{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T12:18:34Z","timestamp":1792412314165,"version":"4.4.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["5\/10\/FR\/26\/2019-RBMCH."],"award-info":[{"award-number":["5\/10\/FR\/26\/2019-RBMCH."]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"DOI":"10.1007\/s12020-024-04137-z","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:17:47Z","timestamp":1735258667000},"page":"323-329","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Interplay between elevated RAB5B gene expression and insulin resistance among women with PCOS-insights from a case-control study"],"prefix":"10.1007","volume":"88","author":[{"given":"Khurshid Ahmad","family":"Padder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohmad Aadil","family":"Yousuf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nusrat","family":"Jahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Douhath","family":"Yousuf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Ashraf","family":"Ganie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,27]]},"reference":[{"issue":"3","key":"4137_CR1","first-page":"2220","volume":"19","author":"XH Xu","year":"2019","unstructured":"X.H. Xu et al. Genetic polymorphisms of melatonin receptors 1A and 1B may result in disordered lipid metabolism in obese patients with polycystic ovary syndrome. Mol. Med Rep. 19(3), 2220\u20132230 (2019)","journal-title":"Mol. Med Rep."},{"issue":"3","key":"4137_CR2","doi-asserted-by":"crossref","first-page":"352","DOI":"10.20945\/2359-3997000000049","volume":"62","author":"RP Crespo","year":"2018","unstructured":"R.P. Crespo et al. An update of genetic basis of PCOS pathogenesis. Arch. Endocrinol. Metab. 62(3), 352\u2013361 (2018)","journal-title":"Arch. Endocrinol. Metab."},{"issue":"25","key":"4137_CR3","doi-asserted-by":"crossref","first-page":"14956","DOI":"10.1073\/pnas.95.25.14956","volume":"95","author":"RS Legro","year":"1998","unstructured":"R.S. Legro et al. Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome. Proc. Natl Acad. Sci. USA 95(25), 14956\u201314960 (1998)","journal-title":"Proc. Natl Acad. Sci. USA"},{"issue":"1","key":"4137_CR4","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1385\/ENDO:30:1:19","volume":"30","author":"E Diamanti-Kandarakis","year":"2006","unstructured":"E. Diamanti-Kandarakis, H. Kandarakis, R.S. Legro, The role of genes and environment in the etiology of PCOS. Endocrine 30(1), 19\u201326 (2006)","journal-title":"Endocrine"},{"issue":"6","key":"4137_CR5","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1210\/er.2011-1034","volume":"33","author":"E Diamanti-Kandarakis","year":"2012","unstructured":"E. Diamanti-Kandarakis, A. Dunaif, Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications. Endocr. Rev. 33(6), 981\u20131030 (2012)","journal-title":"Endocr. Rev."},{"issue":"1","key":"4137_CR6","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/ng.732","volume":"43","author":"Z-J Chen","year":"2011","unstructured":"Z.-J. Chen et al. Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16. 3, 2p21 and 9q33. 3. Nat. Genet. 43(1), 55\u201359 (2011)","journal-title":"Nat. Genet."},{"issue":"9","key":"4137_CR7","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/ng.2384","volume":"44","author":"Y Shi","year":"2012","unstructured":"Y. Shi et al. Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome. Nat. Genet. 44(9), 1020\u20131025 (2012)","journal-title":"Nat. Genet."},{"issue":"8","key":"4137_CR8","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1292\/jvms.17-0001","volume":"80","author":"XX Chi","year":"2018","unstructured":"X.X. Chi et al. The regulatory effect of Genistein on granulosa cell in ovary of rat with PCOS through Bcl-2 and Bax signaling pathways. J. Vet. Med Sci. 80(8), 1348\u20131355 (2018)","journal-title":"J. Vet. Med Sci."},{"issue":"3-4","key":"4137_CR9","doi-asserted-by":"crossref","first-page":"129","DOI":"10.2119\/molmed.2009.00118","volume":"16","author":"R Fornes","year":"2010","unstructured":"R. Fornes et al. Changes in the expression of insulin signaling pathway molecules in endometria from polycystic ovary syndrome women with or without hyperinsulinemia. Mol. Med 16(3-4), 129\u2013136 (2010)","journal-title":"Mol. Med"},{"issue":"9","key":"4137_CR10","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.1210\/en.2013-2148","volume":"155","author":"KL Tessneer","year":"2014","unstructured":"K.L. Tessneer et al. Rab5 activity regulates GLUT4 sorting into insulin-responsive and non-insulin-responsive endosomal compartments: a potential mechanism for development of insulin resistance. Endocrinology 155(9), 3315\u20133328 (2014)","journal-title":"Endocrinology"},{"issue":"4","key":"4137_CR11","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1006\/jmbi.2001.5072","volume":"313","author":"JB Pereira-Leal","year":"2001","unstructured":"J.B. Pereira-Leal, M.C. Seabra, Evolution of the Rab family of small GTP-binding proteins. J. Mol. Biol. 313(4), 889\u2013901 (2001)","journal-title":"J. Mol. Biol."},{"issue":"22","key":"4137_CR12","doi-asserted-by":"crossref","first-page":"3905","DOI":"10.1242\/jcs.015909","volume":"120","author":"SL Schwartz","year":"2007","unstructured":"S.L. Schwartz et al. Rab GTPases at a glance. J. Cell Sci. 120(22), 3905\u20133910 (2007)","journal-title":"J. Cell Sci."},{"key":"4137_CR13","doi-asserted-by":"crossref","first-page":"100937","DOI":"10.1016\/j.molmet.2020.01.001","volume":"35","author":"MA Sanchez-Garrido","year":"2020","unstructured":"M.A. Sanchez-Garrido, M. Tena-Sempere, Metabolic dysfunction in polycystic ovary syndrome: Pathogenic role of androgen excess and potential therapeutic strategies. Mol. Metab. 35, 100937 (2020)","journal-title":"Mol. Metab."},{"issue":"3","key":"4137_CR14","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1172\/JCI115683","volume":"89","author":"DB Wilson","year":"1992","unstructured":"D.B. Wilson, M.P. Wilson, Identification and subcellular localization of human rab5b, a new member of the ras-related superfamily of GTPases. J. Clin. Invest. 89(3), 996\u20131005 (1992)","journal-title":"J. Clin. Invest."},{"key":"4137_CR15","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1007\/s10815-015-0585-0","volume":"32","author":"P Tulay","year":"2015","unstructured":"P. Tulay et al. Investigation of microRNA expression and DNA repair gene transcripts in human oocytes and blastocysts. J. Assist. Reprod. Genet. 32, 1757\u20131764 (2015)","journal-title":"J. Assist. Reprod. Genet."},{"issue":"9","key":"4137_CR16","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1007\/s43032-021-00535-0","volume":"28","author":"F Chen","year":"2021","unstructured":"F. Chen et al. Evaluation of the Efficacy of Sex Hormone\u2013Binding Globulin in Insulin Resistance Assessment Based on HOMA-IR in Patients with PCOS. Reprod. Sci. 28(9), 2504\u20132513 (2021)","journal-title":"Reprod. Sci."},{"key":"4137_CR17","doi-asserted-by":"crossref","unstructured":"R. Azziz, E. Carmina, Z. Chen, A. Dunaif, J.S. Laven, R.S. Legro, D. Lizneva, B. Natterson-Horowtiz, H.J. Teede, B.O Yildiz. Polycystic ovary syndrome. Nat. Rev. Dis. Primers. 2, 16057 (2016)","DOI":"10.1038\/nrdp.2016.57"},{"issue":"5","key":"4137_CR18","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/cen.13808","volume":"89","author":"S Shorakae","year":"2018","unstructured":"S. Shorakae et al. Inter\u2010related effects of insulin resistance, hyperandrogenism, sympathetic dysfunction and chronic inflammation in PCOS. Clin. Endocrinol. (Oxf.) 89(5), 628\u2013633 (2018)","journal-title":"Clin. Endocrinol. (Oxf.)"},{"issue":"5","key":"4137_CR19","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nrendo.2018.24","volume":"14","author":"HF Escobar-Morreale","year":"2018","unstructured":"H.F. Escobar-Morreale, Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nat. Rev. Endocrinol. 14(5), 270\u2013284 (2018)","journal-title":"Nat. Rev. Endocrinol."},{"issue":"6","key":"4137_CR20","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1093\/humrep\/dev085","volume":"30","author":"R Saxena","year":"2015","unstructured":"R. Saxena et al. Han Chinese polycystic ovary syndrome risk variants in women of European ancestry: relationship to FSH levels and glucose tolerance. Hum. Reprod. 30(6), 1454\u20131459 (2015)","journal-title":"Hum. Reprod."},{"issue":"5","key":"4137_CR21","doi-asserted-by":"crossref","first-page":"BSR20190292","DOI":"10.1042\/BSR20190292","volume":"39","author":"J Yu","year":"2019","unstructured":"J. Yu et al. Association of single nucleotide polymorphisms in the RAB5B gene 3\u2032UTR region with polycystic ovary syndrome in Chinese Han women. Biosci. Rep. 39(5), BSR20190292 (2019)","journal-title":"Biosci. Rep."},{"issue":"11","key":"4137_CR22","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1055\/s-2007-978953","volume":"30","author":"S Bao","year":"1998","unstructured":"S. Bao et al. Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects. Horm. Metab. Res 30(11), 656\u2013662 (1998)","journal-title":"Horm. Metab. Res"},{"issue":"6","key":"4137_CR23","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1530\/REP-18-0015","volume":"155","author":"K Zhu","year":"2018","unstructured":"K. Zhu et al. Role of RAB5A in FSHR-mediated signal transduction in human granulosa cells. Reproduction 155(6), 505\u2013514 (2018)","journal-title":"Reproduction"},{"issue":"11","key":"4137_CR24","doi-asserted-by":"crossref","first-page":"812","DOI":"10.6026\/97320630015812","volume":"15","author":"S Bakhashab","year":"2019","unstructured":"S. Bakhashab, N. Ahmed, Ahmed, Genotype based risk predictors for polycystic ovary syndrome in Western Saudi Arabia. Bioinformation 15(11), 812 (2019)","journal-title":"Bioinformation"},{"issue":"4","key":"4137_CR25","first-page":"311","volume":"92","author":"TM Barber","year":"2020","unstructured":"T.M. Barber, P. Hanson, M.O. Weickert, S. Franks, J.A. Wass, Circulating levels of GDF15 in polycystic ovary syndrome: a biomarker of metabolic dysfunction? Clin. Endocrinol. 92(4), 311\u2013317 (2020)","journal-title":"Clin. Endocrinol."},{"issue":"1","key":"4137_CR26","first-page":"198","volume":"106","author":"RS Legro","year":"2021","unstructured":"R.S. Legro, A.R. Kunselman, C.M. Stetter, C.L. Gnatuk, Biomarkers of metabolic dysfunction in polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 106(1), 198\u2013208 (2021). (2021)","journal-title":"J. Clin. Endocrinol. Metab."}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-024-04137-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12020-024-04137-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-024-04137-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T07:33:08Z","timestamp":1742801588000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12020-024-04137-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,27]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["4137"],"URL":"https:\/\/doi.org\/10.1007\/s12020-024-04137-z","relation":{},"ISSN":["1559-0100"],"issn-type":[{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,27]]},"assertion":[{"value":"17 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki and was approved by the Institutional Ethics Committee, Sher-i-Kashmir Institute of Medical Sciences (SKIMS), Srinagar via SIMS1131\/IEC-SKIMS\/2019-428. All the study participants were recruited in the study after taking an informed written consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}