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The purpose of this paper is to assess the impact of pre treatment with MMI on the efficacy of <jats:sup>131<\/jats:sup>I therapy in non-toxic multinodular goitre (NMG).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Thirty-one patients with NMG received <jats:sup>131<\/jats:sup>I treatment in order to reduce the volume of the thyroid (TVR). Those in group 1 (<jats:italic>n<\/jats:italic>\u2009=\u200916) were administered 10\u2009mg of methimazole for 6 weeks. Four days after its discontinuation, they received <jats:sup>131<\/jats:sup>I. Patients in group 2 (<jats:italic>n<\/jats:italic>\u2009=\u200915) were given a placebo instead of MMI. The therapeutic activity of <jats:sup>131<\/jats:sup>I was constant (800\u2009MBq) and was repeated every 6 months. Treatment was discontinued when TVR reached &lt;40\u2009ml.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>In group 1, RAIU increased approximately twofold. Ten patients from group 2 and four patients from group 1 received further doses of <jats:sup>131<\/jats:sup>I. The median of time until TVR decreased below 40\u2009ml was 9 months [6\u201312 months] and 18 months [14\u201322 months] in group 2. At 2 years after the <jats:sup>131<\/jats:sup>I therapy, the occurrence of hypothyroidism did not differ significantly (36% in group 1 and 33% in group2, <jats:italic>p<\/jats:italic>\u2009=\u20090.074).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Radioiodine treatment of NMG preceded with appropriate application of MMI is efficient thanks to increased RAIU, shorter period of treatment, and lower frequency of <jats:sup>131<\/jats:sup>I administration, without an increase in the incidence of post-treatment hypothyroidism.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s12020-019-02100-x","type":"journal-article","created":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T15:07:52Z","timestamp":1570201672000},"page":"136-142","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Enhancing the efficacy of 131I therapy in non-toxic multinodular goitre with appropriate use of methimazole: an analysis of randomized controlled study"],"prefix":"10.1007","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8178-6583","authenticated-orcid":false,"given":"Piotr","family":"Szumowski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeid","family":"Abdelrazek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Syka\u0142a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Mojsak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0141ukasz","family":"\u017bukowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Siewko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Maliszewska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Adamska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Pop\u0142awska-Kita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Kr\u0119towski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janusz","family":"My\u015bliwiec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,10,4]]},"reference":[{"key":"2100_CR1","first-page":"3684","volume":"167","author":"A Vej-Hansen","year":"2005","unstructured":"A. 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