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However, expression of AMH receptor (AMHR-2) has never been studied in human testes, and high intratubular concentrations of AMH have been reported in recent literature. We therefore assessed expression of AMHR-2 in several testicular tissue samples by immunohistochemistry (IHC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The IHC method was first validated on tissue samples from healthy human testis (<jats:italic>n<\/jats:italic>\u2009=\u20092) and from marmoset ovary (<jats:italic>n<\/jats:italic>\u2009=\u20091). The same method was then used for assessment on testicular histopathology specimens from patients with mixed atrophy (MA,<jats:italic>n<\/jats:italic>\u2009=\u20092), spermatogenetic arrest (SA,<jats:italic>n<\/jats:italic>\u2009=\u20092), Sertoli cell-only syndrome (SCO,<jats:italic>n<\/jats:italic>\u2009=\u20091), Klinefelter syndrome (KS,<jats:italic>n<\/jats:italic>\u2009=\u20091), and nonseminomatous germ cell tumors (NSGCT,<jats:italic>n<\/jats:italic>\u2009=\u20091). Tissue samples from two subjects at different pubertal stages (AndroProtect (AP), aged 5 and 14 years) with hematological malignancies were also retrieved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In adult men, AMHR-2 was expressed on peritubular mesenchymal cells, with patterns closely mirroring \u03b1-smooth muscle actin expression. Similar patterns were preserved in almost all conditions; however, in nonseminomatous germ cell tumors the tissue architecture was lost, including AMHR-2 expression. More positive and diffuse staining was observed in tissue samples from prepubertal testes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In specimens from both healthy and affected testes, AMHR-2 expression appears weaker in adult than in prepubertal tissue sections. The persistence of AMHR-2 expression seemingly hints at a possible effect of intratesticular AMH on the tubular walls.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s12020-020-02210-x","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T10:02:52Z","timestamp":1580983372000},"page":"215-221","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Immunohistochemical characterization of the anti-M\u00fcllerian hormone receptor type 2 (AMHR-2) in human testes"],"prefix":"10.1007","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1210-2843","authenticated-orcid":false,"given":"A.","family":"Sansone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9037-5417","authenticated-orcid":false,"given":"A. 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