{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T06:22:25Z","timestamp":1756189345067,"version":"3.37.3"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T00:00:00Z","timestamp":1637539200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T00:00:00Z","timestamp":1637539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/http:\/\/dx.doi.org\/10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL128393"],"award-info":[{"award-number":["R01HL128393"]}],"id":[{"id":"10.13039\/http:\/\/dx.doi.org\/10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/http:\/\/dx.doi.org\/10.13039\/100008569","name":"Oklahoma Center for the Advancement of Science and Technology","doi-asserted-by":"publisher","award":["HR17-123"],"award-info":[{"award-number":["HR17-123"]}],"id":[{"id":"10.13039\/http:\/\/dx.doi.org\/10.13039\/100008569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1007\/s12020-021-02944-2","type":"journal-article","created":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T09:03:01Z","timestamp":1637571781000},"page":"959-963","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["GnRH receptor-activating autoantibodies in polycystic ovary syndrome: identification of functional epitopes and development of epitope mimetic inhibitors"],"prefix":"10.1007","volume":"75","author":[{"given":"Hongliang","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yankai","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jielin","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hariprasad","family":"Gali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A.","family":"Weedin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather R.","family":"Burks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LaTasha B.","family":"Craig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6760-3410","authenticated-orcid":false,"given":"Xichun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,22]]},"reference":[{"issue":"4","key":"2944_CR1","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/nrendo.2010.217","volume":"7","author":"MO Goodarzi","year":"2011","unstructured":"M.O. Goodarzi, D.A. Dumesic, G. Chazenbalk, R. Azziz, Polycystic ovary syndrome: etiology, pathogenesis and diagnosis. Nat. Rev. Endocrinol. 7(4), 219\u2013231 (2011). https:\/\/doi.org\/10.1038\/nrendo.2010.217","journal-title":"Nat. Rev. Endocrinol."},{"issue":"5","key":"2944_CR2","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.ejim.2010.06.008","volume":"21","author":"J Petrikova","year":"2010","unstructured":"J. Petrikova, I. Lazurova, S. Yehuda, Polycystic ovary syndrome and autoimmunity. Eur. J. Intern. Med. 21(5), 369\u2013371 (2010). https:\/\/doi.org\/10.1016\/j.ejim.2010.06.008","journal-title":"Eur. J. Intern. Med."},{"issue":"8","key":"2944_CR3","doi-asserted-by":"publisher","first-page":"bvaa078","DOI":"10.1210\/jendso\/bvaa078","volume":"4","author":"DC Kem","year":"2020","unstructured":"D.C. Kem, H. Li, X. Yu, E. Weedin, A.C. Reynolds, E. Forsythe, M. Beel, H. Fischer, B. Hines, Y. Guo, J. Deng, J.T. Liles, Z. Nuss, M. Elkosseifi, C.E. Aston, H.R. Burks, L.B. Craig, The role of GnRH receptor autoantibodies in polycystic ovary syndrome. J. Endocr. Soc. 4(8), bvaa078 (2020). https:\/\/doi.org\/10.1210\/jendso\/bvaa078","journal-title":"J. Endocr. Soc."},{"issue":"3","key":"2944_CR4","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.xfre.2020.09.015","volume":"1","author":"EA Weedin","year":"2020","unstructured":"E.A. Weedin, H.R. Burks, X. Yu, H. Li, C.E. Aston, D.C. Kem, L.B. Craig, Elevated activity levels of activating autoantibodies to the GnRH receptor in patients with polycystic ovary syndrome. Fertil. Steril. Rep. 1(3), 299\u2013304 (2020). https:\/\/doi.org\/10.1016\/j.xfre.2020.09.015","journal-title":"Fertil. Steril. Rep."},{"issue":"1","key":"2944_CR5","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s12020-021-02761-7","volume":"74","author":"H Li","year":"2021","unstructured":"H. Li, Y. Guo, J. Deng, H. Fischer, E.A. Weedin, H.R. Burks, L.B. Craig, X. Yu, Increased testosterone and proinflammatory cytokines in patients with polycystic ovary syndrome correlate with elevated GnRH receptor autoantibody activity assessed by a fluorescence resonance energy transfer-based bioassay. Endocrine 74(1), 163\u2013171 (2021). https:\/\/doi.org\/10.1007\/s12020-021-02761-7","journal-title":"Endocrine"},{"issue":"1","key":"2944_CR6","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.fertnstert.2016.05.003","volume":"106","author":"D Lizneva","year":"2016","unstructured":"D. Lizneva, L. Suturina, W. Walker, S. Brakta, L. Gavrilova-Jordan, R. Azziz, Criteria, prevalence, and phenotypes of polycystic ovary syndrome. Fertil. Steril. 106(1), 6\u201315 (2016). https:\/\/doi.org\/10.1016\/j.fertnstert.2016.05.003","journal-title":"Fertil. Steril."},{"issue":"4","key":"2944_CR7","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1113\/EP089109","volume":"106","author":"H Li","year":"2021","unstructured":"H. Li, Y. Guo, G. Zhang, J. Deng, H. Fischer, L.B. Craig, X. Yu, D.C. Kem, Gonadotrophin-releasing hormone receptor autoantibodies induce polycystic ovary syndrome-like features in a rat model. Exp. Physiol. 106(4), 902\u2013912 (2021). https:\/\/doi.org\/10.1113\/EP089109","journal-title":"Exp. Physiol."},{"issue":"5","key":"2944_CR8","doi-asserted-by":"publisher","first-page":"339","DOI":"10.2174\/1389203033487054","volume":"4","author":"PM Fischer","year":"2003","unstructured":"P.M. Fischer, The design, synthesis and application of stereochemical and directional peptide isomers: a critical review. Curr. Protein Pept. Sci. 4(5), 339\u2013356 (2003). https:\/\/doi.org\/10.2174\/1389203033487054","journal-title":"Curr. Protein Pept. Sci."},{"issue":"1-2","key":"2944_CR9","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/0014-5793(90)80535-q","volume":"276","author":"AS Kolaskar","year":"1990","unstructured":"A.S. Kolaskar, P.C. Tongaonkar, A semi-empirical method for prediction of antigenic determinants on protein antigens. FEBS Lett. 276(1-2), 172\u2013174 (1990). https:\/\/doi.org\/10.1016\/0014-5793(90)80535-q","journal-title":"FEBS Lett."},{"issue":"12","key":"2944_CR10","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.4155\/fmc.10.259","volume":"2","author":"JM Mason","year":"2010","unstructured":"J.M. Mason, Design and development of peptides and peptide mimetics as antagonists for therapeutic intervention. Future Med. Chem. 2(12), 1813\u20131822 (2010). https:\/\/doi.org\/10.4155\/fmc.10.259","journal-title":"Future Med. Chem."},{"issue":"4","key":"2944_CR11","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1161\/HYPERTENSIONAHA.114.05037","volume":"65","author":"H Li","year":"2015","unstructured":"H. Li, D.C. Kem, L. Zhang, B. Huang, C. Liles, A. Benbrook, H. Gali, V. Veitla, B.J. Scherlag, M.W. Cunningham, X. Yu, Novel retro-inverso peptide inhibitor reverses angiotensin receptor autoantibody-induced hypertension in the rabbit. Hypertension 65(4), 793\u2013799 (2015). https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.114.05037","journal-title":"Hypertension"},{"issue":"3","key":"2944_CR12","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s10840-015-0063-8","volume":"44","author":"H Li","year":"2015","unstructured":"H. Li, L. Zhang, B. Huang, V. Veitla, B.J. Scherlag, M.W. Cunningham, C.E. Aston, D.C. Kem, X. Yu, A peptidomimetic inhibitor suppresses the inducibility of beta1-adrenergic autoantibody-mediated cardiac arrhythmias in the rabbit. J. Interv. Card Electrophysiol. 44(3), 205\u2013212 (2015). https:\/\/doi.org\/10.1007\/s10840-015-0063-8","journal-title":"J. Interv. Card Electrophysiol."},{"issue":"19","key":"2944_CR13","doi-asserted-by":"publisher","first-page":"e013006","DOI":"10.1161\/JAHA.119.013006","volume":"8","author":"H Li","year":"2019","unstructured":"H. Li, G. Zhang, L. Zhou, Z. Nuss, M. Beel, B. Hines, T. Murphy, J. Liles, L. Zhang, D.C. Kem, X. Yu, Adrenergic autoantibody-induced postural tachycardia syndrome in rabbits. J. Am. Heart Assoc. 8(19), e013006 (2019). https:\/\/doi.org\/10.1161\/JAHA.119.013006","journal-title":"J. Am. Heart Assoc."}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-021-02944-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12020-021-02944-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-021-02944-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T14:13:08Z","timestamp":1646143988000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12020-021-02944-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,22]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["2944"],"URL":"https:\/\/doi.org\/10.1007\/s12020-021-02944-2","relation":{},"ISSN":["1355-008X","1559-0100"],"issn-type":[{"type":"print","value":"1355-008X"},{"type":"electronic","value":"1559-0100"}],"subject":[],"published":{"date-parts":[[2021,11,22]]},"assertion":[{"value":"24 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"D.C.K., X.Y., H.L., and L.B.C. hold a US patent (10,975,124) and a US patent application (17\/165,070, D.C.K.) regarding the retro-inverso peptides used in this manuscript. All other authors have no conflict of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the University of Oklahoma Health Sciences Center Institutional Review Board and conforms to the US Federal Policy for the Protection of Human Subjects.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}