{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T08:46:42Z","timestamp":1767084402604,"version":"3.40.2"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Shanghai Sixth People\u2019s Hospital","award":["YNLC201905"],"award-info":[{"award-number":["YNLC201905"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"DOI":"10.1007\/s12020-024-04133-3","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T21:07:25Z","timestamp":1734642445000},"page":"194-202","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Primary tumor resection with or without neck lymph node dissection as a viable initial therapy for medullary thyroid carcinoma with distant metastasis"],"prefix":"10.1007","volume":"88","author":[{"given":"Ziyi","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wangwang","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaiyu","family":"Weng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianyong","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhili","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"issue":"5","key":"4133_CR1","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1210\/endrev\/bnad013","volume":"44","author":"ML Gild","year":"2023","unstructured":"M.L. Gild, R.J. Clifton-Bligh, L.J. Wirth, B.G. Robinson, Medullary thyroid cancer: updates and challenges. Endocr. Rev. 44(5), 934\u2013946 (2023). https:\/\/doi.org\/10.1210\/endrev\/bnad013","journal-title":"Endocr. Rev."},{"issue":"3","key":"4133_CR2","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1007\/s00405-023-08401-2","volume":"281","author":"H Su","year":"2024","unstructured":"H. Su, Q. Men, J. Hao, F. Zhang, Risk factor analysis of distant metastases in patients with primary medullary thyroid cancer: a population-based study. Eur. Arch. Otorhinolaryngol. 281(3), 1525\u20131530 (2024). https:\/\/doi.org\/10.1007\/s00405-023-08401-2","journal-title":"Eur. Arch. Otorhinolaryngol."},{"issue":"3","key":"4133_CR3","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1007\/s12020-024-03809-0","volume":"85","author":"SS Zuhur","year":"2024","unstructured":"S.S. Zuhur, B.O. Ozturk, U. Keskin et al. Disease-free survival and the prognostic factors affecting disease-free survival in patients with medullary thyroid carcinoma: a multicenter cohort study. Endocrine 85(3), 1300\u20131309 (2024). https:\/\/doi.org\/10.1007\/s12020-024-03809-0","journal-title":"Endocrine"},{"issue":"2","key":"4133_CR4","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1089\/thy.2023.0279","volume":"34","author":"B Xu","year":"2024","unstructured":"B. Xu, K. Viswanathan, M.S. Ahadi et al. Association of the genomic profile of medullary thyroid carcinoma with tumor characteristics and clinical outcomes in an international multicenter study. Thyroid 34(2), 167\u2013176 (2024). https:\/\/doi.org\/10.1089\/thy.2023.0279","journal-title":"Thyroid"},{"issue":"8","key":"4133_CR5","doi-asserted-by":"publisher","first-page":"e2968","DOI":"10.1210\/clinem\/dgab214","volume":"106","author":"A Machens","year":"2021","unstructured":"A. Machens, K. Lorenz, F. Weber, H. Dralle, Exceptionality of distant metastasis in node-negative hereditary and sporadic medullary thyroid cancer: lessons learned. J. Clin. Endocrinol. Metab. 106(8), e2968\u2013e2979 (2021). https:\/\/doi.org\/10.1210\/clinem\/dgab214","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"6","key":"4133_CR6","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1089\/thy.2014.0335","volume":"25","author":"SA Wells","year":"2015","unstructured":"S.A. Wells, S.L. Asa, H. Dralle et al. Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma. Thyroid 25(6), 567\u2013610 (2015). https:\/\/doi.org\/10.1089\/thy.2014.0335","journal-title":"Thyroid"},{"issue":"5","key":"4133_CR7","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1111\/cen.14717","volume":"97","author":"Y Shao","year":"2022","unstructured":"Y. Shao, G. Li, T. Wei et al. Distant metastasis in medullary thyroid carcinoma: clinical outcomes and implications of T stage. Clin. Endocrinol. 97(5), 676\u2013684 (2022). https:\/\/doi.org\/10.1111\/cen.14717","journal-title":"Clin. Endocrinol."},{"key":"4133_CR8","doi-asserted-by":"publisher","first-page":"2979","DOI":"10.1210\/clinem\/dgae214","volume":"109","author":"C-Q Liu","year":"2024","unstructured":"C.-Q. Liu, C.-K. Shen, Y.-X. Du et al. Survival outcome and optimal candidates of primary tumor resection for patients with metastatic medullary thyroid cancer. J. Clin. Endocrinol. Metab. 109, 2979\u2013298 (2024). https:\/\/doi.org\/10.1210\/clinem\/dgae214","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"11","key":"4133_CR9","doi-asserted-by":"publisher","first-page":"3386","DOI":"10.1002\/hed.26840","volume":"43","author":"S-M Zhuang","year":"2021","unstructured":"S.-M. Zhuang, L.-E. Xie, F. Pang et al. Role of primary tumor resection in patients with metastatic medullary thyroid cancer who have unresectable distant metastases. Head Neck 43(11), 3386\u20133392 (2021). https:\/\/doi.org\/10.1002\/hed.26840","journal-title":"Head Neck"},{"issue":"1","key":"4133_CR10","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/s41591-020-01195-4","volume":"27","author":"K Ganesh","year":"2021","unstructured":"K. Ganesh, J. Massagu\u00e9, Targeting metastatic cancer. Nat. Med. 27(1), 34\u201344 (2021). https:\/\/doi.org\/10.1038\/s41591-020-01195-4","journal-title":"Nat. Med."},{"key":"4133_CR11","unstructured":"National Comprehensive Cancer Network. Thyroid Carcinoma (Version 4.2024). https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/thyroid.pdf. Accessed 19 Aug 2024"},{"issue":"1","key":"4133_CR12","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-68458-9","volume":"14","author":"Z Tao","year":"2024","unstructured":"Z. Tao, X. Deng, Z. Ding, B. Guo, Y. Fan, Improved survival after primary tumor resection in distant metastasis medullary thyroid carcinoma: a population-based cohort study with propensity score matching. Sci. Rep. 14(1), 17260 (2024). https:\/\/doi.org\/10.1038\/s41598-024-68458-9","journal-title":"Sci. Rep."},{"key":"4133_CR13","unstructured":"L.G. Frederick, D.L. Page, I.D. Fleming, A.G. Fritz, C.M. Balch, D.G. Haller, M. Monica. AJCC cancer staging manual. (Springer New York. 2017)"},{"issue":"5","key":"4133_CR14","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1001\/jama.2023.26348","volume":"331","author":"L Boucai","year":"2024","unstructured":"L. Boucai, M. Zafereo, M.E. Cabanillas, Thyroid cancer: a review. JAMA 331(5), 425\u2013435 (2024). https:\/\/doi.org\/10.1001\/jama.2023.26348","journal-title":"JAMA"},{"issue":"1","key":"4133_CR15","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49824-7","volume":"15","author":"Y Hou","year":"2024","unstructured":"Y. Hou, B. Lin, T. Xu et al. The neurotransmitter calcitonin gene-related peptide shapes an immunosuppressive microenvironment in medullary thyroid cancer. Nat. Commun. 15(1), 5555 (2024). https:\/\/doi.org\/10.1038\/s41467-024-49824-7","journal-title":"Nat. Commun."},{"issue":"3","key":"4133_CR16","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/j.surg.2016.04.027","volume":"160","author":"LY Wang","year":"2016","unstructured":"L.Y. Wang, I.J. Nixon, S.G. Patel et al. Operative management of locally advanced, differentiated thyroid cancer. Surgery 160(3), 738\u2013746 (2016). https:\/\/doi.org\/10.1016\/j.surg.2016.04.027","journal-title":"Surgery"}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-024-04133-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12020-024-04133-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-024-04133-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T07:54:44Z","timestamp":1742802884000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12020-024-04133-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,19]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["4133"],"URL":"https:\/\/doi.org\/10.1007\/s12020-024-04133-3","relation":{},"ISSN":["1559-0100"],"issn-type":[{"type":"electronic","value":"1559-0100"}],"subject":[],"published":{"date-parts":[[2024,12,19]]},"assertion":[{"value":"18 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}