{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:47:25Z","timestamp":1740138445589,"version":"3.37.3"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:00:00Z","timestamp":1696032000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:00:00Z","timestamp":1696032000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Thyroid transcription factor\u20101 (TTF\u20101) assessed by immunohistochemistry (IHC) is a specific biomarker for lung adenocarcinoma, and is commonly used to confirm the pulmonary origin of neuroendocrine tumours (NET). The majority of the available data suggest that TTF-1 is favourable prognostic biomarker for lung adenocarcinomas, whereas its role is more conflicting for lung NET. The main aim of this multicenter retrospective study was to investigate the potentially relevant associations between TTF-1 biomarker and clinical and pathological features of the study population, as well as determine TTF-1 prognostic effect on the clinical outcome of the patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A multicentre retrospective study was conducted on 155 surgically-removed lung NET, with available IHC TTF-1 assessment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Median age was 59.5 years (range 13\u201386), 97 patients (62.6%) were females, 31 cases (20%) were atypical carcinoids, 4 (2.6%) had TNM stage IV. Mitotic count \u22652 per 10 high-power field was found in 35 (22.6%) subjects, whereas necrosis was detected in 20 patients (12.9%). TTF-1 was positive in 78 cases (50.3%). The median overall survival was 46.9 months (range 0.6\u2013323) and the median progression-free survival was 39.1 months (range 0.6\u2013323). Statistically significant associations were found between (1) TTF-1 positivity and female sex (<jats:italic>p<\/jats:italic>\u2009=\u20090.007); and among (2) TTF-1 positivity and the absence of necrosis (<jats:italic>p<\/jats:italic>\u2009=\u20090.018).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This study highlights that TTF-1 positivity differs according to sex in lung NET, with a more common TTF-1 positive staining in female. Moreover, TTF-1 positivity correlated with the absence of necrosis. These data suggest that TTF-1 could potentially represent a gender-related biomarker for lung NET.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s12020-023-03542-0","type":"journal-article","created":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T03:27:27Z","timestamp":1696044447000},"page":"519-526","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Thyroid transcription factor\u20101 expression in lung neuroendocrine tumours: a gender-related biomarker?"],"prefix":"10.1007","volume":"83","author":[{"given":"Anna","family":"La Salvia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Siciliani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Rinzivillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Verrico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Baldelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Puliani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Modica","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella","family":"Zanata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Persano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Fanciulli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimiliano","family":"Bassi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimiliano","family":"Mancini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Bellino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Giannetta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsen","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Panzuto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Pia","family":"Brizzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9324-3946","authenticated-orcid":false,"given":"Antongiulio","family":"Faggiano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,9,30]]},"reference":[{"key":"3542_CR1","doi-asserted-by":"publisher","first-page":"8108","DOI":"10.1074\/jbc.270.14.8108","volume":"270","author":"K Ikeda","year":"1995","unstructured":"K. Ikeda, J.C. Clark, J.R. Shaw-White, M.T. Stahlman, C.J. Boutell, J.A. Whitsett, Gene structure and expression of human thyroid transcription factor\u20101 in respiratory epithelial cells. J. Biol. Chem. 270, 8108\u20138114 (1995)","journal-title":"J. Biol. Chem."},{"key":"3542_CR2","doi-asserted-by":"publisher","first-page":"9957209","DOI":"10.1155\/2021\/9957209","volume":"2021","author":"L Guan","year":"2021","unstructured":"L. Guan, X. Zhao, L. Tang, J. Chen, J. Zhao, M. Guo et al. Thyroid transcription factor-1: structure, expression, function and its relationship with disease. Biomed. Res. Int. 2021, 9957209 (2021). https:\/\/doi.org\/10.1155\/2021\/9957209","journal-title":"Biomed. Res. Int."},{"key":"3542_CR3","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1101\/gad.10.1.60","volume":"10","author":"S Kimura","year":"1996","unstructured":"S. Kimura, Y. Hara, T. Pineau, P. Fernandez-Salguero, C.H. Fox, J.M. Ward et al. The T\/ebp null mouse: thyroid\u2010specific enhancer\u2010binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary. Genes Dev. 10, 60\u201369 (1996)","journal-title":"Genes Dev."},{"key":"3542_CR4","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1046\/j.1365-2559.2000.00801.x","volume":"36","author":"O Kaufmann","year":"2000","unstructured":"O. Kaufmann, M. Dietel, Thyroid transcription factor-1 is the superior immunohistochemical marker for pulmonary adenocarcinomas and large cell carcinomas compared to surfactant proteins A and B. Histopathology 36, 8\u201316 (2000). https:\/\/doi.org\/10.1046\/j.1365-2559.2000.00801.x","journal-title":"Histopathology"},{"key":"3542_CR5","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/j.humpath.2004.02.016","volume":"35","author":"EZ Du","year":"2004","unstructured":"E.Z. Du, P. Goldstraw, J. Zacharias, O. Tiffet, P.J. Craig, A.G. Nicholson et al. TTF-1 expression is specific for lung primary in typical and atypical carcinoids: TTF-1-positive carcinoids are predominantly in peripheral location. Hum. Pathol. 35, 825\u2013831 (2004). https:\/\/doi.org\/10.1016\/j.humpath.2004.02.016","journal-title":"Hum. Pathol."},{"key":"3542_CR6","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1309\/UKN6-PVRK-XHG4-22DA","volume":"123","author":"A Saqi","year":"2005","unstructured":"A. Saqi, D. Alexis, F. Remotti, G. Bhagat, Usefulness of CDX2 and TTF-1 in differentiating gastrointestinal from pulmonary carcinoids. Am. J. Clin. Pathol. 123, 394\u2013404 (2005). https:\/\/doi.org\/10.1309\/UKN6-PVRK-XHG4-22DA","journal-title":"Am. J. Clin. Pathol."},{"key":"3542_CR7","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1309\/AJCPGA0IUA8BHQEZ","volume":"142","author":"C Zhang","year":"2014","unstructured":"C. Zhang, L.A. Schmidt, K. Hatanaka, D. Thomas, A. Lagstein, J.L. Myers, Evaluation of napsin A, TTF-1, p63, p40, and CK5\/6 immunohistochemical stains in pulmonary neuroendocrine tumours. Am. J. Clin. Pathol. 142, 320\u2013324 (2014). https:\/\/doi.org\/10.1309\/AJCPGA0IUA8BHQEZ","journal-title":"Am. J. Clin. Pathol."},{"key":"3542_CR8","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1097\/PAS.0b013e31818d7d8b","volume":"33","author":"A Srivastava","year":"2009","unstructured":"A. Srivastava, J.L. Hornick, Immunohistochemical staining for CDX-2, PDX-1, NESP-55, and TTF-1 can help distinguish gastrointestinal carcinoid tumours from pancreatic endocrine and pulmonary carcinoid tumours. Am. J. Surg. Pathol. 33, 626\u2013632 (2009). https:\/\/doi.org\/10.1097\/PAS.0b013e31818d7d8b","journal-title":"Am. J. Surg. Pathol."},{"key":"3542_CR9","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1002\/path.1612","volume":"204","author":"NH Au","year":"2004","unstructured":"N.H. Au, M. Cheang, D.G. Huntsman, E. Yorida, A. Coldman, W.M. Elliott et al. Evaluation of immunohistochemical markers in non\u2010small cell lung cancer by unsupervised hierarchical clustering analysis: a tissue microarray study of 284 cases and 18 markers. J. Pathol. 204, 101\u2013109 (2004)","journal-title":"J. Pathol."},{"key":"3542_CR10","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1093\/annonc\/mdl287","volume":"17","author":"T Berghmans","year":"2006","unstructured":"T. Berghmans, M. Paesmans, C. Mascaux, B. Martin, A.P. Meert, A. Haller et al. Thyroid transcription factor 1\u2014a new prognostic factor in lung cancer: a meta\u2010analysis. Ann. Oncol. 17, 1673\u20131676 (2006)","journal-title":"Ann. Oncol."},{"key":"3542_CR11","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1111\/his.14819","volume":"82","author":"G Centonze","year":"2023","unstructured":"G. Centonze, P. Maisonneuve, M. Simbolo, V. Lagano, F. Grillo, A. Fabbri et al. Lung carcinoid tumours: histology and Ki-67, the eternal rivalry. Histopathology 82, 324\u2013339 (2023). https:\/\/doi.org\/10.1111\/his.14819","journal-title":"Histopathology"},{"key":"3542_CR12","doi-asserted-by":"publisher","unstructured":"V.E. Georgakopoulou, E. Zygouris, C. Damaskos, A. Pierrakou, P. Papalexis, N. Garmpis et al. Prognostic value of the immunohistochemistry markers CD56, TTF-1, synaptophysin, CEA, EMA and NSE in surgically resected lung carcinoid tumours. Mol. Clin. Oncol. 16, 31 (2022). https:\/\/doi.org\/10.3892\/mco.2021.2464","DOI":"10.3892\/mco.2021.2464"},{"key":"3542_CR13","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1007\/s12020-022-03015-w","volume":"76","author":"A La Salvia","year":"2022","unstructured":"A. La Salvia, I. Persano, A. Siciliani, M. Verrico, M. Bassi, R. Modica et al. Prognostic significance of laterality in lung neuroendocrine tumours. Endocrine 76, 733\u2013746 (2022). https:\/\/doi.org\/10.1007\/s12020-022-03015-w","journal-title":"Endocrine"},{"key":"3542_CR14","doi-asserted-by":"publisher","first-page":"5958","DOI":"10.3390\/jcm11195958","volume":"11","author":"A La Salvia","year":"2022","unstructured":"A. La Salvia, R. Carletti, M. Verrico, T. Feola, G. Puliani, M. Bassi et al. Angioside: the role of angiogenesis and hypoxia in lung neuroendocrine tumours according to primary tumour location in left or right parenchyma. J. Clin. Med. 11, 5958 (2022). https:\/\/doi.org\/10.3390\/jcm11195958","journal-title":"J. Clin. Med."},{"key":"3542_CR15","unstructured":"G. Rindi, H. Moch, W.G. McCluggage et al. Neuroendocrine neoplasms, non-endocrine organs. in WHO Classification of Tumours Endocrine and Neuroendocrine Tumours, 5th edn. ed. by WHO Classification of Tumours Editorial Board (International Agency for Research on Cancer (IARC), Lyon France, 2022)."},{"key":"3542_CR16","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.trecan.2022.01.013","volume":"8","author":"JB Rubin","year":"2022","unstructured":"J.B. Rubin, The spectrum of sex differences in cancer. Trends Cancer 8, 303\u2013315 (2022). https:\/\/doi.org\/10.1016\/j.trecan.2022.01.013","journal-title":"Trends Cancer"},{"key":"3542_CR17","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.1093\/annonc\/mdz414","volume":"30","author":"AD Wagner","year":"2019","unstructured":"A.D. Wagner, S. Oertelt-Prigione, A. Adjei, T. Buclin, V. Cristina, C. Csajka et al. Gender medicine and oncology: report and consensus of an ESMO workshop. Ann. Oncol. 30, 1914\u20131924 (2019). https:\/\/doi.org\/10.1093\/annonc\/mdz414","journal-title":"Ann. Oncol."},{"key":"3542_CR18","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1007\/s10354-006-0347-9","volume":"156","author":"C Marosi","year":"2006","unstructured":"C. Marosi, Gender aspects of treatment and drug related toxicity in medical oncology. Wien. Med. Wochenschr. 156, 534\u2013540 (2006). https:\/\/doi.org\/10.1007\/s10354-006-0347-9","journal-title":"Wien. Med. Wochenschr."},{"key":"3542_CR19","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/j.cgh.2020.02.026","volume":"19","author":"MCS Wong","year":"2021","unstructured":"M.C.S. Wong, J. Huang, V. Lok, J. Wang, F. Fung, H. Ding, Z.J. Zheng, Differences in incidence and mortality trends of colorectal cancer worldwide based on sex, age, and anatomic location. Clin. Gastroenterol. Hepatol. 19, 955\u2013966.e61 (2021). https:\/\/doi.org\/10.1016\/j.cgh.2020.02.026","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"3542_CR20","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1007\/s00345-011-0709-9","volume":"29","author":"H Fajkovic","year":"2011","unstructured":"H. Fajkovic, J.A. Halpern, E.K. Cha, A. Bahadori, T.F. Chromecki, P.I. Karakiewicz, E. Breinl, A.S. Merseburger, S.F. Shariat, Impact of gender on bladder cancer incidence, staging, and prognosis. World J. Urol. 29, 457\u2013463 (2011). https:\/\/doi.org\/10.1007\/s00345-011-0709-9","journal-title":"World J. Urol."},{"key":"3542_CR21","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1093\/eurpub\/ckad029","volume":"33","author":"GRC Clark","year":"2023","unstructured":"G.R.C. Clark, C.G. Fraser, J.A. Strachan, R.J.C. Steele, Sex variation in colorectal cancer mortality: trends and implications for screening. Eur. J. Public Health 33, 331\u2013335 (2023). https:\/\/doi.org\/10.1093\/eurpub\/ckad029","journal-title":"Eur. J. Public Health"},{"key":"3542_CR22","doi-asserted-by":"publisher","first-page":"2376","DOI":"10.1002\/ijc.32716","volume":"146","author":"C Stapelfeld","year":"2020","unstructured":"C. Stapelfeld, C. Dammann, E. Maser, Sex-specificity in lung cancer risk. Int. J. Cancer 146, 2376\u20132382 (2020). https:\/\/doi.org\/10.1002\/ijc.32716","journal-title":"Int. J. Cancer"},{"key":"3542_CR23","doi-asserted-by":"publisher","first-page":"3688","DOI":"10.3390\/cells11223688","volume":"11","author":"P Wele","year":"2022","unstructured":"P. Wele, X. Wu, H. Shi, Sex-dependent differences in colorectal cancer: with a focus on obesity. Cells 11, 3688 (2022). https:\/\/doi.org\/10.3390\/cells11223688","journal-title":"Cells"},{"key":"3542_CR24","doi-asserted-by":"publisher","first-page":"2402","DOI":"10.2337\/dc12-0336","volume":"35","author":"K Esposito","year":"2012","unstructured":"K. Esposito, P. Chiodini, A. Colao, A. Lenzi, D. Giugliano, Metabolic syndrome and risk of cancer: a systematic review and meta-analysis. Diabetes Care 35, 2402\u20132411 (2012). https:\/\/doi.org\/10.2337\/dc12-0336","journal-title":"Diabetes Care"},{"key":"3542_CR25","first-page":"255","volume":"116","author":"TJ Key","year":"1992","unstructured":"T.J. Key, V. Beral, Sex hormones and cancer. IARC Sci. Publ. 116, 255\u2013269 (1992)","journal-title":"IARC Sci. Publ."},{"key":"3542_CR26","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.1093\/jnci\/djq444","volume":"102","author":"JH Lin","year":"2010","unstructured":"J.H. Lin, E. Giovannucci, Sex hormones and colorectal cancer: what have we learned so far? J. Natl Cancer Inst. 102, 1746\u20131747 (2010). https:\/\/doi.org\/10.1093\/jnci\/djq444","journal-title":"J. Natl Cancer Inst."},{"key":"3542_CR27","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.tem.2020.02.010","volume":"31","author":"G Muscogiuri","year":"2020","unstructured":"G. Muscogiuri, L. Barrea, T. Feola, M. Gallo, E. Messina, M.A. Venneri et al. NIKE (Neuroendocrine Tumours, Innovation in Knowledge and Education) Group. Pancreatic Neuroendocrine Neoplasms: does sex matter? Trends Endocrinol. Metab. 31, 631\u2013641 (2020). https:\/\/doi.org\/10.1016\/j.tem.2020.02.010","journal-title":"Trends Endocrinol. Metab."},{"key":"3542_CR28","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.1007\/s11605-022-05345-6","volume":"26","author":"JA Greenberg","year":"2022","unstructured":"J.A. Greenberg, N.A. Ivanov, C.E. Egan, Y.J. Lee, R. Zarnegar, T.J. Fahey 3rd et al. Sex-based clinicopathologic and survival differences among patients with pancreatic neuroendocrine tumours. J. Gastrointest. Surg. 26, 2321\u20132329 (2022). https:\/\/doi.org\/10.1007\/s11605-022-05345-6","journal-title":"J. Gastrointest. Surg."},{"key":"3542_CR29","doi-asserted-by":"publisher","first-page":"e2124750","DOI":"10.1001\/jamanetworkopen.2021.24750","volume":"4","author":"Z Xu","year":"2021","unstructured":"Z. Xu, L. Wang, S. Dai, M. Chen, F. Li, J. Sun et al. Epidemiologic trends of and factors associated with overall survival for patients with gastroenteropancreatic neuroendocrine tumours in the United States. JAMA Netw. Open 4, e2124750 (2021). https:\/\/doi.org\/10.1001\/jamanetworkopen.2021.24750","journal-title":"JAMA Netw. Open"},{"key":"3542_CR30","doi-asserted-by":"publisher","first-page":"523","DOI":"10.2217\/cer-2021-0205","volume":"11","author":"O Abdel-Rahman","year":"2022","unstructured":"O. Abdel-Rahman, S. Ghosh, N. Fazio, Sex-based differences in the outcomes of patients with lung carcinoids. J. Comp. Eff. Res. 11, 523\u2013531 (2022). https:\/\/doi.org\/10.2217\/cer-2021-0205","journal-title":"J. Comp. Eff. Res."},{"issue":"5","key":"3542_CR31","first-page":"2579","volume":"17","author":"C Kesrouani","year":"2016","unstructured":"C. Kesrouani, C. Ghorra, M. Rassy, H.R. Kourie, J. Kattan, Distribution and characteristics of pulmonary neuroendocrine tumors: single institution experience in Lebanon. Asian Pac. J. Cancer Prev. 17(5), 2579\u20132581 (2016)","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"3542_CR32","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/j.humpath.2004.02.016","volume":"35","author":"EZ Du","year":"2004","unstructured":"E.Z. Du, P. Goldstraw, J. Zacharias, O. Tiffet, P.J. Craig, A.G. Nicholson, N. Weidner, E.S. Yi, TTF-1 expression is specific for lung primary in typical and atypical carcinoids: TTF-1-positive carcinoids are predominantly in peripheral location. Hum. Pathol. 35, 825\u2013831 (2004). https:\/\/doi.org\/10.1016\/j.humpath.2004.02.016","journal-title":"Hum. Pathol."},{"key":"3542_CR33","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1002\/(SICI)1097-0177(199803)211:3<215::AID-AJA3>3.0.CO;2-K","volume":"211","author":"X Zeng","year":"1998","unstructured":"X. Zeng, S.E. Wert, R. Federici, K.G. Peters, J.A. Whitsett, VEGF enhances pulmonary vasculogenesis and disrupts lung morphogenesis in vivo. Dev. Dyn. 211, 215\u2013227 (1998). 10.1002\/(SICI)1097-0177(199803)211:3<215:AID-AJA3>3.0.CO;2-K","journal-title":"Dev. Dyn."},{"key":"3542_CR34","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1152\/physrev.00028.2006","volume":"87","author":"Y Maeda","year":"2007","unstructured":"Y. Maeda, V. Dav\u00e9, J.A. Whitsett, Transcriptional control of lung morphogenesis. Physiol. Rev. 87, 219\u2013244 (2007). https:\/\/doi.org\/10.1152\/physrev.00028.2006","journal-title":"Physiol. Rev."},{"key":"3542_CR35","doi-asserted-by":"publisher","DOI":"10.1038\/srep19857","volume":"6","author":"LW Wood","year":"2016","unstructured":"L.W. Wood, N.I. Cox, C.A. Phelps, S.C. Lai, A. Poddar, C. Talbot Jr et al. Thyroid transcription factor 1 reprograms angiogenic activities of secretome. Sci. Rep. 6, 19857 (2016). https:\/\/doi.org\/10.1038\/srep19857","journal-title":"Sci. Rep."},{"key":"3542_CR36","doi-asserted-by":"publisher","first-page":"5489","DOI":"10.21873\/anticanres.12882","volume":"38","author":"A Takeuchi","year":"2018","unstructured":"A. Takeuchi, T. Oguri, Y. Yamashita, K. Sone, S. Fukuda, O. Takakuwa et al. TTF-1 expression predicts the merit of additional antiangiogenic treatment in non-squamous non-small cell lung cancer. Anticancer Res. 38, 5489\u20135495 (2018). https:\/\/doi.org\/10.21873\/anticanres.12882","journal-title":"Anticancer Res."},{"key":"3542_CR37","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1007\/s00259-015-3262-8","volume":"43","author":"A Ianniello","year":"2016","unstructured":"A. Ianniello, M. Sansovini, S. Severi, S. Nicolini, C.M. Grana, K. Massri et al. Peptide receptor radionuclide therapy with (177)Lu-DOTATATE in advanced bronchial carcinoids: prognostic role of thyroid transcription factor 1 and (18)F-FDG PET. Eur. J. Nucl. Med. Mol. Imaging 43, 1040\u20131046 (2016). https:\/\/doi.org\/10.1007\/s00259-015-3262-8","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"3542_CR38","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1080\/0284186X.2018.1441543","volume":"57","author":"T Vesterinen","year":"2018","unstructured":"T. Vesterinen, S. Mononen, K. Salmenkivi, H. Mustonen, J. R\u00e4s\u00e4nen, J.A. Salo et al. Clinicopathological indicators of survival among patients with pulmonary carcinoid tumor. Acta Oncol. 57, 1109\u20131116 (2018). https:\/\/doi.org\/10.1080\/0284186X.2018.1441543","journal-title":"Acta Oncol."}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-023-03542-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12020-023-03542-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-023-03542-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T08:19:41Z","timestamp":1707293981000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12020-023-03542-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,30]]},"references-count":38,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,2]]}},"alternative-id":["3542"],"URL":"https:\/\/doi.org\/10.1007\/s12020-023-03542-0","relation":{},"ISSN":["1559-0100"],"issn-type":[{"type":"electronic","value":"1559-0100"}],"subject":[],"published":{"date-parts":[[2023,9,30]]},"assertion":[{"value":"27 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 September 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study complies with the guidelines for human studies and it was conducted ethically in accordance with the Declaration of Helsinki and approved by the Institutional Review Board of Sapienza University of Rome (reference number 5917).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All patients gave written informed consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}