{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:48:26Z","timestamp":1789422506890,"version":"build-2803163510"},"reference-count":85,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"DOI":"10.1007\/s12020-024-03818-z","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T17:01:36Z","timestamp":1713459696000},"page":"215-232","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Ameliorative effect of ferulic acid on thyroid dysfunction against propyl-thiouracil induced hypothyroid rats"],"prefix":"10.1007","volume":"86","author":[{"given":"Suma","family":"Rongala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aravinda Sai","family":"Kolusu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhuri Suma","family":"Jakkamsetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujit Kumar","family":"Mohanty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavan Kumar","family":"Samudrala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhanu Prakash","family":"Arakareddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,18]]},"reference":[{"key":"3818_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2021.111173","volume":"525","author":"U Feldt-Rasmussen","year":"2021","unstructured":"U. Feldt-Rasmussen, G. Effraimidis, M. Klose, The hypothalamus-pituitary-thyroid (HPT)-axis and its role in physiology and pathophysiology of other hypothalamus-pituitary functions. Mol. Cell. Endocrinol. 525, 111173 (2021). https:\/\/doi.org\/10.1016\/j.mce.2021.111173","journal-title":"Mol. Cell. Endocrinol."},{"key":"3818_CR2","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1089\/thy.2007.0266","volume":"18","author":"B Kim","year":"2008","unstructured":"B. Kim, Thyroid hormone as a determinant of energy expenditure and the basal metabolic rate. Thyroid 18, 141\u2013144 (2008). https:\/\/doi.org\/10.1089\/thy.2007.0266","journal-title":"Thyroid"},{"key":"3818_CR3","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/S2213-8587(13)70030-5","volume":"1","author":"JA Franklyn","year":"2013","unstructured":"J.A. Franklyn, K. Boelaert, Subclinical thyroid disease: where is the evidence? Lancet Diabetes Endocrinol. 1, 172\u2013173 (2013). https:\/\/doi.org\/10.1016\/S2213-8587(13)70030-5","journal-title":"Lancet Diabetes Endocrinol."},{"key":"3818_CR4","unstructured":"Thyroid disorders in India: An epidemiological perspective (2011), https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3169866\/. Accessed 3 Aug 2023"},{"key":"3818_CR5","unstructured":"An approach for development of age-, gender-, and ethnicity-specific thyrotropin reference limits https:\/\/pubmed.ncbi.nlm.nih.gov\/21058882\/ (2011), Accessed 3 Aug 2023"},{"key":"3818_CR6","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1507\/endocrj.EJ15-0253","volume":"62","author":"J-F Ge","year":"2015","unstructured":"J.-F. Ge, Y.-Y. Xu, N. Li, Y. Zhang, G.-L. Qiu, C.-H. Chu, C.-Y. Wang, G. Qin, F.-H. Chen, Resveratrol improved the spatial learning and memory in subclinical hypothyroidism rat induced by hemi-thyroid electrocauterization. Endocr. J. 62, 927\u2013938 (2015). https:\/\/doi.org\/10.1507\/endocrj.EJ15-0253","journal-title":"Endocr. J."},{"key":"3818_CR7","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/s0025-7125(16)30472-2","volume":"75","author":"PA Singer","year":"1991","unstructured":"P.A. Singer, Thyroiditis. Acute, subacute, and chronic. Med. Clin. North Am. 75, 61\u201377 (1991). https:\/\/doi.org\/10.1016\/s0025-7125(16)30472-2","journal-title":"Med. Clin. North Am."},{"key":"3818_CR8","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1152\/physrev.2001.81.3.1097","volume":"81","author":"PM Yen","year":"2001","unstructured":"P.M. Yen, Physiological and molecular basis of thyroid hormone action. Physiol. Rev. 81, 1097\u20131142 (2001). https:\/\/doi.org\/10.1152\/physrev.2001.81.3.1097","journal-title":"Physiol. Rev."},{"key":"3818_CR9","unstructured":"Thyroid Hormones, Oxidative Stress, and Inflammation (2016), https:\/\/www.hindawi.com\/journals\/mi\/2016\/6757154\/. Accessed 3 Aug 2023"},{"key":"3818_CR10","doi-asserted-by":"crossref","unstructured":"D. Sahoo, S. Jena, G. Chainy, Thyroid Dysfunction and Testicular Redox Status: An Intriguing Association. In Book Oxidants, Antioxidants, and Impact of the Oxidative Status in Male Reproduction, 1st edn. (Elsevier, 2018), pp. 149\u2013169","DOI":"10.1016\/B978-0-12-812501-4.00015-8"},{"key":"3818_CR11","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1515\/CCLM.2002.198","volume":"40","author":"U Resch","year":"2002","unstructured":"U. Resch, G. Helsel, F. Tatzber, H. Sinzinger, Antioxidant status in thyroid dysfunction. Clin. Chem. Lab. Med. 40, 1132\u20131134 (2002). https:\/\/doi.org\/10.1515\/CCLM.2002.198","journal-title":"Clin. Chem. Lab. Med."},{"key":"3818_CR12","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1055\/s-2005-870425","volume":"37","author":"LH Duntas","year":"2005","unstructured":"L.H. Duntas, Oxidants, antioxidants in physical exercise and relation to thyroid function. Horm. Metab. Res. 37, 572\u2013576 (2005). https:\/\/doi.org\/10.1055\/s-2005-870425","journal-title":"Horm. Metab. Res."},{"key":"3818_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/10715762.2019.1702656","volume":"54","author":"GBN Chainy","year":"2020","unstructured":"G.B.N. Chainy, D.K. Sahoo, Hormones and oxidative stress: an overview. Free Radic. Res. 54, 1\u201326 (2020). https:\/\/doi.org\/10.1080\/10715762.2019.1702656","journal-title":"Free Radic. Res."},{"key":"3818_CR14","unstructured":"katzung-pharmacology.pdf, (n.d.). https:\/\/pharmacomedicale.org\/images\/cnpm\/CNPM_2016\/katzung-pharmacology.pdf. Accessed 3 Sept 2023"},{"key":"3818_CR15","unstructured":"Levothyroxine: Uses, Dosage, Side Effects, Drugs.Com (n.d.). https:\/\/www.drugs.com\/levothyroxine.html. Accessed 12 Sept 2023"},{"key":"3818_CR16","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/S0140-6736(04)15696-1","volume":"363","author":"CGP Roberts","year":"2004","unstructured":"C.G.P. Roberts, P.W. Ladenson, Hypothyroidism. Lancet 363, 793\u2013803 (2004). https:\/\/doi.org\/10.1016\/S0140-6736(04)15696-1","journal-title":"Lancet"},{"issue":"Suppl","key":"3818_CR17","first-page":"21","volume":"59","author":"N Tandon","year":"2011","unstructured":"N. Tandon, Management of hypothyroidism in adults. J. Assoc. Phys. India 59(Suppl), 21\u201325 (2011)","journal-title":"J. Assoc. Phys. India"},{"key":"3818_CR18","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.foodchem.2017.11.012","volume":"246","author":"A Bento-Silva","year":"2018","unstructured":"A. Bento-Silva, M.C. Vaz Patto, M. do Ros\u00e1rio Bronze, Relevance, structure and analysis of ferulic acid in maize cell walls. Food Chem. 246, 360\u2013378 (2018). https:\/\/doi.org\/10.1016\/j.foodchem.2017.11.012","journal-title":"Food Chem."},{"key":"3818_CR19","doi-asserted-by":"publisher","first-page":"3660","DOI":"10.1021\/jf020028p","volume":"50","author":"P Mattila","year":"2002","unstructured":"P. Mattila, J. Kumpulainen, Determination of free and total phenolic acids in plant-derived foods by HPLC with diode-array detection. J. Agric. Food Chem. 50, 3660\u20133667 (2002). https:\/\/doi.org\/10.1021\/jf020028p","journal-title":"J. Agric. Food Chem."},{"key":"3818_CR20","unstructured":"Surface enhanced Raman spectroscopy of phenolic antioxidants: a systematic evaluation of ferulic acid, p-coumaric acid, caffeic acid and sinapic acid\u2014ScienceDirect (2017). https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0924203116302855. Accessed 5 Aug 2023"},{"key":"3818_CR21","doi-asserted-by":"publisher","unstructured":"G. Nunes Bezerra, M. Pereira, E. Ostrosky, E. Barbosa, M. Moura, M. Ferrari, C.F.S. Arag\u00e3o, A. Barreto Gomes, Compatibility study between ferulic acid and excipients used in cosmetic formulations by TG\/DTG, DSC and FTIR. J. Therm. Anal. Calorim. (2016). https:\/\/doi.org\/10.1007\/s10973-016-5654-9","DOI":"10.1007\/s10973-016-5654-9"},{"key":"3818_CR22","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.ejphar.2012.05.019","volume":"690","author":"M Ramar","year":"2012","unstructured":"M. Ramar, B. Manikandan, T. Raman, A. Priyadarsini, S. Palanisamy, M. Velayudam, A. Munusamy, N. Marimuthu Prabhu, B. Vaseeharan, Protective effect of ferulic acid and resveratrol against alloxan-induced diabetes in mice. Eur. J. Pharmacol. 690, 226\u2013235 (2012). https:\/\/doi.org\/10.1016\/j.ejphar.2012.05.019","journal-title":"Eur. J. Pharmacol."},{"key":"3818_CR23","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1111\/j.1473-2165.2008.00408.x","volume":"7","author":"C Oresajo","year":"2008","unstructured":"C. Oresajo, T. Stephens, P.D. Hino, R.M. Law, M. Yatskayer, P. Foltis, S. Pillai, S.R. Pinnell, Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photodamage in human skin. J. Cosmet. Dermatol. 7, 290\u2013297 (2008). https:\/\/doi.org\/10.1111\/j.1473-2165.2008.00408.x","journal-title":"J. Cosmet. Dermatol."},{"key":"3818_CR24","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1007\/s10753-016-0369-4","volume":"39","author":"F Gerin","year":"2016","unstructured":"F. Gerin, H. Erman, M. Erboga, U. Sener, A. Yilmaz, H. Seyhan, A. Gurel, The effects of ferulic acid against oxidative stress and inflammation in formaldehyde-induced hepatotoxicity. Inflammation 39, 1377\u20131386 (2016). https:\/\/doi.org\/10.1007\/s10753-016-0369-4","journal-title":"Inflammation"},{"key":"3818_CR25","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/s0895-7061(01)02337-8","volume":"15","author":"A Suzuki","year":"2002","unstructured":"A. Suzuki, D. Kagawa, A. Fujii, R. Ochiai, I. Tokimitsu, I. Saito, Short- and long-term effects of ferulic acid on blood pressure in spontaneously hypertensive rats. Am J Hypertens 15, 351\u2013357 (2002). https:\/\/doi.org\/10.1016\/s0895-7061(01)02337-8","journal-title":"Am J Hypertens"},{"key":"3818_CR26","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.2147\/DDDT.S237107","volume":"14","author":"M Roghani","year":"2020","unstructured":"M. Roghani, H. Kalantari, M.J. Khodayar, L. Khorsandi, M. Kalantar, M. Goudarzi, H. Kalantar, Alleviation of liver dysfunction, oxidative stress and inflammation underlies the protective effect of ferulic acid in methotrexate-induced hepatotoxicity. Drug Des. Dev. Ther. 14, 1933 (2020). https:\/\/doi.org\/10.2147\/DDDT.S237107","journal-title":"Drug Des. Dev. Ther."},{"key":"3818_CR27","unstructured":"Ferulic Acid Supplementation Improves Lipid Profiles, Oxidative Stress, and Inflammatory Status in Hyperlipidemic Subjects: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial (2018). https:\/\/pubmed.ncbi.nlm.nih.gov\/29865227\/. Accessed 5 Aug 2023"},{"key":"3818_CR28","doi-asserted-by":"publisher","first-page":"599","DOI":"10.17179\/excli2016-394","volume":"15","author":"PG Jain","year":"2016","unstructured":"P.G. Jain, S.J. Surana, Isolation, characterization and hypolipidemic activity of ferulic acid in high-fat-diet-induced hyperlipidemia in laboratory rats. EXCLI J 15, 599\u2013613 (2016). https:\/\/doi.org\/10.17179\/excli2016-394","journal-title":"EXCLI J"},{"key":"3818_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodcont.2022.108878","volume":"136","author":"R Ordo\u00f1ez","year":"2022","unstructured":"R. Ordo\u00f1ez, L. Atar\u00e9s, A. Chiralt, Antibacterial properties of cinnamic and ferulic acids incorporated to starch and PLA monolayer and multilayer films. Food Control 136, 108878 (2022). https:\/\/doi.org\/10.1016\/j.foodcont.2022.108878","journal-title":"Food Control"},{"key":"3818_CR30","doi-asserted-by":"publisher","first-page":"9437","DOI":"10.1007\/s13277-015-3689-3","volume":"36","author":"C Ero\u011flu","year":"2015","unstructured":"C. Ero\u011flu, M. Se\u00e7me, G. Ba\u011fc\u0131, Y. Dodurga, Assessment of the anticancer mechanism of ferulic acid via cell cycle and apoptotic pathways in human prostate cancer cell lines. Tumour Biol. 36, 9437\u20139446 (2015). https:\/\/doi.org\/10.1007\/s13277-015-3689-3","journal-title":"Tumour Biol."},{"key":"3818_CR31","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.bionut.2014.02.005","volume":"4","author":"M Vijayakumar","year":"2014","unstructured":"M. Vijayakumar, G. Jagadeesan, E. Bharathi, Ameliorative potential of ferulic acid on cardiotoxicity induced by mercuric chloride. Biomed. Prev. Nutr. 4, 239\u2013243 (2014). https:\/\/doi.org\/10.1016\/j.bionut.2014.02.005","journal-title":"Biomed. Prev. Nutr."},{"key":"3818_CR32","doi-asserted-by":"publisher","first-page":"5499","DOI":"10.2147\/DDDT.S90616","volume":"9","author":"S Ojha","year":"2015","unstructured":"S. Ojha, H. Javed, S. Azimullah, S.B. Abul Khair, M.E. Haque, Neuroprotective potential of ferulic acid in the rotenone model of Parkinson\u2019s disease. Drug Des. Dev. Ther. 9, 5499\u20135510 (2015). https:\/\/doi.org\/10.2147\/DDDT.S90616","journal-title":"Drug Des. Dev. Ther."},{"key":"3818_CR33","doi-asserted-by":"publisher","first-page":"2653","DOI":"10.3390\/cells10102653","volume":"10","author":"E-J Wang","year":"2021","unstructured":"E.-J. Wang, M.-Y. Wu, J.-H. Lu, Ferulic acid in animal models of alzheimer\u2019s disease: a systematic review of preclinical studies. Cells 10, 2653 (2021). https:\/\/doi.org\/10.3390\/cells10102653","journal-title":"Cells"},{"key":"3818_CR34","doi-asserted-by":"publisher","first-page":"5108","DOI":"10.3390\/ijms22105108","volume":"22","author":"E Habza-Kowalska","year":"2021","unstructured":"E. Habza-Kowalska, A.A. Kaczor, D. Bartuzi, J. Pi\u0142at, U. Gawlik-Dziki, Some dietary phenolic compounds can activate thyroid peroxidase and inhibit lipoxygenase-preliminary study in the model systems. Int. J. Mol. Sci. 22, 5108 (2021). https:\/\/doi.org\/10.3390\/ijms22105108","journal-title":"Int. J. Mol. Sci."},{"key":"3818_CR35","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1016\/j.toxrep.2020.06.002","volume":"7","author":"S Singh","year":"2020","unstructured":"S. Singh, V.S.S. Panda, P. Dande, Protective effect of a polyherbal bioactive fraction in propylthiouracil-induced thyroid toxicity in ratsby modulation of the hypothalamic\u2013pituitary\u2013thyroid and hypothalamic\u2013pituitary\u2013adrenal axes. Toxicol. Rep. 7, 730\u2013742 (2020). https:\/\/doi.org\/10.1016\/j.toxrep.2020.06.002","journal-title":"Toxicol. Rep."},{"key":"3818_CR36","doi-asserted-by":"publisher","unstructured":"S. Chowdhury, S. Ghosh, A.K. Das, P.C. Sil, Ferulic Acid Protects Hyperglycemia-Induced Kidney Damage by Regulating Oxidative Insult, Inflammation and Autophagy, Frontiers in Pharmacology 10 (2019). https:\/\/doi.org\/10.3389\/fphar.2019.00027. Accessed 5 Aug 2023","DOI":"10.3389\/fphar.2019.00027"},{"issue":"0","key":"3818_CR37","doi-asserted-by":"publisher","first-page":"0","DOI":"10.21608\/ejh.2019.16398.1159","volume":"0","author":"H EL-Tantawi","year":"2019","unstructured":"H. EL-Tantawi, F. Abozeid, Impact of Spirulina on Propylthiouracil-induced Hypothyroidism in Albino rats, a histological, immunohistochemical and biochemical approach. Egypt. J. Histol. 0(0), 0 (2019). https:\/\/doi.org\/10.21608\/ejh.2019.16398.1159","journal-title":"Egypt. J. Histol."},{"key":"3818_CR38","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.cbi.2008.11.006","volume":"177","author":"HS Parmar","year":"2009","unstructured":"H.S. Parmar, A. Kar, Protective role of Mangifera indica, Cucumis melo and Citrullus vulgaris peel extracts in chemically induced hypothyroidism. Chem. Biol. Interact. 177, 254\u2013258 (2009). https:\/\/doi.org\/10.1016\/j.cbi.2008.11.006","journal-title":"Chem. Biol. Interact."},{"key":"3818_CR39","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3526186","volume":"2017","author":"L Xiu","year":"2017","unstructured":"L. Xiu, G. Zhong, D. Liu, S. Chen, H. Liu, F. Chen, Comparative Efficacy and Toxicity of Different Species of Sargassum in Haizao Yuhu Decoction in PTU-Induced Goiter Rats. Evid. Based Complement. Alternat. Med. 2017, e3526186 (2017). https:\/\/doi.org\/10.1155\/2017\/3526186","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"3818_CR40","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OliverH Lowry","year":"1951","unstructured":"OliverH. Lowry, NiraJ. Rosebrough, A.L. Farr, RoseJ. Randall, Protein measurement with the folin phenol reagent. J. Biol. Chem. 193, 265\u2013275 (1951). https:\/\/doi.org\/10.1016\/S0021-9258(19)52451-6","journal-title":"J. Biol. Chem."},{"key":"3818_CR41","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"H. Ohkawa, N. Ohishi, K. Yagi, Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95, 351\u2013358 (1979). https:\/\/doi.org\/10.1016\/0003-2697(79)90738-3","journal-title":"Anal. Biochem."},{"key":"3818_CR42","unstructured":"Measurement of nitrate and nitrite in biological samples using nitrate reductase and Griess reaction (1996). https:\/\/pubmed.ncbi.nlm.nih.gov\/8782580\/. Accessed 19 Sept 2023"},{"key":"3818_CR43","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","volume":"82","author":"GL Ellman","year":"1959","unstructured":"G.L. Ellman, Tissue sulfhydryl groups. Arch. Biochem. Biophys. 82, 70\u201377 (1959). https:\/\/doi.org\/10.1016\/0003-9861(59)90090-6","journal-title":"Arch. Biochem. Biophys."},{"key":"3818_CR44","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/BF02712155","volume":"13","author":"A Nandi","year":"1988","unstructured":"A. Nandi, I.B. Chatterjee, Assay of superoxide dismutase activity in animal tissues. J. Biosci. 13, 305\u2013315 (1988). https:\/\/doi.org\/10.1007\/BF02712155","journal-title":"J. Biosci."},{"key":"3818_CR45","doi-asserted-by":"publisher","first-page":"767","DOI":"10.2337\/db06-1488","volume":"56","author":"WS da-Silva","year":"2007","unstructured":"W.S. da-Silva, J.W. Harney, B.W. Kim, J. Li, S.D.C. Bianco, A. Crescenzi, M.A. Christoffolete, S.A. Huang, A.C. Bianco, The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation. Diabetes 56, 767\u2013776 (2007). https:\/\/doi.org\/10.2337\/db06-1488","journal-title":"Diabetes"},{"key":"3818_CR46","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1177\/0192623313502708","volume":"42","author":"PR Nambiar","year":"2014","unstructured":"P.R. Nambiar, G.S. Palanisamy, C. Okerberg, A. Wolford, K. Walters, L. Buckbinder, W.J. Reagan, Toxicities associated with 1-month treatment with propylthiouracil (PTU) and methimazole (MMI) in male rats. Toxicol. Pathol. 42, 970\u2013983 (2014). https:\/\/doi.org\/10.1177\/0192623313502708","journal-title":"Toxicol. Pathol."},{"key":"3818_CR47","doi-asserted-by":"publisher","first-page":"113","DOI":"10.33762\/bvetr.2013.83631","volume":"12","author":"J Alkalby","year":"2013","unstructured":"J. Alkalby, S. J S, Effect of propylthiouracil-induced hypothyroidism on reproductive effeciency of adult male rats. Bas.j.Vet.Res 12, 113\u2013121 (2013). https:\/\/doi.org\/10.33762\/bvetr.2013.83631","journal-title":"Bas.j.Vet.Res"},{"key":"3818_CR48","doi-asserted-by":"publisher","first-page":"2323","DOI":"10.1038\/oby.2008.351","volume":"16","author":"Y Wang","year":"2008","unstructured":"Y. Wang, M.A. Beydoun, L. Liang, B. Caballero, S.K. Kumanyika, Will all Americans become overweight or obese? estimating the progression and cost of the US obesity epidemic. Obesity 16, 2323\u20132330 (2008). https:\/\/doi.org\/10.1038\/oby.2008.351","journal-title":"Obesity"},{"key":"3818_CR49","first-page":"496","volume":"48","author":"M Umezu","year":"1998","unstructured":"M. Umezu, S. Kagabu, J. Jiang, E. Sato, Evaluation and characterization of congenital hypothyroidism in rdw dwarf rats. Lab Anim Sci 48, 496\u2013501 (1998)","journal-title":"Lab Anim Sci"},{"key":"3818_CR50","doi-asserted-by":"publisher","first-page":"76","DOI":"10.2174\/1874192401105010076","volume":"5","author":"CV Rizos","year":"2011","unstructured":"C.V. Rizos, M.S. Elisaf, E.N. Liberopoulos, Effects of thyroid dysfunction on lipid profile. Open Cardiovasc. Med. J. 5, 76\u201384 (2011). https:\/\/doi.org\/10.2174\/1874192401105010076","journal-title":"Open Cardiovasc. Med. J."},{"key":"3818_CR51","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1000739","volume":"13","author":"X-D Yang","year":"2022","unstructured":"X.-D. Yang, X.-C. Ge, S.-Y. Jiang, Y.-Y. Yang, Potential lipolytic regulators derived from natural products as effective approaches to treat obesity. Front. Endocrinol. 13, 1000739 (2022). https:\/\/doi.org\/10.3389\/fendo.2022.1000739","journal-title":"Front. Endocrinol."},{"key":"3818_CR52","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1017\/S146479310000556X","volume":"75","author":"AJ Hulbert","year":"2000","unstructured":"A.J. Hulbert, Thyroid hormones and their effects: a new perspective. Biol. Rev. 75, 519\u2013631 (2000). https:\/\/doi.org\/10.1017\/S146479310000556X","journal-title":"Biol. Rev."},{"key":"3818_CR53","doi-asserted-by":"publisher","first-page":"10067","DOI":"10.1073\/pnas.1633737100","volume":"100","author":"GJ Grover","year":"2003","unstructured":"G.J. Grover, K. Mellstr\u00f6m, L. Ye, J. Malm, Y.-L. Li, L.-G. Bladh, P.G. Sleph, M.A. Smith, R. George, B. Vennstr\u00f6m, K. Mookhtiar, R. Horvath, J. Speelman, D. Egan, J.D. Baxter, Selective thyroid hormone receptor-\u03b2 activation: a strategy for reduction of weight, cholesterol, and lipoprotein (a) with reduced cardiovascular liability. Proc. Natl Acad. Sci. 100, 10067\u201310072 (2003). https:\/\/doi.org\/10.1073\/pnas.1633737100","journal-title":"Proc. Natl Acad. Sci."},{"key":"3818_CR54","doi-asserted-by":"publisher","first-page":"15490","DOI":"10.1073\/pnas.0702759104","volume":"104","author":"MD Erion","year":"2007","unstructured":"M.D. Erion, E.E. Cable, B.R. Ito, H. Jiang, J.M. Fujitaki, P.D. Finn, B.-H. Zhang, J. Hou, S.H. Boyer, P.D. van Poelje, D.L. Linemeyer, Targeting thyroid hormone receptor-\u03b2 agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index. Proc. Natl Acad. Sci. 104, 15490\u201315495 (2007). https:\/\/doi.org\/10.1073\/pnas.0702759104","journal-title":"Proc. Natl Acad. Sci."},{"key":"3818_CR55","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1006\/bbrc.1998.9174","volume":"249","author":"O Bakker","year":"1998","unstructured":"O. Bakker, F. Hudig, S. Meijssen, W.M. Wiersinga, Effects of triiodothyronine and amiodarone on the promoter of the human LDL receptor gene. Biochem. Biophys. Res. Commun. 249, 517\u2013521 (1998). https:\/\/doi.org\/10.1006\/bbrc.1998.9174","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"3818_CR56","doi-asserted-by":"publisher","unstructured":"H. Liu, D. Peng, Update on dyslipidemia in hypothyroidism: the mechanism of dyslipidemia in hypothyroidism, Endocrine Connections 11 (2022). https:\/\/doi.org\/10.1530\/EC-21-0002","DOI":"10.1530\/EC-21-0002"},{"key":"3818_CR57","first-page":"513","volume":"59","author":"KS Lam","year":"1986","unstructured":"K.S. Lam, M.K. Chan, R.T. Yeung, High-density lipoprotein cholesterol, hepatic lipase and lipoprotein lipase activities in thyroid dysfunction\u2013effects of treatment. Q J Med 59, 513\u2013521 (1986)","journal-title":"Q J Med"},{"key":"3818_CR58","doi-asserted-by":"publisher","unstructured":"M. R, H. H, The relationship between the thyroid gland and the liver, QJM: Monthly Journal of the Association of Physicians 95 (2002). https:\/\/doi.org\/10.1093\/qjmed\/95.9.559","DOI":"10.1093\/qjmed\/95.9.559"},{"key":"3818_CR59","unstructured":"Hepatic injury during propylthiouracil therapy in patients with hyperthyroidism. A cohort study (1993), https:\/\/pubmed.ncbi.nlm.nih.gov\/8439116\/. Accessed 5 Aug 2023"},{"key":"3818_CR60","doi-asserted-by":"crossref","unstructured":"Propylthiouracil-induced acute liver failure: role of liver transplantation (2010), https:\/\/pubmed.ncbi.nlm.nih.gov\/21234410\/. Accessed 5 Aug 2023","DOI":"10.1155\/2010\/910636"},{"key":"3818_CR61","unstructured":"Administration of Nigella sativa during neonatal and juvenile growth period improved liver function of propylthiouracil\u2014induced hypothyroid rats (2020), https:\/\/pubmed.ncbi.nlm.nih.gov\/30189756\/. Accessed 5 Aug 2023"},{"key":"3818_CR62","doi-asserted-by":"publisher","unstructured":"A. Yadav, S. Arora, V. Saini, M.K. Arora, R. Singh, J. Bhattacharjee, Influence of thyroid hormones on biochemical parameters of liver function: a case-control study in North Indian population. Int. J. Med. Update-EJOURNAL 8 (2013). https:\/\/doi.org\/10.4314\/ijmu.v8i1","DOI":"10.4314\/ijmu.v8i1"},{"key":"3818_CR63","doi-asserted-by":"publisher","first-page":"645","DOI":"10.4103\/ijem.IJEM_25_18","volume":"22","author":"P Punekar","year":"2018","unstructured":"P. Punekar, A.K. Sharma, A. Jain, A study of thyroid dysfunction in cirrhosis of liver and correlation with severity of liver disease. Indian J. Endocrinol. Metab. 22, 645\u2013650 (2018). https:\/\/doi.org\/10.4103\/ijem.IJEM_25_18","journal-title":"Indian J. Endocrinol. Metab."},{"key":"3818_CR64","doi-asserted-by":"publisher","first-page":"4593","DOI":"10.1039\/c9fo00114j","volume":"10","author":"AM Mahmoud","year":"2019","unstructured":"A.M. Mahmoud, O.E. Hussein, S.M. Abd El-Twab, W.G. Hozayen, Ferulic acid protects against methotrexate nephrotoxicity via activation of Nrf2\/ARE\/HO-1 signaling and PPAR\u03b3, and suppression of NF-\u03baB\/NLRP3 inflammasome axis. Food Funct. 10, 4593\u20134607 (2019). https:\/\/doi.org\/10.1039\/c9fo00114j","journal-title":"Food Funct."},{"key":"3818_CR65","doi-asserted-by":"publisher","DOI":"10.1177\/09603271221136205","volume":"41","author":"MA Esmat","year":"2022","unstructured":"M.A. Esmat, A. Osman, R.E. Hassan, S.A. Hagag, T.K. El-maghraby, Hepatoprotective effect of ferulic acid and\/or low doses of \u03b3-irradiation against cisplatin-induced liver injury in rats. Hum Exp Toxicol 41, 09603271221136205 (2022). https:\/\/doi.org\/10.1177\/09603271221136205","journal-title":"Hum Exp Toxicol"},{"key":"3818_CR66","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-019-0517-x","volume":"26","author":"H-C Chi","year":"2019","unstructured":"H.-C. Chi, C.-Y. Tsai, M.-M. Tsai, C.-T. Yeh, K.-H. Lin, Molecular functions and clinical impact of thyroid hormone-triggered autophagy in liver-related diseases. J. Biomed. Sci. 26, 24 (2019). https:\/\/doi.org\/10.1186\/s12929-019-0517-x","journal-title":"J. Biomed. Sci."},{"key":"3818_CR67","doi-asserted-by":"publisher","unstructured":"A.G. Cicatiello, D. Di Girolamo, M. Dentice, Metabolic Effects of the Intracellular Regulation of Thyroid Hormone: Old Players, New Concepts, Frontiers in Endocrinology 9 (2018), https:\/\/doi.org\/10.3389\/fendo.2018.00474. Accessed 17 Sept 2023","DOI":"10.3389\/fendo.2018.00474"},{"key":"3818_CR68","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1055\/s-0029-1210336","volume":"83","author":"H Br\u00e4unlich","year":"1984","unstructured":"H. Br\u00e4unlich, Postnatal development of kidney function in rats receiving thyroid hormones. Exp Clin Endocrinol 83, 243\u2013250 (1984). https:\/\/doi.org\/10.1055\/s-0029-1210336","journal-title":"Exp Clin Endocrinol"},{"key":"3818_CR69","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1530\/eje.1.02093","volume":"154","author":"F Vargas","year":"2006","unstructured":"F. Vargas, J.M. Moreno, I. Rodr\u00edguez-G\u00f3mez, R. Wangensteen, A. Osuna, M. Alvarez-Guerra, J. Garc\u00eda-Esta\u00f1, Vascular and renal function in experimental thyroid disorders. Eur J Endocrinol 154, 197\u2013212 (2006). https:\/\/doi.org\/10.1530\/eje.1.02093","journal-title":"Eur J Endocrinol"},{"key":"3818_CR70","unstructured":"Increased prevalence of renal and urinary tract anomalies in children with congenital hypothyroidism (2009). https:\/\/pubmed.ncbi.nlm.nih.gov\/18823909\/. Accessed 5 Aug 2023"},{"key":"3818_CR71","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.clinbiochem.2011.10.012","volume":"45","author":"V Saini","year":"2012","unstructured":"V. Saini, A. Yadav, M.K. Arora, S. Arora, R. Singh, J. Bhattacharjee, Correlation of creatinine with TSH levels in overt hypothyroidism - a requirement for monitoring of renal function in hypothyroid patients? Clin. Biochem. 45, 212\u2013214 (2012). https:\/\/doi.org\/10.1016\/j.clinbiochem.2011.10.012","journal-title":"Clin. Biochem."},{"key":"3818_CR72","doi-asserted-by":"publisher","first-page":"674","DOI":"10.4103\/2230-8210.190555","volume":"20","author":"SK Chakrabarti","year":"2016","unstructured":"S.K. Chakrabarti, S. Ghosh, S. Banerjee, S. Mukherjee, S. Chowdhury, Oxidative stress in hypothyroid patients and the role of antioxidant supplementation. Indian J. Endocrinol. Metab. 20, 674\u2013678 (2016). https:\/\/doi.org\/10.4103\/2230-8210.190555","journal-title":"Indian J. Endocrinol. Metab."},{"key":"3818_CR73","doi-asserted-by":"publisher","first-page":"4175","DOI":"10.1210\/jc.2006-0440","volume":"91","author":"A Dardano","year":"2006","unstructured":"A. Dardano, L. Ghiadoni, Y. Plantinga, N. Caraccio, A. Bemi, E. Duranti, S. Taddei, E. Ferrannini, A. Salvetti, F. Monzani, Recombinant human thyrotropin reduces endothelium-dependent vasodilation in patients monitored for differentiated thyroid carcinoma. J. Clin. Endocrinol. Metab. 91, 4175\u20134178 (2006). https:\/\/doi.org\/10.1210\/jc.2006-0440","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"3818_CR74","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1055\/s-2007-981457","volume":"115","author":"G Baskol","year":"2007","unstructured":"G. Baskol, H. Atmaca, F. Tanriverdi, M. Baskol, D. Kocer, F. Bayram, Oxidative stress and enzymatic antioxidant status in patients with hypothyroidism before and after treatment. Exp. Clin. Endocrinol. Diabetes 115, 522\u2013526 (2007). https:\/\/doi.org\/10.1055\/s-2007-981457","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"3818_CR75","first-page":"63","volume":"5","author":"L JhansiLakshmi","year":"2013","unstructured":"L. JhansiLakshmi, M. Eli, Z. Doddigarla, S. Kumari, Serum lipids and oxidative stress in hypothyroidism.J. Adv. Res. Biol. Sci. 5, 63\u201366 (2013)","journal-title":"J. Adv. Res. Biol. Sci."},{"key":"3818_CR76","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.mce.2011.05.047","volume":"343","author":"C Massart","year":"2011","unstructured":"C. Massart, C. Hoste, A. Virion, J. Ruf, J.E. Dumont, J. Van Sande, Cell biology of H2O2 generation in the thyroid: investigation of the control of dual oxidases (DUOX) activity in intact ex vivo thyroid tissue and cell lines. Mol. Cell Endocrinol. 343, 32\u201344 (2011). https:\/\/doi.org\/10.1016\/j.mce.2011.05.047","journal-title":"Mol. Cell Endocrinol."},{"key":"3818_CR77","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.3390\/antiox9111082","volume":"9","author":"C Thanas","year":"2020","unstructured":"C. Thanas, P.G. Ziros, D.V. Chartoumpekis, C.O. Renaud, G.P. Sykiotis, The Keap1\/Nrf2 signaling pathway in the thyroid-2020 update. Antioxidants 9, 1082 (2020). https:\/\/doi.org\/10.3390\/antiox9111082","journal-title":"Antioxidants"},{"key":"3818_CR78","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1258\/ebm.2009.009241","volume":"235","author":"H Ohye","year":"2010","unstructured":"H. Ohye, M. Sugawara, Dual oxidase, hydrogen peroxide and thyroid diseases. Exp. Biol. Med. 235, 424\u2013433 (2010). https:\/\/doi.org\/10.1258\/ebm.2009.009241","journal-title":"Exp. Biol. Med."},{"key":"3818_CR79","doi-asserted-by":"publisher","first-page":"R31","DOI":"10.1530\/JOE-13-0588","volume":"221","author":"RS Fortunato","year":"2014","unstructured":"R.S. Fortunato, A.C.F. Ferreira, F. Hecht, C. Dupuy, D.P. Carvalho, Sexual dimorphism and thyroid dysfunction: a matter of oxidative stress? J. Endocrinol. 221, R31\u201340 (2014). https:\/\/doi.org\/10.1530\/JOE-13-0588","journal-title":"J. Endocrinol."},{"key":"3818_CR80","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.12853","volume":"43","author":"M Mohibbullah","year":"2019","unstructured":"M. Mohibbullah, K.M.I. Bashir, S.-K. Kim, Y.-K. Hong, A. Kim, S.-K. Ku, J.-S. Choi, Protective effects of a mixed plant extracts derived from Astragalus membranaceus and Laminaria japonica on PTU-induced hypothyroidism and liver damages. J. Food Biochem. 43, e12853 (2019). https:\/\/doi.org\/10.1111\/jfbc.12853","journal-title":"J. Food Biochem."},{"key":"3818_CR81","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6757154","volume":"2016","author":"A Mancini","year":"2016","unstructured":"A. Mancini, C. Di Segni, S. Raimondo, G. Olivieri, A. Silvestrini, E. Meucci, D. Curr\u00f2, Thyroid hormones, oxidative stress, and inflammation. Mediators Inflamm. 2016, 6757154 (2016). https:\/\/doi.org\/10.1155\/2016\/6757154","journal-title":"Mediators Inflamm."},{"key":"3818_CR82","doi-asserted-by":"publisher","first-page":"886","DOI":"10.4103\/ijem.IJEM_265_17","volume":"21","author":"PS Tayde","year":"2017","unstructured":"P.S. Tayde, N.M. Bhagwat, P. Sharma, B. Sharma, P.P. Dalwadi, A. Sonawane, A. Subramanyam, M. Chadha, P.K. Varthakavi, Hypothyroidism and depression: are cytokines the link? Indian J. Endocrinol. Metab. 21, 886\u2013892 (2017). https:\/\/doi.org\/10.4103\/ijem.IJEM_265_17","journal-title":"Indian J. Endocrinol. Metab."},{"key":"3818_CR83","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1507\/endocrj.k10e-333","volume":"58","author":"EE T\u00fcremen","year":"2011","unstructured":"E.E. T\u00fcremen, B. \u00c7etinarslan, T. \u015eahin, Z. Cant\u00fcrk, \u0130. Tarkun, Endothelial dysfunction and low grade chronic inflammation in subclinical hypothyroidism due to autoimmune thyroiditis. Endocr. J. 58, 349\u2013354 (2011). https:\/\/doi.org\/10.1507\/endocrj.k10e-333","journal-title":"Endocr. J."},{"key":"3818_CR84","doi-asserted-by":"publisher","first-page":"3637","DOI":"10.1007\/s11033-019-04721-x","volume":"46","author":"KG Abdel-Wahhab","year":"2019","unstructured":"K.G. Abdel-Wahhab, H.H. Mourad, F.A. Mannaa, F.A. Morsy, L.K. Hassan, R.F. Taher, Role of ashwagandha methanolic extract in the regulation of thyroid profile in hypothyroidism modeled rats. Mol. Biol. Rep. 46, 3637\u20133649 (2019). https:\/\/doi.org\/10.1007\/s11033-019-04721-x","journal-title":"Mol. Biol. Rep."},{"key":"3818_CR85","doi-asserted-by":"publisher","DOI":"10.1016\/j.phyplu.2022.100298","volume":"2","author":"A Kar","year":"2022","unstructured":"A. Kar, S. Panda, M. Singh, S. Biswas, Regulation of PTU-induced hypothyroidism in rats by caffeic acid primarily by activating thyrotropin receptors and by inhibiting oxidative stress. Phytomed. Plus 2, 100298 (2022). https:\/\/doi.org\/10.1016\/j.phyplu.2022.100298","journal-title":"Phytomed. Plus"}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-024-03818-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12020-024-03818-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-024-03818-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T05:36:52Z","timestamp":1727761012000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12020-024-03818-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,18]]},"references-count":85,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["3818"],"URL":"https:\/\/doi.org\/10.1007\/s12020-024-03818-z","relation":{},"ISSN":["1559-0100"],"issn-type":[{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,18]]},"assertion":[{"value":"7 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}