S. Dagdelen, A. Usman, Serum adiponectin levels and changes in glucose metabolism before and after treatment for thyroid dysfunction. Turk. J. Endocrinol. Metab. 17(4), 1849 (2013)","journal-title":"Turk. J. Endocrinol. Metab."},{"issue":"5","key":"1820_CR5","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1530\/EJE-08-0797","volume":"160","author":"E Maratou","year":"2009","unstructured":"E. Maratou, D.J. Hadjidakis, M. Peppa, M. Alevizaki, K. Tsegka, V. Lambadiari, P. Mitrou, E. Boutati, A. Kollias, T. Economopoulos, Studies of insulin resistance in patients with clinical and subclinical hyperthyroidism. Eur. J. Endocrinol. 160(5), 785\u2013790 (2009)","journal-title":"Eur. J. Endocrinol."},{"issue":"Suppl 2","key":"1820_CR6","first-page":"S225","volume":"109","author":"GD Dimitriadis","year":"2001","unstructured":"G.D. Dimitriadis, S.A. Raptis, Thyroid hormone excess and glucose intolerance. Experimental and clinical endocrinology & diabetes: official journal, German Society of Endocrinology [and] German. Diabetes Assoc. 109(Suppl 2), S225\u2013S239 (2001)","journal-title":"Diabetes Assoc."},{"issue":"2","key":"1820_CR7","doi-asserted-by":"publisher","first-page":"248","DOI":"10.2337\/diacare.23.2.248","volume":"23","author":"ZT Bloomgarden","year":"2000","unstructured":"Z.T. Bloomgarden; American Diabetes Association Annual Meeting, 1999: insulin action and the development of type 2 diabetes. Diabetes Care 23(2), 248 (2000)","journal-title":"Diabetes Care"},{"key":"1820_CR8","doi-asserted-by":"crossref","unstructured":"Luo, Y.H., Zhu, M., Wang, D.G., Yang, Y.S., Tan, T., Zhu, H., He, J.F, Yangxin Tongmai formula ameliorates impaired glucose tolerance in children with Graves\u2019 disease through upregulation of the insulin receptor levels. Acta Pharmacol. Sin. 39(6), 923\u2013929 (2018)","DOI":"10.1038\/aps.2017.94"},{"issue":"1","key":"1820_CR9","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.diabres.2013.04.008","volume":"101","author":"L Yang","year":"2013","unstructured":"L. Yang, X. Shen, S. Yan, X. Yuan, J. Lu, W. Wei, HbA1c in the diagnosis of diabetes and abnormal glucose tolerance in patients with Graves\u2019 hyperthyroidism. Diabetes Res. Clin. Pract. 101(1), 28\u201334 (2013)","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"7","key":"1820_CR10","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.2337\/dc09-0076","volume":"32","author":"Z Jian","year":"2009","unstructured":"Z. Jian, L. Hong, X.W. Ran, W.Y. Yang, L. Qiang, Y.D. Peng, Y.B. Li, G. Xin, X.J. Luan, W.Q. Wang, Reference values for continuous glucose monitoring in Chinese subjects. Diabetes Care 32(7), 1188\u20131193 (2009)","journal-title":"Diabetes Care"},{"issue":"1","key":"1820_CR11","first-page":"CR9","volume":"17","author":"Z Jian","year":"2011","unstructured":"Z. Jian, L. Hong, X. Ran, W. Yang, L. Qiang, Y. Peng, Y. Li, G. Xin, X. Luan, W: Wang, Establishment of normal reference ranges for glycemic variability in Chinese subjects using continuous glucose monitoring. Med. Sci. Monit. Int. Med. J. Exp. Clin. Res. 17(1), CR9\u2013CR13 (2011)","journal-title":"Med. Sci. Monit. Int. Med. J. Exp. Clin. Res."},{"issue":"4","key":"1820_CR12","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1507\/endocrj.EJ13-0410","volume":"61","author":"K Torimoto","year":"2014","unstructured":"K. Torimoto, Y. Okada, T. Arao, H. Mori, S. Yamamoto, M. Narisawa, A. Kurozumi, Y. Tanaka, Glucose variability before and after treatment of a patient with Graves\u2019 disease complicated by diabetes mellitus: assessment by continuous glucose monitoring. Endocr. J. 61(4), 321 (2014)","journal-title":"Endocr. J."},{"key":"1820_CR13","first-page":"903524","volume":"2015","author":"F Li","year":"2015","unstructured":"F. Li, X. Xu, L. Fu, X. Su, J. Wu, C. Lu, L. Ye, J. Ma, Influence of acarbose on plasma glucose fluctuations in insulin-treated patients with type 2 diabetes: a pilot study. Int. J. Endocrinol. 2015, 903524 (2015)","journal-title":"Int. J. Endocrinol."},{"key":"1820_CR14","first-page":"1028945","volume":"2016","author":"FF Li","year":"2015","unstructured":"F.F. Li, L.Y. Fu, W.L. Zhang, X.F. Su, J.D. Wu, J. Sun, L. Ye, J.H. Ma, Blood glucose fluctuations in type 2 diabetes patients treated with multiple daily injections. J. Diabetes Res. 2016, 1028945 (2015)","journal-title":"J. Diabetes Res."},{"issue":"9","key":"1820_CR15","doi-asserted-by":"publisher","first-page":"633","DOI":"10.2337\/diab.18.9.633","volume":"18","author":"JW Doar","year":"1969","unstructured":"J.W. Doar, T.C. Stamp, V. Wynn, T.K. Audhya, Effects of oral and intravenous glucose loading in thyrotoxicosis. Studies of plasma glucose, free fatty acid, plasma insulin and blood pyruvate levels. Diabetes 18(9), 633 (1969)","journal-title":"Diabetes"},{"issue":"11","key":"1820_CR16","doi-asserted-by":"publisher","first-page":"740","DOI":"10.2337\/diab.14.11.740","volume":"14","author":"K Kreines","year":"1965","unstructured":"K. Kreines, M. Jett, H.C. Knowles Jr, Observations in hyperthyroidism of abnormal glucose tolerance and other traits related to diabetes mellitus. Diabetes 14(11), 740\u2013744 (1965)","journal-title":"Diabetes"},{"issue":"6","key":"1820_CR17","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1590\/2359-3997000000065","volume":"59","author":"S Anantarapu","year":"2015","unstructured":"S. Anantarapu, S. Vaikkakara, A. Sachan, B.V. Phaneendra, M.M. Suchitra, A.P. Reddy, S. Epuri, A. Mukka, D. Vemvakam, Effects of thyroid hormone replacement on glycated hemoglobin levels in non diabetic subjects with overt hypothyroidism. Arch. Endocrinol. Metab. 59(6), 495 (2015)","journal-title":"Arch. Endocrinol. Metab."},{"issue":"1","key":"1820_CR18","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.etap.2010.09.003","volume":"31","author":"M Messarah","year":"2011","unstructured":"M. Messarah, M. Saoudi, A. Boumendjel, M.S. Boulakoud, A.E. Feki, Oxidative stress induced by thyroid dysfunction in rat erythrocytes and heart. Environ. Toxicol. Pharmacol. 31(1), 33\u201341 (2011)","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"2","key":"1820_CR19","doi-asserted-by":"publisher","first-page":"183","DOI":"10.3892\/br.2017.932","volume":"7","author":"Y Hu","year":"2017","unstructured":"Y. Hu, G. Gao, R.N. Yan, F.F. Li, X.F. Su, J.H. Ma, Glucose metabolism before and after radioiodine therapy of a patient with Graves\u2019 disease: Assessment by continuous glucose monitoring. Biomed. Rep. 7(2), 183 (2017)","journal-title":"Biomed. Rep."},{"issue":"1","key":"1820_CR20","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1210\/jcem-72-1-108","volume":"72","author":"A Iranmanesh","year":"1991","unstructured":"A. Iranmanesh, G. Lizarralde, M.L. Johnson, J.D. Veldhuis, Nature of altered growth hormone secretion in hyperthyroidism*. J. Clin. Endocrinol. Metab. 72(1), 108 (1991)","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"14","key":"1820_CR21","doi-asserted-by":"publisher","first-page":"5966","DOI":"10.1073\/pnas.0805355106","volume":"106","author":"LP Klieverik","year":"2009","unstructured":"L.P. Klieverik, S.F. Janssen, A.V. Riel, E. Foppen, P.H. Bisschop, M.J. Serlie, A. Boelen, M.T. Ackermans, H.P. Sauerwein, E. Fliers, Thyroid hormone modulates glucose production via a sympathetic pathway from the hypothalamic paraventricular nucleus to the liver. Proc. Natl. Acad. Sci. USA 106(14), 5966\u20135971 (2009)","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"7","key":"1820_CR22","first-page":"559","volume":"46","author":"Z Liang","year":"2007","unstructured":"Z. Liang, G.C. Luo, Q.H. Hu, M.Z. Li, N. Chen, D.W. Yan, J. Chai, Z.L. Chen, H.Y. Li, H.T. Ou, Evaluation of insulin secretion and insulin resistance by hyperglycemic clamp in Graves disease patients with impaired glucose tolerance. Zhonghua Nei. Ke. Za. Zhi. 46(7), 559\u2013561 (2007)","journal-title":"Zhonghua Nei. Ke. Za. Zhi."},{"issue":"1","key":"1820_CR23","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1007\/s12020-012-9721-0","volume":"43","author":"X Wang","year":"2013","unstructured":"X. Wang, X.L. Xu, X.L. Zhao, X.W. Ma, H. Yu, H. Gong, S.R. Zhang, F.L. Chen, Hypoglycemia due to insulin binding antibodies in a patient with insulin-treated type 2 diabetes and Graves\u2019 disease. Endocrine 43(1), 236\u2013237 (2013)","journal-title":"Endocrine"},{"key":"1820_CR24","doi-asserted-by":"publisher","first-page":"bcr2016214801","DOI":"10.1136\/bcr-2016-214801","volume":"2016","author":"B Paudyal","year":"2016","unstructured":"B. Paudyal, M. Shakya, B. Basnyat, Spontaneous hypoglycaemia in a patient with Graves\u2019 disease. BMJ Case Rep. 2016, bcr2016214801 (2016)","journal-title":"BMJ Case Rep."},{"issue":"1","key":"1820_CR25","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3803\/EnM.2013.28.1.55","volume":"28","author":"E Roh","year":"2013","unstructured":"E. Roh, Y.A. Kim, E.J. Ku, J.H. Bae, H.M. Kim, Y.M. Cho, Y.J. Park, K.S. Park, S.Y. Kim, S.H. Kwak, Two cases of methimazole-induced insulin autoimmune syndrome in graves\u2019 disease. Endocrinol. Metab. 28(1), 55\u201360 (2013)","journal-title":"Endocrinol. Metab."},{"issue":"1","key":"1820_CR26","first-page":"71","volume":"13","author":"DT Paul","year":"2004","unstructured":"D.T. Paul, F.H. Mollah, M.K. Alam, M. Fariduddin, K. Azad, M.I. Arslan, Glycemic status in hyperthyroid subjects. Mymensingh Med. J. 13(1), 71 (2004)","journal-title":"Mymensingh Med. J."}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-018-1820-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12020-018-1820-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-018-1820-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T19:23:58Z","timestamp":1575401038000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12020-018-1820-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,4]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["1820"],"URL":"https:\/\/doi.org\/10.1007\/s12020-018-1820-0","relation":{},"ISSN":["1355-008X","1559-0100"],"issn-type":[{"value":"1355-008X","type":"print"},{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,4]]},"assertion":[{"value":"29 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare that they have no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}