{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T10:15:11Z","timestamp":1785752111630,"version":"3.56.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T00:00:00Z","timestamp":1723680000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T00:00:00Z","timestamp":1723680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>Over the years we observed changes in the metabolism of glucose, amino acids, fatty acids (FA) and nucleotides in cancer cells in order to maintain their viability and proliferate. Moreover, as the latest data show, cancer also forces a complete change in the behavior of other tissues. For instance, fat-filled adipocytes are often found in the vicinity of invasive solid human tumors. We investigated the effects of papillary thyroid carcinoma (PTC) on the lipid metabolism of healthy tissue distant from the tumor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Thyroid tissue was collected from female patients immediately after surgical removal of the entire thyroid gland. Blood samples were collected from PTC patients and healthy volunteers. Real-time PCR assays were performed to analyze the expression of lipogenic genes and a broad panel of FA was determined using the gas chromatography-mass spectrometry method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The concentration of lipids was higher in paratumor tissue than in healthy thyroid tissue (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005). The lipogenic genes tested were significantly increased in paratumor tissue compared to healthy tissue, especially enzymes related to the synthesis of very long-chain saturated and polyunsaturated FAs (VLCSFAs and PUFAs, respectively) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The FA profile also showed increased levels of C22-C26, VLCSFAs and almost all PUFAs in paratumor tissue (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study suggests that a restructuring of lipid metabolism occurs in the adjacent healthy thyroid gland and that the metabolism of VLCSFAs and PUFAs is higher in the paratumor tissue than in the distant tissue of the healthy thyroid gland.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s12020-024-03993-z","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T11:02:11Z","timestamp":1723719731000},"page":"273-280","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The influence of cancer on the reprogramming of lipid metabolism in healthy thyroid tissues of patients with papillary thyroid carcinoma"],"prefix":"10.1007","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3373-5751","authenticated-orcid":false,"given":"Agata","family":"Zwara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9258-3244","authenticated-orcid":false,"given":"Andrzej","family":"Hellmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Czapiewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1886-6967","authenticated-orcid":false,"given":"Justyna","family":"Korczynska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicja","family":"Sztendel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2877-5652","authenticated-orcid":false,"given":"Adriana","family":"Mika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,15]]},"reference":[{"key":"3993_CR1","doi-asserted-by":"publisher","unstructured":"J. Tang, C. Zhanghuang, Z. Yao, L. Li, Y. Xie, H. Tang, et al. Development and validation of a nomogram to predict cancer-specific survival in middle-aged patients with papillary thyroid cancer: A SEER database study. Heliyon 9, (2023). https:\/\/doi.org\/10.1016\/j.heliyon.2023.e13665","DOI":"10.1016\/j.heliyon.2023.e13665"},{"key":"3993_CR2","unstructured":"Limaiem F, Rehman A, Mazzoni T. Papillary Thyroid Carcinoma. 2024 Mar 13. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan"},{"key":"3993_CR3","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1080\/10408363.2017.1394266","volume":"54","author":"D Navas-Carrillo","year":"2017","unstructured":"D. Navas-Carrillo, J.M. Rodriguez, S. Montoro-Garc\u00eda, E. Orenes-Pi\u00f1ero, High-resolution proteomics and metabolomics in thyroid cancer: Deciphering novel biomarkers. Crit Rev Clin Lab Sci 54, 446\u2013457 (2017). https:\/\/doi.org\/10.1080\/10408363.2017.1394266","journal-title":"Crit Rev Clin Lab Sci"},{"key":"3993_CR4","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1080\/1354750X.2016.1256429","volume":"22","author":"R Farrokhi Yekta","year":"2017","unstructured":"R. Farrokhi Yekta, M. Rezaie Tavirani, A. Arefi Oskouie, M.R. Mohajeri-Tehrani, A.R. Soroush, The metabolomics and lipidomics window into thyroid cancer research. Biomarkers 22, 595\u2013603 (2017). https:\/\/doi.org\/10.1080\/1354750X.2016.1256429","journal-title":"Biomarkers"},{"key":"3993_CR5","doi-asserted-by":"publisher","unstructured":"Z. Wang, Y. Yang, Y. Xing, D. Si, S. Wang, J. Lin, et al. Combined metabolomic and lipidomic analysis uncovers metabolic profile and biomarkers for papillary thyroid carcinoma. Sci Rep 13, (2023). https:\/\/doi.org\/10.1038\/s41598-023-41176-4","DOI":"10.1038\/s41598-023-41176-4"},{"key":"3993_CR6","doi-asserted-by":"publisher","first-page":"1199291","DOI":"10.3389\/fendo.2023.1199291","volume":"14","author":"A Hellmann","year":"2023","unstructured":"A. Hellmann, J. Turyn, A. Zwara, J. Korczynska, A. Taciak, A. Mika, Alterations in the amino acid profile in patients with papillary thyroid carcinoma with and without Hashimoto\u2019s thyroiditis. Front Endocrinol 14, 1199291 (2023). https:\/\/doi.org\/10.3389\/fendo.2023.1199291","journal-title":"Front Endocrinol"},{"key":"3993_CR7","doi-asserted-by":"publisher","unstructured":"J. Lu, Y. Zhang, M. Sun, C. Ding, L. Zhang, Y. Kong, et al. Multi-Omics Analysis of Fatty Acid Metabolism in Thyroid Carcinoma. Front Oncol 11, 1\u201312 (2021). https:\/\/doi.org\/10.3389\/fonc.2021.737127","DOI":"10.3389\/fonc.2021.737127"},{"key":"3993_CR8","doi-asserted-by":"publisher","unstructured":"Y. Tian, X. Nie, S. Xu, Y. Li, T. Huang, H. Tang, et al. Integrative metabonomics as potential method for diagnosis of thyroid malignancy. Sci Rep 5, (2015). https:\/\/doi.org\/10.1038\/srep14869","DOI":"10.1038\/srep14869"},{"issue":"1 Suppl","key":"3993_CR9","doi-asserted-by":"publisher","first-page":"18S","DOI":"10.1177\/0148607115595980","volume":"39","author":"PC Calder","year":"2015","unstructured":"P.C. Calder, Functional Roles of Fatty Acids and Their Effects on Human Health. J Parenteral Enteral Nutr 39(1 Suppl), 18S\u201332S (2015). https:\/\/doi.org\/10.1177\/0148607115595980","journal-title":"J Parenteral Enteral Nutr"},{"key":"3993_CR10","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.tem.2021.03.002","volume":"32","author":"L Huang","year":"2021","unstructured":"L. Huang, L. Gao, C. Chen, Role of Medium-Chain Fatty Acids in Healthy Metabolism: A Clinical Perspective. Trends Endocrinol Metab 32, 351\u2013366 (2021). https:\/\/doi.org\/10.1016\/j.tem.2021.03.002","journal-title":"Trends Endocrinol Metab"},{"key":"3993_CR11","doi-asserted-by":"crossref","unstructured":"P.J.H. Jones, A.H. Lichtenstein, Lipids. In: Present Knowledge in Nutrition: Basic Nutrition and Metabolism. Academic Press, USA; 2020. p. 51\u201369","DOI":"10.1016\/B978-0-323-66162-1.00004-4"},{"key":"3993_CR12","doi-asserted-by":"publisher","first-page":"8117","DOI":"10.1158\/0008-5472.CAN-09-3871","volume":"70","author":"E Rysman","year":"2010","unstructured":"E. Rysman, K. Brusselmans, K. Scheys, L. Timmermans, R. Derua, S. Munck et al. De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation. Cancer Res 70, 8117\u20138126 (2010). https:\/\/doi.org\/10.1158\/0008-5472.CAN-09-3871","journal-title":"Cancer Res"},{"key":"3993_CR13","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1111\/pin.12737","volume":"68","author":"K Kakudo","year":"2018","unstructured":"K. Kakudo, A. Bychkov, Y. Bai, Y. Li, Z. Liu, C.K. Jung, The new 4th edition World Health Organization classification for thyroid tumors, Asian perspectives. Pathol Int 68, 641\u2013664 (2018). https:\/\/doi.org\/10.1111\/pin.12737","journal-title":"Pathol Int"},{"key":"3993_CR14","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","volume":"226","author":"J Folch","year":"1957","unstructured":"J. Folch, M. Lees, G.H. Sloane Stanley, A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226, 497\u2013509 (1957)","journal-title":"J Biol Chem"},{"key":"3993_CR15","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1002\/oby.23711","volume":"31","author":"JI Mart\u00ednez-Montoro","year":"2023","unstructured":"J.I. Mart\u00ednez-Montoro, M.\u00c1. N\u00fa\u00f1ez-S\u00e1nchez, M.A. Martinez-Sanchez, A. Balaguer-Rom\u00e1n, V.E. Fern\u00e1ndez-Ruiz, M. Ferrer-G\u00f3mez et al. Hepatic and serum branched-chain fatty acid profile in patients with nonalcoholic fatty liver disease: A case\u2013control study. Obesity. 31, 1064\u20131074 (2023). https:\/\/doi.org\/10.1002\/oby.23711","journal-title":"Obesity."},{"key":"3993_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-58895-7","volume":"10","author":"A Mika","year":"2020","unstructured":"A. Mika, J. Kobiela, A. Pakiet, A. Czumaj, E. Soko\u0142owska, W. Makarewicz et al. Preferential uptake of polyunsaturated fatty acids by colorectal cancer cells. Sci Rep 10, 1\u20138 (2020). https:\/\/doi.org\/10.1038\/s41598-020-58895-7","journal-title":"Sci Rep"},{"key":"3993_CR17","doi-asserted-by":"publisher","first-page":"e0149305","DOI":"10.1371\/journal.pone.0149305","volume":"11","author":"CA Pickens","year":"2016","unstructured":"C.A. Pickens, K.H. Matsuo, J.I. Fenton, Relationship between Body Mass Index, C-Peptide, and Delta-5-Desaturase Enzyme Activity Estimates in Adult Males. PLoS One 11, e0149305 (2016). https:\/\/doi.org\/10.1371\/journal.pone.0149305","journal-title":"PLoS One"},{"key":"3993_CR18","doi-asserted-by":"publisher","unstructured":"D. Gupta, C.G. Lis, Pretreatment serum albumin as a predictor of cancer survival: a systematic review of the epidemiological literature. Nutr. J. 9, (2010). https:\/\/doi.org\/10.1186\/1475-2891-9-69","DOI":"10.1186\/1475-2891-9-69"},{"key":"3993_CR19","doi-asserted-by":"publisher","first-page":"E305","DOI":"10.21037\/jtd.2016.03.62","volume":"8","author":"C Thongprayoon","year":"2016","unstructured":"C. Thongprayoon, W. Cheungpasitporn, K. Kashani, Serum creatinine level, a surrogate of muscle mass, predicts mortality in critically ill patients. J Thorac Dis 8, E305 (2016). https:\/\/doi.org\/10.21037\/jtd.2016.03.62","journal-title":"J Thorac Dis"},{"key":"3993_CR20","doi-asserted-by":"publisher","first-page":"413","DOI":"10.2450\/2015.0163-15","volume":"14","author":"M Franchini","year":"2016","unstructured":"M. Franchini, E. Capuzzo, G.M. Liumbruno, Lipoprotein apheresis for the treatment of elevated circulating levels of lipoprotein(a): A critical literature review. Blood Transfusion 14, 413\u2013418 (2016). https:\/\/doi.org\/10.2450\/2015.0163-15","journal-title":"Blood Transfusion"},{"key":"3993_CR21","doi-asserted-by":"publisher","first-page":"730855","DOI":"10.3389\/fmed.2021.730855","volume":"8","author":"A Zwara","year":"2021","unstructured":"A. Zwara, K. Wertheim-Tysarowska, A. Mika, Alterations of Ultra Long-Chain Fatty Acids in Hereditary Skin Diseases\u2014Review Article. Front Med 8, 730855 (2021). https:\/\/doi.org\/10.3389\/fmed.2021.730855","journal-title":"Front Med"},{"key":"3993_CR22","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/s41416-019-0650-z","volume":"122","author":"N Koundouros","year":"2020","unstructured":"N. Koundouros, G. Poulogiannis, Reprogramming of fatty acid metabolism in cancer. Br J Cancer 122, 4\u201322 (2020). https:\/\/doi.org\/10.1038\/s41416-019-0650-z","journal-title":"Br J Cancer"},{"key":"3993_CR23","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.addr.2020.07.013","volume":"159","author":"LM Butler","year":"2020","unstructured":"L.M. Butler, Y. Perone, J. Dehairs, L.E. Lupien, V. de Laat, A. Talebi et al. Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention. Adv Drug Deliv Rev 159, 245\u2013293 (2020). https:\/\/doi.org\/10.1016\/j.addr.2020.07.013","journal-title":"Adv Drug Deliv Rev"},{"key":"3993_CR24","doi-asserted-by":"publisher","unstructured":"F. De\u00e1k, R.E. Anderson, J.L. Fessler, D.M. Sherry. Novel Cellular Functions of Very Long Chain-Fatty Acids: Insight From ELOVL4 Mutations. Front Cell Neurosci. 13, 2019, https:\/\/doi.org\/10.3389\/fncel.2019.00428","DOI":"10.3389\/fncel.2019.00428"},{"key":"3993_CR25","doi-asserted-by":"publisher","first-page":"3593","DOI":"10.21037\/tcr-22-761","volume":"11","author":"W Xu","year":"2022","unstructured":"W. Xu, H. Ding, M. Zhang, L. Liu, M. Yin, Z. Weng et al. The prognostic role of fatty acid metabolism-related genes in patients with gastric cancer. Transl Cancer Res 11, 3593\u20133609 (2022). https:\/\/doi.org\/10.21037\/tcr-22-761","journal-title":"Transl Cancer Res"},{"key":"3993_CR26","doi-asserted-by":"publisher","unstructured":"Y. Yan, M.A. Gauthier, A. Malik, I. Fotiadou, M. Ostrovski, D. Dervovic et al. The NOTCH-RIPK4-IRF6-ELOVL4 Axis Suppresses Squamous Cell Carcinoma. Cancers. 15, (2023). https:\/\/doi.org\/10.3390\/cancers15030737","DOI":"10.3390\/cancers15030737"},{"key":"3993_CR27","doi-asserted-by":"publisher","unstructured":"C. Xu, L. Gu, L. Hu, C. Jiang, Q. Li, L. Sun et al. FADS1-arachidonic acid axis enhances arachidonic acid metabolism by altering intestinal microecology in colorectal cancer. Nat Commun. 14, (2023). https:\/\/doi.org\/10.1038\/s41467-023-37590-x","DOI":"10.1038\/s41467-023-37590-x"},{"key":"3993_CR28","doi-asserted-by":"publisher","DOI":"10.1038\/oncsis.2017.51","volume":"6","author":"H Muranaka","year":"2017","unstructured":"H. Muranaka, A. Hayashi, K. Minami, S. Kitajima, S. Kohno, Y. Nishimoto et al. A distinct function of the retinoblastoma protein in the control of lipid composition identified by lipidomic profiling. Oncogenesis. 6, e350 (2017). https:\/\/doi.org\/10.1038\/oncsis.2017.51","journal-title":"Oncogenesis."},{"key":"3993_CR29","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1002\/mco2.27","volume":"2","author":"Y Fu","year":"2021","unstructured":"Y. Fu, T. Zou, X. Shen, P.J. Nelson, J. Li, C. Wu et al. Lipid metabolism in cancer progression and therapeutic strategies. MedComm 2, 27\u201359 (2021). https:\/\/doi.org\/10.1002\/mco2.27","journal-title":"MedComm"},{"key":"3993_CR30","first-page":"4098","volume":"10","author":"Y-L Li","year":"2020","unstructured":"Y.-L. Li, H. Tian, J. Jiang, Y. Zhang, X.-W. Qi, Multifaceted regulation and functions of fatty acid desaturase 2 in human cancers. Am J Cancer Res 10, 4098 (2020)","journal-title":"Am J Cancer Res"},{"key":"3993_CR31","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.3390\/jcm9041095","volume":"9","author":"A Mika","year":"2020","unstructured":"A. Mika, A. Pakiet, A. Czumaj, Z. Kaczynski, I. Liakh, J. Kobiela et al. Decreased triacylglycerol content and elevated contents of cell membrane lipids in colorectal cancer tissue: A lipidomic study. J Clin Med 9, 1095 (2020). https:\/\/doi.org\/10.3390\/jcm9041095","journal-title":"J Clin Med"},{"key":"3993_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12885-023-10914-2","volume":"23","author":"A Pakiet","year":"2023","unstructured":"A. Pakiet, A. J\u0119drzejewska, K. Duzowska, A. Wac\u0142awska, P. Jab\u0142o\u0144ska, J. Zieli\u0144ski et al. Serum fatty acid profiles in breast cancer patients following treatment. BMC Cancer 23, 1\u201314 (2023). https:\/\/doi.org\/10.1186\/s12885-023-10914-2","journal-title":"BMC Cancer"},{"key":"3993_CR33","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s10555-011-9299-7","volume":"30","author":"IM Berquin","year":"2011","unstructured":"I.M. Berquin, I.J. Edwards, S.J. Kridel, Y.Q. Chen, Polyunsaturated fatty acid metabolism in prostate cancer. Cancer Metastasis Rev 30, 295\u2013309 (2011). https:\/\/doi.org\/10.1007\/s10555-011-9299-7","journal-title":"Cancer Metastasis Rev"},{"key":"3993_CR34","doi-asserted-by":"publisher","unstructured":"H. Zhang, N. Chen, C. Ding, H. Zhang, D. Liu, S. Liu. Ferroptosis and EMT resistance in cancer: a comprehensive review of the interplay. Front Oncol 14, (2024). https:\/\/doi.org\/10.3389\/fonc.2024.1344290","DOI":"10.3389\/fonc.2024.1344290"},{"key":"3993_CR35","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.cmet.2013.05.017","volume":"18","author":"E Currie","year":"2013","unstructured":"E. Currie, A. Schulze, R. Zechner, T.C. Walther, R.V. Farese, Perspective Cellular Fatty Acid Metabolism and Cancer. Cell Metab 18, 153\u2013161 (2013). https:\/\/doi.org\/10.1016\/j.cmet.2013.05.017","journal-title":"Cell Metab"},{"key":"3993_CR36","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.trecan.2020.03.001","volume":"6","author":"C Attan\u00e9","year":"2020","unstructured":"C. Attan\u00e9, C. Muller, Drilling for Oil: Tumor-Surrounding Adipocytes Fueling Cancer. Trends Cancer 6, 593\u2013604 (2020). https:\/\/doi.org\/10.1016\/j.trecan.2020.03.001","journal-title":"Trends Cancer"},{"key":"3993_CR37","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s10555-020-09934-2","volume":"40","author":"JF Dumas","year":"2021","unstructured":"J.F. Dumas, L. Brisson, Interaction between adipose tissue and cancer cells: role for cancer progression. Cancer Metastasis Rev 40, 31\u201346 (2021). https:\/\/doi.org\/10.1007\/s10555-020-09934-2","journal-title":"Cancer Metastasis Rev"},{"key":"3993_CR38","doi-asserted-by":"publisher","unstructured":"H. Xu, Y. Chen, M. Gu, C. Liu, Q. Chen, M. Zhan, et al. Fatty Acid Metabolism Reprogramming in Advanced Prostate Cancer. Metabolites. 11 (2021). https:\/\/doi.org\/10.3390\/metabo11110765","DOI":"10.3390\/metabo11110765"}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-024-03993-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12020-024-03993-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-024-03993-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T07:53:28Z","timestamp":1737014008000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12020-024-03993-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,15]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["3993"],"URL":"https:\/\/doi.org\/10.1007\/s12020-024-03993-z","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4605332\/v1","asserted-by":"object"}]},"ISSN":["1559-0100"],"issn-type":[{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,15]]},"assertion":[{"value":"19 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The participants have consented to the submission of the article to the journal","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}