{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:43:34Z","timestamp":1790279014450,"version":"4.1.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T00:00:00Z","timestamp":1712966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T00:00:00Z","timestamp":1712966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Ipsen Pharma GmbH M\u00fcnchen, Germany"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Patients with acromegaly oftentimes exhibit a reduced physical and psychological health-related quality of life (HRQoL). Maladaptive coping styles are associated with poor HRQoL in a number of diseases and patients with pituitary adenomas in general exhibit less effective coping styles than healthy controls. This study aimed to assess coping strategies in acromegaly patients in order to explore leverage points for the improvement of HRQoL.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In this cross-sectional study, we administered self-report surveys for coping strategies and HRQoL (Short Form SF-36, Freiburg questionnaire on coping with illness, FKV-LIS) in patients with acromegaly. These were set into relation with a variety of health variables.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>About half of the 106 patients (44.3% female) with a mean age of 56.4\u2009\u00b1\u20091.3 years showed impaired physical and psychological HRQoL on average 11.2 years after the initial diagnosis. Body mass index, age at survey date and concomitant radiotherapy explained 27.8% of the variance of physical HRQoL, while depressive coping added an additional 9.2%. Depressive coping style and trivialization and wishful thinking were pivotal predictors of an impaired psychological HRQoL with a total explained variance of 51.6%, whereas patient health variables did not affect psychological HRQoL.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Our results show that maladaptive coping styles have a substantial negative impact on psychological HRQoL in patients with acromegaly, whereas physical HRQoL is influenced to a lesser extent. Specialized training programs aimed at improving coping strategies could reduce long-term disease burden and increase HRQoL in the affected patients.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s12020-024-03813-4","type":"journal-article","created":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T12:01:53Z","timestamp":1713009713000},"page":"1108-1115","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The effect of coping strategies on health\u2013related quality of life in acromegaly patients"],"prefix":"10.1007","volume":"84","author":[{"given":"Lisa","family":"Schock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Witold X.","family":"Chmielewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Siegel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Detomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Deutschbein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Giese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Honegger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Unger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilonka","family":"Kreitschmann-Andermahr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,13]]},"reference":[{"issue":"1","key":"3813_CR1","doi-asserted-by":"publisher","first-page":"79","DOI":"10.4158\/ep161373.Or","volume":"23","author":"I Kreitschmann-Andermahr","year":"2017","unstructured":"I. Kreitschmann-Andermahr et al. Predictors of quality of life in 165 patients with acromegaly: results from a single-center study. Endocr. Pr. 23(1), 79\u201388 (2017). https:\/\/doi.org\/10.4158\/ep161373.Or","journal-title":"Endocr. Pr."},{"key":"3813_CR2","doi-asserted-by":"crossref","unstructured":"S. Melmed, Chapter 15 - Acromegaly. In The Pituitary, 5th edn. ed. by S. Melmed (Academic Press, 2022), pp 449\u2013493.","DOI":"10.1016\/B978-0-323-99899-4.00010-X"},{"issue":"24","key":"3813_CR3","doi-asserted-by":"publisher","first-page":"2558","DOI":"10.1056\/NEJMra062453","volume":"355","author":"S Melmed","year":"2006","unstructured":"S. Melmed, Medical progress: Acromegaly. N. Engl. J. Med. 355(24), 2558\u20132573 (2006). https:\/\/doi.org\/10.1056\/NEJMra062453","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"3813_CR4","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1007\/s12020-014-0166-5","volume":"47","author":"P Anagnostis","year":"2014","unstructured":"P. Anagnostis et al. Psychological profile and quality of life in patients with acromegaly in Greece. Is there any difference with other chronic diseases? Endocrine 47(2), 564\u2013571 (2014). https:\/\/doi.org\/10.1007\/s12020-014-0166-5","journal-title":"Endocrine"},{"issue":"5","key":"3813_CR5","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1111\/j.1365-2265.2009.03555.x","volume":"71","author":"C Sievers","year":"2009","unstructured":"C. Sievers et al. Prevalence of mental disorders in acromegaly: a cross-sectional study in 81 acromegalic patients. Clin. Endocrinol. 71(5), 691\u2013701 (2009). https:\/\/doi.org\/10.1111\/j.1365-2265.2009.03555.x","journal-title":"Clin. Endocrinol."},{"issue":"5","key":"3813_CR6","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1111\/j.1365-2265.2007.02951.x","volume":"67","author":"N Sonino","year":"2007","unstructured":"N. Sonino et al. Psychosocial impairment in patients treated for pituitary disease: a controlled study. Clin. Endocrinol. 67(5), 719\u2013726 (2007). https:\/\/doi.org\/10.1111\/j.1365-2265.2007.02951.x","journal-title":"Clin. Endocrinol."},{"issue":"1","key":"3813_CR7","doi-asserted-by":"publisher","first-page":"167","DOI":"10.17219\/acem\/38156","volume":"24","author":"D Szcze\u015bniak","year":"2015","unstructured":"D. Szcze\u015bniak, A. Jawiarczyk-Przyby\u0142owska, J. Rymaszewska, The quality of life and psychological, social and cognitive functioning of patients with acromegaly. Adv. Clin. Exp. Med. 24(1), 167\u2013172 (2015). https:\/\/doi.org\/10.17219\/acem\/38156","journal-title":"Adv. Clin. Exp. Med."},{"issue":"3","key":"3813_CR8","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1159\/000530691","volume":"92","author":"N Sonino","year":"2023","unstructured":"N. Sonino et al. Allostatic Load and Endocrine Disorders. Psychother. Psychosom. 92(3), 162\u2013169 (2023). https:\/\/doi.org\/10.1159\/000530691","journal-title":"Psychother. Psychosom."},{"issue":"3","key":"3813_CR9","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1046\/j.1467-789x.2001.00032.x","volume":"2","author":"KR Fontaine","year":"2001","unstructured":"K.R. Fontaine, I. Barofsky, Obesity and health-related quality of life. Obes. Rev. 2(3), 173\u2013182 (2001). https:\/\/doi.org\/10.1046\/j.1467-789x.2001.00032.x","journal-title":"Obes. Rev."},{"issue":"5","key":"3813_CR10","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1111\/cob.12203","volume":"7","author":"RL Kolotkin","year":"2017","unstructured":"R.L. Kolotkin, J.R. Andersen, A systematic review of reviews: exploring the relationship between obesity, weight loss and health-related quality of life. Clin. Obes. 7(5), 273\u2013289 (2017). https:\/\/doi.org\/10.1111\/cob.12203","journal-title":"Clin. Obes."},{"issue":"8","key":"3813_CR11","doi-asserted-by":"publisher","first-page":"2221","DOI":"10.1007\/s11136-019-02182-0","volume":"28","author":"I Etxeberria","year":"2019","unstructured":"I. Etxeberria, E. Urdaneta, N. Galdona, Factors associated with health-related quality of life (HRQoL): differential patterns depending on age. Qual. Life Res. 28(8), 2221\u20132231 (2019). https:\/\/doi.org\/10.1007\/s11136-019-02182-0","journal-title":"Qual. Life Res."},{"issue":"11","key":"3813_CR12","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1016\/s0959-8049(00)00447-0","volume":"37","author":"R Schwarz","year":"2001","unstructured":"R. Schwarz, A. Hinz, Reference data for the quality of life questionnaire EORTC QLQ-C30 in the general German population. Eur. J. Cancer 37(11), 1345\u20131351 (2001). https:\/\/doi.org\/10.1016\/s0959-8049(00)00447-0","journal-title":"Eur. J. Cancer"},{"issue":"4","key":"3813_CR13","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.oraloncology.2014.01.015","volume":"50","author":"J Klein","year":"2014","unstructured":"J. Klein, J. Livergant, J. Ringash, Health related quality of life in head and neck cancer treated with radiation therapy with or without chemotherapy: a systematic review. Oral. Oncol. 50(4), 254\u2013262 (2014). https:\/\/doi.org\/10.1016\/j.oraloncology.2014.01.015","journal-title":"Oral. Oncol."},{"issue":"3","key":"3813_CR14","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.ygyno.2006.03.050","volume":"102","author":"I Vistad","year":"2006","unstructured":"I. Vistad, S.D. Foss\u00e5, A.A. Dahl, A critical review of patient-rated quality of life studies of long-term survivors of cervical cancer. Gynecol. Oncol. 102(3), 563\u2013572 (2006). https:\/\/doi.org\/10.1016\/j.ygyno.2006.03.050","journal-title":"Gynecol. Oncol."},{"key":"3813_CR15","unstructured":"E.B. Algorani, V. Gupta, Coping Mechanisms. In StatPearls. (StatPearls Publishing Copyright \u00a9 2024, StatPearls Publishing LLC.: Treasure Island (FL), 2024)."},{"issue":"8","key":"3813_CR16","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1055\/s-0031-1275744","volume":"61","author":"S Schipper","year":"2011","unstructured":"S. Schipper et al. [Coping strategies and health-related quality of life in multiple sclerosis patients]. Psychother. Psychosom. Med Psychol. 61(8), 347\u2013355 (2011). https:\/\/doi.org\/10.1055\/s-0031-1275744","journal-title":"Psychother. Psychosom. Med Psychol."},{"issue":"3","key":"3813_CR17","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.hrtlng.2012.12.002","volume":"42","author":"LJ Graven","year":"2013","unstructured":"L.J. Graven, J.S. Grant, Coping and health-related quality of life in individuals with heart failure: an integrative review. Heart Lung 42(3), 183\u2013194 (2013). https:\/\/doi.org\/10.1016\/j.hrtlng.2012.12.002","journal-title":"Heart Lung"},{"issue":"1","key":"3813_CR18","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1002\/pon.920","volume":"15","author":"H Stam","year":"2006","unstructured":"H. Stam et al. Quality of life and current coping in young adult survivors of childhood cancer: positive expectations about the further course of the disease were correlated with better quality of life. Psychooncology 15(1), 31\u201343 (2006). https:\/\/doi.org\/10.1002\/pon.920","journal-title":"Psychooncology"},{"issue":"3","key":"3813_CR19","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1037\/0278-6133.18.3.211","volume":"18","author":"CE Schwartz","year":"1999","unstructured":"C.E. Schwartz, Teaching coping skills enhances quality of life more than peer support: results of a randomized trial with multiple sclerosis patients. Health Psychol. 18(3), 211\u2013220 (1999). https:\/\/doi.org\/10.1037\/\/0278-6133.18.3.211","journal-title":"Health Psychol."},{"issue":"1","key":"3813_CR20","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1177\/0145721720978154","volume":"47","author":"L Kolb","year":"2021","unstructured":"L. Kolb, An Effective Model of Diabetes Care and Education: The ADCES7 Self-Care Behaviors\u2122. Sci. Diabetes Self Manag Care 47(1), 30\u201353 (2021). https:\/\/doi.org\/10.1177\/0145721720978154","journal-title":"Sci. Diabetes Self Manag Care"},{"issue":"4","key":"3813_CR21","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1210\/jc.2010-2490","volume":"96","author":"J Tiemensma","year":"2011","unstructured":"J. Tiemensma et al. Coping strategies in patients after treatment for functioning or nonfunctioning pituitary adenomas. J. Clin. Endocrinol. Metab. 96(4), 964\u2013971 (2011). https:\/\/doi.org\/10.1210\/jc.2010-2490","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"6","key":"3813_CR22","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1007\/s11102-016-0750-1","volume":"19","author":"S Siegel","year":"2016","unstructured":"S. Siegel et al. Coping strategies have a strong impact on quality of life, depression, and embitterment in patients with Cushing\u2019s disease. Pituitary 19(6), 590\u2013600 (2016). https:\/\/doi.org\/10.1007\/s11102-016-0750-1","journal-title":"Pituitary"},{"key":"3813_CR23","doi-asserted-by":"publisher","unstructured":"R.D. Stieglitz, M. Bullinger, I. Kirchberger. SF-36. Fragebogen zum Gesundheitszustand. G\u00f6ttingen: Hogrefe. Preis DM 298. Zeitschrift f\u00fcr Klinische Psychologie und Psychotherapie 28(2), 143\u2013145 (1999). https:\/\/doi.org\/10.1026\/\/0084-5345.28.2.143","DOI":"10.1026\/\/0084-5345.28.2.143"},{"issue":"6","key":"3813_CR24","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1097\/00005650-199206000-00002","volume":"30","author":"JEJ Ware","year":"1992","unstructured":"J.E.J. Ware, C.D. Sherbourne, The MOS 36-ltem Short-Form Health Survey (SF-36): I. Conceptual Framework and Item Selection. Med. Care 30(6), 473\u2013483 (1992)","journal-title":"Med. Care"},{"issue":"2","key":"3813_CR25","first-page":"IX","volume":"35","author":"F Muthny","year":"1996","unstructured":"F. Muthny, References for evaluation scales in quality assurance in rehabilitation-\u22126. Assessment of coping processes with the Freiburg Questionnaire of Illness Coping. Die Rehabilit. 35(2), IX\u2013XVI (1996)","journal-title":"Die Rehabilit."},{"key":"3813_CR26","unstructured":"C.B. Weir, A. Jan, BMI classification percentile and cut off points. In StatPearls. (StatPearls Publishing Copyright \u00a9 2024, StatPearls Publishing LLC.: Treasure Island (FL), 2024)"},{"issue":"5","key":"3813_CR27","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1097\/00005792-199409000-00001","volume":"73","author":"S Ezzat","year":"1994","unstructured":"S. Ezzat et al. Acromegaly. Clinical and biochemical features in 500 patients. Medicine 73(5), 233\u2013240 (1994)","journal-title":"Medicine"},{"issue":"6","key":"3813_CR28","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1530\/eje-10-1050","volume":"164","author":"S Fieffe","year":"2011","unstructured":"S. Fieffe et al. Diabetes in acromegaly, prevalence, risk factors, and evolution: data from the French Acromegaly Registry. Eur. J. Endocrinol. 164(6), 877\u2013884 (2011). https:\/\/doi.org\/10.1530\/eje-10-1050","journal-title":"Eur. J. Endocrinol."},{"issue":"12","key":"3813_CR29","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1097\/00042737-200412000-00007","volume":"16","author":"M Mussell","year":"2004","unstructured":"M. Mussell et al. Predictors of disease-related concerns and other aspects of health-related quality of life in outpatients with inflammatory bowel disease. Eur. J. Gastroenterol. Hepatol. 16(12), 1273\u20131280 (2004). https:\/\/doi.org\/10.1097\/00042737-200412000-00007","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"3813_CR30","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3389\/fendo.2014.00229","volume":"5","author":"VJ Geraedts","year":"2014","unstructured":"V.J. Geraedts et al. Health Outcomes in Acromegaly: Depression and Anxiety are Promising Targets for Improving Reduced Quality of Life. Front Endocrinol. 5, 229 (2014). https:\/\/doi.org\/10.3389\/fendo.2014.00229","journal-title":"Front Endocrinol."},{"issue":"1","key":"3813_CR31","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s11102-016-0761-y","volume":"20","author":"I Crespo","year":"2017","unstructured":"I. Crespo, E. Valassi, S.M. Webb, Update on quality of life in patients with acromegaly. Pituitary 20(1), 185\u2013188 (2017). https:\/\/doi.org\/10.1007\/s11102-016-0761-y","journal-title":"Pituitary"},{"key":"3813_CR32","doi-asserted-by":"publisher","first-page":"40","DOI":"10.3389\/fendo.2017.00040","volume":"8","author":"VJ Geraedts","year":"2017","unstructured":"V.J. Geraedts et al. Predictors of Quality of Life in Acromegaly: No Consensus on Biochemical Parameters. Front Endocrinol. 8, 40 (2017). https:\/\/doi.org\/10.3389\/fendo.2017.00040","journal-title":"Front Endocrinol."},{"key":"3813_CR33","doi-asserted-by":"crossref","unstructured":"M. D. Gellman (Ed.). Encyclopedia of behavioral medicine. Cham: Springer International Publishing (2020)","DOI":"10.1007\/978-3-030-39903-0_1660"},{"issue":"3","key":"3813_CR34","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.amjmed.2022.10.019","volume":"136","author":"GA Fava","year":"2023","unstructured":"G.A. Fava et al. Understanding Health Attitudes and Behavior. Am. J. Med. 136(3), 252\u2013259 (2023). https:\/\/doi.org\/10.1016\/j.amjmed.2022.10.019","journal-title":"Am. J. Med."},{"issue":"3","key":"3813_CR35","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1111\/cen.14844","volume":"98","author":"A Santos","year":"2023","unstructured":"A. Santos et al. The effect of mindfulness therapy in acromegaly, a pilot study. Clin. Endocrinol. 98(3), 363\u2013374 (2023). https:\/\/doi.org\/10.1111\/cen.14844","journal-title":"Clin. Endocrinol."}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-024-03813-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12020-024-03813-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-024-03813-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T07:30:29Z","timestamp":1719387029000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12020-024-03813-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,13]]},"references-count":35,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["3813"],"URL":"https:\/\/doi.org\/10.1007\/s12020-024-03813-4","relation":{},"ISSN":["1559-0100"],"issn-type":[{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,13]]},"assertion":[{"value":"1 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"I.K.-A., N.U. and J.H. received research and\/or travel grants and\/or speaker\u2019s\/advisory board honoraria from companies producing acromegaly medications, i.e. IPSEN Pharma GmbH, Germany; Pfizer Pharma; Recordati Rare Diseases Germany GmbH, Advanz Pharma GmbH. M.D. received travel grants from IPSEN. T.D. received travel grants from Recordati Rare Diseases Germany GmbH and Advanz Pharma GmbH. The other authors report no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All patients included in the analysis provided written informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The study was approved by the local ethics committee of the University Hospital of Essen (17-7650-BO) and was conducted according to the Declaration of Helsinki.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}