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For every patient basal serum Luteinising Hormone (LH) and Follicle Stimulating Hormone (FSH), basal LH\/FSH ratio and pelvic ultrasonographic parameters were also collected. Through the use of Receiver Operating Curves (ROCs) the sensitivity (Se) and specificity (Sp) of basal LH, FSH, LH\/FSH ratio and ultrasonographic parameters were evaluated at each level and Area Under the Curve (AUC) was measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Basal LH model \u22650.14\u2009mIU\/mL reached the highest predictability (90.6% and 78.2%, Se and Sp, respectively). Basal LH\/FSH ratio \u22650.1 showed a sensitivity of 85.90% and a specificity of 78.14%, while basal FSH cut-off (\u22652.36\u2009mIU\/mL) had the lowest predictability, with a less favourable sensitivity (71%) and specificity (70.5%). Cut-off point for uterine length as 35\u2009mm, (83.5% and 42.9% of Se and Sp, respectively) was calculated. For ovarian volumes, ROC curves showed very low sensitivity and specificity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A single basal LH measurement under the cut-off limit may be adequate to exclude an HPG axis activation as CPP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s12020-024-03781-9","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T09:01:24Z","timestamp":1710925284000},"page":"955-963","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Screening for central precocious puberty by single basal Luteinizing Hormone levels"],"prefix":"10.1007","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4905-371X","authenticated-orcid":false,"given":"Alessandra","family":"Li Pomi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perla","family":"Scalini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5889-9280","authenticated-orcid":false,"given":"Salvatore","family":"De Masi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3628-1612","authenticated-orcid":false,"given":"Domenico","family":"Corica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1130-829X","authenticated-orcid":false,"given":"Giorgia","family":"Pepe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8299-2677","authenticated-orcid":false,"given":"Malgorzata","family":"Wasniewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2259-4685","authenticated-orcid":false,"given":"Stefano","family":"Stagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,20]]},"reference":[{"key":"3781_CR1","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1210\/jcem-45-2-307","volume":"45","author":"R Penny","year":"1977","unstructured":"R. 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