{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T03:45:29Z","timestamp":1779335129915,"version":"3.51.4"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T00:00:00Z","timestamp":1687478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T00:00:00Z","timestamp":1687478400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"SENDIMAD","award":["BECA SENDIMAD de Ayuda a la Investigaci\u00f3n en Endocrinolog\u00eda, Nutrici\u00f3n y Diabetes 2019"],"award-info":[{"award-number":["BECA SENDIMAD de Ayuda a la Investigaci\u00f3n en Endocrinolog\u00eda, Nutrici\u00f3n y Diabetes 2019"]}]},{"name":"SENDIMAD","award":["BECA SENDIMAD de Ayuda a la Investigaci\u00f3n en Endocrinolog\u00eda, Nutrici\u00f3n y Diabetes 2019"],"award-info":[{"award-number":["BECA SENDIMAD de Ayuda a la Investigaci\u00f3n en Endocrinolog\u00eda, Nutrici\u00f3n y Diabetes 2019"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"DOI":"10.1007\/s12020-023-03429-0","type":"journal-article","created":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T18:42:29Z","timestamp":1687545749000},"page":"161-170","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Is the 1mg-dexamethasone suppression test a precise marker of glucocorticoid excess and cardiometabolic risk in patients with adrenal incidentalomas?"],"prefix":"10.1007","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0519-0072","authenticated-orcid":false,"given":"Marta","family":"Araujo-Castro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felicia A.","family":"Hanzu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eider","family":"Pascual-Corrales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana M.","family":"Garc\u00eda Cano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Marchan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9ctor F.","family":"Escobar-Morreale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Valderrabano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregori","family":"Casals","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,6,23]]},"reference":[{"key":"3429_CR1","doi-asserted-by":"publisher","unstructured":"I. Bancos, Adrenal incidentalomas: insights into prevalence. Ann. Intern. Med. 2022. https:\/\/doi.org\/10.7326\/m22-2600","DOI":"10.7326\/m22-2600"},{"key":"3429_CR2","doi-asserted-by":"publisher","first-page":"E973","DOI":"10.1210\/clinem\/dgz284","volume":"105","author":"G Reimondo","year":"2020","unstructured":"G. Reimondo, E. Castellano, M. Grosso, R. Priotto, S. Puglisi, A. Pia et al. Adrenal incidentalomas are tied to increased risk of diabetes: findings from a prospective study. J. Clin. Endocrinol. Metab. 105, E973\u2013E981 (2020). https:\/\/doi.org\/10.1210\/clinem\/dgz284","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"3429_CR3","doi-asserted-by":"publisher","first-page":"G1","DOI":"10.1530\/EJE-16-0467","volume":"175","author":"M Fassnacht","year":"2016","unstructured":"M. Fassnacht, W. Arlt, I. Bancos, H. Dralle, J. Newell-Price, A. Sahdev et al. Management of adrenal incidentalomas: European Society of Endocrinology Clinical Practice Guideline in collaboration with the European Network for the Study of Adrenal Tumors. Eur. J. Endocrinol. 175, G1\u2013G34 (2016). https:\/\/doi.org\/10.1530\/EJE-16-0467","journal-title":"Eur. J. Endocrinol."},{"key":"3429_CR4","doi-asserted-by":"publisher","unstructured":"M. Araujo-Castro, Cardiometabolic profile and urinary metabolomic alterations in non-functioning adrenal incidentalomas: a review. Clin. Endocrinol. 2022. https:\/\/doi.org\/10.1111\/cen.14745","DOI":"10.1111\/cen.14745"},{"key":"3429_CR5","doi-asserted-by":"publisher","unstructured":"A. Adamska, V. Ulychnyi, K. Siewko, A. Pop\u0142awska-Kita, M. Szelachowska, M. Adamski, et al. Cardiovascular risk factors in mild adrenal autonomous cortisol secretion in a Caucasian population. Endocr. Connect. 2022;11. https:\/\/doi.org\/10.1530\/EC-22-0074","DOI":"10.1530\/EC-22-0074"},{"key":"3429_CR6","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.7326\/M20-7946","volume":"174","author":"A Kjellbom","year":"2021","unstructured":"A. Kjellbom, O. Lindgren, S. Puvaneswaralingam, M. L\u00f6ndahl, H. Olsen, Association between mortality and levels of autonomous cortisol secretion by adrenal incidentalomas. Ann. Intern. Med. 174, 1041\u20131049 (2021). https:\/\/doi.org\/10.7326\/M20-7946","journal-title":"Ann. Intern. Med."},{"key":"3429_CR7","doi-asserted-by":"publisher","unstructured":"M. Araujo-Castro, A. Garc\u00eda Cano, L. Jim\u00e9nez Mendiguch\u00eda, H.F. Escobar-Morreale, P. Valderr\u00e1bano, Diagnostic accuracy of the different hormonal tests used for the diagnosis of autonomous cortisol secretion. Sci. Rep. 2021;11. https:\/\/doi.org\/10.1038\/s41598-021-00011-4","DOI":"10.1038\/s41598-021-00011-4"},{"key":"3429_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/S42000-021-00308-Z","volume":"20","author":"M Araujo-Castro","year":"2021","unstructured":"M. Araujo-Castro, P.P. Ram\u00edrez, C.R. L\u00e1zaro, R.G. Centeno, P.G. Gimeno, M.T. Fern\u00e1ndez-Ladreda et al. Accuracy of the dexamethasone suppression test for the prediction of autonomous cortisol secretion-related comorbidities in adrenal incidentalomas. Horm 2021 20, 1\u201310 (2021). https:\/\/doi.org\/10.1007\/S42000-021-00308-Z","journal-title":"Horm 2021"},{"key":"3429_CR9","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1007\/s12020-020-02544-6","volume":"72","author":"M Araujo-Castro","year":"2020","unstructured":"M. Araujo-Castro, P. Valderr\u00e1bano, H.F. Escobar-Morreale, F.A. Hanzu, G. Casals, Urine steroid profile as a new promising tool for the evaluation of adrenal tumors. Lit. Rev. Endocr. 72, 40\u201348 (2020). https:\/\/doi.org\/10.1007\/s12020-020-02544-6","journal-title":"Lit. Rev. Endocr."},{"key":"3429_CR10","doi-asserted-by":"publisher","unstructured":"M. Araujo-Castro, G. Casals G., F.A. Hanzu, E. Pascual-Corrales, A.M. Garc\u00eda Cano, V.F. Lanza, et al. Characterisation of the urinary steroid profile of patients with nonfunctioning adrenal incidentalomas: A matched controlled cross-sectional study. Clin. Endocrinol. 2022. https:\/\/doi.org\/10.1111\/cen.14811","DOI":"10.1111\/cen.14811"},{"key":"3429_CR11","doi-asserted-by":"publisher","unstructured":"M. Araujo-Castro, M.A. Sampedro N\u00fa\u00f1ez, M. Marazuela, Autonomous cortisol secretion in adrenal incidentalomas. Endocrine 2019;64. https:\/\/doi.org\/10.1007\/s12020-019-01888-y","DOI":"10.1007\/s12020-019-01888-y"},{"key":"3429_CR12","first-page":"789","volume-title":"The Encyclopedia of Mass Spectrometry","author":"CHL Shackleton","year":"2006","unstructured":"C.H.L Shackleton. Steroid profiling: diagnosis of disorders affecting steroid synthesis and metabolism. In: M.L Gross, W Niessen, R.M Caprioli, (eds.) The Encyclopedia of Mass Spectrometry. 8 Elsevier: Amsterdam, 2006; 789\u2013813","edition":"8"},{"key":"3429_CR13","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/0960-0760(93)90132-G","volume":"45","author":"CHL Shackleton","year":"1993","unstructured":"C.H.L. Shackleton, Mass spectrometry in the diagnosis of steroid-related disorders and in hypertension research. J. Steroid Biochem. Mol. Biol. 45, 127\u2013140 (1993). https:\/\/doi.org\/10.1016\/0960-0760(93)90132-G","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"3429_CR14","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.jchromb.2014.04.015","volume":"960","author":"G Casals","year":"2014","unstructured":"G. Casals, J. Marcos, O.J. Pozo, J. Alcaraz, M.J. Mart\u00ednez de Osaba, W. Jim\u00e9nez, Microwave-assisted derivatization: application to steroid profiling by gas chromatography\/mass spectrometry. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 960, 8\u201313 (2014). https:\/\/doi.org\/10.1016\/j.jchromb.2014.04.015","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"3429_CR15","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.clinbiochem.2013.03.001","volume":"46","author":"G Casals","year":"2013","unstructured":"G. Casals, J. Marcos, \u00d3.J. Pozo, P. Aguilera, C. Herrero, J. To-Figueras, Gas chromatography-mass spectrometry profiling of steroids in urine of patients with acute intermittent porphyria. Clin. Biochem. 46, 819\u2013824 (2013). https:\/\/doi.org\/10.1016\/j.clinbiochem.2013.03.001","journal-title":"Clin. Biochem."},{"key":"3429_CR16","doi-asserted-by":"publisher","unstructured":"A. Vega-Beyhart, J. Laguna-Moreno, D. D\u00edaz-Catal\u00e1n, L. Boswell, M. Mora, I. Halperin, et al. Ketoconazole- and metyrapone-induced reductions on urinary steroid metabolites alter the urinary free cortisol immunoassay reliability in cushing syndrome. Front. Endocrinol. 2022;13. https:\/\/doi.org\/10.3389\/FENDO.2022.833644","DOI":"10.3389\/FENDO.2022.833644"},{"key":"3429_CR17","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","volume":"42","author":"PA Harris","year":"2009","unstructured":"P.A. Harris, R. Taylor, R. Thielke, J. Payne, N. Gonzalez, J.G. Conde, Research electronic data capture (REDCap)-A metadata-driven methodology and workflow process for providing translational research informatics support. J. Biomed. Inform. 42, 377\u2013381 (2009). https:\/\/doi.org\/10.1016\/j.jbi.2008.08.010","journal-title":"J. Biomed. Inform."},{"key":"3429_CR18","doi-asserted-by":"publisher","unstructured":"P.A. Harris, R. Taylor, B.L. Minor, V. Elliott, M. Fernandez, L. O\u2019Neal, et al. The REDCap consortium: building an international community of software platform partners. J. Biomed. Inform. 2019;95. https:\/\/doi.org\/10.1016\/j.jbi.2019.103208.","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"3429_CR19","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1111\/cen.12717","volume":"84","author":"J Brossaud","year":"2016","unstructured":"J. Brossaud, D. Ducint, J.B. Corcuff, Urinary glucocorticoid metabolites: biomarkers to classify adrenal incidentalomas. Clin. Endocrinol. 84, 236\u2013243 (2016). https:\/\/doi.org\/10.1111\/cen.12717","journal-title":"Clin. Endocrinol."},{"key":"3429_CR20","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.clinbiochem.2008.12.027","volume":"42","author":"A Kot\u0142owska","year":"2009","unstructured":"A. Kot\u0142owska, E. Mali\u0144ski, K. Sworczak, J. Kumirska, P. Stepnowski, The urinary steroid profile in patients diagnosed with adrenal incidentaloma. Clin. Biochem. 42, 448\u2013454 (2009). https:\/\/doi.org\/10.1016\/j.clinbiochem.2008.12.027","journal-title":"Clin. Biochem."},{"key":"3429_CR21","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/J.EPRAC.2022.06.007","volume":"28","author":"M Araujo-Castro","year":"2022","unstructured":"M. Araujo-Castro, H.F. Escobar-Morreale, P. Valderr\u00e1bano, P. Valderrabano, A proposal for nomenclature revision of non-functioning adrenal incidentalomas as adrenal lesions of Undetermined Secretion of Adrenal Steroids (ALUSAS). Endocr. Pract. 28, 918\u2013920 (2022). https:\/\/doi.org\/10.1016\/J.EPRAC.2022.06.007","journal-title":"Endocr. Pract."},{"key":"3429_CR22","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1007\/s12672-015-0224-3","volume":"6","author":"TMA Kerkhofs","year":"2015","unstructured":"T.M.A. Kerkhofs, M.N. Kerstens, I.P. Kema, T.P. Willems, H.R. Haak, Diagnostic value of urinary steroid profiling in the evaluation of adrenal tumors. Horm. Cancer 6, 168\u2013175 (2015). https:\/\/doi.org\/10.1007\/s12672-015-0224-3","journal-title":"Horm. Cancer"},{"key":"3429_CR23","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.jchromb.2010.12.021","volume":"879","author":"A Kot\u0142owska","year":"2011","unstructured":"A. Kot\u0142owska, K. Sworczak, P. Stepnowski, Urine metabolomics analysis for adrenal incidentaloma activity detection and biomarker discovery. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 879, 359\u2013363 (2011). https:\/\/doi.org\/10.1016\/j.jchromb.2010.12.021","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"3429_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms18020294","volume":"18","author":"A Kot\u0142owska","year":"2017","unstructured":"A. Kot\u0142owska, T. Puzyn, K. Sworczak, P. Stepnowski, P. Szefer, Metabolomic biomarkers in urine of cushing\u2019s syndrome patients. Int J. Mol. Sci. 18, 1\u201315 (2017). https:\/\/doi.org\/10.3390\/ijms18020294","journal-title":"Int J. Mol. Sci."},{"key":"3429_CR25","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/J.ANDO.2018.04.017","volume":"79","author":"O Chabre","year":"2018","unstructured":"O. Chabre, The difficulties of pseudo-Cushing\u2019s syndrome (or \u201cnon-neoplastic hypercortisolism\u201d). Ann. Endocrinol. 79, 138\u2013145 (2018). https:\/\/doi.org\/10.1016\/J.ANDO.2018.04.017","journal-title":"Ann. Endocrinol."},{"key":"3429_CR26","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/J.BEEM.2015.09.001","volume":"29","author":"YJ Bae","year":"2015","unstructured":"Y.J. Bae, J. Kratzsch, Corticosteroid-binding globulin: modulating mechanisms of bioavailability of cortisol and its clinical implications. Best. Pract. Res Clin. Endocrinol. Metab. 29, 761\u2013772 (2015). https:\/\/doi.org\/10.1016\/J.BEEM.2015.09.001","journal-title":"Best. Pract. Res Clin. Endocrinol. Metab."},{"key":"3429_CR27","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1111\/j.1365-2265.1982.tb00733.x","volume":"16","author":"AW MEIKLE","year":"1982","unstructured":"A.W. MEIKLE, Dexamethasone suppression tests: usefulness of simultaneous measurement of plasma cortisol and dexamethasone. Clin. Endocrinol. 16, 401\u2013408 (1982). https:\/\/doi.org\/10.1111\/j.1365-2265.1982.tb00733.x","journal-title":"Clin. Endocrinol."},{"key":"3429_CR28","doi-asserted-by":"publisher","unstructured":"W. Liu, D. Yuan, M. Han, J. Huang, Y. Xie, Development and validation of a sensitive LC-MS\/MS method for simultaneous quantification of thirteen steroid hormones in human serum and its application to the study of type 2 diabetes mellitus. J. Pharm. Biomed. Anal. 2021;199. https:\/\/doi.org\/10.1016\/J.JPBA.2021.114059","DOI":"10.1016\/J.JPBA.2021.114059"},{"key":"3429_CR29","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1530\/EJE-16-0534","volume":"175","author":"VL Wester","year":"2016","unstructured":"V.L. Wester, J.W. Koper, E.L.T. Van Den Akker, O.H. Franco, R. P. Stolk, E.F.C. Van Rossum, Glucocorticoid receptor haplotype and metabolic syndrome: the Lifelines cohort study. Eur. J. Endocrinol. 175, 645\u2013651 (2016). https:\/\/doi.org\/10.1530\/EJE-16-0534","journal-title":"Eur. J. Endocrinol."},{"key":"3429_CR30","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1359\/JBMR.2002.17.6.979","volume":"17","author":"MS Cooper","year":"2002","unstructured":"M.S. Cooper, E.H. Rabbitt, P.E. Goddard, W.A. Bartlett, M. Hewison, P.M. Stewart, Osteoblastic 11beta-hydroxysteroid dehydrogenase type 1 activity increases with age and glucocorticoid exposure. J. Bone Min. Res 17, 979\u2013986 (2002). https:\/\/doi.org\/10.1359\/JBMR.2002.17.6.979","journal-title":"J. Bone Min. Res"},{"key":"3429_CR31","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1007\/S12020-020-02212-9","volume":"68","author":"V Morelli","year":"2020","unstructured":"V. Morelli, C. Aresta, A. Gaudio, C. Eller-Vainicher, V.V. Zhukouskaya, D. Merlotti et al. Prediction of hypertension, diabetes and fractures in eucortisolemic women by measuring parameters of cortisol milieu. Endocrine 68, 411\u2013419 (2020). https:\/\/doi.org\/10.1007\/S12020-020-02212-9","journal-title":"Endocrine"},{"key":"3429_CR32","doi-asserted-by":"publisher","unstructured":"T. Deutschbein, G. Reimondo, G. Di Dalmazi, I. Bancos, J. Patrova, D.A. Vassiliadi, et al. Age-dependent and sex-dependent disparity in mortality in patients with adrenal incidentalomas and autonomous cortisol secretion: an international, retrospective, cohort study. Lancet Diabetes Endocrinol. 2022. https:\/\/doi.org\/10.1016\/S2213-8587(22)00100-0","DOI":"10.1016\/S2213-8587(22)00100-0"},{"key":"3429_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3171\/2014.11.FOCUS14704.Disclosure","volume":"38","author":"V Bansal","year":"2015","unstructured":"V. Bansal, N. Asmar, W.W.R. Selman, B.B.M. Arafah, N. El Asmar, W.W.R. Selman et al. Pitfalls in the diagnosis and management of Cushing\u2019s syndrome. Neurosurg. Focus 38, 1\u201311 (2015). https:\/\/doi.org\/10.3171\/2014.11.FOCUS14704.Disclosure","journal-title":"Neurosurg. Focus"},{"key":"3429_CR34","doi-asserted-by":"publisher","unstructured":"V. Chortis, I. Bancos, T. Nijman, L.C. Gilligan, A.E. Taylor, C.L. Ronchi, et al. Urine steroid metabolomics as a novel tool for detection of recurrent adrenocortical carcinoma. J. Clin. Endocrinol. Metab. 2020;105. https:\/\/doi.org\/10.1210\/clinem\/dgz141","DOI":"10.1210\/clinem\/dgz141"},{"key":"3429_CR35","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1097\/MED.0000000000000333","volume":"24","author":"I Bancos","year":"2017","unstructured":"I. Bancos, W. Arlt, Diagnosis of a malignant adrenal mass: the role of urinary steroid metabolite profiling. Curr. Opin. Endocrinol. Diabetes Obes. 24, 200\u2013207 (2017). https:\/\/doi.org\/10.1097\/MED.0000000000000333","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-023-03429-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12020-023-03429-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-023-03429-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T08:25:29Z","timestamp":1693211129000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12020-023-03429-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,23]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["3429"],"URL":"https:\/\/doi.org\/10.1007\/s12020-023-03429-0","relation":{},"ISSN":["1559-0100"],"issn-type":[{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,23]]},"assertion":[{"value":"26 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 June 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in the participants of the study were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All patients signed an informed consent to participate in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}