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In this community-based study, we thoroughly investigated fatty acid metabolism, incretin response, glucose tolerance, insulin secretion and insulin sensitivity, and autonomic nerve activity in men with or without OSA.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Fifteen men without diabetes but with signs of severe OSA, defined as apnea\u2013hypopnea index (AHI) &gt;30, and 15 age- and BMI-matched men without OSA (AHI\u2009&lt;\u20095) were recruited from a community-based cohort. Assessments included clinical and anthropometric measurements, a 2-h oral glucose tolerance test (OGTT), and autonomic nerve activity using heart rate variability (HRV).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Men with OSA had higher body fat % than BMI-matched men without OSA (<jats:italic>p<\/jats:italic>\u2009=\u20090.046) and it was associated with markers of insulin resistance. The area under the curve for nonesterified fatty acids (NEFA) during OGTT was higher in men with OSA (<jats:italic>p<\/jats:italic>\u2009=\u20090.021) and fasting NEFA levels were numerically higher (<jats:italic>p<\/jats:italic>\u2009=\u20090.097). The plasma glucose at fasting and during OGTT was higher in men with OSA (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Incretin response was similar between groups. Fasting and OGTT-derived indices indicated impaired insulin sensitivity in men with OSA. Compared with men without OSA, Matsuda index (<jats:italic>p<\/jats:italic>\u2009=\u20090.068) and Gutt index (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) were lower in men with OSA. The HRV measures did not differ between groups.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Our study suggests that fatty acid handling, glucose tolerance, and insulin sensitivity are impaired in men with severe OSA. This might partly be explained by the increased body fat percentage.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s12020-020-02369-3","type":"journal-article","created":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T05:02:26Z","timestamp":1592542946000},"page":"48-57","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Sleep apnea in men is associated with altered lipid metabolism, glucose tolerance, insulin sensitivity, and body fat percentage"],"prefix":"10.1007","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5627-8904","authenticated-orcid":false,"given":"Prasad G.","family":"Kamble","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Theorell-Hagl\u00f6w","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urban","family":"Wiklund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl A.","family":"Franklin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Hammar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Lindberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan W.","family":"Eriksson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,19]]},"reference":[{"issue":"1","key":"2369_CR1","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1152\/physrev.00043.2008","volume":"90","author":"JA Dempsey","year":"2010","unstructured":"J.A. 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