{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T22:07:53Z","timestamp":1773526073669,"version":"3.50.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T00:00:00Z","timestamp":1657324800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T00:00:00Z","timestamp":1657324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"DOI":"10.1007\/s12020-022-03130-8","type":"journal-article","created":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T08:03:07Z","timestamp":1657353787000},"page":"42-46","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Type 1 diabetes mellitus following SARS-CoV-2 mRNA vaccination"],"prefix":"10.1007","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9806-3891","authenticated-orcid":false,"given":"Berna \u0130mge","family":"Aydo\u011fan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U\u011fur","family":"\u00dcnl\u00fct\u00fcrk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Cesur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,7,9]]},"reference":[{"issue":"25","key":"3130_CR1","doi-asserted-by":"publisher","first-page":"e90","DOI":"10.1056\/NEJMoa2106599","volume":"385","author":"T Pilishvili","year":"2021","unstructured":"T. Pilishvili, R. Gierke, K.E. Fleming-Dutra, J.L. Farrar, N.M. Mohr, D.A. Talan, A. Krishnadasan, K.K. Harland, H.A. Smithline, P.C. Hou et al. Effectiveness of mRNA Covid-19 vaccine among U.S. Health Care Personnel. N. Engl. J. Med 385(25), e90 (2021)","journal-title":"N. Engl. J. Med"},{"issue":"27","key":"3130_CR2","doi-asserted-by":"publisher","first-page":"2603","DOI":"10.1056\/NEJMoa2034577","volume":"383","author":"FP Polack","year":"2020","unstructured":"F.P. Polack, S.J. Thomas, N. Kitchin, J. Absalon, A. Gurtman, S. Lockhart, J.L. Perez, G. Perez Marc, E.D. Moreira, C. Zerbini et al. Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. N. Engl. J. Med. 383(27), 2603\u20132615 (2020)","journal-title":"N. Engl. J. Med."},{"issue":"9","key":"3130_CR3","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1089\/thy.2021.0142","volume":"31","author":"O Vera-Lastra","year":"2021","unstructured":"O. Vera-Lastra, A. Ordinola Navarro, M.P. Cruz Domiguez, G. Medina, T.I. Sanchez Valadez, L.J. Jara, Two cases of Graves\u2019 disease following SARS-CoV-2 vaccination: an autoimmune\/inflammatory syndrome induced by adjuvants. Thyroid 31(9), 1436\u20131439 (2021)","journal-title":"Thyroid"},{"issue":"4","key":"3130_CR4","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1007\/s40618-021-01707-0","volume":"45","author":"A Pujol","year":"2021","unstructured":"A. Pujol, L.A. Gomez, C. Gallegos, J. Nicolau, P. Sanchis, M. Gonzalez-Freire, A.A. Lopez-Gonzalez, K. Dotres, L. Masmiquel, Thyroid as a target of adjuvant autoimmunity\/inflammatory syndrome due to mRNA-based SARS-CoV2 vaccination: from Graves\u2019 disease to silent thyroiditis. J. Endocrinol. Investig. 45(4), 875\u2013882 (2021).","journal-title":"J. Endocrinol. Investig."},{"issue":"12","key":"3130_CR5","doi-asserted-by":"publisher","first-page":"5120","DOI":"10.1080\/21645515.2021.2013083","volume":"17","author":"M Sozen","year":"2021","unstructured":"M.Sozen, O.Topaloglu, B. Cetinarslan, A.Selek, Z. Canturk, E.Gezer, D.Koksalan, T.Bayraktaroglu, COVID-19 mRNA vaccine may trigger subacute thyroiditis. Hum. Vaccin Immunother 17(12), 5120\u20135125 (2021).","journal-title":"Hum. Vaccin Immunother"},{"key":"3130_CR6","doi-asserted-by":"publisher","first-page":"102738","DOI":"10.1016\/j.jaut.2021.102738","volume":"125","author":"A Patrizio","year":"2021","unstructured":"A. Patrizio, S.M. Ferrari, A. Antonelli, P. Fallahi, A case of Graves\u2019 disease and type 1 diabetes mellitus following SARS-CoV-2 vaccination. J. Autoimmun. 125, 102738 (2021)","journal-title":"J. Autoimmun."},{"issue":"2","key":"3130_CR7","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1111\/ene.15147","volume":"29","author":"LD Kaulen","year":"2022","unstructured":"L.D. Kaulen, S. Doubrovinskaia, C. Mooshage, B. Jordan, J. Purrucker, C. Haubner, C. Seliger, H.M. Lorenz, S. Nagel, B. Wildemann et al. Neurological autoimmune diseases following vaccinations against SARS-CoV-2: a case series. Eur. J. Neurol. 29(2), 555\u2013563 (2022)","journal-title":"Eur. J. Neurol."},{"issue":"11","key":"3130_CR8","doi-asserted-by":"publisher","first-page":"3267","DOI":"10.1111\/trf.16672","volume":"61","author":"SRV Gadi","year":"2021","unstructured":"S.R.V. Gadi, P.A.R. Brunker, H. Al-Samkari, D.B. Sykes, R.R. Saff, J. Lo, P. Bendapudi, D.E. Leaf, R.K. Leaf, Severe autoimmune hemolytic anemia following receipt of SARS-CoV-2 mRNA vaccine. Transfusion 61(11), 3267\u20133271 (2021)","journal-title":"Transfusion"},{"issue":"1","key":"3130_CR9","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.jaut.2010.07.003","volume":"36","author":"Y Shoenfeld","year":"2011","unstructured":"Y. Shoenfeld, N. Agmon-Levin, \u2018ASIA\u2019 - autoimmune\/inflammatory syndrome induced by adjuvants. J. Autoimmun. 36(1), 4\u20138 (2011)","journal-title":"J. Autoimmun."},{"issue":"1","key":"3130_CR10","doi-asserted-by":"publisher","first-page":"101412","DOI":"10.1016\/j.beem.2020.101412","volume":"34","author":"NL Bragazzi","year":"2020","unstructured":"N.L. Bragazzi, A. Hejly, A. Watad, M. Adawi, H. Amital, Y. Shoenfeld, ASIA syndrome and endocrine autoimmune disorders. Best Pract. Res. Clin. Endocrinol. Metab. 34(1), 101412 (2020)","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"3130_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.clim.2019.03.007","volume":"203","author":"A Watad","year":"2019","unstructured":"A. Watad, N.L. Bragazzi, D. McGonagle, M. Adawi, C. Bridgewood, G. Damiani, J. Alijotas-Reig, E. Esteve-Valverde, M. Quaresma, H. Amital et al. Autoimmune\/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype: Insights from an analysis of 500 cases. Clin. Immunol. 203, 1\u20138 (2019)","journal-title":"Clin. Immunol."},{"issue":"6","key":"3130_CR12","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1111\/jdi.13757","volume":"13","author":"H Sasaki","year":"2022","unstructured":"H. Sasaki, A. Itoh, Y. Watanabe, Y. Nakajima, Y. Saisho, J. Irie, S. Meguro, H. Itoh, Newly developed type 1 diabetes after coronavirus disease 2019 vaccination: a case report. J. Diabetes Investig. 13(6), 1105\u20131108 (2022).","journal-title":"J. Diabetes Investig."},{"issue":"7","key":"3130_CR13","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1111\/jdi.13771","volume":"13","author":"K Sasaki","year":"2022","unstructured":"K. Sasaki, T. Morioka, N. Okada, Y. Natsuki, Y. Kakutani, A. Ochi, Y. Yamazaki, T. Shoji, T. Ohmura, M. Emoto, New-onset fulminant type 1 diabetes following SARS-CoV-2 vaccination: A case report. J. Diabetes Investig. 13(7), 1286\u20131289 (2022).","journal-title":"J. Diabetes Investig."},{"issue":"8","key":"3130_CR14","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.2169\/internalmedicine.9004-21","volume":"61","author":"M Yano","year":"2022","unstructured":"M. Yano, T. Morioka, Y. Natsuki, K. Sasaki, Y. Kakutani, A. Ochi, Y. Yamazaki, T. Shoji, M. Emoto, A case of new-onset type 1 diabetes after covid-19 mRNA vaccination. Intern. Med. 61(8), 1197\u20131200 (2022).","journal-title":"Intern. Med."},{"issue":"5","key":"3130_CR15","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1016\/j.jhep.2021.08.001","volume":"75","author":"F Bril","year":"2021","unstructured":"F. Bril, Autoimmune hepatitis developing after coronavirus disease 2019 (COVID-19) vaccine: One or even several swallows do not make a summer. J. Hepatol. 75(5), 1256\u20131257 (2021)","journal-title":"J. Hepatol."},{"issue":"9","key":"3130_CR16","doi-asserted-by":"publisher","first-page":"2600","DOI":"10.1210\/clinem\/dgab373","volume":"106","author":"BG Iremli","year":"2021","unstructured":"B.G. Iremli, S.N. Sendur, U. Unluturk, Three cases of subacute thyroiditis following SARS-CoV-2 vaccine: postvaccination ASIA syndrome. J. Clin. Endocrinol. Metab. 106(9), 2600\u20132605 (2021)","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"7","key":"3130_CR17","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1055\/a-1172-1352","volume":"52","author":"S Shekhar","year":"2020","unstructured":"S. Shekhar, R. Wurth, C.D.C. Kamilaris, G. Eisenhofer, F.J. Barrera, M. Hajdenberg, J. Tonleu, J.E. Hall, E.L. Schiffrin, F. Porter et al. Endocrine conditions and COVID-19. Horm. Metab. Res. 52(7), 471\u2013484 (2020)","journal-title":"Horm. Metab. Res."},{"issue":"7807","key":"3130_CR18","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/s41586-020-2180-5","volume":"581","author":"J Lan","year":"2020","unstructured":"J. Lan, J. Ge, J. Yu, S. Shan, H. Zhou, S. Fan, Q. Zhang, X. Shi, Q. Wang, L. Zhang et al. Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor. Nature. 581(7807), 215\u2013220 (2020)","journal-title":"Nature."},{"key":"3130_CR19","doi-asserted-by":"publisher","first-page":"596898","DOI":"10.3389\/fendo.2020.596898","volume":"11","author":"D Fignani","year":"2020","unstructured":"D. Fignani, G. Licata, N. Brusco, L. Nigi, G.E. Grieco, L. Marselli, L. Overbergh, C. Gysemans, M.L. Colli, P. Marchetti et al. SARS-CoV-2 receptor angiotensin I-converting enzyme type 2 (ACE2) is expressed in human pancreatic beta-cells and in the human pancreas microvasculature. Front Endocrinol. 11, 596898 (2020)","journal-title":"Front Endocrinol."},{"issue":"3","key":"3130_CR20","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s00592-009-0109-4","volume":"47","author":"JK Yang","year":"2010","unstructured":"J.K. Yang, S.S. Lin, X.J. Ji, L.M. Guo, Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes. Acta Diabetol. 47(3), 193\u2013199 (2010)","journal-title":"Acta Diabetol."},{"issue":"10","key":"3130_CR21","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1111\/dom.14057","volume":"22","author":"J Li","year":"2020","unstructured":"J. Li, X. Wang, J. Chen, X. Zuo, H. Zhang, A. Deng, COVID-19 infection may cause ketosis and ketoacidosis. Diabetes Obes. Metab. 22(10), 1935\u20131941 (2020)","journal-title":"Diabetes Obes. Metab."},{"issue":"1","key":"3130_CR22","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1053\/j.gastro.2020.03.055","volume":"159","author":"F Wang","year":"2020","unstructured":"F. Wang, H. Wang, J. Fan, Y. Zhang, H. Wang, Q. Zhao, Pancreatic injury patterns in patients with coronavirus disease 19 pneumonia. Gastroenterology 159(1), 367\u2013370 (2020)","journal-title":"Gastroenterology"},{"issue":"11","key":"3130_CR23","doi-asserted-by":"publisher","first-page":"e170","DOI":"10.2337\/dc20-1551","volume":"43","author":"R Unsworth","year":"2020","unstructured":"R. Unsworth, S. Wallace, N.S. Oliver, S. Yeung, A. Kshirsagar, H. Naidu, R.M.W. Kwong, P. Kumar, K.M. Logan, New-onset type 1 diabetes in children during COVID-19: multicenter regional findings in the U.K. Diabetes Care 43(11), e170\u2013e171 (2020)","journal-title":"Diabetes Care"},{"issue":"6","key":"3130_CR24","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1016\/j.dsx.2020.11.012","volume":"14","author":"SK Boddu","year":"2020","unstructured":"S.K. Boddu, G. Aurangabadkar, M.S. Kuchay, New onset diabetes, type 1 diabetes and COVID-19. Diabetes Metab. Syndr. 14(6), 2211\u20132217 (2020)","journal-title":"Diabetes Metab. Syndr."},{"issue":"6","key":"3130_CR25","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1016\/j.cmet.2020.11.005","volume":"32","author":"I Kusmartseva","year":"2020","unstructured":"I. Kusmartseva, W. Wu, F. Syed, V. Van Der Heide, M. Jorgensen, P. Joseph, X. Tang, E. Candelario-Jalil, C. Yang, H. Nick et al. Expression of SARS-CoV-2 entry factors in the pancreas of normal organ donors and individuals with COVID-19. Cell Metab. 32(6), 1041\u20131051 (2020). e1046","journal-title":"Cell Metab."},{"issue":"6","key":"3130_CR26","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1016\/j.cmet.2020.11.006","volume":"32","author":"KC Coate","year":"2020","unstructured":"K.C. Coate, J. Cha, S. Shrestha, W. Wang, L.M. Goncalves, J. Almaca, M.E. Kapp, M. Fasolino, A. Morgan, C. Dai et al. SARS-CoV-2 cell entry factors ACE2 and TMPRSS2 are expressed in the microvasculature and ducts of human pancreas but are not enriched in beta cells. Cell Metab. 32(6), 1028\u20131040 (2020). e1024","journal-title":"Cell Metab."},{"issue":"8","key":"3130_CR27","first-page":"517","volume":"21","author":"A Watad","year":"2019","unstructured":"A. Watad, N.L. Bragazzi, H. Amital, Y. Shoenfeld, Hyperstimulation of adaptive immunity as the common pathway for silicone breast implants, autoimmunity, and lymphoma of the breast. Isr. Med. Assoc. J. 21(8), 517\u2013519 (2019)","journal-title":"Isr. Med. Assoc. J."},{"issue":"4","key":"3130_CR28","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1111\/aji.12151","volume":"70","author":"S Colafrancesco","year":"2013","unstructured":"S. Colafrancesco, C. Perricone, L. Tomljenovic, Y. Shoenfeld, Human papilloma virus vaccine and primary ovarian failure: another facet of the autoimmune\/inflammatory syndrome induced by adjuvants. Am. J. Reprod. Immunol. 70(4), 309\u2013316 (2013)","journal-title":"Am. J. Reprod. Immunol."},{"issue":"7","key":"3130_CR29","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1007\/BF03346633","volume":"33","author":"CM Girgis","year":"2010","unstructured":"C.M. Girgis, R.R. Russo, K. Benson, Subacute thyroiditis following the H1N1 vaccine. J. Endocrinol. Invest 33(7), 506 (2010)","journal-title":"J. Endocrinol. Invest"},{"key":"3130_CR30","doi-asserted-by":"publisher","first-page":"617089","DOI":"10.3389\/fimmu.2020.617089","volume":"11","author":"A Vojdani","year":"2020","unstructured":"A. Vojdani, E. Vojdani, D. Kharrazian, Reaction of human monoclonal antibodies to SARS-CoV-2 Proteins with tissue antigens: implications for autoimmune diseases. Front Immunol. 11, 617089 (2020)","journal-title":"Front Immunol."},{"issue":"10","key":"3130_CR31","doi-asserted-by":"publisher","first-page":"12522","DOI":"10.1021\/acsnano.0c07197","volume":"14","author":"YH Chung","year":"2020","unstructured":"Y.H. Chung, V. Beiss, S.N. Fiering, N.F. Steinmetz, COVID-19 vaccine frontrunners and their nanotechnology design. ACS Nano 14(10), 12522\u201312537 (2020)","journal-title":"ACS Nano"},{"issue":"18","key":"3130_CR32","doi-asserted-by":"publisher","first-page":"6582","DOI":"10.3390\/ijms21186582","volume":"21","author":"S Xu","year":"2020","unstructured":"S. Xu, K. Yang, R. Li, L.Zhang, mRNA vaccine era-mechanisms, drug platform and clinical prospection. Int. J. Mol. Sci. 21(18), 6582 (2020).","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"3130_CR33","doi-asserted-by":"publisher","first-page":"e3207","DOI":"10.1002\/dmrr.3207","volume":"36","author":"T Zhong","year":"2020","unstructured":"T. Zhong, R. Tang, S. Gong, J. Li, X. Li, Z. Zhou, The remission phase in type 1 diabetes: Changing epidemiology, definitions, and emerging immuno-metabolic mechanisms. Diabetes Metab. Res. Rev. 36(2), e3207 (2020)","journal-title":"Diabetes Metab. Res. Rev."},{"issue":"Suppl 1","key":"3130_CR34","doi-asserted-by":"publisher","first-page":"230","DOI":"10.2337\/diab.27.1.S230","volume":"27","author":"J Ludvigsson","year":"1978","unstructured":"J. Ludvigsson, L.G. Heding, beta-Cell function in children with diabetes. Diabetes 27(Suppl 1), 230\u2013234 (1978)","journal-title":"Diabetes"},{"issue":"5","key":"3130_CR35","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1159\/000479030","volume":"88","author":"M Fonolleda","year":"2017","unstructured":"M. Fonolleda, M. Murillo, F. Vazquez, J. Bel, M. Vives-Pi, Remission phase in paediatric type 1 diabetes: new understanding and emerging biomarkers. Horm. Res. Paediatr. 88(5), 307\u2013315 (2017)","journal-title":"Horm. Res. Paediatr."},{"issue":"5","key":"3130_CR36","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1111\/pedi.12671","volume":"19","author":"AL Fitas","year":"2018","unstructured":"A.L. Fitas, C. Martins, L.M. Borrego, L. Lopes, A. Jorns, S. Lenzen, C. Limbert, Immune cell and cytokine patterns in children with type 1 diabetes mellitus undergoing a remission phase: a longitudinal study. Pediatr. Diabetes 19(5), 963\u2013971 (2018)","journal-title":"Pediatr. Diabetes"},{"issue":"6","key":"3130_CR37","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.1016\/j.dsx.2020.10.015","volume":"14","author":"MS Kuchay","year":"2020","unstructured":"M.S. Kuchay, P.K. Reddy, S. Gagneja, A. Mathew, S.K. Mishra, Short term follow-up of patients presenting with acute onset diabetes and diabetic ketoacidosis during an episode of COVID-19. Diabetes Metab. Syndr. 14(6), 2039\u20132041 (2020)","journal-title":"Diabetes Metab. Syndr."}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-022-03130-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12020-022-03130-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-022-03130-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T12:18:16Z","timestamp":1663157896000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12020-022-03130-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,9]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["3130"],"URL":"https:\/\/doi.org\/10.1007\/s12020-022-03130-8","relation":{},"ISSN":["1559-0100"],"issn-type":[{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,9]]},"assertion":[{"value":"5 March 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Written informed consent forms were obtained from all cases.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}