{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:55:35Z","timestamp":1792173335731,"version":"4.4.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T00:00:00Z","timestamp":1566950400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T00:00:00Z","timestamp":1566950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1007\/s12020-019-02053-1","type":"journal-article","created":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T14:06:33Z","timestamp":1567001193000},"page":"149-156","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Vitamin B12 insufficiency is associated with increased risk of gestational diabetes mellitus: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0406-1292","authenticated-orcid":false,"given":"Eleni","family":"Kouroglou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Anagnostis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandros","family":"Daponte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Bargiota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,8,28]]},"reference":[{"issue":"6","key":"2053_CR1","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1097\/AOG.0b013e31823974e2","volume":"118","author":"MB Landon","year":"2011","unstructured":"M.B. Landon, S.G. Gabbe, Gestational diabetes mellitus. Obstet. Gynecol. 118(6), 1379\u20131393 (2011). \nhttps:\/\/doi.org\/10.1097\/AOG.0b013e31823974e2","journal-title":"Obstet. Gynecol."},{"key":"2053_CR2","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.maturitas.2018.07.003","volume":"118","author":"SA Paschou","year":"2018","unstructured":"S.A. Paschou, P. Anagnostis, B.H.R. Wolffenbuttel, D.G. Goulis, The need for precision medicine in gestational diabetes mellitus. Maturitas 118, 74\u201375 (2018). \nhttps:\/\/doi.org\/10.1016\/j.maturitas.2018.07.003","journal-title":"Maturitas"},{"issue":"1","key":"2053_CR3","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-013-0452-2","volume":"14","author":"IJ Halperin","year":"2014","unstructured":"I.J. Halperin, D.S. Feig, The role of lifestyle interventions in the prevention of gestational diabetes. Curr. Diabetes Rep. 14(1), 452 (2014). \nhttps:\/\/doi.org\/10.1007\/s11892-013-0452-2","journal-title":"Curr. Diabetes Rep."},{"issue":"24","key":"2053_CR4","doi-asserted-by":"publisher","first-page":"2477","DOI":"10.1056\/NEJMoa042973","volume":"352","author":"CA Crowther","year":"2005","unstructured":"C.A. Crowther, J.E. Hiller, J.R. Moss, A.J. McPhee, W.S. Jeffries, J.S. Robinson, Effect of treatment of gestational diabetes mellitus on pregnancy outcomes. New Engl. J. Med. 352(24), 2477\u20132486 (2005). \nhttps:\/\/doi.org\/10.1056\/NEJMoa042973","journal-title":"New Engl. J. Med."},{"key":"2053_CR5","doi-asserted-by":"publisher","first-page":"S141","DOI":"10.1016\/j.dsx.2016.12.023","volume":"11","author":"MT Mursleen","year":"2017","unstructured":"M.T. Mursleen, S. Riaz, Implication of homocysteine in diabetes and impact of folate and vitamin B12 in diabetic population. Diabetes Metab. Syndr.: Clin. Res. Rev. 11, S141\u2013S146 (2017). \nhttps:\/\/doi.org\/10.1016\/j.dsx.2016.12.023","journal-title":"Diabetes Metab. Syndr.: Clin. Res. Rev."},{"issue":"5","key":"2053_CR6","doi-asserted-by":"publisher","first-page":"528","DOI":"10.3122\/jabfm.2009.05.090044","volume":"22","author":"MC Pflipsen","year":"2009","unstructured":"M.C. Pflipsen, R.C. Oh, A. Saguil, D.A. Seehusen, D. Seaquist, R. Topolski, The prevalence of vitamin B(12) deficiency in patients with type 2 diabetes: a cross-sectional study. J. Am. Board Fam. Med. 22(5), 528\u2013534 (2009). \nhttps:\/\/doi.org\/10.3122\/jabfm.2009.05.090044","journal-title":"J. Am. Board Fam. Med."},{"issue":"6","key":"2053_CR7","doi-asserted-by":"publisher","first-page":"e100379","DOI":"10.1371\/journal.pone.0100379","volume":"9","author":"Q Liu","year":"2014","unstructured":"Q. Liu, S. Li, H. Quan, J. Li, Vitamin B12 status in metformin treated patients: systematic review. PLoS ONE 9(6), e100379\u2013e100379 (2014). \nhttps:\/\/doi.org\/10.1371\/journal.pone.0100379","journal-title":"PLoS ONE"},{"issue":"1","key":"2053_CR8","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/S0104-4230(11)70015-X","volume":"57","author":"M Nervo","year":"2011","unstructured":"M. Nervo, A. Lubini, F.V. Raimundo, G.A. Faulhaber, C. Leite, L.M. Fischer, T.W. Furlanetto, Vitamin B12 in metformin-treated diabetic patients: a cross-sectional study in Brazil. Rev. da Assoc. Med. Bras. (1992) 57(1), 46\u201349 (2011)","journal-title":"Rev. da Assoc. Med. Bras. (1992)"},{"issue":"2","key":"2053_CR9","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1093\/ageing\/afj042","volume":"35","author":"KW Liu","year":"2006","unstructured":"K.W. Liu, L.K. Dai, W. Jean, Metformin-related vitamin B12 deficiency. Age Ageing 35(2), 200\u2013201 (2006). \nhttps:\/\/doi.org\/10.1093\/ageing\/afj042","journal-title":"Age Ageing"},{"issue":"3","key":"2053_CR10","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1097\/SMJ.0b013e3181ce0e4d","volume":"103","author":"DS Bell","year":"2010","unstructured":"D.S. Bell, Metformin-induced vitamin B12 deficiency presenting as a peripheral neuropathy. South. Med. J. 103(3), 265\u2013267 (2010). \nhttps:\/\/doi.org\/10.1097\/SMJ.0b013e3181ce0e4d","journal-title":"South. Med. J."},{"key":"2053_CR11","first-page":"58","volume":"60","author":"AA Kumthekar","year":"2012","unstructured":"A.A. Kumthekar, H.V. Gidwani, A.B. Kumthekar, Metformin associated B12 deficiency. J. Assoc. Physicians India 60, 58\u201360 (2012)","journal-title":"J. Assoc. Physicians India"},{"issue":"12","key":"2053_CR12","doi-asserted-by":"publisher","first-page":"768","DOI":"10.3390\/nu8120768","volume":"8","author":"Nithya Sukumar","year":"2016","unstructured":"N. Sukumar, H. Venkataraman, S. Wilson, I. Goljan, S. Selvamoni, V. Patel, P. Saravanan, Vitamin B12 status among pregnant women in the UK and its association with obesity and gestational diabetes. Nutrients 8(12) (2016). \nhttps:\/\/doi.org\/10.3390\/nu8120768","journal-title":"Nutrients"},{"issue":"11","key":"2053_CR13","doi-asserted-by":"publisher","first-page":"2350","DOI":"10.1007\/s00125-009-1499-0","volume":"52","author":"GV Krishnaveni","year":"2009","unstructured":"G.V. Krishnaveni, J.C. Hill, S.R. Veena, D.S. Bhat, A.K. Wills, C.L. Karat, C.S. Yajnik, C.H. Fall, Low plasma vitamin B12 in pregnancy is associated with gestational \u2018diabesity\u2019 and later diabetes. Diabetologia 52(11), 2350\u20132358 (2009). \nhttps:\/\/doi.org\/10.1007\/s00125-009-1499-0","journal-title":"Diabetologia"},{"issue":"6","key":"2053_CR14","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1111\/j.0001-6349.2004.00540.x","volume":"83","author":"E Tarim","year":"2004","unstructured":"E. Tarim, T. Bagis, E. Kilicdag, S. Erkanli, E. Aslan, N. Sezgin, E. Kuscu, Elevated plasma homocysteine levels in gestational diabetes mellitus. Acta Obstet. et. Gynecol. Scand. 83(6), 543\u2013547 (2004). \nhttps:\/\/doi.org\/10.1111\/j.0001-6349.2004.00540.x","journal-title":"Acta Obstet. et. Gynecol. Scand."},{"issue":"6","key":"2053_CR15","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s00404-006-0191-6","volume":"274","author":"MA Guven","year":"2006","unstructured":"M.A. Guven, M. Kilinc, C. Batukan, H.C. Ekerbicer, T. Aksu, Elevated second trimester serum homocysteine levels in women with gestational diabetes mellitus. Arch. Gynecol. Obstet. 274(6), 333\u2013337 (2006). \nhttps:\/\/doi.org\/10.1007\/s00404-006-0191-6","journal-title":"Arch. Gynecol. Obstet."},{"issue":"6","key":"2053_CR16","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/S0026-0495(03)00032-5","volume":"52","author":"G Seghieri","year":"2003","unstructured":"G. Seghieri, M.C. Breschi, R. Anichini, A. De Bellis, L. Alviggi, I. Maida, F. Franconi, Serum homocysteine levels are increased in women with gestational diabetes mellitus. Metab.: Clin. Exp. 52(6), 720\u2013723 (2003)","journal-title":"Metab.: Clin. Exp."},{"issue":"4","key":"2053_CR17","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/s00404-008-0571-1","volume":"278","author":"B Idzior-Walus","year":"2008","unstructured":"B. Idzior-Walus, K. Cyganek, K. Sztefko, G. Seghieri, M.C. Breschi, M. Walus-Miarka, E. Kawalec, M. Seretny, J. Sieradzki, Total plasma homocysteine correlates in women with gestational diabetes. Arch. Gynecol. Obstet. 278(4), 309\u2013313 (2008). \nhttps:\/\/doi.org\/10.1007\/s00404-008-0571-1","journal-title":"Arch. Gynecol. Obstet."},{"issue":"7","key":"2053_CR18","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1016\/0002-9378(82)90349-0","volume":"144","author":"MW Carpenter","year":"1982","unstructured":"M.W. Carpenter, D.R. Coustan, Criteria for screening tests for gestational diabetes. Am. J. Obstet. Gynecol. 144(7), 768\u2013773 (1982)","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2053_CR19","unstructured":"World Health Organization, Definition and Diagnosis of Diabetes Mellitus and Intermediate Hyperglycemia: A Report of WHO\/IDF Consultation (World Health Organization, Geneva, 2006)"},{"issue":"Suppl 1","key":"2053_CR20","first-page":"S1","volume":"24","author":"American Diabetes Association","year":"2001","unstructured":"American Diabetes Association, Clinical practice recommendations 2001. Diabetes Care 24(Suppl 1), S1\u2013133 (2001)","journal-title":"Diabetes Care"},{"issue":"3","key":"2053_CR21","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1111\/dme.12390","volume":"31","author":"S Finer","year":"2014","unstructured":"S. Finer, P. Saravanan, G. Hitman, C. Yajnik, The role of the one-carbon cycle in the developmental origins of Type 2 diabetes and obesity. Diabet. Med. 31(3), 263\u2013272 (2014). \nhttps:\/\/doi.org\/10.1111\/dme.12390","journal-title":"Diabet. Med."},{"key":"2053_CR22","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-014-0129-4","volume":"13","author":"A Adaikalakoteswari","year":"2014","unstructured":"A. Adaikalakoteswari, R. Jayashri, N. Sukumar, H. Venkataraman, R. Pradeepa, K. Gokulakrishnan, R.M. Anjana, P.G. McTernan, G. Tripathi, V. Patel, S. Kumar, V. Mohan, P. Saravanan, Vitamin B12 deficiency is associated with adverse lipid profile in Europeans and Indians with type 2 diabetes. Cardiovasc. Diabetol. 13, 129 (2014). \nhttps:\/\/doi.org\/10.1186\/s12933-014-0129-4","journal-title":"Cardiovasc. Diabetol."},{"issue":"11","key":"2053_CR23","doi-asserted-by":"publisher","first-page":"4200","DOI":"10.1210\/jc.2017-01155","volume":"102","author":"A Adaikalakoteswari","year":"2017","unstructured":"A. Adaikalakoteswari, M. Vatish, M.T. Alam, S. Ott, S. Kumar, P. Saravanan, Low vitamin B12 in pregnancy is associated with adipose-derived circulating miRs targeting PPARgamma and insulin resistance. J. Clin. Endocrinol. Metab. 102(11), 4200\u20134209 (2017). \nhttps:\/\/doi.org\/10.1210\/jc.2017-01155","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"8","key":"2053_CR24","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.2337\/diacare.24.8.1403","volume":"24","author":"JB Meigs","year":"2001","unstructured":"J.B. Meigs, P.F. Jacques, J. Selhub, D.E. Singer, D.M. Nathan, N. Rifai, R.B. D\u2019Agostino Sr., P.W. Wilson, Fasting plasma homocysteine levels in the insulin resistance syndrome: the Framingham offspring study. Diabetes Care 24(8), 1403\u20131410 (2001)","journal-title":"Diabetes Care"},{"issue":"6","key":"2053_CR25","doi-asserted-by":"publisher","first-page":"361","DOI":"10.4103\/0019-5359.32687","volume":"61","author":"MA Kothekar","year":"2007","unstructured":"M.A. Kothekar, Homocysteine in cardiovascular disease: a culprit or an innocent bystander? Indian J. Med. Sci. 61(6), 361\u2013371 (2007)","journal-title":"Indian J. Med. Sci."},{"issue":"5","key":"2053_CR26","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1093\/ajcn\/86.5.1302","volume":"86","author":"S Taneja","year":"2007","unstructured":"S. Taneja, N. Bhandari, T.A. Strand, H. Sommerfelt, H. Refsum, P.M. Ueland, J. Schneede, R. Bahl, M.K. Bhan, Cobalamin and folate status in infants and young children in a low-to-middle income community in India. Am. J. Clin. Nutr. 86(5), 1302\u20131309 (2007). \nhttps:\/\/doi.org\/10.1093\/ajcn\/86.5.1302","journal-title":"Am. J. Clin. Nutr."},{"issue":"6","key":"2053_CR27","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1053\/meta.2002.32731","volume":"51","author":"V Fonseca","year":"2002","unstructured":"V. Fonseca, M. Keebler, A. Dicker-Brown, C. Desouza, L.A. Poirier, S.N. Murthy, D.B. McNamara, The effect of troglitazone on plasma homocysteine, hepatic and red blood cell S-adenosyl methionine, and S-adenosyl homocysteine and enzymes in homocysteine metabolism in Zucker rats. Metab.: Clin. Exp. 51(6), 783\u2013786 (2002)","journal-title":"Metab.: Clin. Exp."},{"issue":"3 Pt 1","key":"2053_CR28","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1016\/S0002-9378(99)70269-3","volume":"180","author":"MC Walker","year":"1999","unstructured":"M.C. Walker, G.N. Smith, S.L. Perkins, E.J. Keely, P.R. Garner, Changes in homocysteine levels during normal pregnancy. Am. J. Obstet. Gynecol. 180(3 Pt 1), 660\u2013664 (1999)","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2053_CR29","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1146\/annurev.me.44.020193.001005","volume":"44","author":"GM Reaven","year":"1993","unstructured":"G.M. Reaven, Role of insulin resistance in human disease (syndrome X): an expanded definition. Annu. Rev. Med. 44, 121\u2013131 (1993). \nhttps:\/\/doi.org\/10.1146\/annurev.me.44.020193.001005","journal-title":"Annu. Rev. Med."},{"issue":"12","key":"2053_CR30","doi-asserted-by":"publisher","first-page":"4244","DOI":"10.1210\/jcem.81.12.8954022","volume":"81","author":"G Paolisso","year":"1996","unstructured":"G. Paolisso, A. Gambardella, M.R. Tagliamonte, F. Saccomanno, T. Salvatore, P. Gualdiero, M.V. D\u2019Onofrio, B.V. Howard, Does free fatty acid infusion impair insulin action also through an increase in oxidative stress? J. Clin. Endocrinol. Metab. 81(12), 4244\u20134248 (1996). \nhttps:\/\/doi.org\/10.1210\/jcem.81.12.8954022","journal-title":"J. Clin. Endocrinol. Metab."}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-019-02053-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12020-019-02053-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-019-02053-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T23:43:46Z","timestamp":1598485426000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12020-019-02053-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,28]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["2053"],"URL":"https:\/\/doi.org\/10.1007\/s12020-019-02053-1","relation":{},"ISSN":["1355-008X","1559-0100"],"issn-type":[{"value":"1355-008X","type":"print"},{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,28]]},"assertion":[{"value":"15 May 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 August 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}