{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T20:44:51Z","timestamp":1788468291671,"version":"build-2803163510"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T00:00:00Z","timestamp":1743206400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T00:00:00Z","timestamp":1743206400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100007514","name":"University of Pisa","doi-asserted-by":"crossref","award":["Fondi di Ateneo 2019, 2020 and 2021"],"award-info":[{"award-number":["Fondi di Ateneo 2019, 2020 and 2021"]}],"id":[{"id":"10.13039\/501100007514","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"DOI":"10.1007\/s12020-025-04219-6","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T02:03:09Z","timestamp":1744077789000},"page":"137-142","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["In vivo and in vitro evidence for a protective role of autoantibodies against the insulin-like growth factor-1 receptor (IGF-1R) in Graves\u2019 orbitopathy"],"prefix":"10.1007","volume":"89","author":[{"given":"Giulia","family":"Lanzolla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Rotondo Dottore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Comi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giada","family":"Cosentino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dal\u00ec Antonia","family":"Ciampa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Sabini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Menconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Novella","family":"Maglionico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Posarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Rocchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Latrofa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Figus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferruccio","family":"Santini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0365-116X","authenticated-orcid":false,"given":"Michele","family":"Marin\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,29]]},"reference":[{"key":"4219_CR1","doi-asserted-by":"publisher","first-page":"653627","DOI":"10.3389\/fendo.2021.653627","volume":"12","author":"TJ Smith","year":"2021","unstructured":"T.J. Smith, Insulin-like growth factor pathway and the thyroid. Front. Endocrinol. 12, 653627 (2021)","journal-title":"Front. Endocrinol."},{"key":"4219_CR2","doi-asserted-by":"publisher","first-page":"251","DOI":"10.3109\/08916939309014643","volume":"16","author":"DR Weightman","year":"1993","unstructured":"D.R. Weightman, P. Perros, I.H. Sherif, P. Kendall-Taylor, Autoantibodies to IGF-1 binding sites in thyroid associated ophthalmopathy. Autoimmunity 16, 251\u2013577 (1993)","journal-title":"Autoimmunity"},{"key":"4219_CR3","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1089\/thy.2007.0404","volume":"18","author":"TJ Smith","year":"2008","unstructured":"T.J. Smith, C.C. Tsai, M.J. Shih, S. Tsui, B. Chen, R. Han, V. Naik, C.S. King, C. Press, S. Kamat, R.A. Goldberg, R.P. Phipps, R.S. Douglas, A.G. Gianoukakis, Unique attributes of orbital fibroblasts and global alterations in IGF-1 receptor signaling could explain thyroid-associated ophthalmopathy. Thyroid. 18, 983\u2013988 (2008)","journal-title":"Thyroid."},{"key":"4219_CR4","doi-asserted-by":"publisher","first-page":"942","DOI":"10.4049\/jimmunol.168.2.942","volume":"168","author":"J Pritchard","year":"2002","unstructured":"J. Pritchard, N. Horst, W. Cruikshank, T.J. Smith, Igs from patients with Graves\u2019 disease induce the expression of T cell chemoattractants in their fibroblasts. J. Immunol. 168, 942\u2013950 (2002)","journal-title":"J. Immunol."},{"key":"4219_CR5","doi-asserted-by":"publisher","first-page":"6348","DOI":"10.4049\/jimmunol.170.12.6348","volume":"170","author":"J Pritchard","year":"2003","unstructured":"J. Pritchard, R. Han, N. Horst, W.W. Cruikshank, T.J. Smith, Immunoglobulin activation of T cell chemoattractant expression in fibroblasts from patients with Graves\u2019 disease is mediated through the insulin-like growth factor I receptor pathway. J. Immunol. 170, 6348\u20136354 (2003)","journal-title":"J. Immunol."},{"key":"4219_CR6","doi-asserted-by":"publisher","first-page":"2340","DOI":"10.1210\/jc.2016-1315","volume":"101","author":"CC Krieger","year":"2016","unstructured":"C.C. Krieger, R.F. Place, C. Bevilacqua, B. Marcus-Samuels, B.S. Abel, M.C. Skarulis, G.J. Kahaly, S. Neumann, M.C. Gershengorn, TSH\/IGF-1 receptor cross talk in Graves\u2019 ophthalmopathy pathogenesis. J. Clin. Endocrinol. Metab. 101, 2340\u20132347 (2016)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"4219_CR7","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1210\/jc.2012-1771","volume":"98","author":"WB Minich","year":"2013","unstructured":"W.B. Minich, N. Dehina, T. Welsink, C. Schwiebert, N.G. Morgenthaler, J. Kohrle, A. Eckstein, L. Schomburg, Autoantibodies to the IGF1 receptor in Graves\u2019 orbitopathy. J. Clin. Endocrinol. Metab. 98, 752\u2013760 (2013)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"4219_CR8","doi-asserted-by":"publisher","first-page":"2386","DOI":"10.1210\/jc.2011-0307","volume":"96","author":"WM Wiersinga","year":"2011","unstructured":"W.M. Wiersinga, Autoimmunity in Graves\u2019 ophthalmopathy: the result of an unfortunate marriage between TSH receptors and IGF-1 receptors? J. Clin. Endocrinol. Metab. 96, 2386\u20132394 (2011)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"4219_CR9","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1089\/thy.2017.0105","volume":"27","author":"CC Krieger","year":"2017","unstructured":"C.C. Krieger, S. Neumann, B. Marcus-Samuels, M.C. Gershengorn, TSHR\/IGF-1R cross-talk, not IGF-1R stimulating antibodies, mediates Graves\u2019 ophthalmopathy pathogenesis. Thyroid. 27, 746\u2013747 (2017)","journal-title":"Thyroid."},{"key":"4219_CR10","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1089\/thy.2017.0281","volume":"27","author":"TJ Smith","year":"2017","unstructured":"T.J. Smith, J. Janssen, Response to Krieger et al. re: \u201cTSHR\/IGF-1R cross-talk, not IGF-1R stimulating antibodies, mediates Graves\u2019 ophthalmopathy pathogenesis\u201d. Thyroid. 27, 1458\u20131459 (2017)","journal-title":"Thyroid."},{"key":"4219_CR11","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1007\/s40618-018-0943-8","volume":"42","author":"M Marin\u00f2","year":"2019","unstructured":"M. Marin\u00f2, G. Rotondo Dottore, I. Ionni, G. Lanzolla, E. Sabini, D. Ricci, A. Sframeli, B. Mazzi, F. Menconi, F. Latrofa, P. Vitti, C. Marcocci, L. Chiovato, Serum antibodies against the insulin-like growth factor-1 receptor (IGF-1R) in Graves\u2019 disease and Graves\u2019 orbitopathy. J. Endocrinol. Invest. 42, 471\u2013480 (2019)","journal-title":"J. Endocrinol. Invest."},{"key":"4219_CR12","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1007\/s40618-020-01341-2","volume":"43","author":"G Lanzolla","year":"2020","unstructured":"G. Lanzolla, D. Ricci, F. Nicol\u00ec, E. Sabini, A. Sframeli, A. Brancatella, M. Mantuano, G. Rotondo Dottore, I. Bucci, M. Figus, M. Nardi, F. Latrofa, C. Marcocci, M. Marin\u00f2, Putative protective role of autoantibodies against the insulin-like growth factor-1 receptor in Graves\u2019 disease: results of a pilot study. J. Endocrinol. Invest. 43, 1759\u20131768 (2020)","journal-title":"J. Endocrinol. Invest."},{"key":"4219_CR13","doi-asserted-by":"publisher","first-page":"1748","DOI":"10.1056\/NEJMoa1614949","volume":"376","author":"TJ Smith","year":"2017","unstructured":"T.J. Smith, G.J. Kahaly, D.G. Ezra, J.C. Fleming, R.A. Dailey, R.A. Tang, G.J. Harris, A. Antonelli, M. Salvi, R.A. Goldberg, J.W. Gigantelli, S.M. Couch, E.M. Shriver, B.R. Hayek, E.M. Hink, R.M. Woodward, K. Gabriel, G. Magni, R.S. Douglas, Teprotumumab for thyroid-associated ophthalmopathy. N. Engl. J. Med. 376, 1748\u20131761 (2017)","journal-title":"N. Engl. J. Med."},{"key":"4219_CR14","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1056\/NEJMoa1910434","volume":"382","author":"RS Douglas","year":"2020","unstructured":"R.S. Douglas, G.J. Kahaly, A. Patel, S. Sile, E.H.Z. Thompson, R. Perdok, J.C. Fleming, B.T. Fowler, C. Marcocci, M. Marin\u00f2, A. Antonelli, R. Dailey, G.J. Harris, A. Eckstein, J. Schiffman, R. Tang, C. Nelson, M. Salvi, S. Wester, J.W. Sherman, T. Vescio, R.J. Holt, T.J. Smith, Teprotumumab for the treatment of active thyroid eye disease. N. Engl. J. Med. 382, 341\u2013352 (2020)","journal-title":"N. Engl. J. Med."},{"key":"4219_CR15","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.ophtha.2021.10.017","volume":"129","author":"RS Douglas","year":"2022","unstructured":"R.S. Douglas, G.J. Kahaly, S. Ugradar, H. Elflein, K.A. Ponto, B.T. Fowler, R. Dailey, G.J. Harris, J. Schiffman, R. Tang, S. Wester, A.P. Jain, C. Marcocci, M. Marin\u00f2, A. Antonelli, A. Eckstein, D. F\u00fchrer, M. Salvi, S. Sile, M.F. Sedlak, R.J. Holt, T.J. Smith, Teprotumumab efficacy, safety and durability in longer duration thyroid eyedisease and retreatment: Optic-X Study. Ophthalmology. 129, 438\u2013449 (2022)","journal-title":"Ophthalmology."},{"key":"4219_CR16","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1055\/s-0035-1555762","volume":"47","author":"RS Bahn","year":"2015","unstructured":"R.S. Bahn, Current insights into the pathogenesis of Graves\u2019 ophthalmopathy. Horm. Metab. Res. 47, 773\u2013778 (2015)","journal-title":"Horm. Metab. Res."},{"key":"4219_CR17","doi-asserted-by":"publisher","first-page":"3455","DOI":"10.1073\/pnas.77.6.3455","volume":"77","author":"FS Ambesi-Impiombato","year":"1980","unstructured":"F.S. Ambesi-Impiombato, L.A. Parks, H.G. Coon, Culture of hormone-dependent functional epithelial cells from rat thyroids. Proc. Natl. Acad. Sci. USA. 77, 3455\u20133459 (1980)","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"4219_CR18","doi-asserted-by":"publisher","first-page":"e2176","DOI":"10.1210\/clinem\/dgab035","volume":"106","author":"G Rotondo Dottore","year":"2021","unstructured":"G. Rotondo Dottore, I. Bucci, G. Lanzolla, I. Dallan, A. Sframeli, L. Torregrossa, G. Casini, F. Basolo, M. Figus, M. Nardi, C. Marcocci, M. Marin\u00f2, Genetic profiling of orbital fibroblasts from patients with Graves\u2019 orbitopathy. J. Clin. Endocrinol. Metab. 106, e2176\u2013e2190 (2021)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"4219_CR19","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s40618-022-01906-3","volume":"46","author":"G Lanzolla","year":"2023","unstructured":"G. Lanzolla, L. Puccinelli, M. Giudetti, S. Comi, F. Menconi, M.N. Maglionico, C. Posarelli, M. Figus, C. Marcocci, M. Marin\u00f2, Anti-nuclear autoantibodies in Graves\u2019 disease and Graves\u2019 orbitopathy. J. Endocrinol. Invest. 46, 337\u2013344 (2023)","journal-title":"J. Endocrinol. Invest."},{"key":"4219_CR20","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1007\/s40618-023-02017-3","volume":"46","author":"G Lanzolla","year":"2023","unstructured":"G. Lanzolla, L. Di Matteo, S. Comi, G. Cosentino, F. Menconi, M.N. Maglionico, C. Posarelli, M. Figus, M. Marin\u00f2, Absence of a relationship between vitamin D and Graves\u2019 orbitopathy. J. Endocrinol. Invest. 46, 1717\u20131721 (2023)","journal-title":"J. Endocrinol. Invest."},{"key":"4219_CR21","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1089\/thy.2018.0089","volume":"28","author":"B Marcus-Samuels","year":"2018","unstructured":"B. Marcus-Samuels, C.C. Krieger, A. Boutin, G. Kahaly, S. Neumann, M.C. Gershengorn, Evidence that Graves\u2019 ophthalmopathy immunoglobulins do not directly activate IGF-1 receptors. Thyroid. 28, 650\u2013655 (2018)","journal-title":"Thyroid."},{"key":"4219_CR22","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1210\/jc.2012-2270","volume":"98","author":"AJ Varewijck","year":"2013","unstructured":"A.J. Varewijck, A. Boelen, S.W. Lamberts, E. Fliers, L.J. Hofland, W.M. Wiersinga, J.A. Janssen, Circulating IgGs may modulate IGF-I receptor stimulating activity in a subset of patients with Graves\u2019 ophthalmopathy. J. Clin. Endocrinol. Metab. 98, 769\u2013776 (2013)","journal-title":"J. Clin. Endocrinol. Metab."}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-025-04219-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12020-025-04219-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-025-04219-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T06:49:22Z","timestamp":1751611762000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12020-025-04219-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,29]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["4219"],"URL":"https:\/\/doi.org\/10.1007\/s12020-025-04219-6","relation":{},"ISSN":["1559-0100"],"issn-type":[{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,29]]},"assertion":[{"value":"14 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Informed consent was obtained from the individual participant included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}