{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T16:32:26Z","timestamp":1793291546130,"version":"4.5.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:00:00Z","timestamp":1707955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:00:00Z","timestamp":1707955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/http:\/\/dx.doi.org\/10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["WUT: 2020IB029"],"award-info":[{"award-number":["WUT: 2020IB029"]}],"id":[{"id":"10.13039\/http:\/\/dx.doi.org\/10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"DOI":"10.1007\/s12020-024-03716-4","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T12:02:08Z","timestamp":1707998528000},"page":"1229-1237","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Polymorphism rs5780218, rs12998 and rs10158616 in KISS1 gene among the Hubei province Chinese girls with the central precocious puberty"],"prefix":"10.1007","volume":"84","author":[{"given":"Lijuan","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiguang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongchao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5482-1910","authenticated-orcid":false,"given":"Bifeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiantao","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,15]]},"reference":[{"key":"3716_CR1","doi-asserted-by":"publisher","first-page":"491","DOI":"10.23736\/s0026-4946.20.05970-8","volume":"72","author":"M Gangat","year":"2020","unstructured":"M. Gangat, S. Radovick, Precocious puberty. Minerva Pediatr. 72, 491\u2013500 (2020). https:\/\/doi.org\/10.23736\/s0026-4946.20.05970-8","journal-title":"Minerva Pediatr."},{"key":"3716_CR2","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1111\/cen.14475","volume":"95","author":"L Maione","year":"2021","unstructured":"L. Maione, C. Bouvattier, U.B. Kaiser, Central precocious puberty: Recent advances in understanding the aetiology and in the clinical approach. Clin. Endocrinol. 95, 542\u2013555 (2021). https:\/\/doi.org\/10.1111\/cen.14475","journal-title":"Clin. Endocrinol."},{"key":"3716_CR3","first-page":"955","volume":"57","author":"Z Jin","year":"2023","unstructured":"Z. Jin, W. Naijun, Further progress of the etiology, diagnosis and treatment of peripheral precocious puberty. Chin. J. Prev. Med. 57, 955\u2013960 (2023)","journal-title":"Chin. J. Prev. Med."},{"key":"3716_CR4","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/s2213-8587(15)00380-0","volume":"4","author":"AC Latronico","year":"2016","unstructured":"A.C. Latronico, V.N. Brito, J.C. Carel, Causes, diagnosis, and treatment of central precocious puberty. Lancet Diabetes Endo. 4, 265\u2013274 (2016). https:\/\/doi.org\/10.1016\/s2213-8587(15)00380-0","journal-title":"Lancet Diabetes Endo."},{"key":"3716_CR5","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1093\/humupd\/7.3.292","volume":"7","author":"CJ Partsch","year":"2001","unstructured":"C.J. Partsch, W.G. Sippell, Pathogenesis and epidemiology of precocious puberty. Effects of exogenous oestrogens. Human Reprod. Update 7, 292\u2013302 (2001). https:\/\/doi.org\/10.1093\/humupd\/7.3.292","journal-title":"Human Reprod. Update"},{"key":"3716_CR6","doi-asserted-by":"publisher","first-page":"e2015665","DOI":"10.1001\/jamanetworkopen.2020.15665","volume":"3","author":"EV Br\u00e4uner","year":"2020","unstructured":"E.V. Br\u00e4uner, A.S. Busch, C. Eckert-Lind, T. Koch, M. Hickey, A. Juul, Trends in the incidence of central precocious puberty and normal variant puberty among children in Denmark, 1998 to 2017. JAMA Netw. Open 3, e2015665 (2020). https:\/\/doi.org\/10.1001\/jamanetworkopen.2020.15665","journal-title":"JAMA Netw. Open"},{"key":"3716_CR7","doi-asserted-by":"publisher","first-page":"4305","DOI":"10.1210\/jc.2010-1025","volume":"95","author":"L Soriano-Guill\u00e9n","year":"2010","unstructured":"L. Soriano-Guill\u00e9n, R. Corripio, J.I. Labarta, R. Ca\u00f1ete, L. Castro-Feij\u00f3o, R. Espino, J. Argente, Central precocious puberty in children living in Spain: incidence, prevalence, and influence of adoption and immigration. J. Clin. Endocr. Metab. 95, 4305\u20134313 (2010). https:\/\/doi.org\/10.1210\/jc.2010-1025","journal-title":"J. Clin. Endocr. Metab."},{"key":"3716_CR8","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.jpeds.2018.12.022","volume":"208","author":"YJ Kim","year":"2019","unstructured":"Y.J. Kim, A. Kwon, M.K. Jung, K.E. Kim, J. Suh, H.W. Chae, D.H. Kim, S. Ha, G.H. Seo, H.S. Kim, Incidence and prevalence of central precocious puberty in Korea: An epidemiologic study based on a national database. J. Pediatr. 208, 221\u2013228 (2019). https:\/\/doi.org\/10.1016\/j.jpeds.2018.12.022","journal-title":"J. Pediatr."},{"key":"3716_CR9","doi-asserted-by":"publisher","first-page":"e0141844","DOI":"10.1371\/journal.pone.0141844","volume":"10","author":"SH Kim","year":"2015","unstructured":"S.H. Kim, K. Huh, S. Won, K.W. Lee, M.J. Park, A significant increase in the incidence of central precocious puberty among Korean Girls from 2004 to 2010. PloS One 10, e0141844 (2015). https:\/\/doi.org\/10.1371\/journal.pone.0141844","journal-title":"PloS One"},{"key":"3716_CR10","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1007\/s12020-021-02630-3","volume":"72","author":"Y Liu","year":"2021","unstructured":"Y. Liu, T. Yu, X. Li, D. Pan, X. Lai, Y. Chen, X. Wang, X. Yu, S. Fu, S. Huang, C. Lin, S. Liu, Prevalence of precocious puberty among Chinese children: a school population-based study. Endocrine 72, 573\u2013581 (2021). https:\/\/doi.org\/10.1007\/s12020-021-02630-3","journal-title":"Endocrine"},{"key":"3716_CR11","doi-asserted-by":"publisher","first-page":"9229153","DOI":"10.1155\/2022\/9229153","volume":"2022","author":"D Fu","year":"2022","unstructured":"D. Fu, T. Li, Y. Zhang, H. Wang, X. Wu, Y. Chen, B. Cao, H. Wei, Analysis of the incidence and risk factors of precocious puberty in girls during the COVID-19 Pandemic. Int. J. Endocrinol. 2022, 9229153 (2022). https:\/\/doi.org\/10.1155\/2022\/9229153","journal-title":"Int. J. Endocrinol."},{"key":"3716_CR12","doi-asserted-by":"publisher","first-page":"839895","DOI":"10.3389\/fendo.2022.839895","volume":"13","author":"Y Chen","year":"2022","unstructured":"Y. Chen, J. Chen, Y. Tang, Q. Zhang, Y. Wang, Q. Li, X. Li, Z. Weng, J. Huang, X. Wang, S. Liu, Difference of precocious puberty between before and during the COVID-19 pandemic: A cross-sectional study among Shanghai School-Aged Girls. Front. Endocrinol. 13, 839895 (2022). https:\/\/doi.org\/10.3389\/fendo.2022.839895","journal-title":"Front. Endocrinol."},{"key":"3716_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1136\/bmjpo-2023-001987","volume":"7","author":"S Baehr","year":"2023","unstructured":"S. Baehr, D. Schnabel, J. Woelfle, F. Schreiner, B. Gohlke, National survey of referrals for precocious puberty in Germany. BMJ Paediatr. Open 7, 1 (2023). https:\/\/doi.org\/10.1136\/bmjpo-2023-001987","journal-title":"BMJ Paediatr. Open"},{"key":"3716_CR14","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3389\/fendo.2012.00149","volume":"3","author":"SD Bianco","year":"2012","unstructured":"S.D. Bianco, A potential mechanism for the sexual dimorphism in the onset of puberty and incidence of idiopathic central precocious puberty in children: sex-specific kisspeptin as an integrator of puberty signals. Front Endocrinol 3, 149 (2012). https:\/\/doi.org\/10.3389\/fendo.2012.00149","journal-title":"Front Endocrinol"},{"key":"3716_CR15","doi-asserted-by":"publisher","first-page":"365845","DOI":"10.1155\/2015\/365845","volume":"2015","author":"EG Quevedo","year":"2015","unstructured":"E.G. Quevedo, G.M. Aguilar, L.A. Aguilar, S.A. Rubio, S.E. Mart\u00ednez, I.P. Rodr\u00edguez, J.S. Corona, M.I. Mor\u00e1n, R.C. G\u00f3mez, M.C. Moguel, Polymorphisms rs12998 and rs5780218 in KiSS1 suppressor metastasis gene in Mexican patients with breast cancer. Dis. Markers 2015, 365845 (2015). https:\/\/doi.org\/10.1155\/2015\/365845","journal-title":"Dis. Markers"},{"key":"3716_CR16","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s43046-020-00037-1","volume":"32","author":"S Antar","year":"2020","unstructured":"S. Antar, N. Mokhtar, M.A. Abd Elghaffar, A.K. Seleem, Association of polymorphisms in metastasis suppressor genes NME1 and KISS1 with breast cancer development and metastasis. J. Egypt Natl. Cancer 32, 24 (2020). https:\/\/doi.org\/10.1186\/s43046-020-00037-1","journal-title":"J. Egypt Natl. Cancer"},{"key":"3716_CR17","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/s2213-8587(15)00380-0","volume":"4","author":"AC Latronico","year":"2016","unstructured":"A.C. Latronico, V.N. Brito, J.C. Carel, Causes, diagnosis, and treatment of central precocious puberty. lancet Diabetes Endocrinol. 4, 265\u2013274 (2016). https:\/\/doi.org\/10.1016\/s2213-8587(15)00380-0","journal-title":"lancet Diabetes Endocrinol."},{"key":"3716_CR18","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3760\/cma.j.cn112140-20220802-00693","volume":"61","author":"Metabolism CSoPEa","year":"2023","unstructured":"Metabolism CSoPEa, Pediatrics EBoCJo Expert consensus on the diagnosis and treatment of central precocious puberty(2022). Chin. J. Pediatr. 61, 16\u201322 (2023). https:\/\/doi.org\/10.3760\/cma.j.cn112140-20220802-00693","journal-title":"Chin. J. Pediatr."},{"key":"3716_CR19","doi-asserted-by":"publisher","first-page":"dgz229","DOI":"10.1210\/clinem\/dgz229","volume":"105","author":"D Li","year":"2020","unstructured":"D. Li, Y. Wu, J. Cheng, L. Liu, X. Li, D. Chen, S. Huang, Y. Wen, Y. Ke, Y. Yao, Z. Su, L. Zhou, Association of polymorphisms in the Kisspeptin\/GPR54 pathway genes with risk of early puberty in Chinese Girls. J. Clin. Endocrinol. Metab. 105, dgz229 (2020). https:\/\/doi.org\/10.1210\/clinem\/dgz229","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"3716_CR20","doi-asserted-by":"publisher","first-page":"153696","DOI":"10.1016\/j.prp.2021.153696","volume":"229","author":"X Lu","year":"2022","unstructured":"X. Lu, M. Liu, Y. Liao, C. Huang, L. Chai, Y. Jin, Q. Xiong, B. Chen, Meta-analysis of the association between mTORC1-related genes polymorphisms and cancer risk. Pathol. Res. Pract. 229, 153696 (2022). https:\/\/doi.org\/10.1016\/j.prp.2021.153696","journal-title":"Pathol. Res. Pract."},{"key":"3716_CR21","doi-asserted-by":"publisher","first-page":"66","DOI":"10.6065\/apem.2016.21.2.66","volume":"21","author":"YL Shin","year":"2016","unstructured":"Y.L. Shin, An update on the genetic causes of central precocious puberty. Ann. Pediatr. Endocrin. 21, 66\u201369 (2016). https:\/\/doi.org\/10.6065\/apem.2016.21.2.66","journal-title":"Ann. Pediatr. Endocrin."},{"key":"3716_CR22","doi-asserted-by":"publisher","first-page":"925206","DOI":"10.3389\/fendo.2022.925206","volume":"13","author":"Q Xie","year":"2022","unstructured":"Q. Xie, Y. Kang, C. Zhang, Y. Xie, C. Wang, J. Liu, C. Yu, H. Zhao, D. Huang, The Role of Kisspeptin in the Control of the Hypothalamic-Pituitary-Gonadal Axis and Reproduction. Front Endocrinol 13, 925206 (2022). https:\/\/doi.org\/10.3389\/fendo.2022.925206","journal-title":"Front Endocrinol"},{"key":"3716_CR23","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1530\/eje-07-0061","volume":"157","author":"X Luan","year":"2007","unstructured":"X. Luan, Y. Zhou, W. Wang, H. Yu, P. Li, X. Gan, D. Wei, J. Xiao, Association study of the polymorphisms in the KISS1 gene with central precocious puberty in Chinese girls. Eur. J. Endocrinol. 157, 113\u2013118 (2007). https:\/\/doi.org\/10.1530\/eje-07-0061","journal-title":"Eur. J. Endocrinol."},{"key":"3716_CR24","doi-asserted-by":"publisher","unstructured":"Y. Chen, Exposure of Bisphenol-A(BPA) in Relation to ICPP in Girls and the Genetic Mechanism. Shanghai Jiao Tong University School of Medicine. 2020 https:\/\/doi.org\/10.27307\/d.cnki.gsjtu.2019.000236","DOI":"10.27307\/d.cnki.gsjtu.2019.000236"},{"key":"3716_CR25","doi-asserted-by":"publisher","first-page":"9450663","DOI":"10.1155\/2022\/9450663","volume":"2022","author":"Y Li","year":"2022","unstructured":"Y. Li, N. Tao, M. Chen, J. Chu, X. Huang, X. Kong, Gene polymorphisms associated with central precocious puberty and hormone levels in Chinese girls. Int. J. Endocrinol. 2022, 9450663 (2022). https:\/\/doi.org\/10.1155\/2022\/9450663","journal-title":"Int. J. Endocrinol."},{"key":"3716_CR26","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.ando.2018.09.007","volume":"80","author":"P Amorim","year":"2019","unstructured":"P. Amorim, I.P.P. Grande, R.L. Batista, L.F.G. Silveira, A. Freire, M.D. Bronstein, R.S. Jallad, E.B. Trarbach, Association between KISS1 rs5780218 promoter polymorphism and onset of growth hormone secreting pituitary adenoma. Ann. Endocrinol-Paris 80, 96\u2013100 (2019). https:\/\/doi.org\/10.1016\/j.ando.2018.09.007","journal-title":"Ann. Endocrinol-Paris"}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-024-03716-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12020-024-03716-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-024-03716-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T07:30:06Z","timestamp":1719387006000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12020-024-03716-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,15]]},"references-count":26,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["3716"],"URL":"https:\/\/doi.org\/10.1007\/s12020-024-03716-4","relation":{},"ISSN":["1559-0100"],"issn-type":[{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,15]]},"assertion":[{"value":"21 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the Ethics Committee of Wuhan University of Technology (20221011006).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors affirm that research participants provided informed consent for the publication of their anonymized data for this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}