{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:06:00Z","timestamp":1761491160178,"version":"3.37.3"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T00:00:00Z","timestamp":1610064000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T00:00:00Z","timestamp":1610064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1007\/s12020-020-02578-w","type":"journal-article","created":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T12:14:21Z","timestamp":1610108061000},"page":"177-185","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Preliminary results from whole-genome expression analysis in patients with secondary adrenal insufficiency treated with modified-release hydrocortisone"],"prefix":"10.1007","volume":"73","author":[{"given":"Tania","family":"Pilli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandro","family":"Cardinale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Cantara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilda","family":"Dalmazio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaella","family":"Forleo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Capezzone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristian","family":"Bassi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Negrini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Ferracin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2457-1751","authenticated-orcid":false,"given":"Maria Grazia","family":"Castagna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,8]]},"reference":[{"issue":"3","key":"2578_CR1","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1046\/j.1365-2265.1997.1340955.x","volume":"46","author":"TA Howlett","year":"1997","unstructured":"T.A. Howlett, An assessment of optimal hydrocortisone replacement therapy. Clin. Endocrinol. 46(3), 263\u2013268 (1997). https:\/\/doi.org\/10.1046\/j.1365-2265.1997.1340955.x","journal-title":"Clin. Endocrinol."},{"issue":"3","key":"2578_CR2","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1111\/j.1365-2265.2004.02106.x","volume":"61","author":"PM Mah","year":"2004","unstructured":"P.M. Mah, R.C. Jenkins, A. Rostami-Hodjegan, J. Newell-Price, A. Doane, V. Ibbotson, G.T. Tucker, R.J. Ross, Weight-related dosing, timing and monitoring hydrocortisone replacement therapy in patients with adrenal insufficiency. Clin. Endocrinol. 61(3), 367\u2013375 (2004). https:\/\/doi.org\/10.1111\/j.1365-2265.2004.02106.x","journal-title":"Clin. Endocrinol."},{"issue":"7","key":"2578_CR3","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1007\/BF03347262","volume":"28","author":"L Barbetta","year":"2005","unstructured":"L. Barbetta, C. Dall\u2019Asta, T. Re, R. Libe, E. Costa, B. Ambrosi, Comparison of different regimens of glucocorticoid replacement therapy in patients with hypoadrenalism. J. Endocrinol. Investig. 28(7), 632\u2013637 (2005). https:\/\/doi.org\/10.1007\/BF03347262","journal-title":"J. Endocrinol. Investig."},{"issue":"2","key":"2578_CR4","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.beem.2008.09.010","volume":"23","author":"M Debono","year":"2009","unstructured":"M. Debono, J.N. Price, R.J. Ross, Novel strategies for hydrocortisone replacement. Best Pract. Res. Clin. Endocrinol. Metab. 23(2), 221\u2013232 (2009). https:\/\/doi.org\/10.1016\/j.beem.2008.09.010","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"issue":"3","key":"2578_CR5","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1046\/j.1365-2265.1997.780907.x","volume":"46","author":"SR Peacey","year":"1997","unstructured":"S.R. Peacey, C.Y. Guo, A.M. Robinson, A. Price, M.A. Giles, R. Eastell, A.P. Weetman, Glucocorticoid replacement therapy: are patients over treated and does it matter? Clin. Endocrinol. 46(3), 255\u2013261 (1997). https:\/\/doi.org\/10.1046\/j.1365-2265.1997.780907.x","journal-title":"Clin. Endocrinol."},{"issue":"5","key":"2578_CR6","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1530\/EJE-08-0874","volume":"160","author":"M Debono","year":"2009","unstructured":"M. Debono, R.J. Ross, J. Newell-Price, Inadequacies of glucocorticoid replacement and improvements by physiological circadian therapy. Eur. J. Endocrinol. 160(5), 719\u2013729 (2009). https:\/\/doi.org\/10.1530\/EJE-08-0874","journal-title":"Eur. J. Endocrinol."},{"issue":"11","key":"2578_CR7","doi-asserted-by":"publisher","first-page":"917","DOI":"10.3275\/6437","volume":"32","author":"R Giordano","year":"2009","unstructured":"R. Giordano, S. Marzotti, M. Balbo, S. Romagnoli, E. Marinazzo, R. Berardelli, G. Migliaretti, A. Benso, A. Falorni, E. Ghigo, E. Arvat, Metabolic and cardiovascular profile in patients with Addison\u2019s disease under conventional glucocorticoid replacement. J. Endocrinol. Investig. 32(11), 917\u2013923 (2009). https:\/\/doi.org\/10.3275\/6437","journal-title":"J. Endocrinol. Investig."},{"issue":"2","key":"2578_CR8","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1210\/jc.2011-1901","volume":"97","author":"M Oksnes","year":"2012","unstructured":"M. Oksnes, S. Bensing, A.L. Hulting, O. Kampe, A. Hackemann, G. Meyer, K. Badenhoop, C. Betterle, A. Parolo, R. Giordano, A. Falorni, L. Papierska, W. Jeske, A.A. Kasperlik-Zaluska, V.K. Chatterjee, E.S. Husebye, K. Lovas, Quality of life in European patients with Addison\u2019s disease: validity of the disease-specific questionnaire AddiQoL. J. Clin. Endocrinol. Metab. 97(2), 568\u2013576 (2012). https:\/\/doi.org\/10.1210\/jc.2011-1901","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"2578_CR9","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1530\/EJE-09-0170","volume":"161","author":"G Johannsson","year":"2009","unstructured":"G. Johannsson, R. Bergthorsdottir, A.G. Nilsson, H. Lennernas, T. Hedner, S. Skrtic, Improving glucocorticoid replacement therapy using a novel modified-release hydrocortisone tablet: a pharmacokinetic study. Eur. J. Endocrinol. 161(1), 119\u2013130 (2009). https:\/\/doi.org\/10.1530\/EJE-09-0170","journal-title":"Eur. J. Endocrinol."},{"issue":"2","key":"2578_CR10","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1210\/jc.2011-1926","volume":"97","author":"G Johannsson","year":"2012","unstructured":"G. Johannsson, A.G. Nilsson, R. Bergthorsdottir, P. Burman, P. Dahlqvist, B. Ekman, B.E. Engstrom, T. Olsson, O. Ragnarsson, M. Ryberg, J. Wahlberg, B.M. Biller, J.P. Monson, P.M. Stewart, H. Lennernas, S. Skrtic, Improved cortisol exposure-time profile and outcome in patients with adrenal insufficiency: a prospective randomized trial of a novel hydrocortisone dual-release formulation. J. Clin. Endocrinol. Metab. 97(2), 473\u2013481 (2012). https:\/\/doi.org\/10.1210\/jc.2011-1926","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"2578_CR11","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1007\/s12020-015-0681-z","volume":"51","author":"R Giordano","year":"2016","unstructured":"R. Giordano, F. Guaraldi, E. Marinazzo, F. Fumarola, A. Rampino, R. Berardelli, I. Karamouzis, M. Lucchiari, T. Manetta, G. Mengozzi, E. Arvat, E. Ghigo, Improvement of anthropometric and metabolic parameters, and quality of life following treatment with dual-release hydrocortisone in patients with Addison\u2019s disease. Endocrine 51(2), 360\u2013368 (2016). https:\/\/doi.org\/10.1007\/s12020-015-0681-z","journal-title":"Endocrine"},{"issue":"5","key":"2578_CR12","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1530\/EJE-14-1114","volume":"172","author":"M Quinkler","year":"2015","unstructured":"M. Quinkler, MR. Nilsen, K. Zopf, M. Ventz, M. Oksnes, Modified-release hydrocortisone decreases BMI and HbA1c in patients with primary and secondary adrenal insufficiency. Eur. J. Endocrinol. 172(5), 619\u2013626 (2015). https:\/\/doi.org\/10.1530\/EJE-14-1114","journal-title":"Eur. J. Endocrinol."},{"issue":"3","key":"2578_CR13","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/S2213-8587(17)30398-4","volume":"6","author":"AM Isidori","year":"2018","unstructured":"A.M. Isidori, M.A. Venneri, C. Graziadio, C. Simeoli, D. Fiore, V. Hasenmajer, E. Sbardella, D. Gianfrilli, C. Pozza, P. Pasqualetti, S. Morrone, A. Santoni, F. Naro, A. Colao, R. Pivonello, A. Lenzi, Effect of once-daily, modified-release hydrocortisone versus standard glucocorticoid therapy on metabolism and innate immunity in patients with adrenal insufficiency (DREAM): a single-blind, randomised controlled trial. Lancet Diabetes Endocrinol. 6(3), 173\u2013185 (2018). https:\/\/doi.org\/10.1016\/S2213-8587(17)30398-4","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"5","key":"2578_CR14","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1111\/cen.13554","volume":"88","author":"V Guarnotta","year":"2018","unstructured":"V. Guarnotta, A. Ciresi, G. Pillitteri, C. Giordano, Improved insulin sensitivity and secretion in prediabetic patients with adrenal insufficiency on dual-release hydrocortisone treatment: a 36-month retrospective analysis. Clin. Endocrinol. 88(5), 665\u2013672 (2018). https:\/\/doi.org\/10.1111\/cen.13554","journal-title":"Clin. Endocrinol."},{"issue":"1","key":"2578_CR15","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1530\/EC-17-0368","volume":"7","author":"LM Mongioi","year":"2018","unstructured":"L.M. Mongioi, R.A. Condorelli, S. La Vignera, A.E. Calogero, Dual-release hydrocortisone treatment: glycometabolic profile and health-related quality of life. Endocr. Connect. 7(1), 211\u2013219 (2018). https:\/\/doi.org\/10.1530\/EC-17-0368","journal-title":"Endocr. Connect."},{"issue":"7","key":"2578_CR16","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1530\/EC-19-0176","volume":"8","author":"V Guarnotta","year":"2019","unstructured":"V. Guarnotta, C. Stefano Di, A. Santoro, A. Ciresi, A. Coppola, C. Giordano, Dual-release hydrocortisone vs conventional glucocorticoids in adrenal insufficiency. Endocr. Connect. 8(7), 853\u2013862 (2019). https:\/\/doi.org\/10.1530\/EC-19-0176","journal-title":"Endocr. Connect."},{"issue":"3","key":"2578_CR17","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1007\/s12020-017-1512-1","volume":"60","author":"S Frara","year":"2018","unstructured":"S. Frara, S. Chiloiro, T. Porcelli, A. Giampietro, G. Mazziotti, L. De Marinis, A. Giustina, Bone safety of dual-release hydrocortisone in patients with hypopituitarism. Endocrine 60(3), 528\u2013531 (2018). https:\/\/doi.org\/10.1007\/s12020-017-1512-1","journal-title":"Endocrine"},{"issue":"7","key":"2578_CR18","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1038\/nrendo.2009.106","volume":"5","author":"GP Chrousos","year":"2009","unstructured":"G.P. Chrousos, Stress and disorders of the stress system. Nat. Rev. Endocrinol. 5(7), 374\u2013381 (2009). https:\/\/doi.org\/10.1038\/nrendo.2009.106","journal-title":"Nat. Rev. Endocrinol."},{"issue":"8","key":"2578_CR19","doi-asserted-by":"publisher","first-page":"2998","DOI":"10.1210\/jc.2018-00346","volume":"103","author":"MA Venneri","year":"2018","unstructured":"M.A. Venneri, V. Hasenmajer, D. Fiore, E. Sbardella, R. Pofi, C. Graziadio, D. Gianfrilli, C. Pivonello, M. Negri, F. Naro, A.B. Grossman, A. Lenzi, R. Pivonello, A.M. Isidori, Circadian rhythm of glucocorticoid administration entrains clock genes in immune cells: a DREAM Trial Ancillary Study. J. Clin. Endocrinol. Metab. 103(8), 2998\u20133009 (2018). https:\/\/doi.org\/10.1210\/jc.2018-00346","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"2578_CR20","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-48634-y","volume":"9","author":"P Nanni","year":"2019","unstructured":"P. Nanni, L. Landuzzi, M.C. Manara, A. Righi, G. Nicoletti, C. Cristalli, M. Pasello, A. Parra, M. Carrabotta, M. Ferracin, A. Palladini, M.L. Ianzano, V. Giusti, F. Ruzzi, M. Magnani, D.M. Donati, P. Picci, P.L. Lollini, K. Scotlandi, Bone sarcoma patient-derived xenografts are faithful and stable preclinical models for molecular and therapeutic investigations. Sci. Rep. 9(1), 12174 (2019). https:\/\/doi.org\/10.1038\/s41598-019-48634-y","journal-title":"Sci. Rep."},{"issue":"1","key":"2578_CR21","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1530\/eje-13-0159","volume":"169","author":"F Ceccato","year":"2013","unstructured":"F. Ceccato, M. Barbot, M. Zilio, S. Ferasin, G. Occhi, A. Daniele, S. Mazzocut, M. Iacobone, C. Betterle, F. Mantero, C. Scaroni, Performance of salivary cortisol in the diagnosis of Cushing\u2019s syndrome, adrenal incidentaloma, and adrenal insufficiency. Eur. J. Endocrinol. 169(1), 31\u201336 (2013). https:\/\/doi.org\/10.1530\/eje-13-0159","journal-title":"Eur. J. Endocrinol."},{"issue":"3","key":"2578_CR22","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/nri3386","volume":"13","author":"C Scheiermann","year":"2013","unstructured":"C. Scheiermann, Y. Kunisaki, P.S. Frenette, Circadian control of the immune system. Nat. Rev. Immunol. 13(3), 190\u2013198 (2013). https:\/\/doi.org\/10.1038\/nri3386","journal-title":"Nat. Rev. Immunol."},{"issue":"5488","key":"2578_CR23","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.1126\/science.289.5488.2344","volume":"289","author":"A Balsalobre","year":"2000","unstructured":"A. Balsalobre, S.A. Brown, L. Marcacci, F. Tronche, C. Kellendonk, H.M. Reichardt, G. Schutz, U. Schibler, Resetting of circadian time in peripheral tissues by glucocorticoid signaling. Science 289(5488), 2344\u20132347 (2000). https:\/\/doi.org\/10.1126\/science.289.5488.2344","journal-title":"Science"},{"issue":"4","key":"2578_CR24","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1530\/EJE-16-0969","volume":"176","author":"I Bancos","year":"2017","unstructured":"I. Bancos, J. Hazeldine, V. Chortis, P. Hampson, A.E. Taylor, J.M. Lord, W. Arlt, Primary adrenal insufficiency is associated with impaired natural killer cell function: a potential link to increased mortality. Eur. J. Endocrinol. 176(4), 471\u2013480 (2017). https:\/\/doi.org\/10.1530\/EJE-16-0969","journal-title":"Eur. J. Endocrinol."},{"issue":"10","key":"2578_CR25","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/j.it.2003.08.003","volume":"24","author":"LA Pitcher","year":"2003","unstructured":"L.A. Pitcher, N.S. van Oers, T-cell receptor signal transmission: who gives an ITAM? Trends Immunol. 24(10), 554\u2013560 (2003). https:\/\/doi.org\/10.1016\/j.it.2003.08.003","journal-title":"Trends Immunol."},{"key":"2578_CR26","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1146\/annurev.immunol.19.1.197","volume":"19","author":"A Moretta","year":"2001","unstructured":"A. Moretta, C. Bottino, M. Vitale, D. Pende, C. Cantoni, M.C. Mingari, R. Biassoni, L. Moretta, Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu. Rev. Immunol. 19, 197\u2013223 (2001). https:\/\/doi.org\/10.1146\/annurev.immunol.19.1.197","journal-title":"Annu. Rev. Immunol."},{"issue":"9","key":"2578_CR27","doi-asserted-by":"publisher","first-page":"3077","DOI":"10.4049\/jimmunol.1700588","volume":"200","author":"A Suarez-Fueyo","year":"2018","unstructured":"A. Suarez-Fueyo, S.J. Bradley, T. Katsuyama, S. Solomon, E. Katsuyama, V.C. Kyttaris, V.R. Moulton, G.C. Tsokos, Downregulation of CD3zeta in NK cells from systemic lupus erythematosus patients confers a proinflammatory phenotype. J. Immunol. 200(9), 3077\u20133086 (2018). https:\/\/doi.org\/10.4049\/jimmunol.1700588","journal-title":"J. Immunol."},{"issue":"9","key":"2578_CR28","doi-asserted-by":"publisher","first-page":"3609","DOI":"10.1172\/JCI45816","volume":"121","author":"E Mamessier","year":"2011","unstructured":"E. Mamessier, A. Sylvain, M.L. Thibult, G. Houvenaeghel, J. Jacquemier, R. Castellano, A. Goncalves, P. Andre, F. Romagne, G. Thibault, P. Viens, D. Birnbaum, F. Bertucci, A. Moretta, D. Olive, Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity. J. Clin. Investig. 121(9), 3609\u20133622 (2011). https:\/\/doi.org\/10.1172\/JCI45816","journal-title":"J. Clin. Investig."},{"issue":"5","key":"2578_CR29","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1210\/jc.2008-2380","volume":"94","author":"M Debono","year":"2009","unstructured":"M. Debono, C. Ghobadi, A. Rostami-Hodjegan, H. Huatan, M.J. Campbell, J. Newell-Price, K. Darzy, D.P. Merke, W. Arlt, R.J. Ross, Modified-release hydrocortisone to provide circadian cortisol profiles. J. Clin. Endocrinol. Metab. 94(5), 1548\u20131554 (2009). https:\/\/doi.org\/10.1210\/jc.2008-2380","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2578_CR30","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1159\/000486004","volume":"49","author":"GA Ueland","year":"2018","unstructured":"G.A. Ueland, E.S. Husebye, Metabolic complications in adrenal insufficiency. Front. Horm. Res. 49, 104\u2013113 (2018). https:\/\/doi.org\/10.1159\/000486004","journal-title":"Front. Horm. Res."},{"issue":"9","key":"2578_CR31","doi-asserted-by":"publisher","first-page":"3082","DOI":"10.1210\/jcem.84.9.5978","volume":"84","author":"L Plat","year":"1999","unstructured":"L. Plat, R. Leproult, M. L\u2019Hermite-Baleriaux, F. Fery, J. Mockel, K.S. Polonsky, E. Van Cauter, Metabolic effects of short-term elevations of plasma cortisol are more pronounced in the evening than in the morning. J. Clin. Endocrinol. Metab. 84(9), 3082\u20133092 (1999). https:\/\/doi.org\/10.1210\/jcem.84.9.5978","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"31","key":"2578_CR32","doi-asserted-by":"publisher","first-page":"16150","DOI":"10.1074\/jbc.M116.731521","volume":"291","author":"Y Sun","year":"2016","unstructured":"Y. Sun, J.F. Cote, K. Du, Elmo2 is a regulator of insulin-dependent Glut4 membrane translocation. J. Biol. Chem. 291(31), 16150\u201316161 (2016). https:\/\/doi.org\/10.1074\/jbc.M116.731521","journal-title":"J. Biol. Chem."},{"issue":"2","key":"2578_CR33","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.abb.2003.08.020","volume":"419","author":"JA Chavez","year":"2003","unstructured":"J.A. Chavez, S.A. Summers, Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes. Arch. Biochem. Biophys. 419(2), 101\u2013109 (2003). https:\/\/doi.org\/10.1016\/j.abb.2003.08.020","journal-title":"Arch. Biochem. Biophys."},{"issue":"42","key":"2578_CR34","doi-asserted-by":"publisher","first-page":"28445","DOI":"10.1074\/jbc.M804637200","volume":"283","author":"CM Marobbio","year":"2008","unstructured":"C.M. Marobbio, G. Giannuzzi, E. Paradies, C.L. Pierri, F. Palmieri, alpha-Isopropylmalate, a leucine biosynthesis intermediate in yeast, is transported by the mitochondrial oxalacetate carrier. J. Biol. Chem. 283(42), 28445\u201328453 (2008). https:\/\/doi.org\/10.1074\/jbc.M804637200","journal-title":"J. Biol. Chem."},{"issue":"6","key":"2578_CR35","doi-asserted-by":"publisher","first-page":"302","DOI":"10.4161\/isl.3.6.17806","volume":"3","author":"MC Sugden","year":"2011","unstructured":"M.C. Sugden, M.J. Holness, The pyruvate carboxylase-pyruvate dehydrogenase axis in islet pyruvate metabolism: going round in circles? Islets 3(6), 302\u2013319 (2011). https:\/\/doi.org\/10.4161\/isl.3.6.17806","journal-title":"Islets"},{"key":"2578_CR36","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.cellsig.2018.03.001","volume":"46","author":"SS Rajasekaran","year":"2018","unstructured":"S.S. Rajasekaran, J. Kim, G.C. Gaboardi, J. Gromada, S.B. Shears, K.T. Dos Santos, E.L. Nolasco, S.S. Ferreira, C. Illies, M. Kohler, C. Gu, S.H. Ryu, J.O. Martins, E. Dare, C.J. Barker, P.O. Berggren, Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic beta-cells. Cell. Signal. 46, 120\u2013128 (2018). https:\/\/doi.org\/10.1016\/j.cellsig.2018.03.001","journal-title":"Cell. Signal."},{"issue":"2","key":"2578_CR37","doi-asserted-by":"publisher","first-page":"R51","DOI":"10.1530\/JOE-16-0046","volume":"230","author":"J Kunes","year":"2016","unstructured":"J. Kunes, V. Prazienkova, A. Popelova, B. Mikulaskova, J. Zemenova, L. Maletinska, Prolactin-releasing peptide: a new tool for obesity treatment. J. Endocrinol. 230(2), R51\u2013R58 (2016). https:\/\/doi.org\/10.1530\/JOE-16-0046","journal-title":"J. Endocrinol."},{"issue":"14","key":"2578_CR38","doi-asserted-by":"publisher","first-page":"10429","DOI":"10.1074\/jbc.275.14.10429","volume":"275","author":"M Renz","year":"2000","unstructured":"M. Renz, E. Tomlinson, B. Hultgren, N. Levin, Q. Gu, R.A. Shimkets, D.A. Lewin, T.A. Stewart, Quantitative expression analysis of genes regulated by both obesity and leptin reveals a regulatory loop between leptin and pituitary-derived ACTH. J. Biol. Chem. 275(14), 10429\u201310436 (2000). https:\/\/doi.org\/10.1074\/jbc.275.14.10429","journal-title":"J. Biol. Chem."},{"key":"2578_CR39","doi-asserted-by":"publisher","first-page":"640","DOI":"10.3389\/fphys.2018.00640","volume":"9","author":"V Francisco","year":"2018","unstructured":"V. Francisco, J. Pino, V. Campos-Cabaleiro, C. Ruiz-Fernandez, A. Mera, M.A. Gonzalez-Gay, R. Gomez, O. Gualillo, Obesity, fat mass and immune system: role for leptin. Front. Physiol. 9, 640 (2018). https:\/\/doi.org\/10.3389\/fphys.2018.00640","journal-title":"Front. Physiol."},{"issue":"33","key":"2578_CR40","doi-asserted-by":"publisher","first-page":"13714","DOI":"10.1074\/jbc.M117.778506","volume":"292","author":"CG Mitrofan","year":"2017","unstructured":"C.G. Mitrofan, S.L. Appleby, G.B. Nash, Z. Mallat, E.R. Chilvers, P.D. Upton, N.W. Morrell, Bone morphogenetic protein 9 (BMP9) and BMP10 enhance tumor necrosis factor-alpha-induced monocyte recruitment to the vascular endothelium mainly via activin receptor-like kinase 2. J. Biol. Chem. 292(33), 13714\u201313726 (2017). https:\/\/doi.org\/10.1074\/jbc.M117.778506","journal-title":"J. Biol. Chem."}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-020-02578-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12020-020-02578-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-020-02578-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T17:23:36Z","timestamp":1623950616000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12020-020-02578-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,8]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["2578"],"URL":"https:\/\/doi.org\/10.1007\/s12020-020-02578-w","relation":{},"ISSN":["1355-008X","1559-0100"],"issn-type":[{"type":"print","value":"1355-008X"},{"type":"electronic","value":"1559-0100"}],"subject":[],"published":{"date-parts":[[2021,1,8]]},"assertion":[{"value":"28 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Approval was obtained from the Ethics Committee of University of Siena. The procedures used in this study adhere to the tenets of the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}