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This study investigates whether 2D-SWE can reliably differentiate malignant thyroid nodules in patients with chronic autoimmune thyroiditis (CAT), despite the challenges posed by fibrosis, which can increase tissue stiffness and complicate diagnosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>This retrospective observational study evaluated 130 thyroid nodules (91 benign, 39 malignant) in patients with underlying CAT using conventional ultrasound (B-mode) and 2D-SWE with SuperSonic Mach30 equipment (Supersonic Imagine, Aix-en-Provence, France). Pathology reports served as the reference standard.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Out of the 130 nodules, 30% were malignant, and 70% were benign. 2D-SWE proved to be an excellent distinguisher between benign and malignant nodules. Malignant nodules had significantly higher elasticity indices compared to benign nodules (mean elasticity index: 47.2\u2009kPa vs. 18.1\u2009kPa, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001; maximum elasticity index: 75\u2009kPa vs. 26.2\u2009kPa, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). The mean elasticity index was the most reliable elastographic parameter (AUC 0.907, sensitivity 87.2% [95% CI: 77.3\u201394.0%], specificity 84.6% [95% CI: 75.4\u201391.5%], and NPV 93.9% for a cut-off value of 30.5\u2009kPa).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Our results confirm that 2D-SWE can accurately diagnose malignant thyroid nodules in cases with CAT (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), supporting its use as a complementary tool to conventional ultrasound.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s12020-025-04159-1","type":"journal-article","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T23:43:48Z","timestamp":1737243828000},"page":"482-490","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Shear wave elastography for thyroid nodule evaluation in patients with chronic autoimmune thyroiditis"],"prefix":"10.1007","volume":"88","author":[{"given":"Monica","family":"Latia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea","family":"Bena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Moisa-Luca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0218tefania","family":"Bunceanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Stoian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,19]]},"reference":[{"key":"4159_CR1","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1001\/jama.2018.0898","volume":"319","author":"C Durante","year":"2018","unstructured":"C. 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