{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T08:52:30Z","timestamp":1780044750194,"version":"3.53.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T00:00:00Z","timestamp":1633996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T00:00:00Z","timestamp":1633996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1007\/s12020-021-02895-8","type":"journal-article","created":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T18:20:33Z","timestamp":1634062833000},"page":"478-486","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Controversy on the management of patients carrying RET p.V804M mutation"],"prefix":"10.1007","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4294-3624","authenticated-orcid":false,"given":"Ali S.","family":"Alzahrani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meshael","family":"Alswailem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balgees","family":"Alghamdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafiullah","family":"Rafiullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Aldawish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hindi","family":"Al-Hindi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,12]]},"reference":[{"issue":"11","key":"2895_CR1","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1056\/NEJMra1501993","volume":"375","author":"JA Fagin","year":"2016","unstructured":"J.A. Fagin, S.A. Wells Jr, Biologic and clinical perspectives on thyroid cancer. N. Engl. J. Med. 375(11), 1054\u201367 (2016). https:\/\/doi.org\/10.1056\/NEJMra1501993","journal-title":"N. Engl. J. Med."},{"key":"2895_CR2","doi-asserted-by":"publisher","unstructured":"J.S. Mathiesen, G. Effraimidis, M. Rossing, \u00c5.K. Rasmussen, L. Hoejberg, L. Bastholt et al. Multiple endocrine neoplasia type 2: a reveiw. Semin Cancer Biol. (2021). https:\/\/doi.org\/10.1016\/j.semcancer.2021.03.035","DOI":"10.1016\/j.semcancer.2021.03.035"},{"key":"2895_CR3","doi-asserted-by":"publisher","unstructured":"C. Romei, R.A. Elisei, Narrative review of genetic alterations in primary thyroid epithelial cancer. Int. J. Mol. Sci. 22(4) (2021). https:\/\/doi.org\/10.3390\/ijms22041726","DOI":"10.3390\/ijms22041726"},{"issue":"6428","key":"2895_CR4","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/363458a0","volume":"363","author":"LM Mulligan","year":"1993","unstructured":"L.M. Mulligan, J.B. Kwok, C.S. Healey, M.J. Elsdon, C. Eng, E. Gardner et al. Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A. Nature 363(6428), 458\u201360 (1993). https:\/\/doi.org\/10.1038\/363458a0","journal-title":"Nature"},{"issue":"6","key":"2895_CR5","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1089\/thy.2014.0335","volume":"25","author":"SA Wells Jr","year":"2015","unstructured":"S.A. Wells Jr, S.L. Asa, H. Dralle, R. Elisei, D.B. Evans, R.F. Gagel et al. Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma. Thyroid 25(6), 567\u2013610 (2015). https:\/\/doi.org\/10.1089\/thy.2014.0335","journal-title":"Thyroid"},{"issue":"11","key":"2895_CR6","doi-asserted-by":"publisher","first-page":"4275","DOI":"10.1210\/jc.2017-02529","volume":"103","author":"C Loveday","year":"2018","unstructured":"C. Loveday, K. Josephs, D. Chubb, A. Gunning, L. Izatt, M. Tischkowitz et al. p.Val804Met, the most frequent pathogenic mutation in RET, confers a very low lifetime risk of medullary thyroid cancer. J. Clin. Endocrinol. Metab. 103(11), 4275\u201382 (2018). https:\/\/doi.org\/10.1210\/jc.2017-02529","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"3","key":"2895_CR7","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1530\/ec-18-0506","volume":"8","author":"RMB Maciel","year":"2019","unstructured":"R.M.B. Maciel, C.P. Camacho, L.V.M. Assump\u00e7\u00e3o, N.E. Bufalo, A.L. Carvalho, G.A. de Carvalho et al. Genotype and phenotype landscape of MEN2 in 554 medullary thyroid cancer patients: the BrasMEN study. Endocr. Connect 8(3), 289\u201398 (2019). https:\/\/doi.org\/10.1530\/ec-18-0506","journal-title":"Endocr. Connect"},{"issue":"19","key":"2895_CR8","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1001\/jama.1996.03540190047028","volume":"276","author":"C Eng","year":"1996","unstructured":"C. Eng, D. Clayton, I. Schuffenecker, G. Lenoir, G. Cote, R.F. Gagel et al. The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis. Jama 276(19), 1575\u20139 (1996)","journal-title":"Jama"},{"key":"2895_CR9","doi-asserted-by":"publisher","unstructured":"R. Elisei, A. Tacito, T. Ramone, R. Ciampi, V. Bottici, V. Cappagli et al. Twenty-five years experience on RET genetic screening on hereditary MTC: an update on the prevalence of germline RET mutations. Genes 10(9) (2019). https:\/\/doi.org\/10.3390\/genes10090698","DOI":"10.3390\/genes10090698"},{"key":"2895_CR10","doi-asserted-by":"publisher","unstructured":"Nationwide French Study of RET Variants Detected from 2003 to 2013 Suggests a Possible Influence of Polymorphisms as Modifiers. Thyroid 27(12), 1511\u201322 (2017). https:\/\/doi.org\/10.1089\/thy.2016.0399","DOI":"10.1089\/thy.2016.0399"},{"issue":"12","key":"2895_CR11","first-page":"2415","volume":"10","author":"A Bolino","year":"1995","unstructured":"A. Bolino, I. Schuffenecker, Y. Luo, M. Seri, M. Silengo, T. Tocco et al. RET mutations in exons 13 and 14 of FMTC patients. Oncogene 10(12), 2415\u20139 (1995)","journal-title":"Oncogene"},{"issue":"6","key":"2895_CR12","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/j.surg.2009.09.021","volume":"146","author":"AL Shifrin","year":"2009","unstructured":"A.L. Shifrin, C. Xenachis, A. Fay, T.J. Matulewicz, Y.H. Kuo, J.J. Vernick, One hundred and seven family members with the rearranged during transfection V804M proto-oncogene mutation presenting with simultaneous medullary and papillary thyroid carcinomas, rare primary hyperparathyroidism, and no pheochromocytomas: is this a new syndrome\u2013MEN 2C? Surgery 146(6), 998\u20131005 (2009). https:\/\/doi.org\/10.1016\/j.surg.2009.09.021","journal-title":"Surgery"},{"issue":"9","key":"2895_CR13","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1097\/01.mlg.0000233509.83679.ee","volume":"116","author":"AR Shaha","year":"2006","unstructured":"A.R. Shaha, T. Cohen, R. Ghossein, R.M. Tuttle, Late-onset medullary carcinoma of the thyroid: need for genetic testing and prophylactic thyroidectomy in adult family members. Laryngoscope 116(9), 1704\u20137 (2006). https:\/\/doi.org\/10.1097\/01.mlg.0000233509.83679.ee","journal-title":"Laryngoscope"},{"issue":"2","key":"2895_CR14","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1530\/eje-10-0333","volume":"163","author":"C Romei","year":"2010","unstructured":"C. Romei, S. Mariotti, L. Fugazzola, A. Taccaliti, F. Pacini, G. Opocher et al. Multiple endocrine neoplasia type 2 syndromes (MEN 2): results from the ItaMEN network analysis on the prevalence of different genotypes and phenotypes. Eur. J. Endocrinol. 163(2), 301\u20138 (2010). https:\/\/doi.org\/10.1530\/eje-10-0333","journal-title":"Eur. J. Endocrinol."},{"issue":"3","key":"2895_CR15","doi-asserted-by":"publisher","first-page":"E509","DOI":"10.1210\/jc.2010-1234","volume":"96","author":"V Rohmer","year":"2011","unstructured":"V. Rohmer, G. Vidal-Trecan, A. Bourdelot, P. Niccoli, A. Murat, J.L. Wemeau et al. Prognostic Factors of Disease-Free survival after thyroidectomy in 170 young patients with a RET germline mutation: a Multicenter Study of the Groupe Fran\u00e7ais d\u2019Etude des Tumeurs Endocrines. J. Clin. Endocrinol. Metab. 96(3), E509\u2013E18 (2011). https:\/\/doi.org\/10.1210\/jc.2010-1234","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"7","key":"2895_CR16","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1089\/thy.2013.0620","volume":"24","author":"TA Rich","year":"2014","unstructured":"T.A. Rich, L. Feng, N. Busaidy, G.J. Cote, R.F. Gagel, M. Hu et al. Prevalence by age and predictors of medullary thyroid cancer in patients with lower risk germline RET proto-oncogene mutations. Thyroid 24(7), 1096\u2013106 (2014). https:\/\/doi.org\/10.1089\/thy.2013.0620","journal-title":"Thyroid"},{"issue":"11","key":"2895_CR17","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1002\/bjs.4718","volume":"91","author":"H Gibelin","year":"2004","unstructured":"H. Gibelin, S. Bezieau, C. Misso, M.H. Bouin-Pineau, R. Mar\u00e9chaud, J.L. Kraimps, Germline RET V804M mutation associated with multiple endocrine neoplasia type 2A. Br. J. Surg. 91(11), 1458\u20139 (2004). https:\/\/doi.org\/10.1002\/bjs.4718","journal-title":"Br. J. Surg."},{"issue":"5","key":"2895_CR18","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1007\/s40618-014-0224-0","volume":"38","author":"MN Basaran","year":"2015","unstructured":"M.N. Basaran, M.M. Tuna, E. Karak\u0131l\u0131\u00e7, B.A. Do\u011fan, N.N. \u0130mga, D. Berker et al. Characterization of V804M-mutated RET proto-oncogene associated with familial medullary thyroid cancer, report of the largest Turkish family. J. Endocrinol. Investig. 38(5), 541\u20136 (2015). https:\/\/doi.org\/10.1007\/s40618-014-0224-0","journal-title":"J. Endocrinol. Investig."},{"issue":"1","key":"2895_CR19","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/j.1365-2265.2007.02830.x","volume":"67","author":"M Recasens","year":"2007","unstructured":"M. Recasens, J. Oriola, J.M. Fern\u00e1ndez-Real, J. Roig, J.I. Rodr\u00edguez-Hermosa, J.A. Font et al. Asymptomatic bilateral adrenal pheochromocytoma in a patient with a germline V804M mutation in the RET proto-oncogene. Clin. Endocrinol. 67(1), 29\u201333 (2007). https:\/\/doi.org\/10.1111\/j.1365-2265.2007.02830.x","journal-title":"Clin. Endocrinol."},{"issue":"24","key":"2895_CR20","doi-asserted-by":"publisher","first-page":"2944","DOI":"10.1002\/ajmg.a.32023","volume":"143a","author":"JC Sapp","year":"2007","unstructured":"J.C. Sapp, J.T. Turner, J.M. van de Kamp, F.S. van Dijk, R.B. Lowry, L.G. Biesecker, Newly delineated syndrome of congenital lipomatous overgrowth, vascular malformations, and epidermal nevi (CLOVE syndrome) in seven patients. Am. J. Med Genet A. 143a(24), 2944\u201358 (2007). https:\/\/doi.org\/10.1002\/ajmg.a.32023","journal-title":"Am. J. Med Genet A."},{"issue":"1","key":"2895_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/MCD.0b013e328317a716","volume":"18","author":"AI Alomari","year":"2009","unstructured":"A.I. Alomari, Characterization of a distinct syndrome that associates complex truncal overgrowth, vascular, and acral anomalies: a descriptive study of 18 cases of CLOVES syndrome. Clin. Dysmorphol. 18(1), 1\u20137 (2009). https:\/\/doi.org\/10.1097\/MCD.0b013e328317a716","journal-title":"Clin. Dysmorphol."},{"issue":"6","key":"2895_CR22","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1016\/j.ajhg.2012.05.006","volume":"90","author":"KC Kurek","year":"2012","unstructured":"K.C. Kurek, V.L. Luks, U.M. Ayturk, A.I. Alomari, S.J. Fishman, S.A. Spencer et al. Somatic mosaic activating mutations in PIK3CA cause CLOVES syndrome. Am. J. Hum. Genet. 90(6), 1108\u201315 (2012). https:\/\/doi.org\/10.1016\/j.ajhg.2012.05.006","journal-title":"Am. J. Hum. Genet."},{"issue":"2","key":"2895_CR23","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1002\/ajmg.a.36836","volume":"167a","author":"KM Keppler-Noreuil","year":"2015","unstructured":"K.M. Keppler-Noreuil, J.J. Rios, V.E. Parker, R.K. Semple, M.J. Lindhurst, J.C. Sapp et al. PIK3CA-related overgrowth spectrum (PROS): diagnostic and testing eligibility criteria, differential diagnosis, and evaluation. Am. J. Med Genet A. 167a(2), 287\u201395 (2015). https:\/\/doi.org\/10.1002\/ajmg.a.36836","journal-title":"Am. J. Med Genet A."},{"key":"2895_CR24","doi-asserted-by":"publisher","unstructured":"D.M. Pendrick, J.A. Oberg, S.J. Hsiao, W.K. Chung, C. Koval, A. Sireci et al. Identification of a secondary RET mutation in a pediatric patient with relapsed acute myeloid leukemia leads to the diagnosis and treatment of asymptomatic metastatic medullary thyroid cancer in a parent: a case for sequencing the germline. Cold Spring Harb Mol Case Stud. 5(2) (2019). https:\/\/doi.org\/10.1101\/mcs.a003889","DOI":"10.1101\/mcs.a003889"},{"issue":"11","key":"2895_CR25","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1136\/jmg.38.11.784","volume":"38","author":"L Kasprzak","year":"2001","unstructured":"L. Kasprzak, S. Nolet, L. Gaboury, C. Pavia, C. Villabona, F. Rivera-Fillat et al. Familial medullary thyroid carcinoma and prominent corneal nerves associated with the germline V804M and V778I mutations on the same allele of RET. J. Med Genet. 38(11), 784\u20137 (2001). https:\/\/doi.org\/10.1136\/jmg.38.11.784","journal-title":"J. Med Genet."},{"issue":"12","key":"2895_CR26","doi-asserted-by":"publisher","first-page":"E363","DOI":"10.1002\/hed.23241","volume":"35","author":"KT Nakao","year":"2013","unstructured":"K.T. Nakao, T. Usui, M. Ikeda, Y. Mori, T. Yamamoto, S.T. Kawashima et al. Novel tandem germline RET proto-oncogene mutations in a patient with multiple endocrine neoplasia type 2B: report of a case and a literature review of tandem RET mutations with in silico analysis. Head. Neck 35(12), E363\u20138 (2013). https:\/\/doi.org\/10.1002\/hed.23241","journal-title":"Head. Neck"},{"issue":"3","key":"2895_CR27","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1530\/eje-12-0919","volume":"168","author":"A Machens","year":"2013","unstructured":"A. Machens, K. Lorenz, C. Sekulla, W. H\u00f6ppner, K. Frank-Raue, F. Raue et al. Molecular epidemiology of multiple endocrine neoplasia 2: implications for RET screening in the new millenium. Eur. J. Endocrinol. 168(3), 307\u201314 (2013). https:\/\/doi.org\/10.1530\/eje-12-0919","journal-title":"Eur. J. Endocrinol."},{"issue":"6","key":"2895_CR28","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1002\/humu.23430","volume":"39","author":"A Machens","year":"2018","unstructured":"A. Machens, K. Lorenz, F. Weber, H. Dralle, Genotype-specific progression of hereditary medullary thyroid cancer. Hum. Mutat. 39(6), 860\u20139 (2018). https:\/\/doi.org\/10.1002\/humu.23430","journal-title":"Hum. Mutat."},{"issue":"6","key":"2895_CR29","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1111\/j.1365-2265.2005.02394.x","volume":"63","author":"DL Learoyd","year":"2005","unstructured":"D.L. Learoyd, J. Gosnell, M.S. Elston, T.J. Saurine, A.L. Richardson, L.W. Delbridge et al. Experience of prophylactic thyroidectomy in multiple endocrine neoplasia type 2A kindreds with RET codon 804 mutations. Clin. Endocrinol. 63(6), 636\u201341 (2005). https:\/\/doi.org\/10.1111\/j.1365-2265.2005.02394.x","journal-title":"Clin. Endocrinol."},{"issue":"6","key":"2895_CR30","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1089\/thy.2009.0021","volume":"19","author":"AE Rothberg","year":"2009","unstructured":"A.E. Rothberg, V.M. Raymond, S.B. Gruber, J. Sisson, Familial medullary thyroid carcinoma associated with cutaneous lichen amyloidosis. Thyroid 19(6), 651\u20135 (2009). https:\/\/doi.org\/10.1089\/thy.2009.0021","journal-title":"Thyroid"},{"issue":"6","key":"2895_CR31","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1089\/thy.2008.0403","volume":"19","author":"RT Kloos","year":"2009","unstructured":"R.T. Kloos, C. Eng, D.B. Evans, G.L. Francis, R.F. Gagel, H. Gharib et al. Medullary thyroid cancer: management guidelines of the American Thyroid Association. Thyroid 19(6), 565\u2013612 (2009). https:\/\/doi.org\/10.1089\/thy.2008.0403","journal-title":"Thyroid"},{"issue":"2","key":"2895_CR32","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s12022-010-9117-8","volume":"21","author":"C Griffith","year":"2010","unstructured":"C. Griffith, S. Zhang, S. Mukhopadhyay, Synchronous metastatic medullary and papillary thyroid carcinomas in a patient with germline RET mutation: case report, molecular analysis, and implications for pathogenesis. Endocr. Pathol. 21(2), 115\u20139 (2010). https:\/\/doi.org\/10.1007\/s12022-010-9117-8","journal-title":"Endocr. Pathol."},{"issue":"11","key":"2895_CR33","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1007\/s40618-015-0290-y","volume":"38","author":"B Febrero","year":"2015","unstructured":"B. Febrero, J.M. Rodr\u00edguez, A. R\u00edos, P. Portillo, P. Parrilla, Papillary thyroid carcinoma and multiple endocrine neoplasia type 2. J. Endocrinol. Investig. 38(11), 1233\u20137 (2015). https:\/\/doi.org\/10.1007\/s40618-015-0290-y","journal-title":"J. Endocrinol. Investig."},{"issue":"8","key":"2895_CR34","doi-asserted-by":"publisher","first-page":"2635","DOI":"10.1245\/s10434-012-2357-8","volume":"19","author":"RL Wong","year":"2012","unstructured":"R.L. Wong, H.S. Kazaure, S.A. Roman, J.A. Sosa, Simultaneous medullary and differentiated thyroid cancer: a population-level analysis of an increasingly common entity. Ann. Surg. Oncol. 19(8), 2635\u201342 (2012). https:\/\/doi.org\/10.1245\/s10434-012-2357-8","journal-title":"Ann. Surg. Oncol."},{"issue":"1","key":"2895_CR35","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1245\/s10434-011-1795-z","volume":"19","author":"A Machens","year":"2012","unstructured":"A. Machens, H. Dralle, Simultaneous medullary and papillary thyroid cancer: a novel entity? Ann. Surg. Oncol. 19(1), 37\u201344 (2012). https:\/\/doi.org\/10.1245\/s10434-011-1795-z","journal-title":"Ann. Surg. Oncol."},{"issue":"1","key":"2895_CR36","doi-asserted-by":"publisher","first-page":"156","DOI":"10.3346\/jkms.2013.28.1.156","volume":"28","author":"YS Choi","year":"2013","unstructured":"Y.S. Choi, H.J. Kwon, B.K. Kim, S.K. Kwon, Y.H. Park, J.H. Kim et al. A case of medullary thyroid carcinoma with de novo V804M RET germline mutation. jkms 28(1), 156\u20139 (2013). https:\/\/doi.org\/10.3346\/jkms.2013.28.1.156","journal-title":"jkms"},{"issue":"2","key":"2895_CR37","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.gene.2013.12.003","volume":"536","author":"T Ercolino","year":"2014","unstructured":"T. Ercolino, R. Lai, V. Giach\u00e8, S. Melchionda, M. Carella, A. Delitala et al. Patient affected by neurofibromatosis type 1 and thyroid C-cell hyperplasia harboring pathogenic germ-line mutations in both NF1 and RET genes. Gene 536(2), 332\u20135 (2014). https:\/\/doi.org\/10.1016\/j.gene.2013.12.003","journal-title":"Gene"},{"issue":"4","key":"2895_CR38","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1210\/jcem.87.4.8403","volume":"87","author":"F Lombardo","year":"2002","unstructured":"F. Lombardo, E. Baudin, E. Chiefari, F. Arturi, S. Bardet, B. Caillou et al. Familial medullary thyroid carcinoma: clinical variability and low aggressiveness associated with RET mutation at codon 804. J. Clin. Endocrinol. Metab. 87(4), 1674\u201380 (2002). https:\/\/doi.org\/10.1210\/jcem.87.4.8403","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"4","key":"2895_CR39","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1002\/(SICI)1097-0215(19960822)69:4<312::AID-IJC13>3.0.CO;2-7","volume":"69","author":"M Fink","year":"1996","unstructured":"M. Fink, A. Weinh\u00fcsel, B. Niederle, O.A. Haas, Distinction between sporadic and hereditary medullary thyroid carcinoma (MTC) by mutation analysis of the RET proto-oncogene. \u201cStudy Group Multiple Endocrine Neoplasia Austria (SMENA)\u201d. Int J. Cancer 69(4), 312\u20136 (1996). 10.1002\/(sici)1097-0215(19960822)69:4<312::Aid-ijc13>3.0.Co;2-7","journal-title":"Int J. Cancer"}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-021-02895-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12020-021-02895-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-021-02895-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T08:42:58Z","timestamp":1643964178000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12020-021-02895-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,12]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["2895"],"URL":"https:\/\/doi.org\/10.1007\/s12020-021-02895-8","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-799440\/v1","asserted-by":"object"}]},"ISSN":["1355-008X","1559-0100"],"issn-type":[{"value":"1355-008X","type":"print"},{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,12]]},"assertion":[{"value":"9 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}