{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T08:19:12Z","timestamp":1793434752622,"version":"4.5.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T00:00:00Z","timestamp":1714780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T00:00:00Z","timestamp":1714780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["307576\/2022-1"],"award-info":[{"award-number":["307576\/2022-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"DOI":"10.1007\/s12020-024-03840-1","type":"journal-article","created":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T13:01:37Z","timestamp":1714827697000},"page":"1116-1124","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Skin assessment in congenital untreated isolated GH deficiency"],"prefix":"10.1007","volume":"84","author":[{"given":"Cynthia S.","family":"Barros-Oliveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Joseli Melo","family":"de Jesus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane C.","family":"Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Salvatori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano Antunes","family":"de Souza Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto Fernandes Soares","family":"Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Bartke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanderlan O.","family":"Batista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keila R.","family":"Villar-Gouy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal M.","family":"Masternak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c2ngela C.","family":"Leal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas B.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla R. P.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elenilde G.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davi A.","family":"Oliveira Sim\u00f5es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"de Santana Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel H.","family":"Aguiar-Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,4]]},"reference":[{"issue":"2","key":"3840_CR1","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1210\/er.2018-00216","volume":"40","author":"MH Aguiar-Oliveira","year":"2019","unstructured":"M.H. Aguiar-Oliveira, A. Bartke, Growth hormone deficiency: health and longevity. Endocr Rev 40(2), 575\u2013601 (2019). https:\/\/doi.org\/10.1210\/er.2018-00216","journal-title":"Endocr Rev"},{"key":"3840_CR2","doi-asserted-by":"publisher","first-page":"101469","DOI":"10.1016\/j.ghir.2022.101469","volume":"65","author":"LA Oliveira-Neto","year":"2022","unstructured":"L.A. Oliveira-Neto, J.K.F. Nascimento, R. Salvatori, A.A. Oliveira-Santos, R.S. Gir\u00e3o, E.V. Silva, A.L.M. Santos, M.M. Cunha, M.A.V. Bittencourt, G.T. Rodrigues, B.M.R. Andrade, A.H.A. Oliveira, E.H.O. Valen\u00e7a, M.H. Aguiar-Oliveira, Growth of teeth and bones in adult subjects with congenital untreated isolated growth hormone deficiency. Growth Horm IGF Res 65, 101469 (2022). https:\/\/doi.org\/10.1016\/j.ghir.2022.101469","journal-title":"Growth Horm IGF Res"},{"issue":"2","key":"3840_CR3","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1111\/srt.12424","volume":"24","author":"AK D\u0105browska","year":"2018","unstructured":"A.K. D\u0105browska, F. Spano, S. Derler, C. Adlhart, N.D. Spencer, R.M. Rossi, The relationship between skin function, barrier properties, and body-dependent factors. Skin Res Technol 24(2), 165\u2013174 (2018). https:\/\/doi.org\/10.1111\/srt.12424","journal-title":"Skin Res Technol"},{"issue":"5","key":"3840_CR4","doi-asserted-by":"publisher","first-page":"250","DOI":"10.4161\/derm.1.5.9499","volume":"1","author":"CC Zouboulis","year":"2009","unstructured":"C.C. Zouboulis, The skin as an endocrine organ. Dermatoendocrinol 1(5), 250\u2013252 (2009). https:\/\/doi.org\/10.4161\/derm.1.5.9499","journal-title":"Dermatoendocrinol"},{"issue":"1","key":"3840_CR5","doi-asserted-by":"publisher","first-page":"9","DOI":"10.14310\/horm.2002.11109","volume":"3","author":"CC Zouboulis","year":"2004","unstructured":"C.C. Zouboulis, The human skin as a hormone target and an endocrine gland. Hormones (Athens) 3(1), 9\u201326 (2004). https:\/\/doi.org\/10.14310\/horm.2002.11109","journal-title":"Hormones (Athens)"},{"issue":"3","key":"3840_CR6","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/s11154-016-9378-8","volume":"17","author":"C Kanaka-Gantenbein","year":"2016","unstructured":"C. Kanaka-Gantenbein, C. Kogia, M.B. Abdel-Naser, G.P. Chrousos, Skin manifestations of growth hormone-induced diseases. Rev Endocr Metab Disord 17(3), 259\u2013267 (2016). https:\/\/doi.org\/10.1007\/s11154-016-9378-8","journal-title":"Rev Endocr Metab Disord"},{"issue":"3","key":"3840_CR7","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1111\/1523-1747","volume":"99","author":"A Tavakkol","year":"1992","unstructured":"A. Tavakkol, J.T. Elder, C.E. Griffiths, K.D. Cooper, H. Talwar, G.J. Fisher, K.M. Keane, S.K. Foltin, J.J. Voorhees, Expression of growth hormone receptor, insulin-like growth factor 1 (IGF-1) and IGF-1 receptor mRNA and proteins in human skin. J Invest Dermatol 99(3), 343\u2013349 (1992). https:\/\/doi.org\/10.1111\/1523-1747","journal-title":"J Invest Dermatol"},{"issue":"4","key":"3840_CR8","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.clindermatol.2006.04.011","volume":"24","author":"A Ben-Shlomo","year":"2006","unstructured":"A. Ben-Shlomo, S. Melmed, Skin manifestations in acromegaly. Clin Dermatol 24(4), 256\u2013259 (2006). https:\/\/doi.org\/10.1016\/j.clindermatol.2006.04.011","journal-title":"Clin Dermatol"},{"issue":"2","key":"3840_CR9","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.ghir.2012.02.006","volume":"22","author":"M Borlu","year":"2012","unstructured":"M. Borlu, Z. Karaca, H. Yildiz, F. Tanriverdi, B. Demirel, G. Elbuken, I. Cakir, H.S. Dokmetas, R. Colak, K. Unluhizarci, F. Kelestimur, Acromegaly is associated with decreased skin transepidermal water loss and temperature, and increased skin pH and sebum secretion partially reversible after treatment. Growth Horm IGF Res 22(2), 82\u201386 (2012). https:\/\/doi.org\/10.1016\/j.ghir.2012.02.006","journal-title":"Growth Horm IGF Res"},{"issue":"2","key":"3840_CR10","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1159\/000525069","volume":"14","author":"FA Khamdan","year":"2022","unstructured":"F.A. Khamdan, M.A. Shah, M.A. Khamdan, E. Albasri, Acromegaly presenting with resistant acne vulgaris. Case Rep Dermatol 14(2), 151\u2013156 (2022). https:\/\/doi.org\/10.1159\/000525069","journal-title":"Case Rep Dermatol"},{"issue":"4","key":"3840_CR11","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1210\/edrv.21.4.0404","volume":"21","author":"D Deplewski","year":"2000","unstructured":"D. Deplewski, R.L. Rosenfield, Role of hormones in pilosebaceous unit development. Endocr Rev 21(4), 363\u2013392 (2000). https:\/\/doi.org\/10.1210\/edrv.21.4.0404","journal-title":"Endocr Rev"},{"issue":"2","key":"3840_CR12","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1530\/eje.0.1450147","volume":"145","author":"M Lange","year":"2001","unstructured":"M. Lange, J. Thulesen, U. Feldt-Rasmussen, N.E. Skakkebaek, N. Vahl, J.O. J\u00f8rgensen, J.S. Christiansen, S.S. Poulsen, S.B. Sneppen, A. Juul, Skin morphological changes in growth hormone deficiency and acromegaly. Eur J Endocrinol 145(2), 147\u2013153 (2001). https:\/\/doi.org\/10.1530\/eje.0.1450147","journal-title":"Eur J Endocrinol"},{"issue":"3","key":"3840_CR13","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1007\/s12020-014-0276-0","volume":"47","author":"F Tanriverdi","year":"2014","unstructured":"F. Tanriverdi, Z. Karaca, K. Unluhizarci, F. Kelestimur, Unusual effects of GH deficiency in adults: a review about the effects of GH on skin, sleep, and coagulation. Endocrine 47(3), 679\u2013689 (2014). https:\/\/doi.org\/10.1007\/s12020-014-0276-0","journal-title":"Endocrine"},{"issue":"3","key":"3840_CR14","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1210\/jcem.84.3.5599","volume":"84","author":"R Salvatori","year":"1999","unstructured":"R. Salvatori, C.Y. Hayashida, M.H. Aguiar-Oliveira, J.A. Phillips, A.H.O. Souza, R.G. Gondo, S.P.A. Toledo, M.M. Concei\u00e7\u00e3o, M. Prince, H.G. Maheshwari, G. Baumann, M.A. Levine, Familial Dwarfism due to a novel mutation of the growth hormone-releasing hormone receptor gene. J Clin Endocrinol Metab 84(3), 917\u2013923 (1999). https:\/\/doi.org\/10.1210\/jcem.84.3.5599","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"3840_CR15","doi-asserted-by":"publisher","first-page":"4118","DOI":"10.1210\/jcem.84.11.6133","volume":"84","author":"MH Aguiar-Oliveira","year":"1999","unstructured":"M.H. Aguiar-Oliveira, M.S. Gill, A. de, E.S. Barretto, M.R. Alc\u00e2ntara, F. Miraki-Moud, C.A. Menezes, A.H. Souza, C.E. Martinelli, F.A. Pereira, R. Salvatori, M.A. Levine, S.M. Shalet, C. Camacho-Hubner, P.E. Clayton, Effect of severe growth hormone (GH) deficiency due to a mutation in the GH-releasing hormone receptor on insulin-like growth factors (IGFs), IGF-binding proteins, and ternary complex formation throughout life. J Clin Endocrinol Metab 84(11), 4118\u20134126 (1999). https:\/\/doi.org\/10.1210\/jcem.84.11.6133","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"3840_CR16","doi-asserted-by":"publisher","first-page":"919","DOI":"10.20945\/2359-3997000000567","volume":"66","author":"MH Aguiar-Oliveira","year":"2022","unstructured":"M.H. Aguiar-Oliveira, R. Salvatori, The state of Sergipe contribution to GH research: from Souza Leite to Itabaianinha syndrome. Arch Endocrinol Metab 66(6), 919\u2013928 (2022). https:\/\/doi.org\/10.20945\/2359-3997000000567","journal-title":"Arch Endocrinol Metab"},{"issue":"2","key":"3840_CR17","doi-asserted-by":"publisher","first-page":"R85","DOI":"10.1530\/EJE-16-1047","volume":"177","author":"MH Aguiar-Oliveira","year":"2017","unstructured":"M.H. Aguiar-Oliveira, A.H.O. Souza, C.R.P. Oliveira, V.C. Campos, L.A. Oliveira-Neto, R. Salvatori, MECHANISMS IN ENDOCRINOLOGY: The multiple facets of GHRH\/GH\/IGF-I axis: lessons from lifetime, untreated, isolated GH deficiency due to a GHRH receptor gene mutation. Eur J Endocrinol 177(2), R85\u2013R97 (2017). https:\/\/doi.org\/10.1530\/EJE-16-1047","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"3840_CR18","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s11154-020-09591-4","volume":"22","author":"MH Aguiar-Oliveira","year":"2021","unstructured":"M.H. Aguiar-Oliveira, R. Salvatori, Disruption of the GHRH receptor and its impact on children and adults: the Itabaianinha syndrome. Rev Endocr Metab Disord 22(1), 81\u201389 (2021). https:\/\/doi.org\/10.1007\/s11154-020-09591-4","journal-title":"Rev Endocr Metab Disord"},{"key":"3840_CR19","doi-asserted-by":"publisher","first-page":"3285","DOI":"10.1210\/jc.2014-2132","volume":"99","author":"E Gomes-Santos","year":"2014","unstructured":"E. Gomes-Santos, R. Salvatori, T.O. Ferrao, C.R. Oliveira, R.D. Diniz, J.A. Santana et al. Increased visceral adiposity and cortisol to cortisone ratio in adults with congenital lifetime isolated GH deficiency. J Clin Endocrinol Metab 99, 3285\u20133289 (2014)","journal-title":"J Clin Endocrinol Metab"},{"key":"3840_CR20","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1210\/jc.2005-2555","volume":"91","author":"MR Alc\u00e2ntara","year":"2006","unstructured":"M.R. Alc\u00e2ntara, R. Salvatori, P.R. Alc\u00e2ntara, L.M. N\u00f3brega, V.S. Campos, E.C. Oliveira et al. Thyroid morphology and function in adults with untreated isolated growth hormone deficiency. J Clin Endocrinol Metab 91, 860\u2013864 (2006)","journal-title":"J Clin Endocrinol Metab"},{"key":"3840_CR21","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s12020-013-9896-z","volume":"44","author":"M Menezes","year":"2013","unstructured":"M. Menezes, R. Salvatori, L.D. Melo, I.E. Rocha, C.R. Oliveira, R.M. Pereira et al. Prolactin and sex steroids levels in congenital lifetime isolated GH deficiency. Endocrine 44, 207\u2013211 (2013)","journal-title":"Endocrine"},{"issue":"2","key":"3840_CR22","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1210\/jc.2009-1879","volume":"95","author":"MH Aguiar-Oliveira","year":"2010","unstructured":"M.H. Aguiar-Oliveira, F.T. Oliveira, R.M. Pereira, C.R. Oliveira, A. Blackford, E.H. Valenca, E.G. Santos, M.B. Gois-Junior, R.A. Meneguz-Moreno, V.P. Araujo, L.A. Oliveira-Neto, R.P. Almeida, M.A. Santos, N.T. Farias, D.C. Silveira, G.W. Cabral, F.R. Calazans, J.D. Seabra, T.F. Lopes, E.O. Rodrigues, L.A. Porto, I.P. Oliveira, E.V. Melo, M. Martari, R. Salvatori, Longevity in untreated congenital growth hormone deficiency due to a homozygous mutation in the GHRH receptor gene. J Clin Endocrinol Metab 95(2), 714\u2013721 (2010). https:\/\/doi.org\/10.1210\/jc.2009-1879","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"3840_CR23","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1016\/j.psyneuen.2009.01.001","volume":"34","author":"JA Barbosa","year":"2009","unstructured":"J.A. Barbosa, R. Salvatori, C.R. Oliveira, R.M. Pereira, C.T. Farias, A.V. Britto, N.T. Farias, A. Blackford, M.H. Aguiar-Oliveira, Quality of life in congenital, untreated, lifetime isolated growth hormone deficiency. Psychoneuroendocrinology 34(6), 894\u2013900 (2009). https:\/\/doi.org\/10.1016\/j.psyneuen.2009.01.001","journal-title":"Psychoneuroendocrinology"},{"issue":"1","key":"3840_CR24","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1007\/s12020-018-1763-5","volume":"63","author":"AL Andrade-Guimar\u00e3es","year":"2019","unstructured":"A.L. Andrade-Guimar\u00e3es, M.H. Aguiar-Oliveira, R. Salvatori, V.O. Carvalho, F. Alvim-Pereira, C.R.A. Daniel, G.A.M. Brasileiro, A.A. Santana-Ribeiro, H.A. Santos-Carvalho, C.R.P. Oliveira, E.R. Vieira, M.B. Gois-Junior, Adult individuals with congenital, untreated, severe isolated growth hormone deficiency have satisfactory muscular function. Endocrine 63(1), 112\u2013119 (2019). https:\/\/doi.org\/10.1007\/s12020-018-1763-5","journal-title":"Endocrine"},{"key":"3840_CR25","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.ghir.2018.03.004","volume":"41","author":"CG Marinho","year":"2018","unstructured":"C.G. Marinho, L.M. Mermejo, R. Salvatori, J.A.Junior Assirati, C.R.P. Oliveira, E.G. Santos, \u00c2.C.G.B. Leal, C.S. Barros-Oliveira, N.P. Damascena, C.A. Lima, C.T. Farias, A.C. Moreira, M.H. Aguiar-Oliveira, Occurrence of neoplasms in individuals with congenital, severe GH deficiency from the Itabaianinha kindred. Growth Horm IGF Res 41, 71\u201374 (2018). https:\/\/doi.org\/10.1016\/j.ghir.2018.03.004","journal-title":"Growth Horm IGF Res"},{"issue":"3","key":"3840_CR26","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1007\/s12020-019-01998-7","volume":"65","author":"CS Barros-Oliveira","year":"2019","unstructured":"C.S. Barros-Oliveira, R. Salvatori, J.S.S. Dos Santos, P.F.C. Santos, A.A. Oliveira-Santos, C.G. Marinho, E.G. Santos, \u00c2.C.G.B. Leal, V.C. Campos, N.P. Damascena, C.R.P. Oliveira, M.H. Aguiar-Oliveira, Sweat and vitamin D status in congenital, lifetime, untreated GH deficiency. Endocrine 65(3), 710\u2013713 (2019). https:\/\/doi.org\/10.1007\/s12020-019-01998-7","journal-title":"Endocrine"},{"issue":"4","key":"3840_CR27","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.fsc.2020.06.008","volume":"28","author":"MM Hamilton","year":"2020","unstructured":"M.M. Hamilton, R. Kao, Recognizing and managing complications in laser resurfacing, chemical peels, and dermabrasion. Facial Plast Surg Clin North Am 28(4), 493\u2013501 (2020). https:\/\/doi.org\/10.1016\/j.fsc.2020.06.008","journal-title":"Facial Plast Surg Clin North Am"},{"issue":"5","key":"3840_CR28","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1097\/00055735-200310000-00004","volume":"14","author":"DE Holck","year":"2003","unstructured":"D.E. Holck, J.D. Ng, Facial skin rejuvenation. Curr Opin Ophthalmol 14(5), 246\u2013252 (2003). https:\/\/doi.org\/10.1097\/00055735-200310000-00004","journal-title":"Curr Opin Ophthalmol"},{"issue":"4","key":"3840_CR29","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1530\/EJE-10-0859","volume":"164","author":"R Steuerman","year":"2011","unstructured":"R. Steuerman, O. Shevah, Z. Laron, Congenital IGF1 deficiency tends to confer protection against post-natal development of malignancies. Eur J Endocrinol 164(4), 485\u2013489 (2011). https:\/\/doi.org\/10.1530\/EJE-10-0859","journal-title":"Eur J Endocrinol"},{"issue":"9","key":"3840_CR30","doi-asserted-by":"publisher","first-page":"e220394","DOI":"10.1530\/ERC-22-0394","volume":"30","author":"Z Laron","year":"2023","unstructured":"Z. Laron, H. Werner, Congenital IGF-1 deficiency protects from cancer: lessons from Laron syndrome. Endocr Relat Cancer 30(9), e220394 (2023). https:\/\/doi.org\/10.1530\/ERC-22-0394","journal-title":"Endocr Relat Cancer"},{"issue":"10","key":"3840_CR31","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1038\/onc.2009.440","volume":"29","author":"DA Lewis","year":"2010","unstructured":"D.A. Lewis, J.B. Travers, A.K. Somani, D.F. Spandau, The IGF-1\/IGF-1R signaling axis in the skin: a new role for the dermis in aging-associated skin cancer. Oncogene 29(10), 1475\u20131485 (2010). https:\/\/doi.org\/10.1038\/onc.2009.440","journal-title":"Oncogene"},{"issue":"13","key":"3840_CR32","doi-asserted-by":"publisher","first-page":"11176","DOI":"10.3390\/ijms241311176","volume":"24","author":"L St\u0103tescu","year":"2023","unstructured":"L. St\u0103tescu, L.M. Trandafir, E. \u021aarc\u0103, M. Moscalu, M.M. Leon Constantin, L.I. Butnariu, M.F. Trandafirescu, M.C. T\u00eernovanu, R. Heredea, A.V. P\u0103tra\u0219cu, D. Botezat, E. Cojocaru, Advancing cancer research: current knowledge on cutaneous neoplasia. Int J Mol Sci 24(13), 11176 (2023). https:\/\/doi.org\/10.3390\/ijms241311176","journal-title":"Int J Mol Sci"},{"issue":"3","key":"3840_CR33","doi-asserted-by":"publisher","first-page":"356","DOI":"10.3390\/molecules2203035","volume":"22","author":"MG Kemp","year":"2017","unstructured":"M.G. Kemp, D.F. Spandau, J.B. Travers, Impact of age and insulin-like growth factor-1 on DNA damage responses in UV-irradiated human skin. Molecules 22(3), 356 (2017). https:\/\/doi.org\/10.3390\/molecules2203035","journal-title":"Molecules"},{"key":"3840_CR34","doi-asserted-by":"publisher","first-page":"e8076","DOI":"10.1136\/bmj.e8076","volume":"345","author":"E Kharazmi","year":"2012","unstructured":"E. Kharazmi, M. Fallah, K. Sundquist, K. Hemminki, Familial risk of early and late onset cancer: nationwide prospective cohort study. BMJ 345, e8076 (2012). https:\/\/doi.org\/10.1136\/bmj.e8076","journal-title":"BMJ"},{"issue":"4","key":"3840_CR35","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1152\/physrev.00044.2003","volume":"84","author":"A Slominski","year":"2004","unstructured":"A. Slominski, D.J. Tobin, S. Shibahara, J. Wortsman, Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol Rev 84(4), 1155\u20131228 (2004). https:\/\/doi.org\/10.1152\/physrev.00044.2003","journal-title":"Physiol Rev"},{"issue":"1","key":"3840_CR36","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1111\/php.12335","volume":"91","author":"TH Nasti","year":"2015","unstructured":"T.H. Nasti, L. Timares, MC1R, eumelanin and pheomelanin: their role in determining the susceptibility to skin cancer. Photochem Photobiol 91(1), 188\u2013200 (2015). https:\/\/doi.org\/10.1111\/php.12335","journal-title":"Photochem Photobiol"},{"issue":"4","key":"3840_CR37","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1096\/fj.06-6649rev","volume":"21","author":"GE Costin","year":"2007","unstructured":"G.E. Costin, V.J. Hearing, Human skin pigmentation: melanocytes modulate skin color in response to stress. FASEB J 21(4), 976\u2013994 (2007). https:\/\/doi.org\/10.1096\/fj.06-6649rev","journal-title":"FASEB J"},{"issue":"3","key":"3840_CR38","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/S0733-8635(18)30651-X","volume":"6","author":"RM Halder","year":"1988","unstructured":"R.M. Halder, K.M. Bang, Skin cancer in blacks in the United States. Dermatol Clin 6(3), 397\u2013405 (1988)","journal-title":"Dermatol Clin"},{"issue":"3","key":"3840_CR39","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1111\/j.1751-1097.2007.00226.x","volume":"84","author":"M Brenner","year":"2008","unstructured":"M. Brenner, V.J. Hearing, The protective role of melanin against UV damage in human skin. Photochem Photobiol 84(3), 539\u2013549 (2008). https:\/\/doi.org\/10.1111\/j.1751-1097.2007.00226.x","journal-title":"Photochem Photobiol"},{"issue":"1","key":"3840_CR40","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s12020-013-0118-5","volume":"47","author":"AH Souza","year":"2014","unstructured":"A.H. Souza, M.I. Farias, R. Salvatori, G.M. Silva, J.A. Santana, F.A. Pereira, F.J. de Paula, E.H. Valen\u00e7a, E.V. Melo, R.A. Barbosa, R.M. Pereira, M.B. Gois-Junior, M.H. Aguiar-Oliveira, Lifetime, untreated isolated GH deficiency due to a GH-releasing hormone receptor mutation has beneficial consequences on bone status in older individuals and does not influence their abdominal aorta calcification. Endocrine 47(1), 191\u2013197 (2014). https:\/\/doi.org\/10.1007\/s12020-013-0118-5","journal-title":"Endocrine"},{"issue":"5","key":"3840_CR41","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1016\/j.jid.2022.09.660","volume":"143","author":"EJ Horesh","year":"2023","unstructured":"E.J. Horesh, J. Gherardini, M. Alam, J. Rodriguez-Feliz, A.J. Bauman, J. Ch\u00e9ret, R. Paus, Human hair follicles operate a functional peripheral equivalent of the hypothalamic-pituitary-somatotropic axis ex vivo. J Invest Dermatol 143(5), 868\u2013871 (2023). https:\/\/doi.org\/10.1016\/j.jid.2022.09.660","journal-title":"J Invest Dermatol"},{"issue":"7","key":"3840_CR42","doi-asserted-by":"publisher","first-page":"e13420","DOI":"10.1111\/acel.13420","volume":"20","author":"TD Saccon","year":"2021","unstructured":"T.D. Saccon, A. Schneider, C.G. Marinho, A.D.C. Nunes, S. Noureddine, J. Dhahbi, Y.O. Nunez Lopez, G. LeMunyan, R. Salvatori, C.R.P. Oliveira, A.A. Oliveira-Santos, N. Musi, A. Bartke, M.H. Aguiar-Oliveira, M.M. Masternak, Circulating microRNA profile in humans and mice with congenital GH deficiency. Aging Cell 20(7), e13420 (2021). https:\/\/doi.org\/10.1111\/acel.13420","journal-title":"Aging Cell"},{"key":"3840_CR43","doi-asserted-by":"publisher","unstructured":"R. Paus, A. Sevilla, J.M. Grichnik, Human Hair graying revisited: principles, misconceptions, and key research frontiers. J Invest Dermatol (2023). https:\/\/doi.org\/10.1016\/j.jid.2023.09.276","DOI":"10.1016\/j.jid.2023.09.276"},{"issue":"2","key":"3840_CR44","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.mehy.2015.04.014","volume":"85","author":"SM Ostojic","year":"2015","unstructured":"S.M. Ostojic, Eumelanin-driven production of molecular hydrogen: a novel element of skin defense? Med Hypotheses 85(2), 237\u2013238 (2015). https:\/\/doi.org\/10.1016\/j.mehy.2015.04.014","journal-title":"Med Hypotheses"},{"issue":"1","key":"3840_CR45","doi-asserted-by":"publisher","first-page":"a015370","DOI":"10.1101\/cshperspect.a015370","volume":"5","author":"L Ritti\u00e9","year":"2015","unstructured":"L. Ritti\u00e9, G.J. Fisher, Natural and sun-induced aging of human skin. Cold Spring Harb Perspect Med 5(1), a015370 (2015). https:\/\/doi.org\/10.1101\/cshperspect.a015370","journal-title":"Cold Spring Harb Perspect Med"},{"key":"3840_CR46","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7649","volume":"6","author":"W Yang","year":"2015","unstructured":"W. Yang, V.R. Sherman, B. Gludovatz, E. Schaible, P. Stewart, R.O. Ritchie, M.A. Meyers, On the tear resistance of skin. Nat Commun 6, 6649 (2015). https:\/\/doi.org\/10.1038\/ncomms7649","journal-title":"Nat Commun"},{"issue":"5","key":"3840_CR47","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.1210\/jcem.87.5.8474","volume":"87","author":"JA Barreto-Filho","year":"2002","unstructured":"J.A. Barreto-Filho, M.R. Alc\u00e2ntara, R. Salvatori, M.A. Barreto, A.C. Sousa, V. Bastos, A.H. Souza, R.M. Pereira, P.E. Clayton, M.S. Gill, M.H. Aguiar-Oliveira, Familial isolated growth hormone deficiency is associated with increased systolic blood pressure, central obesity, and dyslipidemia. J Clin Endocrinol Metab 87(5), 2018\u20132023 (2002). https:\/\/doi.org\/10.1210\/jcem.87.5.8474","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"3840_CR48","doi-asserted-by":"publisher","first-page":"2069","DOI":"10.2147\/IJN.S124564","volume":"15","author":"PD Menezes","year":"2017","unstructured":"P.D. Menezes, L.A. Frank, B.D. Lima, Y.M. de Carvalho, M.R. Serafini, L.J. Quintans-J\u00fanior, A.R. Pohlmann, S.S. Guterres, A.A. Ara\u00fajo, Hesperetin-loaded lipid-core nanocapsules in polyamide: a new textile formulation for topical drug delivery. Int J Nanomedicine 15(12), 2069\u20132079 (2017). https:\/\/doi.org\/10.2147\/IJN.S124564","journal-title":"Int J Nanomedicine"},{"issue":"12","key":"3840_CR49","doi-asserted-by":"publisher","first-page":"117954761985897","DOI":"10.1177\/1179547619858977","volume":"18","author":"PDP Menezes","year":"2019","unstructured":"P.D.P. Menezes, C.V.C. Gomes, Y.M.B.G. de Carvalho, N.G.L. Santos, V.M. Andrade, A.M.S. Oliveira, C.M. de Lima, A.A.S. Ara\u00fajo, Evaluation of the Use of compressive stockings impregnated with hesperetin-based nanocapsules in the healing of venous ulcers: a case report. Clin Med Insights Case Rep 18(12), 1179547619858977 (2019). https:\/\/doi.org\/10.1177\/1179547619858977","journal-title":"Clin Med Insights Case Rep"},{"issue":"5","key":"3840_CR50","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1111\/j.1365-2265.2006.02631.x","volume":"65","author":"F Tanriverdi","year":"2006","unstructured":"F. Tanriverdi, M. Borlu, H. Atmaca, C.A. Koc, K. Unluhizarci, S. Utas, F. Kelestimur, Investigation of the skin characteristics in patients with severe GH deficiency and the effects of 6 months of GH replacement therapy: a randomized placebo-controlled study. Clin Endocrinol (Oxf) 65(5), 579\u2013585 (2006). https:\/\/doi.org\/10.1111\/j.1365-2265.2006.02631.x","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"5","key":"3840_CR51","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s00403-019-01908-x","volume":"311","author":"TX Cong","year":"2019","unstructured":"T.X. Cong, D. Hao, X. Wen, X.H. Li, G. He, X. Jiang, From pathogenesis of acne vulgaris to anti-acne agents. Arch Dermatol Res 311(5), 337\u2013349 (2019). https:\/\/doi.org\/10.1007\/s00403-019-01908-x","journal-title":"Arch Dermatol Res"},{"issue":"12","key":"3840_CR52","doi-asserted-by":"publisher","first-page":"4664","DOI":"10.1210\/jc.2007-1636","volume":"92","author":"JL Oliveira","year":"2007","unstructured":"J.L. Oliveira, M.H. Aguiar-Oliveira, A. D\u2019Oliveira Jr, R.M. Pereira, C.R. Oliveira, C.T. Farias, J.A. Barreto-Filho, F.D. Anjos-Andrade, C. Marques-Santos, A.C. Nascimento-Junior, E.O. Alves, F.T. Oliveira, V.C. Campos, R. Ximenes, A. Blackford, G. Parmigiani, R. Salvatori, Congenital growth hormone (GH) deficiency and atherosclerosis: effects of GH replacement in GH-naive adults. J Clin Endocrinol Metab 92(12), 4664\u20134670 (2007). https:\/\/doi.org\/10.1210\/jc.2007-1636","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"3840_CR53","doi-asserted-by":"publisher","first-page":"46","DOI":"10.3945\/jn.115.217711","volume":"146","author":"HS Yoon","year":"2016","unstructured":"H.S. Yoon, J.R. Kim, G.Y. Park, J.E. Kim, D.H. Lee, K.W. Lee, J.H. Chung, Cocoa flavanol supplementation influences skin conditions of photo-aged women: A 24-week double-blind, randomized, controlled trial. J Nutr 146(1), 46\u201350 (2016). https:\/\/doi.org\/10.3945\/jn.115.217711","journal-title":"J Nutr"}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-024-03840-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12020-024-03840-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-024-03840-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T07:30:40Z","timestamp":1719387040000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12020-024-03840-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,4]]},"references-count":53,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["3840"],"URL":"https:\/\/doi.org\/10.1007\/s12020-024-03840-1","relation":{},"ISSN":["1559-0100"],"issn-type":[{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,4]]},"assertion":[{"value":"18 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"R. Salvatori served in Novordisk and Ascendis advisory board.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This research protocol and the statement of consent were approved by the Institutional Review Board of the Federal University of Sergipe. All participants were informed about the purpose of this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the subjects for anonymous publication of their individual details. The consent form is held by the authors and is available for review as requested.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"All authors have reviewed the contents of the manuscript being submitted, approve of its contents, and validate the accuracy of the data.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}