{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:46:58Z","timestamp":1740138418180,"version":"3.37.3"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T00:00:00Z","timestamp":1654128000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T00:00:00Z","timestamp":1654128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>To date, few data are available on the prognostic role of lymphocyte subsets in pediatric Graves\u2019 Disease (GD). The aim of this retrospective study is to analyze the role of lymphocyte subtypes in predicting the severity of GD.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Data of 10 pediatric subjects aged &lt;18 years with GD onset in the period November 2017\u2013April 2021 were collected. The lymphocyte population was assessed at the onset of GD as well as hormonal and clinical data. The follow-up period was 2.4\u2009\u00b1\u20090.8 years.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Pearson correlation coefficient between CD4+\u2009\/CD8+\u2009ratio and fT3 levels and thyroid volume at diagnosis was 0.72 <jats:italic>(p<\/jats:italic>\u2009=\u2009<jats:italic>0.04)<\/jats:italic> and 0.81 <jats:italic>(p<\/jats:italic>\u2009=\u2009<jats:italic>0.004)<\/jats:italic> respectively; that between CD4+\u2009\/CD8+\u2009ratio and the TRAb titer at diagnosis and after 6, 12 and 24 months was 0.89, 0.89, 0.73 and 0.77 respectively (<jats:italic>p<\/jats:italic>\u2009=\u2009<jats:italic>0.02<\/jats:italic>, <jats:italic>p<\/jats:italic>\u2009=\u2009<jats:italic>0.01<\/jats:italic>, <jats:italic>p<\/jats:italic>\u2009=\u2009<jats:italic>0.03<\/jats:italic> and <jats:italic>0.04<\/jats:italic>). The correlation coefficient of anti-thyroid drug (ATD) dose after 6 and 12 months with CD4+\u2009\/CD8 ratio was 0.88 and 0.78 (<jats:italic>p<\/jats:italic>\u2009=\u2009<jats:italic>0.001 and p<\/jats:italic>\u2009=\u2009<jats:italic>0.02<\/jats:italic> respectively). Patients with a higher CD4+\u2009\/CD8+\u2009ratio at diagnosis displayed higher fT3 levels (28.73\u2009\u00b1\u20092.18 vs 13.48\u2009\u00b1\u20092.19\u2009pmol\/L, <jats:italic>p<\/jats:italic>\u2009=\u2009<jats:italic>0.03<\/jats:italic>) and higher TRAb titers (28.9\u2009\u00b1\u200911.2 vs 4.88\u2009\u00b1\u20090.97, <jats:italic>p<\/jats:italic>\u2009=\u2009<jats:italic>0.01<\/jats:italic>).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>CD4+\/CD8+\u2009ratio appears as a promising predictive tool to be considered together with other prognostic factors to better manage pediatric GD. These preliminary data need to be confirmed over a longer follow-up period and in larger cohorts.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s12020-022-03088-7","type":"journal-article","created":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T18:03:01Z","timestamp":1654192981000},"page":"319-324","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["\u201cLymphocyte population in peripheral blood in children and adolescents with graves disease. 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