{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T23:35:16Z","timestamp":1785368116932,"version":"3.55.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T00:00:00Z","timestamp":1662595200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T00:00:00Z","timestamp":1662595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"DOI":"10.1007\/s12020-022-03182-w","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T10:02:57Z","timestamp":1662631377000},"page":"570-579","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pre- and peri-operative characteristics, complications and outcomes of patients with biochemically silent pheochromocytomas; a case series"],"prefix":"10.1007","volume":"78","author":[{"given":"Athanasios","family":"Fountas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Kanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spyridoula","family":"Glycofridi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Christou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasia","family":"Kalantzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Giagourta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athina","family":"Markou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Ntali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrysanthi","family":"Aggeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleftheria","family":"Saoulidou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Dimakopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George N.","family":"Zografos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodora","family":"Kounadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stelios","family":"Tigas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8587-7797","authenticated-orcid":false,"given":"Labrini","family":"Papanastasiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,8]]},"reference":[{"key":"3182_CR1","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.ejim.2018.01.015","volume":"51","author":"AMA Berends","year":"2018","unstructured":"A.M.A. Berends, E. Buitenwerf, R.R. de Krijger, N. Veeger, A.N.A. van der Horst-Schrivers, T.P. Links, M.N. Kerstens, Incidence of pheochromocytoma and sympathetic paraganglioma in the Netherlands: A nationwide study and systematic review. Eur. J. Intern. Med. 51, 68\u201373 (2018). https:\/\/doi.org\/10.1016\/j.ejim.2018.01.015","journal-title":"Eur. J. Intern. Med."},{"issue":"1","key":"3182_CR2","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1530\/eje-20-0628","volume":"184","author":"AA Leung","year":"2021","unstructured":"A.A. Leung, J.L. Pasieka, M.D. Hyrcza, D. Pacaud, Y. Dong, J.M. Boyd, H. Sadrzadeh, G.A. Kline, Epidemiology of pheochromocytoma and paraganglioma: population-based cohort study. Eur. J. Endocrinol. 184(1), 19\u201328 (2021). https:\/\/doi.org\/10.1530\/eje-20-0628","journal-title":"Eur. J. Endocrinol."},{"issue":"5","key":"3182_CR3","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1210\/jc.2018-01707","volume":"104","author":"LM Gruber","year":"2019","unstructured":"L.M. Gruber, R.P. Hartman, G.B. Thompson, T.J. McKenzie, M.L. Lyden, B.M. Dy, W.F. Young, I. Bancos, Pheochromocytoma Characteristics and Behavior Differ Depending on Method of Discovery. J. Clin. Endocrinol. Metab. 104(5), 1386\u20131393 (2019). https:\/\/doi.org\/10.1210\/jc.2018-01707","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"3182_CR4","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1586\/eem.12.76","volume":"8","author":"R Clifton-Bligh","year":"2013","unstructured":"R. Clifton-Bligh, Diagnosis of silent pheochromocytoma and paraganglioma. Expert Rev. Endocrinol. Metab. 8(1), 47\u201357 (2013). https:\/\/doi.org\/10.1586\/eem.12.76","journal-title":"Expert Rev. Endocrinol. Metab."},{"issue":"4","key":"3182_CR5","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.beem.2011.10.008","volume":"26","author":"M Mannelli","year":"2012","unstructured":"M. Mannelli, J.W. Lenders, K. Pacak, G. Parenti, G. Eisenhofer, Subclinical phaeochromocytoma. Best practice & research. Clin. Endocrinol. Metab. 26(4), 507\u2013515 (2012). https:\/\/doi.org\/10.1016\/j.beem.2011.10.008","journal-title":"Clin. Endocrinol. Metab."},{"issue":"2","key":"3182_CR6","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1097\/SLE.0b013e318213bb1f","volume":"21","author":"GN Zografos","year":"2011","unstructured":"G.N. Zografos, A.K. Farfaras, E. Kassi, D.N. Vaidakis, A. Markou, G. Kaltsas, G. Piaditis, Laparoscopic resection of pheochromocytomas with delayed vein ligation. Surgical Laparosc., Endosc. percutaneous Tech. 21(2), 116\u2013119 (2011). https:\/\/doi.org\/10.1097\/SLE.0b013e318213bb1f","journal-title":"Surgical Laparosc., Endosc. percutaneous Tech."},{"issue":"4","key":"3182_CR7","doi-asserted-by":"publisher","first-page":"388","DOI":"10.14310\/horm.2002.1759","volume":"16","author":"C Aggeli","year":"2017","unstructured":"C. Aggeli, A.M. Nixon, C. Parianos, G. Vletsis, L. Papanastasiou, A. Markou, T. Kounadi, G. Piaditis, G.N. Zografos, Surgery for pheochromocytoma: A 20-year experience of a single institution. Hormones (Athens, Greece) 16(4), 388\u2013395 (2017). https:\/\/doi.org\/10.14310\/horm.2002.1759","journal-title":"Hormones (Athens, Greece)"},{"issue":"1","key":"3182_CR8","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-97964-3","volume":"11","author":"JH Kim","year":"2021","unstructured":"J.H. Kim, H.C. Lee, S.J. Kim, S.B. Yoon, S.H. Kong, H.W. Yu, Y.J. Chai, J.Y. Choi, K.E. Lee, K.W. Lee, S.K. Min, C.S. Shin, K.J. Park, Perioperative hemodynamic instability in pheochromocytoma and sympathetic paraganglioma patients. Sci. Rep. 11(1), 18574 (2021). https:\/\/doi.org\/10.1038\/s41598-021-97964-3","journal-title":"Sci. Rep."},{"issue":"6","key":"3182_CR9","doi-asserted-by":"publisher","first-page":"485","DOI":"10.7326\/0003-4819-120-6-199403150-00006","volume":"120","author":"BS Aprill","year":"1994","unstructured":"B.S. Aprill, A.J. Drake 3rd, D.H. Lasseter, K.M. Shakir, Silent adrenal nodules in von Hippel-Lindau disease suggest pheochromocytoma. Ann. Intern. Med. 120(6), 485\u2013487 (1994). https:\/\/doi.org\/10.7326\/0003-4819-120-6-199403150-00006","journal-title":"Ann. Intern. Med."},{"issue":"4","key":"3182_CR10","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1002\/(SICI)1096-9098(199904)70:4<247::AID-JSO9>3.0.CO;2-O","volume":"70","author":"NB T\u00fct\u00fcnc\u00fc","year":"1999","unstructured":"N.B. T\u00fct\u00fcnc\u00fc, O. Gedik, Adrenal incidentaloma: report of 33 cases. J. surgical Oncol. 70(4), 247\u2013250 (1999). 10.1002\/(sici)1096-9098(199904)70:4<247::aid-jso9>3.0.co;2-o","journal-title":"J. surgical Oncol."},{"issue":"2","key":"3182_CR11","first-page":"86","volume":"19","author":"SK Kota","year":"2012","unstructured":"S.K. Kota, S.K. Kota, S. Panda, K.D. Modi, Pheochromocytoma: an uncommon presentation of an asymptomatic and biochemically silent adrenal incidentaloma. Malays. J. Med. Sci.: MJMS. 19(2), 86\u201391 (2012)","journal-title":"Malays. J. Med. Sci.: MJMS."},{"issue":"5","key":"3182_CR12","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1002\/jso.24031","volume":"112","author":"MG Heavner","year":"2015","unstructured":"M.G. Heavner, L.S. Krane, S.M. Winters, M. Mirzazadeh, Pheochromocytoma diagnosed pathologically with previous negative serum markers. J. surgical Oncol. 112(5), 492\u2013495 (2015). https:\/\/doi.org\/10.1002\/jso.24031","journal-title":"J. surgical Oncol."},{"issue":"4","key":"3182_CR13","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1080\/00015458.2016.1139838","volume":"116","author":"N Sundahl","year":"2016","unstructured":"N. Sundahl, S. Van Slycke, N. Brusselaers, A rare case of clinically and biochemically silent giant right pheochromocytoma: case report and review of literature. Acta chirurgica Belgica. 116(4), 239\u2013242 (2016). https:\/\/doi.org\/10.1080\/00015458.2016.1139838","journal-title":"Acta chirurgica Belgica."},{"issue":"3","key":"3182_CR14","doi-asserted-by":"publisher","first-page":"302","DOI":"10.4158\/ep15725.or","volume":"22","author":"H Turkova","year":"2016","unstructured":"H. Turkova, T. Prodanov, M. Maly, V. Martucci, K. Adams, J. Widimsky Jr., C.C. Chen, A. Ling, E. Kebebew, C.A. Stratakis, T. Fojo, K. Pacak, Characteristics and outcomes of metastatic SDHB and sporadic pheochromocytoma\/paraganglioma: An national institutes of health study. Endocr. Pract.: Off. J. Am. Coll. Endocrinol. Am. Assoc. Clin. Endocrinologists. 22(3), 302\u2013314 (2016). https:\/\/doi.org\/10.4158\/ep15725.or","journal-title":"Endocr. Pract.: Off. J. Am. Coll. Endocrinol. Am. Assoc. Clin. Endocrinologists."},{"issue":"10","key":"3182_CR15","doi-asserted-by":"publisher","first-page":"000714","DOI":"10.12890\/2017_000714","volume":"4","author":"L Petramala","year":"2017","unstructured":"L. Petramala, A. Concistr\u00e8, F. Olmati, V. Saraceno, G. Iannucci, A. Ciardi, G. De Toma, C. Letizia, Silent Adrenal Pheochromocytoma Coexistent with Corticomedullary Hyperplasia: A Case Incidentally Discovered. Eur. J. case Rep. Intern. Med. 4(10), 000714 (2017). https:\/\/doi.org\/10.12890\/2017_000714","journal-title":"Eur. J. case Rep. Intern. Med."},{"key":"3182_CR16","doi-asserted-by":"publisher","unstructured":"S. Kumar, K.M. Parmar, D. Aggarwal, K. Jhangra: Simple adrenal cyst masquerading clinically silent giant cystic pheochromocytoma. BMJ case reports 12(9) (2019). https:\/\/doi.org\/10.1136\/bcr-2019-230730","DOI":"10.1136\/bcr-2019-230730"},{"key":"3182_CR17","doi-asserted-by":"publisher","first-page":"100876","DOI":"10.1016\/j.eucr.2019.100876","volume":"24","author":"RZ El-Doueihi","year":"2019","unstructured":"R.Z. El-Doueihi, I. Salti, M. Maroun-Aouad, A. El Hajj, Bilateral biochemically silent pheochromocytoma, not silent after all. Urol. Case Rep. 24, 100876 (2019). https:\/\/doi.org\/10.1016\/j.eucr.2019.100876","journal-title":"Urol. Case Rep."},{"issue":"11","key":"3182_CR18","doi-asserted-by":"publisher","first-page":"5421","DOI":"10.1210\/jc.2019-00202","volume":"104","author":"KMA Dreijerink","year":"2019","unstructured":"K.M.A. Dreijerink, J.A. Rijken, C.J. Compaijen, H. Timmers, A.N.A. van der Horst-Schrivers, R.S. van Leeuwaarde, P.S. van Dam, C.R. Leemans, E. van Dam, C. Dickhoff, C.J. Dommering, P. de Graaf, G.J.C. Zwezerijnen, P. van der Valk, C.W. Menke-Van der Houven van Oordt, E.F. Hensen, E.P.M. Corssmit, E.M.W. Eekhoff, Biochemically Silent Sympathetic Paraganglioma, Pheochromocytoma, or Metastatic Disease in SDHD Mutation Carriers. J. Clin. Endocrinol. Metab. 104(11), 5421\u20135426 (2019). https:\/\/doi.org\/10.1210\/jc.2019-00202","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"3182_CR19","doi-asserted-by":"publisher","unstructured":"A. Montebello, E. Ceci Bonello, M. Giordano Imbroll, M. Gruppetta, Biochemically silent phaeochromocytoma presenting with non-specific loin pain. BMJ case reports 14(8) (2021). https:\/\/doi.org\/10.1136\/bcr-2021-244258","DOI":"10.1136\/bcr-2021-244258"},{"issue":"6","key":"3182_CR20","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1056\/NEJMra1806651","volume":"381","author":"HPH Neumann","year":"2019","unstructured":"H.P.H. Neumann, W.F. Young Jr., C. Eng, Pheochromocytoma and Paraganglioma. N. Engl. J. Med. 381(6), 552\u2013565 (2019). https:\/\/doi.org\/10.1056\/NEJMra1806651","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"3182_CR21","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1210\/jc.2014-1498","volume":"99","author":"JW Lenders","year":"2014","unstructured":"J.W. Lenders, Q.Y. Duh, G. Eisenhofer, A.P. Gimenez-Roqueplo, S.K. Grebe, M.H. Murad, M. Naruse, K. Pacak, W.F. Young Jr,, Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline. J. Clin. Endocrinol. Metab. 99(6), 1915\u20131942 (2014). https:\/\/doi.org\/10.1210\/jc.2014-1498","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"3","key":"3182_CR22","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1111\/cen.13284","volume":"86","author":"M Isaacs","year":"2017","unstructured":"M. Isaacs, P. Lee,, Preoperative alpha-blockade in phaeochromocytoma and paraganglioma: is it always necessary. Clin. Endocrinol. 86(3), 309\u2013314 (2017). https:\/\/doi.org\/10.1111\/cen.13284","journal-title":"Clin. Endocrinol."},{"issue":"2","key":"3182_CR23","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1093\/bja\/aew392","volume":"118","author":"H Groeben","year":"2017","unstructured":"H. Groeben, B.J. Nottebaum, P.F. Alesina, A. Traut, H.P. Neumann, M.K. Walz,, Perioperative \u03b1-receptor blockade in phaeochromocytoma surgery: an observational case series. Br. J. Anaesth. 118(2), 182\u2013189 (2017). https:\/\/doi.org\/10.1093\/bja\/aew392","journal-title":"Br. J. Anaesth."},{"issue":"5","key":"3182_CR24","doi-asserted-by":"publisher","first-page":"G1","DOI":"10.1530\/eje-16-0033","volume":"174","author":"PF Plouin","year":"2016","unstructured":"P.F. Plouin, L. Amar, O.M. Dekkers, M. Fassnacht, A.P. Gimenez-Roqueplo, J.W. Lenders, C. Lussey-Lepoutre, O. Steichen, European Society of Endocrinology Clinical Practice Guideline for long-term follow-up of patients operated on for a phaeochromocytoma or a paraganglioma. Eur. J. Endocrinol. 174(5), G1\u2013g10 (2016). https:\/\/doi.org\/10.1530\/eje-16-0033","journal-title":"Eur. J. Endocrinol."},{"issue":"12","key":"3182_CR25","doi-asserted-by":"publisher","first-page":"4826","DOI":"10.1210\/jc.2008-1093","volume":"93","author":"HJ Timmers","year":"2008","unstructured":"H.J. Timmers, K. Pacak, T.T. Huynh, M. Abu-Asab, M. Tsokos, M.J. Merino, B.E. Baysal, K.T. Adams, G. Eisenhofer,, Biochemically silent abdominal paragangliomas in patients with mutations in the succinate dehydrogenase subunit B gene. J. Clin. Endocrinol. Metab. 93(12), 4826\u20134832 (2008). https:\/\/doi.org\/10.1210\/jc.2008-1093","journal-title":"J. Clin. Endocrinol. Metab."}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-022-03182-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12020-022-03182-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-022-03182-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T09:31:15Z","timestamp":1667640675000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12020-022-03182-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,8]]},"references-count":25,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["3182"],"URL":"https:\/\/doi.org\/10.1007\/s12020-022-03182-w","relation":{},"ISSN":["1559-0100"],"issn-type":[{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,8]]},"assertion":[{"value":"5 June 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was registered with and approved by the \u2018G. Gennimatas\u2019 General Hospital of Athens ethics committee and its reporting conforms to the Guidelines for Good Clinical Practice, Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all patients participating in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}