{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T15:29:22Z","timestamp":1782833362073,"version":"3.54.5"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T00:00:00Z","timestamp":1558483200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T00:00:00Z","timestamp":1558483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1007\/s12020-019-01950-9","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T19:04:01Z","timestamp":1558551841000},"page":"25-34","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Efficacy and safety of long-acting growth hormone in children with short stature: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"65","author":[{"given":"Yingying","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianxian","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuelun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanze","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,5,22]]},"reference":[{"issue":"8","key":"1950_CR1","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1210\/jcem-18-8-901","volume":"18","author":"MS Raben","year":"1958","unstructured":"M.S. Raben, Treatment of a pituitary dwarf with human growth hormone. J. Clin. Endocrinol. Metab. 18(8), 901\u2013903 (1958). \n                    https:\/\/doi.org\/10.1210\/jcem-18-8-901","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"Suppl","key":"1950_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1651-2227.1986.tb10356.x","volume":"325","author":"H Flodh","year":"1986","unstructured":"H. Flodh,, Human growth hormone produced with recombinant DNA technology: development and production. Acta Paediatr. Scand. 325(Suppl), 1\u20139 (1986).","journal-title":"Acta Paediatr. Scand."},{"key":"1950_CR3","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1159\/000316130","volume":"18","author":"E Richmond","year":"2010","unstructured":"E. Richmond, A.D. Rogol, Current indications for growth hormone therapy for children and adolescents. Endocr. Dev. 18, 92\u2013108 (2010). \n                    https:\/\/doi.org\/10.1159\/000316130","journal-title":"Endocr. Dev."},{"key":"1950_CR4","doi-asserted-by":"publisher","unstructured":"L. Baxter, J. Bryant, C.B. Cave, R. Milne, Recombinant growth hormone for children and adolescents with Turner syndrome. The Cochrane database of systematic reviews(1), Cd003887 (2007). \n                    https:\/\/doi.org\/10.1002\/14651858.CD003887.pub2","DOI":"10.1002\/14651858.CD003887.pub2"},{"issue":"18","key":"1950_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3310\/hta6180","volume":"6","author":"J Bryant","year":"2002","unstructured":"J. Bryant, C. Cave, B. Mihaylova, D. Chase, L. McIntyre, K. Gerard, R. Milne, Clinical effectiveness and cost-effectiveness of growth hormone in children: a systematic review and economic evaluation. Health Technol. Assess. 6(18), 1\u2013168 (2002)","journal-title":"Health Technol. Assess."},{"key":"1950_CR6","doi-asserted-by":"publisher","unstructured":"D. Vimalachandra, E.M. Hodson, N.S. Willis, J.C. Craig, C. Cowell, J.F. Knight, Growth hormone for children with chronic kidney disease. The Cochrane database of systematic reviews (3), Cd003264 (2006). \n                    https:\/\/doi.org\/10.1002\/14651858.CD003264.pub2","DOI":"10.1002\/14651858.CD003264.pub2"},{"issue":"6","key":"1950_CR7","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1210\/jcem-70-6-1616","volume":"70","author":"JO Jorgensen","year":"1990","unstructured":"J.O. Jorgensen, N. Moller, T. Lauritzen, J.S. Christiansen, Pulsatile versus continuous intravenous administration of growth hormone (GH) in GH-deficient patients: effects on circulating insulin-like growth factor-I and metabolic indices. J. Clin. Endocrinol. Metab. 70(6), 1616\u20131623 (1990). \n                    https:\/\/doi.org\/10.1210\/jcem-70-6-1616","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"3","key":"1950_CR8","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1210\/jcem.86.3.7323","volume":"86","author":"T Laursen","year":"2001","unstructured":"T. Laursen, C.H. Gravholt, L. Heickendorff, J. Drustrup, A.M. Kappelgaard, J.O. Jorgensen, J.S. Christiansen, Long-term effects of continuous subcutaneous infusion versus daily subcutaneous injections of growth hormone (GH) on the insulin-like growth factor system, insulin sensitivity, body composition, and bone and lipoprotein metabolism in GH-deficient adults. J. Clin. Endocrinol. Metab. 86(3), 1222\u20131228 (2001). \n                    https:\/\/doi.org\/10.1210\/jcem.86.3.7323","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"1950_CR9","doi-asserted-by":"publisher","first-page":"143","DOI":"10.4158\/EP.14.2.143","volume":"14","author":"RG Rosenfeld","year":"2008","unstructured":"R.G. Rosenfeld, B. Bakker, Compliance and persistence in pediatric and adult patients receiving growth hormone therapy. Endocr. Pract. 14(2), 143\u2013154 (2008). \n                    https:\/\/doi.org\/10.4158\/ep.14.2.143","journal-title":"Endocr. Pract."},{"issue":"1","key":"1950_CR10","doi-asserted-by":"publisher","first-page":"e16223","DOI":"10.1371\/journal.pone.0016223","volume":"6","author":"WS Cutfield","year":"2011","unstructured":"W.S. Cutfield, J.G. Derraik, A.J. Gunn, K. Reid, T. Delany, E. Robinson, P.L. Hofman, Non-compliance with growth hormone treatment in children is common and impairs linear growth. PloS ONE 6(1), e16223 (2011). \n                    https:\/\/doi.org\/10.1371\/journal.pone.0016223","journal-title":"PloS ONE"},{"issue":"2","key":"1950_CR11","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1136\/adc.2006.114249","volume":"93","author":"RR Kapoor","year":"2008","unstructured":"R.R. Kapoor, S.A. Burke, S.E. Sparrow, I.A. Hughes, D.B. Dunger, K.K. Ong, C.L. Acerini, Monitoring of concordance in growth hormone therapy. Arch. Dis. Child. 93(2), 147\u2013148 (2008). \n                    https:\/\/doi.org\/10.1136\/adc.2006.114249","journal-title":"Arch. Dis. Child."},{"issue":"5","key":"1950_CR12","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1590\/S0004-27302008000500024","volume":"52","author":"MH Aguiar-Oliveira","year":"2008","unstructured":"M.H. Aguiar-Oliveira, R.A. Meneguz-Moreno, A.C. Nascimento-Junior, [News options and preparations in growth hormone therapy]. Arq. Bras. de. Endocrinol. e Metabol. 52(5), 917\u2013924 (2008)","journal-title":"Arq. Bras. de. Endocrinol. e Metabol."},{"key":"1950_CR13","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.12688\/f1000research.12057.1","volume":"6","author":"CL Boguszewski","year":"2017","unstructured":"C.L. Boguszewski, Update on GH therapy in adults. F1000Research 6, 2017 (2017). \n                    https:\/\/doi.org\/10.12688\/f1000research.12057.1","journal-title":"F1000Research"},{"key":"1950_CR14","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1159\/000439333","volume":"30","author":"PH Saenger","year":"2015","unstructured":"P.H. Saenger, J. Mejia-Corletto, Long-acting growth hormone: an update. Endocr. Dev. 30, 79\u201397 (2015). \n                    https:\/\/doi.org\/10.1159\/000439333","journal-title":"Endocr. Dev."},{"issue":"6","key":"1950_CR15","doi-asserted-by":"publisher","first-page":"C1","DOI":"10.1530\/EJE-16-0111","volume":"174","author":"JS Christiansen","year":"2016","unstructured":"J.S. Christiansen, P.F. Backeljauw, M. Bidlingmaier, B.M. Biller, M.C. Boguszewski, F.F. Casanueva, P. Chanson, P. Chatelain, C.S. Choong, D.R. Clemmons, L.E. Cohen, P. Cohen, J. Frystyk, A. Grimberg, Y. Hasegawa, M.W. Haymond, K. Ho, A.R. Hoffman, J.M. Holly, R. Horikawa, C. Hoybye, J.O. Jorgensen, G. Johannsson, A. Juul, L. Katznelson, J.J. Kopchick, K.O. Lee, K.W. Lee, X. Luo, S. Melmed, B.S. Miller, M. Misra, V. Popovic, R.G. Rosenfeld, J. Ross, R.J. Ross, P. Saenger, C.J. Strasburger, M.O. Thorner, H. Werner, K. Yuen, Growth Hormone Research Society perspective on the development of long-acting growth hormone preparations. Eur. J. Endocrinol. 174(6), C1\u2013C8 (2016). \n                    https:\/\/doi.org\/10.1530\/eje-16-0111","journal-title":"Eur. J. Endocrinol."},{"issue":"5","key":"1950_CR16","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.ghir.2015.07.004","volume":"25","author":"C Hoybye","year":"2015","unstructured":"C. Hoybye, P. Cohen, A.R. Hoffman, R. Ross, B.M. Biller, J.S. Christiansen, Status of long-acting-growth hormone preparations\u20132015. Growth Horm. IGF Res. 25(5), 201\u2013206 (2015). \n                    https:\/\/doi.org\/10.1016\/j.ghir.2015.07.004","journal-title":"Growth Horm. IGF Res."},{"issue":"8","key":"1950_CR17","doi-asserted-by":"publisher","first-page":"R171","DOI":"10.1530\/EC-17-0203","volume":"6","author":"K Sprogoe","year":"2017","unstructured":"K. Sprogoe, E. Mortensen, D.B. Karpf, J.A. Leff, The rationale and design of TransCon Growth Hormone for the treatment of growth hormone deficiency. Endocr. Connect. 6(8), R171\u2013R181 (2017). \n                    https:\/\/doi.org\/10.1530\/ec-17-0203","journal-title":"Endocr. Connect."},{"issue":"4","key":"1950_CR18","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1097\/MED.0000000000000416","volume":"25","author":"KCJ Yuen","year":"2018","unstructured":"K.C.J. Yuen, B.S. Miller, B.M.K. Biller, The current state of long-acting growth hormone preparations for growth hormone therapy. Curr. Opin. Endocrinol. diabetes. Obes. 25(4), 267\u2013273 (2018). \n                    https:\/\/doi.org\/10.1097\/med.0000000000000416","journal-title":"Curr. Opin. Endocrinol. diabetes. Obes."},{"issue":"2","key":"1950_CR19","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1530\/EJE-13-0148","volume":"169","author":"JS Hwang","year":"2013","unstructured":"J.S. Hwang, H.S. Lee, W.Y. Chung, H.S. Han, D.K. Jin, H.S. Kim, C.W. Ko, B.C. Lee, D.Y. Lee, K.H. Lee, J.H. Shin, B.K. Suh, H.W. Yoo, H.J. Ji, J.H. Lee, Y.J. Bae, D.H. Kim, S.W. Yang, Efficacy and safety of LB03002, a once-weekly sustained-release human GH for 12-month treatment in Korean children with GH deficiency. Eur. J. Endocrinol. 169(2), 179\u2013185 (2013). \n                    https:\/\/doi.org\/10.1530\/eje-13-0148","journal-title":"Eur. J. Endocrinol."},{"issue":"1","key":"1950_CR20","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1159\/000489262","volume":"90","author":"JS Hwang","year":"2018","unstructured":"J.S. Hwang, H.S. Lee, K.H. Lee, H.W. Yoo, D.Y. Lee, B.K. Suh, C.W. Ko, W.Y. Chung, D.K. Jin, C.H. Shin, H.S. Han, S. Han, H.S. Kim, Once-weekly administration of sustained-release growth hormone in korean prepubertal children with idiopathic short stature: a randomized, controlled phase II study. Horm. Res. Paediatr. 90(1), 54\u201363 (2018). \n                    https:\/\/doi.org\/10.1159\/000489262","journal-title":"Horm. Res. Paediatr."},{"issue":"5","key":"1950_CR21","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1210\/jc.2016-3547","volume":"102","author":"N Zelinska","year":"2017","unstructured":"N. Zelinska, V. Iotova, J. Skorodok, O. Malievsky, V. Peterkova, L. Samsonova, R.G. Rosenfeld, Z. Zadik, M. Jaron-Mendelson, R. Koren, L. Amitzi, D. Raduk, O. Hershkovitz, G. Hart, Long-acting C-terminal peptide-modified hGH (MOD-4023): Results of a safety and dose-finding study in GHD children. J. Clin. Endocrinol. Metab. 102(5), 1578\u20131587 (2017). \n                    https:\/\/doi.org\/10.1210\/jc.2016-3547","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"5","key":"1950_CR22","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1210\/jc.2016-3776","volume":"102","author":"P Chatelain","year":"2017","unstructured":"P. Chatelain, O. Malievskiy, K. Radziuk, G. Senatorova, M.O. Abdou, E. Vlachopapadopoulou, Y. Skorodok, V. Peterkova, J.A. Leff, M. Beckert, A Randomized Phase 2 Study of Long-Acting TransCon GH vs Daily GH in Childhood GH Deficiency. J. Clin. Endocrinol. Metab. 102(5), 1673\u20131682 (2017). \n                    https:\/\/doi.org\/10.1210\/jc.2016-3776","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"1950_CR23","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1210\/jc.2011-2234","volume":"97","author":"F Peter","year":"2012","unstructured":"F. Peter, M. Bidlingmaier, C. Savoy, H.J. Ji, P.H. Saenger, Three-year efficacy and safety of LB03002, a once-weekly sustained-release growth hormone (GH) preparation, in prepubertal children with GH deficiency (GHD). J. Clin. Endocrinol. Metab. 97(2), 400\u2013407 (2012). \n                    https:\/\/doi.org\/10.1210\/jc.2011-2234","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"1950_CR24","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1210\/jc.2013-2502","volume":"99","author":"V Khadilkar","year":"2014","unstructured":"V. Khadilkar, K.A. Radjuk, E. Bolshova, R. Khadgawat, M. El Kholy, M. Desai, V. Peterkova, V. Mericq, J. Kratzsch, E.C. Siepl, D. Martin, P. Lopez, H.J. Ji, Y.J. Bae, J.H. Lee, P.H. Saenger, 24-month use of once-weekly GH, LB03002, in prepubertal children with GH deficiency. J. Clin. Endocrinol. Metab. 99(1), 126\u2013132 (2014). \n                    https:\/\/doi.org\/10.1210\/jc.2013-2502","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"1950_CR25","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1530\/EJE-16-0905","volume":"177","author":"X Luo","year":"2017","unstructured":"X. Luo, L. Hou, L. Liang, G. Dong, S. Shen, Z. Zhao, C.X. Gong, Y. Li, M.L. Du, Z. Su, H. Du, C. Yan, Long-acting PEGylated recombinant human growth hormone (Jintrolong) for children with growth hormone deficiency: phase II and phase III multicenter, randomized studies. Eur. J. Endocrinol. 177(2), 195\u2013205 (2017). \n                    https:\/\/doi.org\/10.1530\/eje-16-0905","journal-title":"Eur. J. Endocrinol."},{"issue":"3","key":"1950_CR26","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1530\/EJE-16-0748","volume":"176","author":"CJ Strasburger","year":"2017","unstructured":"C.J. Strasburger, P. Vanuga, J. Payer, M. Pfeifer, V. Popovic, L. Bajnok, M. Goth, V. Olsovska, L. Trejbalova, J. Vadasz, E. Fima, R. Koren, L. Amitzi, M. Bidlingmaier, O. Hershkovitz, G. Hart, B.M. Biller, MOD-4023, a long-acting carboxy-terminal peptide-modified human growth hormone: results of a Phase 2 study in growth hormone-deficient adults. Eur. J. Endocrinol. 176(3), 283\u2013294 (2017). \n                    https:\/\/doi.org\/10.1530\/eje-16-0748","journal-title":"Eur. J. Endocrinol."},{"issue":"3","key":"1950_CR27","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1530\/EJE-11-0536","volume":"165","author":"J de Schepper","year":"2011","unstructured":"J. de Schepper, M.H. Rasmussen, Z. Gucev, A. Eliakim, T. Battelino, Long-acting pegylated human GH in children with GH deficiency: a single-dose, dose-escalation trial investigating safety, tolerability, pharmacokinetics and pharmacodynamics. Eur. J. Endocrinol. 165(3), 401\u2013409 (2011). \n                    https:\/\/doi.org\/10.1530\/eje-11-0536","journal-title":"Eur. J. Endocrinol."},{"issue":"6","key":"1950_CR28","doi-asserted-by":"publisher","first-page":"2595","DOI":"10.1210\/jc.2013-1437","volume":"98","author":"KC Yuen","year":"2013","unstructured":"K.C. Yuen, G.S. Conway, V. Popovic, G.R. Merriam, T. Bailey, A.H. Hamrahian, B.M. Biller, M. Kipnes, J.A. Moore, E. Humphriss, G.M. Bright, J.L. Cleland, A long-acting human growth hormone with delayed clearance (VRS-317): results of a double-blind, placebo-controlled, single ascending dose study in growth hormone-deficient adults. J. Clin. Endocrinol. Metab. 98(6), 2595\u20132603 (2013). \n                    https:\/\/doi.org\/10.1210\/jc.2013-1437","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"5","key":"1950_CR29","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1159\/000470842","volume":"87","author":"DM Fisher","year":"2017","unstructured":"D.M. Fisher, R.G. Rosenfeld, M. Jaron-Mendelson, L. Amitzi, R. Koren, G. Hart, Pharmacokinetic and pharmacodynamic modeling of MOD-4023, a long-acting human growth. Horm., Growth Horm. Defic. Child. Horm. Res. Paediatr. 87(5), 324\u2013332 (2017). \n                    https:\/\/doi.org\/10.1159\/000470842","journal-title":"Horm., Growth Horm. Defic. Child. Horm. Res. Paediatr."},{"issue":"4","key":"1950_CR30","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1111\/cen.13409","volume":"87","author":"T Battelino","year":"2017","unstructured":"T. Battelino, M.H. Rasmussen, J. De Schepper, N. Zuckerman-Levin, Z. Gucev, L. Savendahl, Somapacitan, a once-weekly reversible albumin-binding GH derivative, in children with GH deficiency: a randomized dose-escalation trial. Clin. Endocrinol. 87(4), 350\u2013358 (2017). \n                    https:\/\/doi.org\/10.1111\/cen.13409","journal-title":"Clin. Endocrinol."},{"issue":"8","key":"1950_CR31","doi-asserted-by":"publisher","first-page":"2926","DOI":"10.1210\/jc.2006-0514","volume":"91","author":"M Bidlingmaier","year":"2006","unstructured":"M. Bidlingmaier, J. Kim, C. Savoy, M.J. Kim, N. Ebrecht, S. de la Motte, C.J. Strasburger, Comparative pharmacokinetics and pharmacodynamics of a new sustained-release growth hormone (GH), LB03002, versus daily GH in adults with GH deficiency. J. Clin. Endocrinol. Metab. 91(8), 2926\u20132930 (2006). \n                    https:\/\/doi.org\/10.1210\/jc.2006-0514","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"3","key":"1950_CR32","first-page":"155","volume":"20","author":"S Wacharasindhu","year":"2002","unstructured":"S. Wacharasindhu, S. Aroonparkmongkol, S. Srivuthana, Measurement of IGF-1, IGFBP-3 and free IGF-1 levels by ELISA in growth hormone (GH) deficient children before and after GH replacement. Asian Pac. J. Allergy Immunol. 20(3), 155\u2013160 (2002)","journal-title":"Asian Pac. J. Allergy Immunol."},{"issue":"6","key":"1950_CR33","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1159\/000452150","volume":"86","author":"A Grimberg","year":"2016","unstructured":"A. Grimberg, S.A. DiVall, C. Polychronakos, D.B. Allen, L.E. Cohen, J.B. Quintos, W.C. Rossi, C. Feudtner, M.H. Murad, Guidelines for Growth Hormone and Insulin-Like Growth Factor-I Treatment in Children and Adolescents: Growth Hormone Deficiency, Idiopathic Short Stature, and Primary Insulin-Like Growth Factor-I Deficiency. Horm. Res. Paediatr. 86(6), 361\u2013397 (2016). \n                    https:\/\/doi.org\/10.1159\/000452150","journal-title":"Horm. Res. Paediatr."},{"issue":"5350","key":"1950_CR34","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1126\/science.279.5350.563","volume":"279","author":"JM Chan","year":"1998","unstructured":"J.M. Chan, M.J. Stampfer, E. Giovannucci, P.H. Gann, J. Ma, P. Wilkinson, C.H. Hennekens, M. Pollak, Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study. Science 279(5350), 563\u2013566 (1998)","journal-title":"Science"},{"issue":"9113","key":"1950_CR35","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1016\/S0140-6736(97)10384-1","volume":"351","author":"SE Hankinson","year":"1998","unstructured":"S.E. Hankinson, W.C. Willett, G.A. Colditz, D.J. Hunter, D.S. Michaud, B. Deroo, B. Rosner, F.E. Speizer, M. Pollak, Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet 351(9113), 1393\u20131396 (1998). \n                    https:\/\/doi.org\/10.1016\/s0140-6736(97)10384-1","journal-title":"Lancet"},{"issue":"7","key":"1950_CR36","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1093\/jnci\/91.7.620","volume":"91","author":"J Ma","year":"1999","unstructured":"J. Ma, M.N. Pollak, E. Giovannucci, J.M. Chan, Y. Tao, C.H. Hennekens, M.J. Stampfer, Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3. J. Natl. Cancer Inst. 91(7), 620\u2013625 (1999)","journal-title":"J. Natl. Cancer Inst."},{"key":"1950_CR37","doi-asserted-by":"publisher","unstructured":"E. Witkowska-Sedek, D. Labochka, A. Stelmaszczyk-Emmel, A. Majcher, A. Kucharska, M. Sobol, K. Kadziela, B. Pyrzak, Evaluation of glucose metabolism in children with growth hormone deficiency during long-term growth hormone treatment. J. Physiol. Pharmacol. 69(2), (2018). \n                    https:\/\/doi.org\/10.26402\/jpp.2018.2.08","DOI":"10.26402\/jpp.2018.2.08"}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-019-01950-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12020-019-01950-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-019-01950-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T23:30:10Z","timestamp":1590017410000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12020-019-01950-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,22]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["1950"],"URL":"https:\/\/doi.org\/10.1007\/s12020-019-01950-9","relation":{},"ISSN":["1355-008X","1559-0100"],"issn-type":[{"value":"1355-008X","type":"print"},{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,22]]},"assertion":[{"value":"14 February 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}