{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:56:31Z","timestamp":1786982191049,"version":"build-2736575974"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"DOI":"10.1007\/s12020-024-03892-3","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T15:02:05Z","timestamp":1717167725000},"page":"855-863","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Alteration in gut microbial characteristics of patients with acromegaly"],"prefix":"10.1007","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3482-541X","authenticated-orcid":false,"given":"Afruz","family":"Babayeva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0921-5863","authenticated-orcid":false,"given":"Ceren","family":"Ozkul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4855-6078","authenticated-orcid":false,"given":"Meric","family":"Coskun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arzu","family":"Uzun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1041-6881","authenticated-orcid":false,"given":"Mehmet Muhittin","family":"Yalcin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9815-8230","authenticated-orcid":false,"given":"Meltem","family":"Yalinay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0457-6560","authenticated-orcid":false,"given":"Mujde","family":"Akturk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6168-937X","authenticated-orcid":false,"given":"Fusun Balos","family":"Toruner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0601-6893","authenticated-orcid":false,"given":"Mehmet Ayhan","family":"Karakoc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8905-3771","authenticated-orcid":false,"given":"Ilhan","family":"Yetkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6707-7761","authenticated-orcid":false,"given":"Alev Eroglu","family":"Altinova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,31]]},"reference":[{"issue":"24","key":"3892_CR1","doi-asserted-by":"publisher","first-page":"2558","DOI":"10.1056\/NEJMRA062453","volume":"355","author":"S Melmed","year":"2006","unstructured":"S. Melmed, Medical progress: Acromegaly. N. Engl. J. Med. 355(24), 2558\u20132573 (2006). https:\/\/doi.org\/10.1056\/NEJMRA062453","journal-title":"N. Engl. J. Med."},{"key":"3892_CR2","doi-asserted-by":"publisher","unstructured":"L. Maione, P. Chanson, National acromegaly registries. Best Pract. Res. Clin. Endocrinol. Metab., 33, (2019), https:\/\/doi.org\/10.1016\/J.BEEM.2019.02.001","DOI":"10.1016\/J.BEEM.2019.02.001"},{"issue":"3","key":"3892_CR3","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/S00018-018-2943-4","volume":"76","author":"A Adak","year":"2019","unstructured":"A. Adak, M.R. Khan, An insight into gut microbiota and its functionalities. Cell Mol. Life Sci. 76(3), 473\u2013493 (2019). https:\/\/doi.org\/10.1007\/S00018-018-2943-4","journal-title":"Cell Mol. Life Sci."},{"issue":"1","key":"3892_CR4","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/J.TIG.2012.09.005","volume":"29","author":"XC Morgan","year":"2013","unstructured":"X.C. Morgan, N. Segata, C. Huttenhower, Biodiversity and functional genomics in the human microbiome. Trends Genet 29(1), 51\u201358 (2013). https:\/\/doi.org\/10.1016\/J.TIG.2012.09.005","journal-title":"Trends Genet"},{"issue":"5","key":"3892_CR5","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1210\/ER.2018-00280","volume":"40","author":"M Rastelli","year":"2019","unstructured":"M. Rastelli, P.D. Cani, C. Knauf, The Gut Microbiome Influences Host Endocrine Functions. Endocr. Rev. 40(5), 1271\u20131284 (2019). https:\/\/doi.org\/10.1210\/ER.2018-00280","journal-title":"Endocr. Rev."},{"issue":"8","key":"3892_CR6","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1210\/ME.2014-1108","volume":"28","author":"G Clarke","year":"2014","unstructured":"G. Clarke, R.M. Stilling, P.J. Kennedy, C. Stanton, J.F. Cryan, T.G. Dinan, Minireview: Gut microbiota: the neglected endocrine organ. Mol. Endocrinol. 28(8), 1221\u20131238 (2014). https:\/\/doi.org\/10.1210\/ME.2014-1108","journal-title":"Mol. Endocrinol."},{"key":"3892_CR7","doi-asserted-by":"publisher","first-page":"101333","DOI":"10.1016\/j.ghir.2020.101333","volume":"53-54","author":"EA Jensen","year":"2020","unstructured":"E.A. Jensen, J.A. Young, S.C. Mathes, E.O. List, R.K. Carroll, J. Kuhn et al. Crosstalk between the growth hormone\/insulin-like growth factor-1 axis and the gut microbiome: A new frontier for microbial endocrinology. Growth Horm. IGF Res. 53-54, 101333 (2020). https:\/\/doi.org\/10.1016\/j.ghir.2020.101333","journal-title":"Growth Horm. IGF Res."},{"issue":"3","key":"3892_CR8","doi-asserted-by":"publisher","first-page":"R67","DOI":"10.1530\/JME-20-0288","volume":"66","author":"F De Vadder","year":"2021","unstructured":"F. De Vadder, A. Joly, F. Leulier, Microbial and nutritional influence on endocrine control of growth. J. Mol. Endocrinol. 66(3), R67\u2013R73 (2021). https:\/\/doi.org\/10.1530\/JME-20-0288","journal-title":"J. Mol. Endocrinol."},{"issue":"4","key":"3892_CR9","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqaa026","volume":"161","author":"EA Jensen","year":"2020","unstructured":"E.A. Jensen, J.A. Young, Z. Jackson, J. Busken, E.O. List, R.K. Carroll et al. Growth Hormone Deficiency and Excess Alter the Gut Microbiome in Adult Male Mice. Endocrinology 161(4), bqaa026 (2020). https:\/\/doi.org\/10.1210\/endocr\/bqaa026","journal-title":"Endocrinology"},{"issue":"4","key":"3892_CR10","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1007\/S11102-021-01137-4","volume":"24","author":"A Hacioglu","year":"2021","unstructured":"A. Hacioglu, A. Gundogdu, U. Nalbantoglu, Z. Karaca, M.E. Urhan, S. Sahin et al. Gut microbiota in patients with newly diagnosed acromegaly: a pilot cross-sectional study. Pituitary 24(4), 600\u2013610 (2021). https:\/\/doi.org\/10.1007\/S11102-021-01137-4","journal-title":"Pituitary"},{"issue":"3","key":"3892_CR11","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1007\/S11102-022-01223-1","volume":"25","author":"S Sahin","year":"2022","unstructured":"S. Sahin, A. Gundogdu, U. Nalbantoglu, P. Kadioglu, Z. Karaca, A. Hacioglu et al. Acromegaly is associated with a distinct oral and gut microbiota. Pituitary 25(3), 520\u2013530 (2022). https:\/\/doi.org\/10.1007\/S11102-022-01223-1","journal-title":"Pituitary"},{"key":"3892_CR12","doi-asserted-by":"publisher","unstructured":"B. Lin, M. Wang, R. Gao, Z. Ye, Y. Yu, W. He et al. Characteristics of Gut Microbiota in Patients with GH-Secreting Pituitary Adenoma. Microbiol. Spectr., 10 (2022), https:\/\/doi.org\/10.1128\/SPECTRUM.00425-21","DOI":"10.1128\/SPECTRUM.00425-21"},{"issue":"5","key":"3892_CR13","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1007\/S00262-021-03080-6","volume":"71","author":"D Nie","year":"2022","unstructured":"D. Nie, Q. Fang, J. Cheng, B. Li, M. Li, H. Wang et al. The intestinal flora of patients with GHPA affects the growth and the expression of PD-L1 of tumor. Cancer Immunol. Immunother. 71(5), 1233\u20131245 (2022). https:\/\/doi.org\/10.1007\/S00262-021-03080-6","journal-title":"Cancer Immunol. Immunother."},{"issue":"11","key":"3892_CR14","doi-asserted-by":"publisher","first-page":"3933","DOI":"10.1210\/JC.2014-2700","volume":"99","author":"L Katznelson","year":"2014","unstructured":"L. Katznelson, E.R. Laws Jr, S. Melmed, M.E. Molitch, M.H. Murad, A. Utz, J.A.L. Wass, Acromegaly: an endocrine society clinical practice guideline. J. Clin. Endocrinol. Metab. 99(11), 3933\u20133951 (2014). https:\/\/doi.org\/10.1210\/JC.2014-2700","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"6","key":"3892_CR15","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1002\/BIT.20347","volume":"89","author":"Y Yu","year":"2005","unstructured":"Y. Yu, C. Lee, J. Kim, S. Hwang, Group-specific primer and probe sets to detect methanogenic communities using quantitative real-time polymerase chain reaction. Biotechnol. Bioeng. 89(6), 670\u2013679 (2005). https:\/\/doi.org\/10.1002\/BIT.20347","journal-title":"Biotechnol. Bioeng."},{"issue":"8","key":"3892_CR16","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1038\/S41587-019-0209-9","volume":"37","author":"E Bolyen","year":"2019","unstructured":"E. Bolyen, J.R. Rideout, M.R. Dillon, N.A. Bokulich, C.C. Abnet, G.A. Al-Ghalith et al. Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2. Nat. Biotechnol. 37(8), 852\u2013857 (2019). https:\/\/doi.org\/10.1038\/S41587-019-0209-9","journal-title":"Nat. Biotechnol."},{"issue":"7","key":"3892_CR17","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1038\/NMETH.3869","volume":"13","author":"BJ Callahan","year":"2016","unstructured":"B.J. Callahan, P.J. McMurdie, M.J. Rosen, A.W. Han, A.J.A. Johnson, S.P. Holmes, DADA2: High-resolution sample inference from Illumina amplicon data. Nat. Methods 13(7), 581\u2013583 (2016). https:\/\/doi.org\/10.1038\/NMETH.3869","journal-title":"Nat. Methods"},{"key":"3892_CR18","doi-asserted-by":"publisher","unstructured":"P.J. McMurdie, S. Holmes, phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data, PLoS One 8, (2013) https:\/\/doi.org\/10.1371\/JOURNAL.PONE.0061217","DOI":"10.1371\/JOURNAL.PONE.0061217"},{"key":"3892_CR19","unstructured":"R Core Team, R Core Team 2021 R: A language and environment for statistical computing. R foundation for statistical computing. R Foundation for Statistical Computing, vol. 2, (2019). https:\/\/www.R-project.org\/"},{"key":"3892_CR20","doi-asserted-by":"publisher","unstructured":"N. Segata, J. Izard, L. Waldron, D. Gevers, L. Miropolsky, W. S. Garrett, C. Huttenhower, Metagenomic biomarker discovery and explanation. Genome Biol. 12, (2011), https:\/\/doi.org\/10.1186\/gb-2011-12-6-r60","DOI":"10.1186\/gb-2011-12-6-r60"},{"key":"3892_CR21","doi-asserted-by":"publisher","unstructured":"M.I. Love, W. Huber, S. Anders, Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2, Genome Biol. 15, (2014), https:\/\/doi.org\/10.1186\/S13059-014-0550-8.","DOI":"10.1186\/S13059-014-0550-8"},{"key":"3892_CR22","doi-asserted-by":"publisher","unstructured":"X. Wang, Y. Wu, Y. Liu, F. Chen, S. Chen, F. Zhang et al., Altered gut microbiome profile in patients with knee osteoarthritis. Front. Microbiol. 14, (2023), https:\/\/doi.org\/10.3389\/FMICB.2023.1153424.","DOI":"10.3389\/FMICB.2023.1153424"},{"issue":"4","key":"3892_CR23","doi-asserted-by":"publisher","first-page":"248","DOI":"10.5114\/REUM\/169918","volume":"61","author":"A Wydra","year":"2023","unstructured":"A. Wydra, M. Stelmachowska-Bana\u015b, I. Czajka-Oraniec, Skeletal complications in acromegaly. Reumatologia 61(4), 248\u2013255 (2023). https:\/\/doi.org\/10.5114\/REUM\/169918","journal-title":"Reumatologia"},{"issue":"4","key":"3892_CR24","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1007\/s11102-022-01233-z","volume":"25","author":"ICM Pelsma","year":"2022","unstructured":"I.C.M. Pelsma, H.M. Kroon, V.R. van Trigt, A.M. Pereira, M. Kloppenburg, N.R. Biermasz, K.M.J.A. Claessen, Clinical and radiographic assessment of peripheral joints in controlled acromegaly. Pituitary 25(4), 622\u2013635 (2022). https:\/\/doi.org\/10.1007\/s11102-022-01233-z","journal-title":"Pituitary"},{"issue":"10","key":"3892_CR25","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1016\/J.JOCA.2016.05.008","volume":"24","author":"ZY Huang","year":"2016","unstructured":"Z.Y. Huang, T. Stabler, F.X. Pei, V.B. Kraus, Both systemic and local lipopolysaccharide (LPS) burden are associated with knee OA severity and inflammation. Osteoarthritis Cartilage 24(10), 1769\u20131775 (2016). https:\/\/doi.org\/10.1016\/J.JOCA.2016.05.008","journal-title":"Osteoarthritis Cartilage"},{"key":"3892_CR26","doi-asserted-by":"publisher","unstructured":"Q. Zeng, D. Li, Y. He, Y. Li, Z. Yang, X. Zhao, et al. Discrepant gut microbiota markers for the classification of obesity-related metabolic abnormalities. Sci. Rep. 9 (2019), https:\/\/doi.org\/10.1038\/S41598-019-49462-W","DOI":"10.1038\/S41598-019-49462-W"},{"issue":"1","key":"3892_CR27","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/J.CELREP.2018.12.028","volume":"26","author":"K Wang","year":"2019","unstructured":"K. Wang, M. Liao, N. Zhou, L. Bao, K. Ma, Z. Zheng et al. Parabacteroides distasonis Alleviates Obesity and Metabolic Dysfunctions via Production of Succinate and Secondary Bile Acids. Cell Rep. 26(1), 222\u2013235.e5 (2019). https:\/\/doi.org\/10.1016\/J.CELREP.2018.12.028","journal-title":"Cell Rep."},{"issue":"4","key":"3892_CR28","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1128\/CMR.00008-07","volume":"20","author":"HM Wexler","year":"2007","unstructured":"H. M. Wexler, \u201cBacteroides: the good, the bad, and the nitty-gritty\u201d. Clin Microbiol Rev 20(4), 593\u2013621 (2007). https:\/\/doi.org\/10.1128\/CMR.00008-07","journal-title":"Clin Microbiol Rev"},{"issue":"1","key":"3892_CR29","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1128\/JB.138.1.99-104.1979","volume":"138","author":"TL Miller","year":"1979","unstructured":"T.L. Miller, S.E. Jenesel, Enzymology of butyrate formation by Butyrivibrio fibrisolvens. J. Bacteriol. 138(1), 99\u2013104 (1979). https:\/\/doi.org\/10.1128\/JB.138.1.99-104.1979","journal-title":"J. Bacteriol."},{"key":"3892_CR30","doi-asserted-by":"publisher","unstructured":"T.W. Yang, W.H. Lee, S.J. Tu, W.C. Huang, H.M. Chen, T.H. Sun, et al., Enterotype-based Analysis of Gut Microbiota along the Conventional Adenoma-Carcinoma Colorectal Cancer Pathway. Sci. Rep. 9, (2019), https:\/\/doi.org\/10.1038\/S41598-019-45588-Z","DOI":"10.1038\/S41598-019-45588-Z"},{"key":"3892_CR31","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/J.NUT.2018.11.019","volume":"63\u201364","author":"PC Chen","year":"2019","unstructured":"P.C. Chen, Y.W. Chien, S.C. Yang, The alteration of gut microbiota in newly diagnosed type 2 diabetic patients. Nutrition 63\u201364, 51\u201356 (2019). https:\/\/doi.org\/10.1016\/J.NUT.2018.11.019","journal-title":"Nutrition"},{"issue":"7418","key":"3892_CR32","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/NATURE11450","volume":"490","author":"J Qin","year":"2012","unstructured":"J. Qin, Y. Li, Z. Cai, S. Li, J. Zhu, F. Zhang et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 490(7418), 55\u201360 (2012). https:\/\/doi.org\/10.1038\/NATURE11450","journal-title":"Nature"},{"issue":"9","key":"3892_CR33","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1016\/j.cmi.2020.10.033","volume":"27","author":"N Zheng","year":"2021","unstructured":"N. Zheng, S.H. Li, B. Dong, W. Sun, H.R. Li, Y.L. Zhang et al. Comparison of the gut microbiota of short-term and long-term medical workers and non-medical controls: a cross-sectional analysis. Clin. Microbiol. Infect. 27(9), 1285\u20131292 (2021). https:\/\/doi.org\/10.1016\/j.cmi.2020.10.033","journal-title":"Clin. Microbiol. Infect."}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-024-03892-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12020-024-03892-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-024-03892-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T08:02:01Z","timestamp":1722412921000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12020-024-03892-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,31]]},"references-count":33,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["3892"],"URL":"https:\/\/doi.org\/10.1007\/s12020-024-03892-3","relation":{},"ISSN":["1559-0100"],"issn-type":[{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,31]]},"assertion":[{"value":"22 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}