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The aim was to analyze sense of smell and taste in patients with CS and explore the effect of therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study cohort comprised 20 patients with florid CS treated between 2018 and 2020 in the outpatient clinic of the LMU Munich. We compared these 20 patients with CS to 40 healthy subjects matched for age, sex, and smoking status. Patients\u2019 sense of smell and taste was examined at diagnosis and 3 months after successful therapeutic surgery leading to clinical and biochemical remission. Odor threshold, discrimination, and identification were measured with \u201cSniffin\u2019 Sticks\u201d, taste was measured with \u201cTaste Strips\u201d. Perceived sense of smell and taste was retrieved via a questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with florid CS had significantly reduced smell (total smell score 30.3 vs. 34.4,<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0005) and taste scores (9.5 vs. 12.0,<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0005) compared to controls and significantly more frequently hyposmia (55 vs. 2.5%,<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0005), hypogeusia (40 vs. 0%,<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0005), and self-reported chemosensory impairment (60 vs. 0%,<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0005). Three months after successful surgery, CS patients showed significant improvement of odor threshold (8.1 vs. 7.0,<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0005), odor discrimination (12.0 vs. 11.0,<jats:italic>p<\/jats:italic>\u2009=\u20090.003), total smell score (33.4 vs. 30.3,<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0005), and taste (11.5 vs. 9.5,<jats:italic>p<\/jats:italic>\u2009=\u20090.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Chemosensory dysfunction is a novel and clinically relevant feature of CS.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s12020-021-02707-z","type":"journal-article","created":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T21:02:36Z","timestamp":1617656556000},"page":"674-681","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Chemosensory dysfunction in Cushing\u2019s syndrome"],"prefix":"10.1007","volume":"73","author":[{"given":"Elena","family":"Heger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"German","family":"Rubinstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leah T.","family":"Braun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Zopp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Honegger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max","family":"Seidensticker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Reincke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0941-9513","authenticated-orcid":false,"given":"Andrea","family":"O\u00dfwald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,4,5]]},"reference":[{"issue":"7","key":"2707_CR1","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/S2213-8587(16)30005-5","volume":"4","author":"R Clayton","year":"2016","unstructured":"R. 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