{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:23:58Z","timestamp":1790522638888,"version":"4.1.0"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1007\/s12020-020-02572-2","type":"journal-article","created":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T21:03:26Z","timestamp":1610053406000},"page":"529-538","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["125I-Angiotensin 1\u20137 binds to a different site than angiotensin 1\u20137 in tissue membrane preparations"],"prefix":"10.1007","volume":"72","author":[{"given":"Filipe F.","family":"Stoyell-Conti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarin","family":"Itty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christy","family":"Abraham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katya","family":"Rigatto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal A.","family":"West","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6434-2136","authenticated-orcid":false,"given":"Robert C.","family":"Speth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,7]]},"reference":[{"key":"2572_CR1","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1152\/physiologyonline.1999.14.6.271","volume":"14","author":"MI Phillips","year":"1999","unstructured":"M.I. Phillips, K.M. Schmidt-Ott, The discovery of renin 100 years ago. News Physiol. Sci. 14, 271\u2013274 (1999). https:\/\/doi.org\/10.1152\/physiologyonline.1999.14.6.271","journal-title":"News Physiol. Sci."},{"key":"2572_CR2","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1111\/j.1748-1716.1898.tb00272.x","volume":"8","author":"R Tigerstedt","year":"1898","unstructured":"R. Tigerstedt, P.G. Bergmann, Niere und kreislauf. Scand. Arch. Physiol. 8, 223\u2013271 (1898)","journal-title":"Scand. Arch. Physiol."},{"issue":"4","key":"2572_CR3","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1124\/pr.114.010454","volume":"67","author":"SS Karnik","year":"2015","unstructured":"S.S. Karnik, H. Unal, J.R. Kemp, K.C. Tirupula, S. Eguchi, P.M. Vanderheyden, W.G. Thomas, Angiotensin receptors: interpreters of pathophysiological angiotensinergic stimuli. Pharmacol. Rev. 67(4), 754\u2013819 (2015). https:\/\/doi.org\/10.1124\/pr.114.010454","journal-title":"Pharmacol. Rev."},{"issue":"3","key":"2572_CR4","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1002\/cphy.c130040","volume":"4","author":"MA Sparks","year":"2014","unstructured":"M.A. Sparks, S.D. Crowley, S.B. Gurley, M. Mirotsou, T.M. Coffman, Classical renin-angiotensin system in kidney. Physiol. Compr. Physiol. 4(3), 1201\u20131228 (2014). https:\/\/doi.org\/10.1002\/cphy.c130040","journal-title":"Physiol. Compr. Physiol."},{"issue":"5","key":"2572_CR5","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1161\/01.HYP.0000123070.31763.55","volume":"43","author":"DN Granger","year":"2004","unstructured":"D.N. Granger, T. Vowinkel, T. Petnehazy, Modulation of the inflammatory response in cardiovascular disease. Hypertension 43(5), 924\u2013931 (2004)","journal-title":"Hypertension"},{"issue":"7","key":"2572_CR6","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.tips.2008.05.003","volume":"29","author":"C Marchesi","year":"2008","unstructured":"C. Marchesi, P. Paradis, E.L. Schiffrin, Role of the renin-angiotensin system in vascular inflammation. Trends Pharmacol. Sci. 29(7), 367\u2013374 (2008)","journal-title":"Trends Pharmacol. Sci."},{"issue":"1","key":"2572_CR7","doi-asserted-by":"publisher","first-page":"C82","DOI":"10.1152\/ajpcell.00287.2006","volume":"292","author":"PK Mehta","year":"2007","unstructured":"P.K. Mehta, K.K. Griendling, Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system. Am. J. Physiol. Cell Physiol. 292(1), C82\u2013C97 (2007)","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"Suppl 1","key":"2572_CR8","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.3109\/07853890.2011.653393","volume":"44","author":"AC Montezano","year":"2012","unstructured":"A.C. Montezano, R.M. Touyz, Oxidative stress, Noxs, and hypertension: experimental evidence and clinical controversies. Ann. Med. 44(Suppl 1), S2\u2013S16 (2012)","journal-title":"Ann. Med."},{"issue":"1","key":"2572_CR9","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s11906-003-0014-0","volume":"5","author":"M Ruiz-Ortega","year":"2003","unstructured":"M. Ruiz-Ortega, M. Ruperez, V. Esteban, J. Egido, Molecular mechanisms of angiotensin II-induced vascular injury. Curr. Hypertens. Rep. 5(1), 73\u201379 (2003)","journal-title":"Curr. Hypertens. Rep."},{"issue":"12","key":"2572_CR10","doi-asserted-by":"publisher","first-page":"18640","DOI":"10.18632\/oncotarget.15553","volume":"8","author":"R Coulson","year":"2017","unstructured":"R. Coulson, S.H. Liew, A.A. Connelly, N.S. Yee, S. Deb, B. Kumar, A.C. Vargas, S.A. O\u2019Toole, A.C. Parslow, A. Poh, T. Putoczki, R.J. Morrow, M. Alorro, K.A. Lazarus, E.F.W. Yeap, K.L. Walton, C.A. Harrison, N.J. Hannan, A.J. George, C.D. Clyne, M. Ernst, A.M. Allen, A.L. Chand, The angiotensin receptor blocker, Losartan, inhibits mammary tumor development and progression to invasive carcinoma. Oncotarget 8(12), 18640\u201318656 (2017). https:\/\/doi.org\/10.18632\/oncotarget.15553","journal-title":"Oncotarget"},{"issue":"11","key":"2572_CR11","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1038\/nrc2945","volume":"10","author":"AJ George","year":"2010","unstructured":"A.J. George, W.G. Thomas, R.D. Hannan, The renin-angiotensin system and cancer: old dog, new tricks. Nat. Rev. Cancer 10(11), 745\u2013759 (2010). https:\/\/doi.org\/10.1038\/nrc2945","journal-title":"Nat. Rev. Cancer"},{"issue":"6 Pt A","key":"2572_CR12","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/j.bbamcr.2016.03.010","volume":"1863","author":"E Oh","year":"2016","unstructured":"E. Oh, J.Y. Kim, Y. Cho, H. An, N. Lee, H. Jo, C. Ban, J.H. Seo, Overexpression of angiotensin II type 1 receptor in breast cancer cells induces epithelial-mesenchymal transition and promotes tumor growth and angiogenesis. Biochimica et. Biophysica Acta 1863(6 Pt A), 1071\u20131081 (2016). https:\/\/doi.org\/10.1016\/j.bbamcr.2016.03.010","journal-title":"Biochimica et. Biophysica Acta"},{"issue":"25","key":"2572_CR13","doi-asserted-by":"publisher","first-page":"10284","DOI":"10.1073\/pnas.0900351106","volume":"106","author":"DR Rhodes","year":"2009","unstructured":"D.R. Rhodes, B. Ateeq, Q. Cao, S.A. Tomlins, R. Mehra, B. Laxman, S. Kalyana-Sundaram, R.J. Lonigro, B.E. Helgeson, M.S. Bhojani, A. Rehemtulla, C.G. Kleer, D.F. Hayes, P.C. Lucas, S. Varambally, A.M. Chinnaiyan, AGTR1 overexpression defines a subset of breast cancer and confers sensitivity to losartan, an AGTR1 antagonist. Proc. Natl Acad. Sci. USA 106(25), 10284\u201310289 (2009). https:\/\/doi.org\/10.1073\/pnas.0900351106","journal-title":"Proc. Natl Acad. Sci. USA"},{"issue":"1","key":"2572_CR14","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1097\/cej.0000000000000269","volume":"26","author":"T Song","year":"2017","unstructured":"T. Song, C.H. Choi, M.K. Kim, M.L. Kim, B.S. Yun, S.J. Seong, The effect of angiotensin system inhibitors (angiotensin-converting enzyme inhibitors or angiotensin receptor blockers) on cancer recurrence and survival: a meta-analysis. Eur. J. Cancer Prev. 26(1), 78\u201385 (2017). https:\/\/doi.org\/10.1097\/cej.0000000000000269","journal-title":"Eur. J. Cancer Prev."},{"issue":"6","key":"2572_CR15","doi-asserted-by":"publisher","first-page":"5282","DOI":"10.1007\/s12035-017-0754-5","volume":"55","author":"SA Bhat","year":"2018","unstructured":"S.A. Bhat, R. Goel, S. Shukla, R. Shukla, K. Hanif, Angiotensin receptor blockade by inhibiting glial activation promotes hippocampal neurogenesis via activation of Wnt\/beta-catenin signaling in hypertension. Mol. Neurobiol. 55(6), 5282\u20135298 (2018). https:\/\/doi.org\/10.1007\/s12035-017-0754-5","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"2572_CR16","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s13195-015-0167-5","volume":"8","author":"AG Elkahloun","year":"2016","unstructured":"A.G. Elkahloun, R. Hafko, J.M. Saavedra, An integrative genome-wide transcriptome reveals that candesartan is neuroprotective and a candidate therapeutic for Alzheimer\u2019s disease. Alzheimers Res. Ther. 8(1), 5 (2016). https:\/\/doi.org\/10.1186\/s13195-015-0167-5","journal-title":"Alzheimers Res. Ther."},{"issue":"3","key":"2572_CR17","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.3233\/jad-171119","volume":"62","author":"PG Kehoe","year":"2018","unstructured":"P.G. Kehoe, The coming of age of the angiotensin hypothesis in Alzheimer\u2019s disease: progress toward disease prevention and treatment? J. Alzheimer\u2019s Dis. 62(3), 1443\u20131466 (2018). https:\/\/doi.org\/10.3233\/jad-171119","journal-title":"J. Alzheimer\u2019s Dis."},{"issue":"1","key":"2572_CR18","doi-asserted-by":"publisher","first-page":"29","DOI":"10.2174\/1567205052772740","volume":"2","author":"E Savaskan","year":"2005","unstructured":"E. Savaskan, The role of the brain renin-angiotensin system in neurodegenerative disorders. Curr. Alzheimer Res. 2(1), 29\u201335 (2005)","journal-title":"Curr. Alzheimer Res."},{"issue":"3","key":"2572_CR19","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1006\/frne.1997.0153","volume":"18","author":"AK Johnson","year":"1997","unstructured":"A.K. Johnson, R.L. Thunhorst, The neuroendocrinology of thirst and salt appetite: visceral sensory signals and mechanisms of central integration. Front. Neuroendocrinol. 18(3), 292\u2013353 (1997)","journal-title":"Front. Neuroendocrinol."},{"issue":"5","key":"2572_CR20","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.physbeh.2010.01.030","volume":"99","author":"EG Krause","year":"2010","unstructured":"E.G. Krause, A.D. de Kloet, R.R. Sakai, Post-ingestive signals and satiation of water and sodium intake of male rats. Physiol. Behav. 99(5), 657\u2013662 (2010)","journal-title":"Physiol. Behav."},{"issue":"1","key":"2572_CR21","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1113\/expphysiol.2008.044446","volume":"94","author":"D Daniels","year":"2009","unstructured":"D. Daniels, E.G. Mietlicki, E.L. Nowak, S.J. Fluharty, Angiotensin II stimulates water and NaCl intake through separate cell signalling pathways in rats. Exp. Physiol. 94(1), 130\u2013137 (2009)","journal-title":"Exp. Physiol."},{"issue":"2","key":"2572_CR22","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/s41569-019-0244-8","volume":"17","author":"M Paz Ocaranza","year":"2020","unstructured":"M. Paz Ocaranza, J.A. Riquelme, L. Garc\u00eda, J.E. Jalil, M. Chiong, R.A.S. Santos, S. Lavandero, Counter-regulatory renin-angiotensin system in cardiovascular disease. Nat. Rev. Cardiol. 17(2), 116\u2013129 (2020). https:\/\/doi.org\/10.1038\/s41569-019-0244-8","journal-title":"Nat. Rev. Cardiol."},{"issue":"2","key":"2572_CR23","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-014-0512-2","volume":"17","author":"DM Bennion","year":"2015","unstructured":"D.M. Bennion, E. Haltigan, R.W. Regenhardt, U.M. Steckelings, C. Sumners, Neuroprotective mechanisms of the ACE2-angiotensin-(1\u20137)-Mas axis in stroke. Curr. Hypertens Rep. 17(2), 3 (2015). https:\/\/doi.org\/10.1007\/s11906-014-0512-2","journal-title":"Curr. Hypertens Rep."},{"key":"2572_CR24","doi-asserted-by":"publisher","first-page":"153","DOI":"10.2147\/ibpc.s34425","volume":"6","author":"LA Danyel","year":"2013","unstructured":"L.A. Danyel, P. Schmerler, L. Paulis, T. Unger, U.M. Steckelings, Impact of AT2-receptor stimulation on vascular biology, kidney function, and blood pressure. Integr Blood Press. Control 6, 153\u2013161 (2013). https:\/\/doi.org\/10.2147\/ibpc.s34425","journal-title":"Integr Blood Press. Control"},{"issue":"1-3","key":"2572_CR25","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/S0167-0115(99)00023-3","volume":"81","author":"M de Gasparo","year":"1999","unstructured":"M. de Gasparo, H.M. Siragy, The AT2 receptor: fact, fancy and fantasy. Regulatory Pept. 81(1-3), 11\u201324 (1999)","journal-title":"Regulatory Pept."},{"issue":"10","key":"2572_CR26","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1042\/cs20180189","volume":"132","author":"MM Gironacci","year":"2018","unstructured":"M.M. Gironacci, A. Vicario, G. Cerezo, M.G. Silva, The depressor axis of the renin-angiotensin system and brain disorders: a translational approach. Clin. Sci. 132(10), 1021\u20131038 (2018). https:\/\/doi.org\/10.1042\/cs20180189","journal-title":"Clin. Sci."},{"issue":"2-3","key":"2572_CR27","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.ejphar.2008.02.090","volume":"585","author":"D Iusuf","year":"2008","unstructured":"D. Iusuf, R.H. Henning, W.H. van Gilst, A.J. Roks, Angiotensin-(1\u20137): pharmacological properties and pharmacotherapeutic perspectives. Eur. J. Pharmacol. 585(2-3), 303\u2013312 (2008)","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"2572_CR28","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s00424-012-1146-3","volume":"465","author":"SH Padia","year":"2013","unstructured":"S.H. Padia, R.M. Carey, AT2 receptors: beneficial counter-regulatory role in cardiovascular and renal function. Pflug. Arch. 465(1), 99\u2013110 (2013)","journal-title":"Pflug. Arch."},{"key":"2572_CR29","doi-asserted-by":"publisher","unstructured":"R.A.S. Santos, A.C.S.E. Silva, C. Maric, D.M.R. Silva, R.P. Machado, I. de Buhr, S. Heringer-Walther, S.V.B. Pinheiro, M.T. Lopes, M. Bader, E.P. Mendes, V.S. Lemos, M.J. Campagnole-Santos, H.P. Schultheiss, R. Speth, T. Walther. Angiotensin-(1\u20137) is an endogenous ligand for the G protein-coupled receptor Mas. Proc. Natl Acad. Sci. USA 100(14), 8258\u20138263 (2003). https:\/\/doi.org\/10.1073\/pnas.1432869100","DOI":"10.1073\/pnas.1432869100"},{"key":"2572_CR30","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.cellsig.2018.06.007","volume":"50","author":"I Gaidarov","year":"2018","unstructured":"I. Gaidarov, J. Adams, J. Frazer, T. Anthony, X. Chen, J. Gatlin, G. Semple, D.J. Unett, Angiotensin (1\u20137) does not interact directly with MAS1, but can potently antagonize signaling from the AT1 receptor. Cell Signal. 50, 9\u201324 (2018). https:\/\/doi.org\/10.1016\/j.cellsig.2018.06.007","journal-title":"Cell Signal."},{"issue":"1","key":"2572_CR31","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-12074-3","volume":"7","author":"LB Teixeira","year":"2017","unstructured":"L.B. Teixeira, E.S.L.T. Parreiras, T. Bruder-Nascimento, D.A. Duarte, S.C. Simoes, R.M. Costa, D.Y. Rodriguez, P.A.B. Ferreira, C.A.A. Silva, E.P. Abrao, E.B. Oliveira, M. Bouvier, R.C. Tostes, C.M. Costa-Neto, Ang-(1\u20137) is an endogenous beta-arrestin-biased agonist of the AT1 receptor with protective action in cardiac hypertrophy. Sci. Rep. 7(1), 11903 (2017). https:\/\/doi.org\/10.1038\/s41598-017-12074-3","journal-title":"Sci. Rep."},{"issue":"7","key":"2572_CR32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103520","volume":"9","author":"KC Tirupula","year":"2014","unstructured":"K.C. Tirupula, R. Desnoyer, R.C. Speth, S.S. Karnik, Atypical signaling and functional desensitization response of MAS receptor to peptide ligands. PLoS ONE 9(7), e103520 (2014). https:\/\/doi.org\/10.1371\/journal.pone.0103520","journal-title":"PLoS ONE"},{"key":"2572_CR33","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/0304-4165(73)90203-1","volume":"313","author":"KJ Catt","year":"1973","unstructured":"K.J. Catt, A. Baukal, Prolonged retention of high specific activity by 125I-labeled angiotensin II-a consequence of \u2018decay catastrophe\u2019. Biochim. Biophys. Acta 313, 221\u2013225 (1973)","journal-title":"Biochim. Biophys. Acta"},{"key":"2572_CR34","doi-asserted-by":"crossref","unstructured":"R.C. Speth, J.W. Harding. Radiolabeling of angiotensin peptides. D.H. Wang (ed.) Angiotensin Protocols, vol. 51. Methods in Molecular Medicine (Humana Press, Totowa, NJ, 2001), pp. 275\u2013295","DOI":"10.1385\/1-59259-087-X:275"},{"key":"2572_CR35","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/194495a0","volume":"194","author":"WM Hunter","year":"1962","unstructured":"W.M. Hunter, F.C. Greenwood, Preparation of iodine-131 labeled human growth hormone of high specific activity. Nature 194, 495\u2013496 (1962)","journal-title":"Nature"},{"key":"2572_CR36","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.prostaglandins.2018.11.001","volume":"140","author":"QF Chen","year":"2019","unstructured":"Q.F. Chen, H. Hao, X.D. Kuang, Q.D. Hu, Y.H. Huang, X.Y. Zhou, BML-111, a lipoxin receptor agonist, protects against acute injury via regulating the renin angiotensin-aldosterone system. Prostaglandins Other Lipid Mediat. 140, 9\u201317 (2019). https:\/\/doi.org\/10.1016\/j.prostaglandins.2018.11.001","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"2572_CR37","doi-asserted-by":"publisher","unstructured":"E.D.C. Frantz, R.F. Medeiros, I.G. Giori, J.B.S. Lima, T. Bento-Bernardes, T.G. Gaique, C. Fernandes-Santos, T. Fernandes, E.M. Oliveira, C.P. Vieira, C.A. Conte-Junior, K.J. Oliveira, A.C.L. Nobrega, Exercise training modulates the hepatic renin\u2013angiotensin system in fructose-fed rats. 102(9), 1208\u20131220 (2017). https:\/\/doi.org\/10.1113\/ep085924","DOI":"10.1113\/ep085924"},{"issue":"1-3","key":"2572_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.regpep.2010.02.001","volume":"161","author":"MC Munoz","year":"2010","unstructured":"M.C. Munoz, J.F. Giani, F.P. Dominici, Angiotensin-(1\u20137) stimulates the phosphorylation of Akt in rat extracardiac tissues in vivo via receptor Mas. Regulatory Pept. 161(1-3), 1\u20137 (2010). https:\/\/doi.org\/10.1016\/j.regpep.2010.02.001","journal-title":"Regulatory Pept."},{"issue":"4","key":"2572_CR39","doi-asserted-by":"publisher","first-page":"5492","DOI":"10.3892\/mmr.2018.8527","volume":"17","author":"H Xiao","year":"2018","unstructured":"H. Xiao, X. Liu, Y. Wang, G. Wang, C. Yin, Angiotensin(1\u20137) prevents lipopolysaccharideinduced hepatocellular inflammatory response by inhibiting the p38MAPK\/AP1 signaling pathway. Mol. Med. Rep. 17(4), 5492\u20135497 (2018). https:\/\/doi.org\/10.3892\/mmr.2018.8527","journal-title":"Mol. Med. Rep."},{"key":"2572_CR40","doi-asserted-by":"publisher","first-page":"7423","DOI":"10.1016\/S0021-9258(17)32866-1","volume":"251","author":"JP Bennett Jr","year":"1976","unstructured":"J.P. Bennett Jr, S.H. Snyder, Angiotensin II binding to mammalian brain membranes. J. Biol. Chem. 251, 7423\u20137430 (1976)","journal-title":"J. Biol. Chem."},{"key":"2572_CR41","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/S0021-9258(19)43003-2","volume":"249","author":"H Glossmann","year":"1974","unstructured":"H. Glossmann, A.J. Baukal, K.J. Catt, Properties of angiotensin II receptors in the bovine and rat adrenal cortex. J. Biol. Chem. 249, 825\u2013834 (1974)","journal-title":"J. Biol. Chem."},{"key":"2572_CR42","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/0014-2999(89)90145-3","volume":"170","author":"AT Chiu","year":"1989","unstructured":"A.T. Chiu, D.E. McCall, T.T. Nguyen, D.J. Carini, J.V. Duncia, W.F. Herblin, R.T. Uyeda, P.C. Wong, R.R. Wexler, A.L. Johnson, P.B.M.W.M. Timmermans, Discrimination of angiotensin II receptor subtypes by dithiothreitol. Eur. J. Pharmacol. 170, 117\u2013118 (1989)","journal-title":"Eur. J. Pharmacol."},{"key":"2572_CR43","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/0006-291X(89)92133-5","volume":"163","author":"S Whitebread","year":"1989","unstructured":"S. Whitebread, M. Mele, B. Kamber, M. de Gasparo, Preliminary biochemical characterization of two angiotensin II receptor subtypes. Biochem. Biophys. Res. Commun. 163, 284\u2013291 (1989)","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2572_CR44","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1210\/endo-125-1-223","volume":"125","author":"KL Grove","year":"1989","unstructured":"K.L. Grove, R.C. Speth, Rat epididymis contains functional angiotensin II receptors. Endocrinology 125, 223\u2013230 (1989)","journal-title":"Endocrinology"},{"key":"2572_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0006-8993(91)91098-L","volume":"548","author":"RC Speth","year":"1991","unstructured":"R.C. Speth, B.P. Rowe, K.L. Grove, M.R. Carter, D.L. Saylor, Sulfhydryl reducing agents distinguish two subtypes of angiotensin II receptors in the rat brain. Brain Res. 548, 1\u20138 (1991)","journal-title":"Brain Res."},{"issue":"10","key":"2572_CR46","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1021\/jm00062a009","volume":"36","author":"S Doulut","year":"1993","unstructured":"S. Doulut, I. Dubuc, M. Rodriguez, F. Vecchini, H. Fulcrand, H. Barelli, F. Checler, E. Bourdel, A. Aumelas, J.C. Lallement, Synthesis and analgesic effects of N-[3-[(hydroxyamino) carbonyl]-1-oxo-2(R)-benzylpropyl]-L-isoleucyl-L-leucine, a new potent inhibitor of multiple neurotensin\/neuromedin N degrading enzymes. J. Med. Chem. 36(10), 1369\u20131379 (1993)","journal-title":"J. Med. Chem."},{"issue":"12","key":"2572_CR47","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1038\/nrd4390","volume":"13","author":"RE Vandenbroucke","year":"2014","unstructured":"R.E. Vandenbroucke, C. Libert, Is there new hope for therapeutic matrix metalloproteinase inhibition? Nat. Rev. Drug Discov. 13(12), 904\u2013927 (2014). https:\/\/doi.org\/10.1038\/nrd4390","journal-title":"Nat. Rev. Drug Discov."},{"issue":"6","key":"2572_CR48","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1161\/hypertensionaha.116.08118","volume":"68","author":"S Galandrin","year":"2016","unstructured":"S. Galandrin, C. Denis, C. Boularan, J. Marie, C. M\u2019Kadmi, C. Pilette, C. Dubroca, Y. Nicaise, M.H. Seguelas, D. N\u2019Guyen, J.L. Ban\u00e8res, A. Pathak, J.M. S\u00e9nard, C. Gal\u00e9s, Cardioprotective angiotensin-(1\u20137) peptide acts as a natural-biased ligand at the angiotensin II type 1 receptor. Hypertension 68(6), 1365\u20131374 (2016). https:\/\/doi.org\/10.1161\/hypertensionaha.116.08118","journal-title":"Hypertension"},{"issue":"1\u20133","key":"2572_CR49","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/s0167-0115(99)00067-1","volume":"84","author":"MM Gironacci","year":"1999","unstructured":"M.M. Gironacci, M.P. Coba, C. Pena, Angiotensin-(1\u20137) binds at the type 1 angiotensin II receptors in rat renal cortex. Regulatory Pept. 84(1\u20133), 51\u201354 (1999). https:\/\/doi.org\/10.1016\/s0167-0115(99)00067-1","journal-title":"Regulatory Pept."},{"issue":"2","key":"2572_CR50","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1161\/hypertensionaha.111.173344","volume":"58","author":"MM Gironacci","year":"2011","unstructured":"M.M. Gironacci, H.P. Adamo, G. Corradi, R.A. Santos, P. Ortiz, O.A. Carretero, Angiotensin (1\u20137) induces MAS receptor internalization. Hypertension 58(2), 176\u2013181 (2011). https:\/\/doi.org\/10.1161\/hypertensionaha.111.173344","journal-title":"Hypertension"},{"issue":"6","key":"2572_CR51","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1161\/01.HYP.0000037979.53963.8F","volume":"40","author":"G Wiemer","year":"2002","unstructured":"G. Wiemer, L.W. Dobrucki, F.R. Louka, T. Malinski, H. Heitsch, AVE 0991, a nonpeptide mimic of the effects of angiotensin-(1\u20137) on the endothelium. Hypertension 40(6), 847\u2013852 (2002)","journal-title":"Hypertension"},{"issue":"4","key":"2572_CR52","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1161\/01.hyp.0000141438.64887.42","volume":"44","author":"SV Pinheiro","year":"2004","unstructured":"S.V. Pinheiro, A.C. Simoes e Silva, W.O. Sampaio, R.D. de Paula, E.P. Mendes, E.D. Bontempo, J.B. Pesquero, T. Walther, N. Alenina, M. Bader, M. Bleich, R.A. Santos, Nonpeptide AVE 0991 is an angiotensin-(1\u20137) receptor Mas agonist in the mouse kidney. Hypertension 44(4), 490\u2013496 (2004). https:\/\/doi.org\/10.1161\/01.hyp.0000141438.64887.42","journal-title":"Hypertension"},{"issue":"7","key":"2572_CR53","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1016\/j.peptides.2011.05.012","volume":"32","author":"JL Zhuo","year":"2011","unstructured":"J.L. Zhuo, X.C. Li, New insights and perspectives on intrarenal renin-angiotensin system: focus on intracrine\/intracellular angiotensin II. Peptides 32(7), 1551\u20131565 (2011)","journal-title":"Peptides"},{"issue":"2","key":"2572_CR54","doi-asserted-by":"publisher","first-page":"F337","DOI":"10.1152\/ajprenal.90437.2008","volume":"296","author":"J Zimpelmann","year":"2009","unstructured":"J. Zimpelmann, K.D. Burns, Angiotensin-(1\u20137) activates growth-stimulatory pathways in human mesangial cells. Am. J. Physiol. Ren. Physiol. 296(2), F337\u2013346 (2009). https:\/\/doi.org\/10.1152\/ajprenal.90437.2008","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"1-2","key":"2572_CR55","doi-asserted-by":"publisher","first-page":"28","DOI":"10.2119\/2007-00073.Fraga-Silva","volume":"14","author":"RA Fraga-Silva","year":"2008","unstructured":"R.A. Fraga-Silva, S.V. Pinheiro, A.C. Gon\u00e7alves, N. Alenina, M. Bader, R.A. Santos, The antithrombotic effect of angiotensin-(1\u20137) involves mas-mediated NO release from platelets. Mol. Med. 14(1-2), 28\u201335 (2008). https:\/\/doi.org\/10.2119\/2007-00073.Fraga-Silva","journal-title":"Mol. Med."},{"key":"2572_CR56","doi-asserted-by":"publisher","first-page":"4095","DOI":"10.1073\/pnas.85.11.4095","volume":"85","author":"MT Schiavone","year":"1988","unstructured":"M.T. Schiavone, R.A. Santos, K.B. Brosnihan, M.C. Khosla, C.M. Ferrario, Release of vasopressin from the rat hypothalamo-neurohypophysial system by angiotensin-(1\u20137) heptapeptide. Proc. Natl Acad. Sci. USA 85, 4095\u20134098 (1988)","journal-title":"Proc. Natl Acad. Sci. USA"},{"issue":"1","key":"2572_CR57","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1152\/physrev.00023.2016","volume":"98","author":"RAS Santos","year":"2018","unstructured":"R.A.S. Santos, W.O. Sampaio, A.C. Alzamora, D. Motta-Santos, N. Alenina, M. Bader, M.J. Campagnole-Santos, The ACE2\/Angiotensin-(1\u20137)\/MAS axis of the renin-angiotensin system: focus on angiotensin-(1\u20137). Physiological Rev. 98(1), 505\u2013553 (2018). https:\/\/doi.org\/10.1152\/physrev.00023.2016","journal-title":"Physiological Rev."},{"issue":"9","key":"2572_CR58","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1111\/bph.13742","volume":"174","author":"SS Karnik","year":"2017","unstructured":"S.S. Karnik, K.D. Singh, K. Tirupula, H. Unal, Significance of angiotensin 1\u20137 coupling with MAS1 receptor and other GPCRs to the renin-angiotensin system: IUPHAR Review 22. Br. J. Pharmacol. 174(9), 737\u2013753 (2017). https:\/\/doi.org\/10.1111\/bph.13742","journal-title":"Br. J. Pharmacol."},{"issue":"5","key":"2572_CR59","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1161\/01.HYP.0000160325.59323.b8","volume":"45","author":"PE Walters","year":"2005","unstructured":"P.E. Walters, T.A. Gaspari, R.E. Widdop, Angiotensin-(1\u20137) acts as a vasodepressor agent via angiotensin II type 2 receptors in conscious rats. Hypertension 45(5), 960\u2013966 (2005). https:\/\/doi.org\/10.1161\/01.HYP.0000160325.59323.b8","journal-title":"Hypertension"},{"issue":"1","key":"2572_CR60","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1161\/hypertensionaha.116.07572","volume":"68","author":"A Tetzner","year":"2016","unstructured":"A. Tetzner, K. Gebolys, C. Meinert, S. Klein, A. Uhlich, J. Trebicka, O. Villacanas, T. Walther, G-Protein-coupled receptor MrgD is a receptor for angiotensin-(1\u20137) involving adenylyl cyclase, cAMP, and phosphokinase A. Hypertension 68(1), 185\u2013194 (2016). https:\/\/doi.org\/10.1161\/hypertensionaha.116.07572","journal-title":"Hypertension"},{"key":"2572_CR61","doi-asserted-by":"publisher","first-page":"48623","DOI":"10.1074\/jbc.C100512200","volume":"276","author":"AL Albiston","year":"2001","unstructured":"A.L. Albiston, S.G. McDowall, D. Matsacos, P. Sim, E. Clune, T. Mustafa, J. Lee, F.A. Mendelsohn, R.J. Simpson, L.M. Connolly, S.Y. Chai, Evidence that the angiotensin IV (AT4) receptor is the enzyme insulin regulated aminopeptidase. J. Biol. Chem. 276, 48623\u201348626 (2001)","journal-title":"J. Biol. Chem."},{"issue":"6","key":"2572_CR62","doi-asserted-by":"publisher","first-page":"F594","DOI":"10.1152\/ajprenal.00609.2014","volume":"308","author":"BA Wilson","year":"2015","unstructured":"B.A. Wilson, N. Cruz-Diaz, A.C. Marshall, N.T. Pirro, Y. Su, T.M. Gwathmey, J.C. Rose, M.C. Chappell, An angiotensin-(1\u20137) peptidase in the kidney cortex, proximal tubules, and human HK-2 epithelial cells that is distinct from insulin-degrading enzyme. Am. J. Physiol. Ren. Physiol. 308(6), F594\u2013601 (2015). https:\/\/doi.org\/10.1152\/ajprenal.00609.2014","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"36","key":"2572_CR63","doi-asserted-by":"publisher","first-page":"24185","DOI":"10.1074\/jbc.M109.029116","volume":"284","author":"MD Tortorella","year":"2009","unstructured":"M.D. Tortorella, A.G. Tomasselli, K.J. Mathis, M.E. Schnute, S.S. Woodard, G. Munie, J.M. Williams, N. Caspers, A.J. Wittwer, A.M. Malfait, H.S. Shieh, Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors. J. Biol. Chem. 284(36), 24185\u201324191 (2009). https:\/\/doi.org\/10.1074\/jbc.M109.029116","journal-title":"J. Biol. Chem."},{"key":"2572_CR64","doi-asserted-by":"publisher","unstructured":"Rasmussen H.S. Batimastat and Marimastat in Cancer. In: Teicher B.A. (eds) Antiangiogenic agents in cancer therapy. Cancer Drug Discovery and Development (Humana Press, Totowa, NJ, 1999). https:\/\/doi.org\/10.1007\/978-1-59259-453-5_23","DOI":"10.1007\/978-1-59259-453-5_23"},{"issue":"38","key":"2572_CR65","doi-asserted-by":"publisher","first-page":"27781","DOI":"10.1074\/jbc.M703286200","volume":"282","author":"AR Johnson","year":"2007","unstructured":"A.R. Johnson, A.G. Pavlovsky, D.F. Ortwine, F. Prior, C.F. Man, D.A. Bornemeier, C.A. Banotai, W.T. Mueller, P. McConnell, C. Yan, V. Baragi, C. Lesch, W.H. Roark, M. Wilson, K. Datta, R. Guzman, H.K. Han, R.D. Dyer, Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects. J. Biol. Chem. 282(38), 27781\u201327791 (2007). https:\/\/doi.org\/10.1074\/jbc.M703286200","journal-title":"J. Biol. Chem."},{"issue":"2","key":"2572_CR66","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.ab.2007.04.043","volume":"366","author":"ML Moss","year":"2007","unstructured":"M.L. Moss, F.H. Rasmussen, Fluorescent substrates for the proteinases ADAM17, ADAM10, ADAM8, and ADAM12 useful for high-throughput inhibitor screening. Anal. Biochem. 366(2), 144\u2013148 (2007). https:\/\/doi.org\/10.1016\/j.ab.2007.04.043","journal-title":"Anal. Biochem."},{"key":"2572_CR67","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/978-3-0348-0364-9_7","volume":"103","author":"MM Benjamin","year":"2012","unstructured":"M.M. Benjamin, R.A. Khalil, Matrix metalloproteinase inhibitors as investigative tools in the pathogenesis and management of vascular disease. Exp. Suppl. 103, 209\u2013279 (2012). https:\/\/doi.org\/10.1007\/978-3-0348-0364-9_7","journal-title":"Exp. Suppl."}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-020-02572-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12020-020-02572-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-020-02572-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T10:19:25Z","timestamp":1621246765000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12020-020-02572-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,7]]},"references-count":67,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["2572"],"URL":"https:\/\/doi.org\/10.1007\/s12020-020-02572-2","relation":{},"ISSN":["1355-008X","1559-0100"],"issn-type":[{"value":"1355-008X","type":"print"},{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,7]]},"assertion":[{"value":"2 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All animal procedures were approved by the Nova Southeastern University Institutional Animal Care and Use Committee (IACUC), and were carried out in accordance with the guidelines specified in the National Research Council of the National Academies Guide for the Care and Use of Laboratory Animals, 8th edition.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}