{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T10:37:10Z","timestamp":1721644630077},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T00:00:00Z","timestamp":1592265600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T00:00:00Z","timestamp":1592265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Universit\u00e0 degli Studi di Brescia","award":["local funds 2015-2016-2017"],"award-info":[{"award-number":["local funds 2015-2016-2017"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1007\/s12020-020-02373-7","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T13:03:46Z","timestamp":1592399026000},"page":"604-614","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Differential effects of metformin on reductive activity and energy production in pituitary tumor cells compared to myogenic precursors"],"prefix":"10.1007","volume":"69","author":[{"given":"Giovanni","family":"Tulipano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Paghera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Missale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Giustina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,6,16]]},"reference":[{"key":"2373_CR1","doi-asserted-by":"publisher","first-page":"R17","DOI":"10.1530\/JME-19-0083","volume":"63","author":"S Thakur","year":"2019","unstructured":"S. Thakur, B. Daley, J. Klubo-Gwiezdzinska, The role of the antidiabetic drug metformin in the treatment of endocrine tumors. J. Mol. Endocrinol. 63, R17\u2013R35 (2019)","journal-title":"J. Mol. Endocrinol."},{"key":"2373_CR2","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1007\/s11102-010-0288-6","volume":"14","author":"G Tulipano","year":"2011","unstructured":"G. Tulipano, M. Giovannini, M. Spinello, V. Sibilia, A. Giustina, D. Cocchi, AMP-activated protein kinase regulates normal rat somatotroph cell function and growth of rat pituitary adenomatous cells. Pituitary 14, 242\u2013252 (2011)","journal-title":"Pituitary"},{"key":"2373_CR3","doi-asserted-by":"publisher","first-page":"37538","DOI":"10.18632\/oncotarget.16556","volume":"8","author":"J An","year":"2017","unstructured":"J. An, X. Pei, Z. Zang, Z. Zhou, J. Hu, X. Zheng, Y. Zhang, J. He, L. Duan, R. Shen et al. Metformin inhibits proliferation and growth hormone secretion of GH3 pituitary adenoma cells. Oncotarget 8, 37538\u201337549 (2017)","journal-title":"Oncotarget"},{"key":"2373_CR4","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.mce.2017.09.030","volume":"470","author":"L Faggi","year":"2018","unstructured":"L. Faggi, A. Giustina, G. Tulipano, Effects of metformin on cell growth and AMPK activity in pituitary adenoma cell cultures, focusing on the interaction with adenylyl cyclase activating signals. Mol. Cell. Endocrinol. 470, 60\u201374 (2018)","journal-title":"Mol. Cell. Endocrinol."},{"key":"2373_CR5","doi-asserted-by":"publisher","first-page":"3501","DOI":"10.1210\/jc.2019-00056","volume":"104","author":"MC V\u00e1zquez-Borrego","year":"2019","unstructured":"M.C. V\u00e1zquez-Borrego, A.C. Fuentes-Fayos, A.D. Herrera Martinez, F.L. L-Lopez, A. Ibanez-Costa, P. Moreno-Moreno, M.R. Alhambra-Exp\u00f3sito, A. Barrera-Mart\u00edn, C. Blanco-Acevedo, E. Dios et al. Biguanides exert antitumoral actions in pituitary tumor cells through AMPK-dependent and \u2013independent mechanisms. J. Clin. Endocrinol. Metabol. 104, 3501\u20133513 (2019)","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"2373_CR6","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/2049-3002-2-12","volume":"2","author":"S Andrzejewski","year":"2014","unstructured":"S. Andrzejewski, S.P. Gravel, M. Pollak, J. St-Pierre, Metformin directly acts on mitochondria to alter cellular bioenergetics. Cancer Metabol. 2, 12 (2014)","journal-title":"Cancer Metabol."},{"key":"2373_CR7","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1038\/nature13270","volume":"510","author":"AK Madiraju","year":"2014","unstructured":"A.K. Madiraju, D.M. Erion, Y. Rahimi, X.M. Zhang, D.T. Braddock, R.A. Albright, B.J. Prigaro, J.L. Wood, S. Bhanot, M.J. MacDonald et al. Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase. Nature 510, 542\u2013546 (2014)","journal-title":"Nature"},{"key":"2373_CR8","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.redox.2017.08.018","volume":"14","author":"AR Cameron","year":"2018","unstructured":"A.R. Cameron, L. Logie, K. Patel, S. Erhardt, S. Bacon, P. Middleton, J. Harthill, C. Forteath, J.T. Coats, C. Kerra et al. Metformin selectively targets redox control of complex I energy transduction. Redox Biol. 14, 187\u2013197 (2018)","journal-title":"Redox Biol."},{"key":"2373_CR9","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1042\/CS20110386","volume":"122","author":"B Viollet","year":"2012","unstructured":"B. Viollet, B. Guigas, N. Sanz Garcia, J. Leclerc, M. Foretz, F. Andreelli, Cellular and molecular mechanisms of metformin: an overview. Clin. Sci. 122, 253\u2013270 (2012)","journal-title":"Clin. Sci."},{"key":"2373_CR10","doi-asserted-by":"publisher","first-page":"20369","DOI":"10.1074\/jbc.M113.482646","volume":"288","author":"VS Vytla","year":"2013","unstructured":"V.S. Vytla, R.S. Ochs, Metformin increases mitochondrial energy formation in L6 muscle cell cultures. J. Biol. Chem. 288, 20369\u201320377 (2013)","journal-title":"J. Biol. Chem."},{"key":"2373_CR11","doi-asserted-by":"publisher","first-page":"2839","DOI":"10.1074\/jbc.RA118.006670","volume":"294","author":"A Alshawi","year":"2018","unstructured":"A. Alshawi, L. Agius, Low metformin causes a more oxidized mitochondrial NADH\/NAD redox state in hepatocytes and inhibits gluconeogenesis by a redox-independent mechanism. J. Biol. Chem. 294, 2839\u20132853 (2018)","journal-title":"J. Biol. Chem."},{"key":"2373_CR12","doi-asserted-by":"publisher","first-page":"4030","DOI":"10.1158\/1078-0432.CCR-17-3167","volume":"24","author":"S Thakur","year":"2018","unstructured":"S. Thakur, B. Daley, K. Gaskins, V.V. Vasko, M. Boufraqech, D. Patel, C. Sourbier, J. Reece, S.Y. Cheng, E. Kebebew et al. Metformin targets Mitochondrial Glycerophosphate Dehydrogenase (mGPDH) to control Rate of Oxidative Phosphorylation and growth of thyroid cancer in vitro and in vivo. Clin. Cancer Res. 24, 4030\u20134043 (2018)","journal-title":"Clin. Cancer Res."},{"key":"2373_CR13","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.ab.2009.03.040","volume":"389","author":"MJ Rardin","year":"2009","unstructured":"M.J. Rardin, S.E. Wiley, R.K. Naviaux, A.N. Murphy, J.E. Dixon, Monitoring phosphorylation of the pyruvate dehydrogenase complex. Anal. Biochem. 389, 157\u2013164 (2009)","journal-title":"Anal. Biochem."},{"key":"2373_CR14","doi-asserted-by":"publisher","first-page":"188","DOI":"10.4093\/dmj.2015.39.3.188","volume":"39","author":"NH Jeoung","year":"2015","unstructured":"N.H. Jeoung, Pyruvate dehydrogenase kinases: therapeutic targets for diabetes and cancers. Diabetes Metab. J. 39, 188\u2013197 (2015)","journal-title":"Diabetes Metab. J."},{"key":"2373_CR15","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/S0197-0186(01)00097-3","volume":"40","author":"S Takahashi","year":"2002","unstructured":"S. Takahashi, T. Abe, J. Gotoh, Y. Fukuuchi, Substrate-dependence of reduction of MTT: a tetrazolium dye differs in cultured astroglia and neurons. Neurochem. Int. 40, 441\u2013448 (2002)","journal-title":"Neurochem. Int."},{"key":"2373_CR16","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.mce.2012.10.017","volume":"365","author":"G Tulipano","year":"2013","unstructured":"G. Tulipano, L. Faggi, M. Losa, P. Mortini, M. Spinello, V. Sibilia, F. Pagani, D. Cocchi, A. Giustina, Effects of AMPK activation and combined treatment with AMPK activators and somatostatin on hormone secretion and cell growth in cultured GH-secreting pituitary tumor cells. Mol. Cell. Endocrinol. 365, 197\u2013206 (2013)","journal-title":"Mol. Cell. Endocrinol."},{"key":"2373_CR17","first-page":"10","volume":"54","author":"E Vega-Avila","year":"2011","unstructured":"E. Vega-Avila, M.K. Pugsley, An overview of colorimetric assay methods used to assess survival or proliferation of mammalian cells. Proc. Western Pharmacol. Soc. 54, 10\u201314 (2011)","journal-title":"Proc. Western Pharmacol. Soc."},{"key":"2373_CR18","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1111\/jne.12231","volume":"27","author":"G Tulipano","year":"2015","unstructured":"G. Tulipano, L. Faggi, A. Cacciamali, M. Spinello, D. Cocchi, A. Giustina, Role of AMP-activated protein kinase (AMPK) activators in antiproliferative multi-drug pituitary tumor therapies: effects of combined treatments with compounds affecting the mTOR-p70S6 kinase axis in cultured pituitary tumour cells. J. Neuroendocrinol. 27, 20\u201332 (2015)","journal-title":"J. Neuroendocrinol."},{"key":"2373_CR19","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1093\/neuonc\/now128","volume":"19","author":"H Lin","year":"2017","unstructured":"H. Lin, S. Patel, V.S. Affleck, I. Wilson, D.M. Turnbull, A.R. Joshi, R. Maxwell, E.A. Stoll, Fatty acid oxidation is required for the respiration and proliferation of malignant glioma cells. Neuro-oncology 19, 43\u201354 (2017)","journal-title":"Neuro-oncology"},{"key":"2373_CR20","doi-asserted-by":"publisher","first-page":"2436","DOI":"10.1016\/j.bbamcr.2016.01.017","volume":"1863","author":"T Bender","year":"2016","unstructured":"T. Bender, J.C. Martinou, The mitochondrial pyruvate carrier in health and disease: to carry or not to carry? Biochimica et Biophysica Acta 1863, 2436\u20132442 (2016)","journal-title":"Biochimica et Biophysica Acta"},{"key":"2373_CR21","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.mce.2017.02.014","volume":"451","author":"K Linher-Melville","year":"2017","unstructured":"K. Linher-Melville, G. Singh, The complex roles of STAT3 and STAT5 in maintaining redox balance: Lessons from STAT-mediated xCT expression in cancer cells. Mol. Cell. Endocrinol. 451, 40\u201352 (2017)","journal-title":"Mol. Cell. Endocrinol."},{"key":"2373_CR22","first-page":"391","volume":"45","author":"MJ MacDonald","year":"2013","unstructured":"M.J. MacDonald, M.J. Longacre, T.F. Warner, A. Thonpho, High level of ATP citrate lyase expression in human and rat pancreatic islets. Hormone Metabol. Res. 45, 391\u2013393 (2013)","journal-title":"Hormone Metabol. Res."},{"key":"2373_CR23","doi-asserted-by":"publisher","first-page":"4429","DOI":"10.1158\/0008-5472.CAN-13-0080","volume":"73","author":"SM Fendt","year":"2013","unstructured":"S.M. Fendt, E.L. Bell, M.A. Keibler, S.M. Davidson, G.J. Wirth, B. Fiske, J.R. Mayers, M. Schwab, G. Bellinger, A. Csibi et al. Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism. Cancer Res. 73, 4429\u20134438 (2013)","journal-title":"Cancer Res."},{"key":"2373_CR24","doi-asserted-by":"publisher","first-page":"221","DOI":"10.2220\/biomedres.34.221","volume":"34","author":"K Urakami","year":"2013","unstructured":"K. Urakami, V. Zangiacomi, C. Yamaguchi, M. Kusuhara, Impact of 2-deoxy-D-glucose on the target metabolome profile of a human endometrial cancer cell line. Biomed. Res. 34, 221\u2013229 (2013)","journal-title":"Biomed. Res."},{"key":"2373_CR25","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.canlet.2014.01.015","volume":"346","author":"YW Choi","year":"2014","unstructured":"Y.W. Choi, I.K. Lim, Sensitization of metformin-cytotoxicity by dichloroacetate via reprogramming glucose metabolism in cancer cells. Cancer Lett. 346, 300\u2013308 (2014)","journal-title":"Cancer Lett."},{"key":"2373_CR26","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1158\/0008-5472.CAN-09-2782","volume":"70","author":"I Ben Sahra","year":"2010","unstructured":"I. Ben Sahra, K. Laurent, S. Giuliano, F. Larbret, G. Ponzio, P. Gounon, Y. Le Marchand-Brustel, S. Giorgetti-Peraldi, M. Cormont, C. Bertolotto et al. Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells. Cancer Res. 70, 2465\u20132475 (2010)","journal-title":"Cancer Res."},{"key":"2373_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ccell.2019.03.007","volume":"35","author":"M Elgendy","year":"2019","unstructured":"M. Elgendy, M. Cir\u00f2, A. Hosseini, J. Weiszmqann, L. Mazzarella, E. Ferrari, R. Cazzoli, G. Curigliano, A. DeCensi, B. Bonanni et al. Combination of hypoglycemia and metformin impairs tumor metabolic plasticity and growth by modulating the PP2A-GSK3b-MCL-1 axis. Cancer Cell 35, 1\u201318 (2019)","journal-title":"Cancer Cell"},{"key":"2373_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40170-018-0193-4","volume":"7","author":"Y Zhuang","year":"2019","unstructured":"Y. Zhuang, R.C. Ly, C.V. Frazier, J. Yu, S. Qin, X.-Y. Fan, M.P. Goetz, J.C. Boughey, R. Weinshilboum, L. Wang, The novel function of tumor protein D54 in regulating pyruvate dehydrogenase and metformin cytotoxicity in breast cancer. Cancer Metabol. 7, 1 (2019)","journal-title":"Cancer Metabol."},{"key":"2373_CR29","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1038\/s41574-018-0058-5","volume":"14","author":"S Melmed","year":"2018","unstructured":"S. Melmed, M.D. Bronstein, P. Chanson, A. Klibanski, F.F. Casanueva, J.A.H. Wass, C.J. Strasburger, A. Luger, D.R. Clemmons, A. Giustina, A. Consensus, Statement on acromegaly therapeutic outcomes. Nat. Rev. Endocrinol. 14, 552\u2013561 (2018)","journal-title":"Nat. Rev. Endocrinol."}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-020-02373-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12020-020-02373-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-020-02373-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T23:13:06Z","timestamp":1623798786000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12020-020-02373-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,16]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["2373"],"URL":"https:\/\/doi.org\/10.1007\/s12020-020-02373-7","relation":{},"ISSN":["1355-008X","1559-0100"],"issn-type":[{"value":"1355-008X","type":"print"},{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,16]]},"assertion":[{"value":"21 February 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 May 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}