{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T02:58:51Z","timestamp":1794020331876,"version":"4.8.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T00:00:00Z","timestamp":1587945600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T00:00:00Z","timestamp":1587945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/http:\/\/dx.doi.org\/10.13039\/501100005857","name":"Uniwersytet Przyrodniczy w Poznaniu","doi-asserted-by":"publisher","award":["506.534.04.05"],"award-info":[{"award-number":["506.534.04.05"]}],"id":[{"id":"10.13039\/http:\/\/dx.doi.org\/10.13039\/501100005857","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Short stature in children is a significant medical problem which, without proper diagnosis and treatment, can lead to long-term consequences for physical and psychological health in adult life. Since human height is a polygenic and highly heritable trait, numerous variants in the genes involved in growth\u2014including the growth hormone (<jats:italic>GH1<\/jats:italic>) gene\u2014have been identified as causes of short stature.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In this study, we performed for the first time molecular analysis of the <jats:italic>GH1<\/jats:italic> gene in a cohort (<jats:italic>n<\/jats:italic>\u2009=\u2009186) of Polish children and adolescents with short stature, suffering from growth hormone deficiency (GHD) or idiopathic short stature (ISS), and a control cohort (<jats:italic>n<\/jats:italic>\u2009=\u2009178).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Thirteen SNP variants were identified, including four missense variants, six in 5\u2032UTR, and three in introns. The frequency of minor missense variants was low (&lt;0.02) and similar in the compared cohorts. However, two of these variants, Ala39Val (rs151263636) and Arg42Leu (rs371953554), were found (heterozygote status) in only two GHD patients. These substitutions, according to databases, can potentially be deleterious.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Mutations of <jats:italic>GH1<\/jats:italic> causing short stature are very rare in the Polish population, but two potentially causative variants need further studies in a larger cohort of GHD patients.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s12020-020-02305-5","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T10:02:46Z","timestamp":1587981766000},"page":"157-164","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Polymorphism of the growth hormone gene GH1 in Polish children and adolescents with short stature"],"prefix":"10.1007","volume":"69","author":[{"given":"Katarzyna Anna","family":"Majewska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Kedzia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Przemyslaw","family":"Kontowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Prauzinska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaroslaw","family":"Szydlowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Switonski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1041-3576","authenticated-orcid":false,"given":"Joanna","family":"Nowacka-Woszuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,27]]},"reference":[{"issue":"3","key":"2305_CR1","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.ehb.2009.09.005","volume":"7","author":"BP McEvoy","year":"2009","unstructured":"B.P. McEvoy, P.M. Visscher, Genetics of human height. Econ. Hum. Biol. 7(3), 294\u2013306 (2009)","journal-title":"Econ. Hum. Biol."},{"key":"2305_CR2","doi-asserted-by":"publisher","first-page":"928","DOI":"10.5604\/17322693.1218181","volume":"70","author":"J Oswiecimska","year":"2016","unstructured":"J. Oswiecimska, W. Roczniak, A. Mikolajczak, A. Szymlak, Growth hormone deficiency in children and young adults. Postepy Hig. Med. Dosw. 70, 928\u2013937 (2016)","journal-title":"Postepy Hig. Med. Dosw."},{"issue":"1","key":"2305_CR3","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-019-1840-4","volume":"17","author":"S Esposito","year":"2019","unstructured":"S. Esposito, A. Leonardi, L. Lanciotti, M. Cofini, G. Muzi, L. Penta, Vitamin D and growth hormone in children: a review of the current scientific knowledge. J. Transl. Med. 17(1), 87 (2019)","journal-title":"J. Transl. Med."},{"key":"2305_CR4","unstructured":"P. Bang, Pediatric implications of normal insulin-GH-IGF-axis physiology. In: K.R. Feingold, B. Anawalt, A. Boyce, G. Chrousos, K. Dungan, A. Grossman, J.M. Hershman, G. Kaltsas, C. Koch, P. Kopp, M. Korbonits, R. McLachlan, J.E. Morley, M. New, L. Perreault, J. Purnell, R. Rebar, F. Singer, D.L. Trence, A. Vinik, D.P. Wilson (eds), Endotext (MDText.com, Inc., South Dartmouth, MA, 2000\u20132019)"},{"key":"2305_CR5","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.ghir.2017.12.003","volume":"38","author":"M Grunauer","year":"2018","unstructured":"M. Grunauer, A.A.L. Jorge, Genetic short stature. Growth Horm. IGF Res. 38, 29\u201333 (2018)","journal-title":"Growth Horm. IGF Res."},{"issue":"6","key":"2305_CR6","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1002\/cpp.2105","volume":"24","author":"R Sommer","year":"2017","unstructured":"R. Sommer, M. Bullinger, J. Chaplin, J.K. Do, M. Power, A. Pleil, J. Quitmann, Experiencing health-related quality of life in paediatric short stature\u2014a cross-cultural analysis of statements from patients and parents. Clin. Psychol. Psychother. 24(6), 1370\u20131376 (2017)","journal-title":"Clin. Psychol. Psychother."},{"issue":"5","key":"2305_CR7","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1515\/jpem-2017-0489","volume":"31","author":"M Polak","year":"2018","unstructured":"M. Polak, D. Konrad, B. T\u00f8nnes Pedersen, G. Puras, M. \u0160najderov\u00e1, Still too little, too late? Ten years of growth hormone therapy baseline data from the NordiNet\u00ae International Outcome Study. J. Pediatr. Endocrinol. Metab. 31(5), 521\u2013532 (2018)","journal-title":"J. Pediatr. Endocrinol. Metab."},{"issue":"1","key":"2305_CR8","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1530\/eje.1.01797","volume":"152","author":"PE Mullis","year":"2005","unstructured":"P.E. Mullis, Genetic control of growth. Eur. J. Endocrinol. 152(1), 11\u201331 (2005)","journal-title":"Eur. J. Endocrinol."},{"issue":"3","key":"2305_CR9","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1210\/er.2013-1067","volume":"35","author":"KS Alatzoglou","year":"2014","unstructured":"K.S. Alatzoglou, E.A. Webb, P. Le Tissier, M.T. Dattani, Isolated growth hormone deficiency (GHD) in childhood and adolescence: recent advances. Endocr. Rev. 35(3), 376\u2013432 (2014)","journal-title":"Endocr. Rev."},{"issue":"10","key":"2305_CR10","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1507\/endocrj.EJ17-0150","volume":"64","author":"A Hattori","year":"2017","unstructured":"A. Hattori, Y. Katoh-Fukui, A. Nakamura, K. Matsubara, T. Kamimaki, H. Tanaka, S. Dateki, M. Adachi, K. Muroya, S. Yoshida, S. Ida, M. Mitani, K. Nagasaki, T. Ogata, E. Suzuki, K. Hata, K. Nakabayashi, Y. Matsubara, S. Narumi, T. Tanaka, M. Fukami, Next generation sequencing-based mutation screening of 86 patients with idiopathic short stature. Endocr. J. 64(10), 947\u2013954 (2017)","journal-title":"Endocr. J."},{"issue":"1","key":"2305_CR11","doi-asserted-by":"publisher","first-page":"70","DOI":"10.20945\/2359-3997000000105","volume":"63","author":"GA Vasques","year":"2019","unstructured":"G.A. Vasques, N.L.M. Andrade, A.A.L. Jorge, Genetic causes of isolated short stature. Arch. Endocrinol. Metab. 63(1), 70\u201378 (2019)","journal-title":"Arch. Endocrinol. Metab."},{"issue":"4","key":"2305_CR12","doi-asserted-by":"publisher","first-page":"R145","DOI":"10.1530\/EJE-15-0937","volume":"174","author":"JM Wit","year":"2016","unstructured":"J.M. Wit, W. Oostdijk, M. Losekoot, H.A. van Duyvenvoorde, C.A. Ruivenkamp, S.G. Kant, Mechanisms in endocrinology: novel genetic causes of short stature. Eur. J. Endocrinol. 174(4), R145\u2013R173 (2016)","journal-title":"Eur. J. Endocrinol."},{"key":"2305_CR13","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.ghir.2016.04.001","volume":"29","author":"S Birla","year":"2016","unstructured":"S. Birla, R. Khadgawat, V.P. Jyotsna, V. Jain, M.K. Garg, A.S. Bhalla, A. Sharma, Identification of novel GHRHR and GH1 mutations in patients with isolated growth hormone deficiency. Growth Horm. IGF Res. 29, 50\u201356 (2016)","journal-title":"Growth Horm. IGF Res."},{"key":"2305_CR14","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.ghir.2017.08.006","volume":"36","author":"T Sundralingam","year":"2017","unstructured":"T. Sundralingam, K.H. Tennekoon, S. de Silva, S. De Silva, A.S. Hewage, Pathogenic and likely pathogenic genetic alterations and polymorphisms in growth hormone gene (GH1) and growth hormone releasing hormone receptor gene (GHRHR) in a cohort of isolated growth hormone eficient (IGHD) children in Sri Lanka. Growth Horm. IGF Res. 36, 22\u201329 (2017)","journal-title":"Growth Horm. IGF Res."},{"issue":"4","key":"2305_CR15","doi-asserted-by":"publisher","first-page":"426","DOI":"10.4274\/jcrpe.galenos.2019.2018.0305","volume":"11","author":"A Kautsar","year":"2019","unstructured":"A. Kautsar, J.M. Wit, A. Pulungan, Isolated growth hormone deficiency type II due to a novel GH1 mutation: a case report. J. Clin. Res. Pediatr. Endocrinol. 11(4), 426\u2013431 (2019)","journal-title":"J. Clin. Res. Pediatr. Endocrinol."},{"issue":"1","key":"2305_CR16","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1507\/endocrj.44.149","volume":"44","author":"I Miyata","year":"1997","unstructured":"I. Miyata, J.D. Cogan, M.A. Prince, T. Kamijo, M. Ogawa, J.A. Phillips 3rd, Detection of growth hormone gene defects by dideoxy fingerprinting (ddF). Endocr. J. 44(1), 149\u2013154 (1997)","journal-title":"Endocr. J."},{"issue":"8","key":"2305_CR17","doi-asserted-by":"publisher","first-page":"3877","DOI":"10.1210\/jcem.86.8.7757","volume":"86","author":"G Binder","year":"2001","unstructured":"G. Binder, E. Keller, M. Mix, G.G. Massa, W.H. Stokvis-Brantsma, J.M. Wit, M.B. Ranke, Isolated GH deficiency with dominant inheritance: new mutations, new insights. J. Clin. Endocrinol. Metab. 86(8), 3877\u20133881 (2001)","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"2305_CR18","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s12098-011-0614-7","volume":"79","author":"KS Alatzoglou","year":"2012","unstructured":"K.S. Alatzoglou, M.T. Dattani, Phenotype-genotype correlations in congenital isolated growth hormone deficiency (IGHD). Indian J. Pediatr. 79(1), 99\u2013106 (2012)","journal-title":"Indian J. Pediatr."},{"issue":"6","key":"2305_CR19","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.beem.2016.09.005","volume":"30","author":"M Giordano","year":"2016","unstructured":"M. Giordano, Genetic causes of isolated and combined pituitary hormone deficiency. Best Pract. Res. Clin. Endocrinol. Metab. 30(6), 679\u2013691 (2016)","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"issue":"5","key":"2305_CR20","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1210\/en.2013-2146","volume":"155","author":"D Babu","year":"2014","unstructured":"D. Babu, S. Mellone, I. Fusco, A. Petri, G.E. Walker, S. Bellone, F. Prodam, P. Momigliano-Richiardi, G. Bona, M. Giordano, Novel mutations in the GH gene (GH1) uncover putative splicing regulatory elements. Endocrinology 155(5), 1786\u20131792 (2014)","journal-title":"Endocrinology"},{"issue":"6","key":"2305_CR21","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1111\/cen.13400","volume":"87","author":"C Cabrera-Salcedo","year":"2017","unstructured":"C. Cabrera-Salcedo, A.S. Shah, M. Andrew, L. Tyzinski, V. Hwa, I. Gutmark-Little, P. Backeljauw, A. Dauber, Isolated growth hormone deficiency due to the R183H mutation in GH1: clinical analysis of a four-generation family. Clin. Endocrinol. 87(6), 874\u2013876 (2017)","journal-title":"Clin. Endocrinol."},{"issue":"4","key":"2305_CR22","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1002\/mgg3.395","volume":"6","author":"MI P\u00e9rez Mill\u00e1n","year":"2018","unstructured":"M.I. P\u00e9rez Mill\u00e1n, S.A. Vishnopolska, A.Z. Daly, J.P. Bustamante, A. Seilicovich, I. Bergad\u00e1, D. Braslavsky, A.C. Keselman, R.M. Lemons, A.H. Mortensen, M.A. Marti, S.A. Camper, J.O. Kitzman, Next generation sequencing panel based on single molecule molecular inversion probes for detecting genetic variants in children with hypopituitarism. Mol. Genet. Genom. Med. 6(4), 514\u2013525 (2018)","journal-title":"Mol. Genet. Genom. Med."},{"issue":"9","key":"2305_CR23","doi-asserted-by":"publisher","first-page":"3191","DOI":"10.1210\/jc.2008-2783","volume":"94","author":"KS Alatzoglou","year":"2009","unstructured":"K.S. Alatzoglou, J.P. Turton, D. Kelberman, P.E. Clayton, A. Mehta, C. Buchanan, S. Aylwin, E.C. Crowne, H.T. Christesen, N.T. Hertel, P.J. Trainer, M.O. Savage, J. Raza, K. Banerjee, S.K. Sinha, S. Ten, T. Mushtaq, R. Brauner, T.D. Cheetham, P.C. Hindmarsh, P.E. Mullis, M.T. Dattani, Expanding the spectrum of mutations in GH1 and GHRHR: genetic screening in a large cohort of patients with congenital isolated growth hormone deficiency. J. Clin. Endocrinol. Metab. 94(9), 3191\u20133199 (2009)","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"5","key":"2305_CR24","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1111\/j.1365-2265.2008.03414.x","volume":"70","author":"LCG de Graaff","year":"2009","unstructured":"L.C.G. de Graaff, J. Argente, D.C.M. Veenma, M.A.C. Herrebout, E.C.H. Friesema, A.G. Uitterlinden, M.L. Drent, A. Campos-Barros, A.C.S. Hokken-Koelega, Genetic screening of a Dutch population with isolated GH deficiency (IGHD). Clin. Endocrinol. 70(5), 742\u2013750 (2009)","journal-title":"Clin. Endocrinol."},{"issue":"11","key":"2305_CR25","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1002\/humu.23847","volume":"40","author":"E Cohen","year":"2019","unstructured":"E. Cohen, S. Belkacem, S. Fedala, N. Collot, E. Khallouf, F. Dastot, M. Polak, P. Duquesnoy, F. Brioude, S. Rose, G. Viot, A. Soleyan, J.C. Carel, M.L. Sobrier, P. Chanson, F. Gatelais, C. Heinrichs, N. Kaffel, R. Coutant, S. Sava\u015f Erdeve, E. Kurnaz, Z. Aycan, C. Thalassinos, S. Lyonnet, Z. \u015e\u0131klar, M. Berberoglu, C. Brachet, S. Amselem, M. Legendre, Contribution of functionally assessed GHRHR mutations to idiopathic isolated growth hormone deficiency in patients without GH1 mutations. Hum. Mutat. 40(11), 2033\u20132043 (2019)","journal-title":"Hum. Mutat."},{"issue":"3","key":"2305_CR26","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1093\/hmg\/ddv486","volume":"25","author":"ML Sobrier","year":"2016","unstructured":"M.L. Sobrier, Y.C. Tsai, C. P\u00e9rez, B. Leheup, T. Bouceba, P. Duquesnoy, B. Copin, D. Sizova, A. Penzo, B.Z. Stanger, N.E. Cooke, S.A. Liebhaber, S. Amselem, Functional characterization of a human POU1F1 mutation associated with isolated growth hormone deficiency: a novel etiology for IGHD. Hum. Mol. Genet. 25(3), 472\u2013483 (2016)","journal-title":"Hum. Mol. Genet."},{"issue":"4","key":"2305_CR27","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1055\/a-0867-1026","volume":"51","author":"S Birla","year":"2019","unstructured":"S. Birla, P. Vijayakumar, S. Sehgal, S. Bhatnagar, K. Pallavi, A. Sharma, Characterization of a novel POU1F1 mutation identified on screening 160 growth hormone deficiency patients. Horm. Metab. Res. 51(4), 248\u2013255 (2019)","journal-title":"Horm. Metab. Res."},{"issue":"3","key":"2305_CR28","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1159\/000496989","volume":"91","author":"CA Quigley","year":"2019","unstructured":"C.A. Quigley, Y.G. Li, M.R. Brown, S.G. Pillai, P. Banerjee, R.S. Scott, W.F. Blum, J.S. Parks, Genetic polymorphisms associated with idiopathic short stature and first-year response to growth hormone treatment. Horm. Res. Paediatr. 91(3), 164\u2013174 (2019)","journal-title":"Horm. Res. Paediatr."},{"issue":"34","key":"2305_CR29","doi-asserted-by":"publisher","first-page":"15140","DOI":"10.1073\/pnas.1009622107","volume":"107","author":"GP Sykiotis","year":"2010","unstructured":"G.P. Sykiotis, L. Plummer, V.A. Hughes, M. Au, S. Durrani, S. Nayak-Young, A.A. Dwyer, R. Quinton, J.E. Hall, J.F. Gusella, S.B. Seminara, W.F. Crowley Jr, N. Pitteloud, Oligogenic basis of isolated gonadotropin-releasing hormone deficiency. Proc. Natl. Acad. Sci. USA 107(34), 15140\u201315144 (2010)","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"6","key":"2305_CR30","doi-asserted-by":"publisher","first-page":"2050","DOI":"10.1210\/jc.2007-2617","volume":"93","author":"A Grimberg","year":"2008","unstructured":"A. Grimberg, E. Stewart, M.P. Wajnrajch, Gender of pediatric recombinant human growth hormone recipients in the United States and globally. J. Clin. Endocrinol. Metab. 93(6), 2050\u20132056 (2008)","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"5","key":"2305_CR31","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1530\/EJE-16-1024","volume":"177","author":"M Polak","year":"2017","unstructured":"M. Polak, J. Blair, P. Kotnik, E. Pournara, B.T. Pedersen, T.R. Rohrer, Early growth hormone treatment start in childhood growth hormone deficiency improves near adult height: analysis from NordiNet\u00ae International Outcome Study. Eur. J. Endocrinol. 177(5), 421\u2013429 (2017)","journal-title":"Eur. J. Endocrinol."},{"issue":"1","key":"2305_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000502231","volume":"92","author":"PF Collett-Solberg","year":"2019","unstructured":"P.F. Collett-Solberg, G. Ambler, P.F. Backeljauw, M. Bidlingmaier, B.M.K. Biller, M.C.S. Boguszewski, P.T. Cheung, C.S.Y. Choong, L.E. Cohen, P. Cohen, A. Dauber, C.L. Deal, C. Gong, Y. Hasegawa, A.R. Hoffman, P.L. Hofman, R. Horikawa, A.A.L. Jorge, A. Juul, P. Kamenick\u00fd, V. Khadilkar, J.J. Kopchick, B. Kristr\u00f6m, M.L.A. Lopes, X. Luo, B.S. Miller, M. Misra, I. Netchine, S. Radovick, M.B. Ranke, A.D. Rogol, R.G. Rosenfeld, P. Saenger, J.M. Wit, J. Woelfle, Diagnosis, genetics, and therapy of short stature in children: a Growth Hormone Research Society International perspective. Horm. Res. Paediatr. 92(1), 1\u201314 (2019)","journal-title":"Horm. Res. Paediatr."}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-020-02305-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12020-020-02305-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-020-02305-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T00:33:02Z","timestamp":1619483582000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12020-020-02305-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,27]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["2305"],"URL":"https:\/\/doi.org\/10.1007\/s12020-020-02305-5","relation":{},"ISSN":["1355-008X","1559-0100"],"issn-type":[{"value":"1355-008X","type":"print"},{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,27]]},"assertion":[{"value":"8 January 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 April 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee (local Ethics Committee at Poznan University of Medical Sciences, No. 1070\/15) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}