{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:17:14Z","timestamp":1789129034717,"version":"build-2803163510"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100011958","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","award":["2034-00084B"],"award-info":[{"award-number":["2034-00084B"]}],"id":[{"id":"10.13039\/501100011958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF18OC0052064"],"award-info":[{"award-number":["NNF18OC0052064"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF18OC0052064"],"award-info":[{"award-number":["NNF18OC0052064"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF18OC0052064"],"award-info":[{"award-number":["NNF18OC0052064"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF18OC0052064"],"award-info":[{"award-number":["NNF18OC0052064"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Osteoglycin is hypothesized to be metabolically active and may enhance insulin action. We hypothesized that osteoglycin levels increase during hyperglycemia as a physiological response to enhance the effects of insulin.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Eight healthy males were included in a cross-over study consisting of three study days following an 8\u2009h fast. First, we performed an oral glucose tolerance test (OGTT); second, an isoglycemic intravenous glucose infusion (IIGI); and third, a control period consisting of a three hour fast. We analyzed blood samples for circulating osteoglycin levels during the study days. Repeated measures ANOVA was performed to compare levels of s-osteoglycin between OGTT, IIGI, and the fasting control.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>There were no differences in baseline osteoglycin levels among study days (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). We observed no significant changes neither in absolute s-osteoglycin levels by time (<jats:italic>p<\/jats:italic>\u2009=\u20090.14) nor over time by study day (<jats:italic>p<\/jats:italic>\u2009=\u20090.99). Likewise, we observed no significant changes in percentage s-osteoglycin levels neither by time (<jats:italic>p<\/jats:italic>\u2009=\u20090.11) nor over time by study day (<jats:italic>p<\/jats:italic>\u2009=\u20090.89).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>We found that s-osteoglycin levels were stable for three hours during OGTT, IIGI, and fasting in healthy males. Based on the present study, circulating s-osteoglycin levels may be measured independently of fasting or non-fasting conditions. Furthermore, circulating physiological levels of glucose and insulin did not affect s-osteoglycin levels.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s12020-024-03789-1","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T17:01:50Z","timestamp":1711645310000},"page":"1117-1121","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Serum osteoglycin is stable during various glycemic challenges in healthy men"],"prefix":"10.1007","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4325-8023","authenticated-orcid":false,"given":"Jakob","family":"Starup-Linde","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidse","family":"Westberg-Rasmussen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikke","family":"Viggers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheer Kejlberg","family":"Al-Mashhadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aase","family":"Handberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Vestergaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren","family":"Gregersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,28]]},"reference":[{"issue":"5","key":"3789_CR1","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1007\/s11914-019-00523-z","volume":"17","author":"J Starup-Linde","year":"2019","unstructured":"J. Starup-Linde, R. Viggers, A. Handberg, Osteoglycin and bone-a systematic review. Curr. Osteoporos. Rep. 17(5), 250\u20135 (2019)","journal-title":"Curr. Osteoporos. Rep."},{"key":"3789_CR2","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.molmet.2018.05.004","volume":"13","author":"NJ Lee","year":"2018","unstructured":"N.J. Lee, N. Ali, L. Zhang, Y. Qi, I. Clarke, R.F. Enriquez et al. Osteoglycin, a novel coordinator of bone and glucose homeostasis. Mol. Metab. 13, 30\u201344 (2018)","journal-title":"Mol. Metab."},{"issue":"10","key":"3789_CR3","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.3390\/jcm10102209","volume":"10","author":"S Gonz\u00e1lez-Salvatierra","year":"2021","unstructured":"S. Gonz\u00e1lez-Salvatierra, C. Garc\u00eda-Fontana, F. And\u00fajar-Vera, A.B. Grau-Perales, L. Mart\u00ednez-Heredia, M.D. Avil\u00e9s-P\u00e9rez et al. Osteoglycin as a potential biomarker of mild kidney function impairment in type 2 diabetes patients. J. Clin. Med. 10(10), 2209 (2021)","journal-title":"J. Clin. Med."},{"key":"3789_CR4","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.bone.2016.11.007","volume":"95","author":"KI Tanaka","year":"2017","unstructured":"K.I. Tanaka, I. Kanazawa, H. Kaji, T. Sugimoto, Association of osteoglycin and FAM5C with bone turnover markers, bone mineral density, and vertebral fractures in postmenopausal women with type 2 diabetes mellitus. Bone 95, 5\u201310 (2017)","journal-title":"Bone"},{"key":"3789_CR5","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.649718","volume":"12","author":"JK Starup-Linde","year":"2021","unstructured":"J.K. Starup-Linde, R. Viggers, B. Langdahl, S. Gregersen, S. Lykkeboe, A. Handberg et al. Associations of circulating osteoglycin with bone parameters and metabolic markers in patients with diabetes. Front Endocrinol. (Lausanne) 12, 649718 (2021)","journal-title":"Front Endocrinol. 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