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The unique physiological state of pregnancy increases cortisol secretion through the hypothalamic-pituitary-adrenal (HPA) axis and leads to elevated levels of all components of the renin-angiotensin-aldosterone system (RAAS). This can cause overlapping symptoms with abnormal cortisol and aldosterone secretion, making diagnosis very challenging. This case involves a 29-year-old woman who developed hypercortisolism at 33 weeks of pregnancy. Despite receiving treatment for her symptoms and having a successful delivery, she continued to experience hypertension and hypokalaemia after giving birth. Eventually, she was diagnosed with ACTH-independent Cushing\u2019s syndrome and primary aldosteronism due to independent cortisol and aldosterone secretion from bilateral adrenal adenomas. Following a thorough diagnosis, classification, treatment, and follow-up, the patient achieved a clinical cure while preserving normal adrenal function. Further investigation revealed that both diseases were caused by KCNJ5 and PRKACA mutations found in the bilateral adrenal adenomas.<\/jats:p>","DOI":"10.1007\/s12020-024-04058-x","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T03:36:28Z","timestamp":1728358588000},"page":"822-829","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Diagnostic and therapeutic approaches to a case of pregnancy complicated by bilateral adrenocortical adenomas with primary aldosteronism and Cushing\u2019s syndrome"],"prefix":"10.1007","volume":"87","author":[{"given":"Yanxi","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoming","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4519-397X","authenticated-orcid":false,"given":"Yan","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,8]]},"reference":[{"key":"4058_CR1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-020-01070-0","volume":"22","author":"A Agrawal","year":"2020","unstructured":"A. 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Rivier, W.Vale, Evidence for local stimulation of ACTH secretion by corticotropin-releasing factor in human placenta. Nature 328, 717\u2013719 (1987). https:\/\/doi.org\/10.1038\/328717a0","journal-title":"Nature"},{"key":"4058_CR6","doi-asserted-by":"publisher","first-page":"750","DOI":"10.2174\/138920111795470868","volume":"12","author":"B Marciniak","year":"2011","unstructured":"B. Marciniak, J. Patro-Ma\u0142ysza, E. Poniedzia\u0142ek-Czajkowska, Z. Kimber-Trojnar, B. Leszczy\u0144ska-Gorzelak, J. Oleszczuk, Glucocorticoids in pregnancy. Curr. Pharm. Biotechnol. 12, 750\u2013757 (2011). https:\/\/doi.org\/10.2174\/138920111795470868","journal-title":"Curr. Pharm. Biotechnol."},{"key":"4058_CR7","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s11154-022-09731-y","volume":"24","author":"N Younes","year":"2023","unstructured":"N. Younes, M. St-Jean, I. Bourdeau, A.Lacroix, Endogenous Cushingas syndrome during pregnancy. 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