{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T07:16:26Z","timestamp":1784013386167,"version":"3.55.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"CSIR, New Delhi","award":["MLP 2035"],"award-info":[{"award-number":["MLP 2035"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"DOI":"10.1007\/s12020-025-04251-6","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T12:22:00Z","timestamp":1747225320000},"page":"565-577","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Isovitexin, a natural adiponectin agonist, prevents glucocorticoid-induced osteosarcopenia"],"prefix":"10.1007","volume":"89","author":[{"given":"Chirag","family":"Kulkarni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saroj","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamima","family":"Khatoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreyanko","family":"Sadhukhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaveri R.","family":"Washimkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhilesh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivani","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Rajput","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konica","family":"Porwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhav Nilakanth","family":"Mugale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srikanta Kumar","family":"Rath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madan Madhav","family":"Godbole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabyasachi","family":"Sanyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navin","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambrish","family":"Mithal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naibedya","family":"Chattopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,14]]},"reference":[{"key":"4251_CR1","doi-asserted-by":"publisher","first-page":"5768","DOI":"10.3390\/ijms20225768","volume":"20","author":"JM Webster","year":"2019","unstructured":"J.M. Webster, C.G. Fenton, R. Langen, R.S. Hardy, Exploring the interface between inflammatory and therapeutic glucocorticoid induced bone and muscle loss. Int. J. Mol. Sci. 20, 5768 (2019). https:\/\/doi.org\/10.3390\/ijms20225768","journal-title":"Int. J. Mol. Sci."},{"key":"4251_CR2","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.tem.2006.03.009","volume":"17","author":"G Mazziotti","year":"2006","unstructured":"G. Mazziotti, A. Angeli, J.P. Bilezikian, E. Canalis, A. Giustina, Glucocorticoid-induced osteoporosis: an update. Trends Endocrinol. Metab. 17, 144\u2013149 (2006). https:\/\/doi.org\/10.1016\/j.tem.2006.03.009","journal-title":"Trends Endocrinol. Metab."},{"key":"4251_CR3","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1590\/s0004-27302007000800028","volume":"51","author":"G Mazziotti","year":"2007","unstructured":"G. Mazziotti, A. Giustina, E. Canalis, J.P. Bilezikian, Glucocorticoid-induced osteoporosis: clinical and therapeutic aspects. Arq. Bras. Endocrinol. Metabol. 51, 1404\u20131412 (2007). https:\/\/doi.org\/10.1590\/s0004-27302007000800028","journal-title":"Arq. Bras. Endocrinol. Metabol."},{"key":"4251_CR4","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-56853-6","volume":"10","author":"S Pal","year":"2020","unstructured":"S. Pal, N. Mittapelly, A. Husain, S. Kushwaha, S. Chattopadhyay, P. Kumar, E. Ramakrishna, S. Kumar, R. Maurya, S. Sanyal, J.R. Gayen, P.R. Mishra, N. Chattopadhyay, A butanolic fraction from the standardized stem extract of Cassia occidentalis L delivered by a self-emulsifying drug delivery system protects rats from glucocorticoid-induced osteopenia and muscle atrophy. Sci. Rep. 10, 195 (2020). https:\/\/doi.org\/10.1038\/s41598-019-56853-6","journal-title":"Sci. Rep."},{"key":"4251_CR5","unstructured":"M. Arazzi, G. Di Fulvio Di, L.O. Pietro, X. Grabocka, M.O. Longo, G. Micioni, A. Pezzutto, L. Piscitani, A. Schiazza, S. Silvestri, G. Vigilante, L. Amoroso, M. Bonomini, [Therapy of glucocorticoid induced osteoporosis]. Giornale italiano di nefrologia: organo ufficiale della Societa italiana di nefrologia. 34, (2017)."},{"key":"4251_CR6","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.jep.2019.01.029","volume":"235","author":"S Pal","year":"2019","unstructured":"S. Pal, P. Kumar, E. Ramakrishna, S. Kumar, K. Porwal, B. Kumar, K.R. Arya, R. Maurya, N. Chattopadhyay, Extract and fraction of Cassia occidentalis L. (a synonym of Senna occidentalis) have osteogenic effect and prevent glucocorticoid-induced osteopenia. J. Ethnopharmacol. 235, 8\u201318 (2019). https:\/\/doi.org\/10.1016\/j.jep.2019.01.029","journal-title":"J. Ethnopharmacol."},{"key":"4251_CR7","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3390\/ijms20010083","volume":"20","author":"G Russow","year":"2018","unstructured":"G. Russow, D. Jahn, J. Appelt, S. M\u00e4rdian, S. Tsitsilonis, J. Keller, Anabolic therapies in osteoporosis and bone regeneration. Int. J. Mol. Sci. 20, 83 (2018). https:\/\/doi.org\/10.3390\/ijms20010083","journal-title":"Int. J. Mol. Sci."},{"key":"4251_CR8","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1007\/s00223-022-00979-9","volume":"111","author":"S Pal","year":"2022","unstructured":"S. Pal, S. Sharma, K. Porwal, M. Riyazuddin, C. Kulkarni, S. Chattopadhyay, S. Sanyal, J.R. Gayen, N. Chattopadhyay, Oral administration of isovitexin, a naturally occurring apigenin derivative showed osteoanabolic effect in ovariectomized mice: a comparative study with teriparatide. Calcif. Tissue Int. 111, 196\u2013210 (2022). https:\/\/doi.org\/10.1007\/s00223-022-00979-9","journal-title":"Calcif. Tissue Int."},{"key":"4251_CR9","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.bone.2017.08.005","volume":"105","author":"SP China","year":"2017","unstructured":"S.P. China, S. Pal, S. Chattopadhyay, K. Porwal, S. Kushwaha, S. Bhattacharyya, M. Mittal, A.A. Gurjar, T. Barbhuyan, A.K. Singh, A.K. Trivedi, J.R. Gayen, S. Sanyal, N. Chattopadhyay, Globular adiponectin reverses osteo-sarcopenia and altered body composition in ovariectomized rats. Bone 105, 75\u201386 (2017). https:\/\/doi.org\/10.1016\/j.bone.2017.08.005","journal-title":"Bone"},{"key":"4251_CR10","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1007\/s12272-024-01509-x","volume":"47","author":"S Rajput","year":"2024","unstructured":"S. Rajput, C. Kulkarni, S. Sharma, M.S. Tomar, S. Khatoon, A. Gupta, S. Sanyal, A. Shrivastava, J.K. Ghosh, N. Chattopadhyay, Osteogenic effect of an adiponectin-derived short peptide that rebalances bone remodeling: a potential disease-modifying approach for postmenopausal osteoporosis therapy. Arch. Pharmacal. Res. 47, 736\u2013755 (2024). https:\/\/doi.org\/10.1007\/s12272-024-01509-x","journal-title":"Arch. Pharmacal. Res."},{"key":"4251_CR11","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/nature12656","volume":"503","author":"M Okada-Iwabu","year":"2013","unstructured":"M. Okada-Iwabu, T. Yamauchi, M. Iwabu, T. Honma, K. Hamagami, K. Matsuda, M. Yamaguchi, H. Tanabe, T. Kimura-Someya, M. Shirouzu, H. Ogata, K. Tokuyama, K. Ueki, T. Nagano, A. Tanaka, S. Yokoyama, T. Kadowaki, A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature 503, 493\u2013499 (2013). https:\/\/doi.org\/10.1038\/nature12656","journal-title":"Nature"},{"key":"4251_CR12","doi-asserted-by":"publisher","first-page":"e0230227","DOI":"10.1371\/journal.pone.0230227","volume":"15","author":"SK Choi","year":"2020","unstructured":"S.K. Choi, Y. Kwon, S. Byeon, C.E. Haam, Y.H. Lee, AdipoRon, adiponectin receptor agonist, improves vascular function in the mesenteric arteries of type 2 diabetic mice. PLoS One 15, e0230227 (2020). https:\/\/doi.org\/10.1371\/journal.pone.0230227","journal-title":"PLoS One"},{"key":"4251_CR13","doi-asserted-by":"publisher","first-page":"3530","DOI":"10.2337\/db13-1619","volume":"63","author":"AK Singh","year":"2014","unstructured":"A.K. Singh, A.A. Joharapurkar, M.P. Khan, J.S. Mishra, N. Singh, M. Yadav, Z. Hossain, K. Khan, S. Kumar, N.A. Dhanesha, D.P. Mishra, R. Maurya, S. Sharma, M.R. Jain, A.K. Trivedi, M.M. Godbole, J.R. Gayen, N. Chattopadhyay, S. Sanyal, Orally active osteoanabolic agent GTDF binds to adiponectin receptors, with a preference for AdipoR1, induces adiponectin-associated signaling, and improves metabolic health in a rodent model of diabetes. Diabetes 63, 3530\u20133544 (2014). https:\/\/doi.org\/10.2337\/db13-1619","journal-title":"Diabetes"},{"key":"4251_CR14","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.mce.2016.09.013","volume":"439","author":"AK Singh","year":"2017","unstructured":"A.K. Singh, S. Shree, S. Chattopadhyay, S. Kumar, A. Gurjar, S. Kushwaha, H. Kumar, A.K. Trivedi, N. Chattopadhyay, R. Maurya, R. Ramachandran, S. Sanyal, Small molecule adiponectin receptor agonist GTDF protects against skeletal muscle atrophy. Mol. Cell. Endocrinol. 439, 273\u2013285 (2017). https:\/\/doi.org\/10.1016\/j.mce.2016.09.013","journal-title":"Mol. Cell. Endocrinol."},{"key":"4251_CR15","doi-asserted-by":"publisher","first-page":"174634","DOI":"10.1016\/j.ejphar.2021.174634","volume":"913","author":"S Pal","year":"2021","unstructured":"S. Pal, M. Singh, K. Porwal, S. Rajak, N. Das, S. Rajput, A.K. Trivedi, R. Maurya, R.A. Sinha, M.I. Siddiqi, S. Sanyal, N. Chattopadhyay, Adiponectin receptors by increasing mitochondrial biogenesis and respiration promote osteoblast differentiation: Discovery of isovitexin as a new class of small molecule adiponectin receptor modulator with potential osteoanabolic function. Eur. J. Pharmacol. 913, 174634 (2021). https:\/\/doi.org\/10.1016\/j.ejphar.2021.174634","journal-title":"Eur. J. Pharmacol."},{"key":"4251_CR16","doi-asserted-by":"publisher","first-page":"176800","DOI":"10.1016\/j.ejphar.2024.176800","volume":"978","author":"S Khatoon","year":"2024","unstructured":"S. Khatoon, N. Das, S. Chattopadhyay, A. Joharapurkar, A. Singh, V. Patel, A. Nirwan, A. Kumar, M.N. Mugale, D.P. Mishra, J. Kumaravelu, R. Guha, M.R. Jain, N. Chattopadhyay, S. Sanyal, Apigenin-6-C-glucoside ameliorates MASLD in rodent models via selective agonism of adiponectin receptor 2. Eur. J. Pharmacol. 978, 176800 (2024). https:\/\/doi.org\/10.1016\/j.ejphar.2024.176800","journal-title":"Eur. J. Pharmacol."},{"key":"4251_CR17","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.3390\/nu11061238","volume":"11","author":"D Hou","year":"2019","unstructured":"D. Hou, L. Yousaf, Y. Xue, J. Hu, J. Wu, X. Hu, N. Feng, Q. Shen, Mung Bean (Vigna radiata L.): bioactive polyphenols, polysaccharides, peptides, and health benefits. Nutrients 11, 1238 (2019). https:\/\/doi.org\/10.3390\/nu11061238","journal-title":"Nutrients"},{"key":"4251_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfca.2021.103895","volume":"100","author":"JP Kalinov\u00e1","year":"2021","unstructured":"J.P. Kalinov\u00e1, N. Vrchotov\u00e1, J. T\u0159\u00edska, Vitexin and isovitexin levels in sprouts of selected plants. J. Food Composition Anal. 100, 103895 (2021)","journal-title":"J. Food Composition Anal."},{"key":"4251_CR19","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.jff.2013.10.016","volume":"6","author":"S Khole","year":"2014","unstructured":"S. Khole, S. Chatterjee, P. Variyar, A. Sharma, T. Devasagayam, S. Ghaskadbi, Bioactive constituents of germinated fenugreek seeds with strong antioxidant potential. J. Funct. Foods 6, 270\u2013279 (2014)","journal-title":"J. Funct. Foods"},{"key":"4251_CR20","doi-asserted-by":"publisher","first-page":"989","DOI":"10.3390\/nu15040989","volume":"15","author":"LF Laurindo","year":"2023","unstructured":"L.F. Laurindo, S.M. Barbalho, A.C. Ara\u00fajo, E.L. Guiguer, A. Mondal, G. Bachtel, A. Bishayee, A\u00e7a\u00ed (Euterpe oleracea Mart.) in health and disease: a critical review. Nutrients 15, 989 (2023). https:\/\/doi.org\/10.3390\/nu15040989","journal-title":"Nutrients"},{"key":"4251_CR21","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.phytochem.2018.12.013","volume":"160","author":"T Rho","year":"2019","unstructured":"T. Rho, M.S. Choi, M. Jung, H.W. Kil, Y.D. Hong, K.D. Yoon, Identification of fermented tea (Camellia sinensis) polyphenols and their inhibitory activities against amyloid-beta aggregation. Phytochemistry 160, 11\u201318 (2019). https:\/\/doi.org\/10.1016\/j.phytochem.2018.12.013","journal-title":"Phytochemistry"},{"key":"4251_CR22","doi-asserted-by":"publisher","first-page":"951800","DOI":"10.3389\/fendo.2022.951800","volume":"13","author":"C Kulkarni","year":"2022","unstructured":"C. Kulkarni, S. Sharma, P.S. Bora, S. Verma, S. Rajput, K. Porwal, S.K. Rath, J.R. Gayen, U. Sharma, N. Chattopadhyay, A novel extraction method enhanced the osteogenic and anti-osteoporosis effect of tea extract without any hepatotoxicity in ovariectomized rats. Front. Endocrinol. 13, 951800 (2022). https:\/\/doi.org\/10.3389\/fendo.2022.951800","journal-title":"Front. Endocrinol."},{"key":"4251_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110448","volume":"129","author":"K Porwal","year":"2020","unstructured":"K. Porwal, S. Pal, C. Kulkarni, P. Singh, S. Sharma, P. Singh, G. Prajapati, J.R. Gayen, R.S. Ampapathi, A. Mullick, N. Chattopadhyay, A prebiotic, short-chain fructo-oligosaccharides promotes peak bone mass and maintains bone mass in ovariectomized rats by an osteogenic mechanism. Biomed. Pharmacother. 129, 110448 (2020). https:\/\/doi.org\/10.1016\/j.biopha.2020.110448","journal-title":"Biomed. Pharmacother."},{"key":"4251_CR24","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1130003","volume":"14","author":"C Kulkarni","year":"2023","unstructured":"C. Kulkarni, S. Sharma, K. Porwal, S. Rajput, S. Sadhukhan, V. Singh, A. Singh, S. Baranwal, S. Kumar, A. Girme, A.R. Pandey, S.P. Singh, K.V. Sashidhara, N. Kumar, L. Hingorani, N. Chattopadhyay, A standardized extract of Coleus forskohlii root protects rats from ovariectomy-induced loss of bone mass and strength, and impaired bone material by osteogenic and anti-resorptive mechanisms. Front. Endocrinol. 14, 1130003 (2023). https:\/\/doi.org\/10.3389\/fendo.2023.1130003","journal-title":"Front. Endocrinol."},{"key":"4251_CR25","doi-asserted-by":"publisher","first-page":"e2271","DOI":"10.1210\/clinem\/dgab027","volume":"106","author":"P Sihota","year":"2021","unstructured":"P. Sihota, R.N. Yadav, R. Dhaliwal, J.C. Bose, V. Dhiman, D. Neradi, S. Karn, S. Sharma, S. Aggarwal, V.G. Goni, V. Mehandia, D. Vashishth, S.K. Bhadada, N. Kumar, Investigation of mechanical, material, and compositional determinants of human trabecular bone quality in type 2 diabetes. J. Clin. Endocrinol. Metab. 106, e2271\u2013e2289 (2021). https:\/\/doi.org\/10.1210\/clinem\/dgab027","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"4251_CR26","doi-asserted-by":"publisher","first-page":"1233613","DOI":"10.3389\/fendo.2023.1233613","volume":"14","author":"K Porwal","year":"2023","unstructured":"K. Porwal, S. Sharma, S. Kumar, M.S. Tomar, S. Sadhukhan, S. Rajput, C. Kulkarni, A. Shrivastava, N. Kumar, N. Chattopadhyay, Hormonal and non-hormonal oral contraceptives given long-term to pubertal rats differently affect bone mass, quality and metabolism. Front. Endocrinol. 14, 1233613 (2023). https:\/\/doi.org\/10.3389\/fendo.2023.1233613","journal-title":"Front. Endocrinol."},{"key":"4251_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2023.110373","volume":"373","author":"KR Washimkar","year":"2023","unstructured":"K.R. Washimkar, M.S. Tomar, S. Ishteyaque, A. Kumar, A. Shrivastava, M.N. Mugale, Benzo[a]pyrene treatment modulates Nrf2\/Keap1 axis and changes the metabolic profile in rat lung cancer. Chemico-Biological Interact. 373, 110373 (2023). https:\/\/doi.org\/10.1016\/j.cbi.2023.110373","journal-title":"Chemico-Biological Interact."},{"key":"4251_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.122064","volume":"331","author":"KR Washimkar","year":"2023","unstructured":"K.R. Washimkar, M.S. Tomar, C. Kulkarni, S. Verma, A. Shrivastava, N. Chattopadhyay, M.N. Mugale, Longitudinal assessment of bleomycin-induced pulmonary fibrosis by evaluating TGF-\u03b21\/Smad2, Nrf2 signaling and metabolomic analysis in mice. Life Sci. 331, 122064 (2023). https:\/\/doi.org\/10.1016\/j.lfs.2023.122064","journal-title":"Life Sci."},{"key":"4251_CR29","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1254\/jjp.90.236","volume":"90","author":"Y Wang","year":"2002","unstructured":"Y. Wang, M. Ohtsuka-Isoya, P. Shao, S. Sakamoto, H. Shinoda, Effects of methylprednisolone on bone formation and resorption in rats. Japanese J. Pharmacol. 90, 236\u2013246 (2002). https:\/\/doi.org\/10.1254\/jjp.90.236","journal-title":"Japanese J. Pharmacol."},{"key":"4251_CR30","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1016\/j.phymed.2013.07.007","volume":"20","author":"MP Khan","year":"2013","unstructured":"M.P. Khan, J.S. Mishra, K. Sharan, M. Yadav, A.K. Singh, A. Srivastava, S. Kumar, S. Bhaduaria, R. Maurya, S. Sanyal, N. Chattopadhyay, A novel flavonoid C-glucoside from Ulmus wallichiana preserves bone mineral density, microarchitecture and biomechanical properties in the presence of glucocorticoid by promoting osteoblast survival: a comparative study with human parathyroid hormone. Phytomedicine 20, 1256\u20131266 (2013). https:\/\/doi.org\/10.1016\/j.phymed.2013.07.007","journal-title":"Phytomedicine"},{"key":"4251_CR31","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1038\/bonekey.2012.182","volume":"1","author":"P Garnero","year":"2012","unstructured":"P. Garnero, The contribution of collagen crosslinks to bone strength. BoneKEy Rep. 1, 182 (2012). https:\/\/doi.org\/10.1038\/bonekey.2012.182","journal-title":"BoneKEy Rep."},{"key":"4251_CR32","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.clinbiomech.2012.10.003","volume":"28","author":"C Albert","year":"2013","unstructured":"C. Albert, J. Jameson, J.M. Toth, P. Smith, G. Harris, Bone properties by nanoindentation in mild and severe osteogenesis imperfecta. Clin. Biomech. 28, 110\u2013116 (2013). https:\/\/doi.org\/10.1016\/j.clinbiomech.2012.10.003","journal-title":"Clin. Biomech."},{"key":"4251_CR33","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1097\/gme.0b013e3181d2ce7f","volume":"17","author":"K Sharan","year":"2010","unstructured":"K. Sharan, G. Swarnkar, J.A. Siddiqui, A. Kumar, P. Rawat, M. Kumar, G.K. Nagar, L. Manickavasagam, S.P. Singh, G. Mishra, Wahajuddin, G.K. Jain, R. Maurya, N. Chattopadhyay, A novel flavonoid, 6-C-beta-d-glucopyranosyl-(2S,3S)-(+)-3\u2019,4\u2019,5,7-tetrahydroxyflavanone, isolated from Ulmus wallichiana Planchon mitigates ovariectomy-induced osteoporosis in rats. Menopause 17, 577\u2013586 (2010). https:\/\/doi.org\/10.1097\/gme.0b013e3181d2ce7f","journal-title":"Menopause"},{"key":"4251_CR34","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.ejphar.2018.02.028","volume":"826","author":"S Bhattacharyya","year":"2018","unstructured":"S. Bhattacharyya, S. Pal, N. Chattopadhyay, Targeted inhibition of sclerostin for post-menopausal osteoporosis therapy: a critical assessment of the mechanism of action. Eur. J. Pharmacol. 826, 39\u201347 (2018). https:\/\/doi.org\/10.1016\/j.ejphar.2018.02.028","journal-title":"Eur. J. Pharmacol."},{"key":"4251_CR35","doi-asserted-by":"publisher","first-page":"441","DOI":"10.5535\/arm.2018.42.3.441","volume":"42","author":"SG Park","year":"2018","unstructured":"S.G. Park, S.U. Jeong, J.H. Lee, S.H. Ryu, H.J. Jeong, Y.J. Sim, D.K. Kim, G.C. Kim, The changes of CTX, DPD, osteocalcin, and bone mineral density during the postmenopausal period. Ann. Rehabilitation Med. 42, 441\u2013448 (2018). https:\/\/doi.org\/10.5535\/arm.2018.42.3.441","journal-title":"Ann. Rehabilitation Med."},{"key":"4251_CR36","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1210\/er.2006-0029","volume":"28","author":"P Chavassieux","year":"2007","unstructured":"P. Chavassieux, E. Seeman, P.D. Delmas, Insights into material and structural basis of bone fragility from diseases associated with fractures: how determinants of the biomechanical properties of bone are compromised by disease. Endocr. Rev. 28, 151\u2013164 (2007). https:\/\/doi.org\/10.1210\/er.2006-0029","journal-title":"Endocr. Rev."},{"key":"4251_CR37","doi-asserted-by":"publisher","first-page":"3649","DOI":"10.1002\/art.34639","volume":"64","author":"M Takahata","year":"2012","unstructured":"M. Takahata, J.R. Maher, S.C. Juneja, J. Inzana, L. Xing, E.M. Schwarz, A.J. Berger, H.A. Awad, Mechanisms of bone fragility in a mouse model of glucocorticoid-treated rheumatoid arthritis: implications for insufficiency fracture risk. Arthritis Rheumatism 64, 3649\u20133659 (2012). https:\/\/doi.org\/10.1002\/art.34639","journal-title":"Arthritis Rheumatism"},{"key":"4251_CR38","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1007\/s00223-013-9695-9","volume":"92","author":"L Spevak","year":"2013","unstructured":"L. Spevak, C.R. Flach, T. Hunter, R. Mendelsohn, A. Boskey, Fourier transform infrared spectroscopic imaging parameters describing acid phosphate substitution in biologic hydroxyapatite. Calcif. Tissue Int. 92, 418\u2013428 (2013). https:\/\/doi.org\/10.1007\/s00223-013-9695-9","journal-title":"Calcif. Tissue Int."},{"key":"4251_CR39","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1007\/s00198-009-0860-y","volume":"20","author":"C Rey","year":"2009","unstructured":"C. Rey, C. Combes, C. Drouet, M.J. Glimcher, Bone mineral: update on chemical composition and structure. Osteoporos. International 20, 1013\u20131021 (2009). https:\/\/doi.org\/10.1007\/s00198-009-0860-y","journal-title":"Osteoporos. International"},{"key":"4251_CR40","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1359\/jbmr.090414","volume":"24","author":"S Gourion-Arsiquaud","year":"2009","unstructured":"S. Gourion-Arsiquaud, D. Faibish, E. Myers, L. Spevak, J. Compston, A. Hodsman, E. Shane, R.R. Recker, E.R. Boskey, A.L. Boskey, Use of FTIR spectroscopic imaging to identify parameters associated with fragility fracture. J. Bone Miner. Research 24, 1565\u20131571 (2009). https:\/\/doi.org\/10.1359\/jbmr.090414","journal-title":"J. Bone Miner. Research"},{"key":"4251_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2024.117126","volume":"185","author":"S Sharma","year":"2024","unstructured":"S. Sharma, S. Kumar, M.S. Tomar, D. Chauhan, C. Kulkarni, S. Rajput, S. Sadhukhan, K. Porwal, R. Guha, A. Shrivastava, J.R. Gayen, N. Kumar, N. Chattopadhyay, Multiscale effects of the calcimimetic drug, etelcalcetide on bone health of rats with secondary hyperparathyroidism induced by chronic kidney disease. Bone 185, 117126 (2024). https:\/\/doi.org\/10.1016\/j.bone.2024.117126","journal-title":"Bone"},{"key":"4251_CR42","doi-asserted-by":"publisher","first-page":"2184","DOI":"10.1039\/d1fo03867b","volume":"13","author":"S Sharma","year":"2022","unstructured":"S. Sharma, K. Porwal, C. Kulkarni, S. Pal, P. Sihota, S. Kumar, M.C. Tiwari, R. Katekar, A. Kumar, P. Singh, S. Rajput, R. Guha, N. Kumar, J.R. Gayen, N. Chattopadhyay, Diosmin, a citrus fruit-derived phlebotonic bioflavonoid protects rats from chronic kidney disease-induced loss of bone mass and strength without deteriorating the renal function. Food Funct. 13, 2184\u20132199 (2022). https:\/\/doi.org\/10.1039\/d1fo03867b","journal-title":"Food Funct."},{"key":"4251_CR43","doi-asserted-by":"publisher","first-page":"154044","DOI":"10.1016\/j.metabol.2019.154044","volume":"103","author":"AA Gurjar","year":"2020","unstructured":"A.A. Gurjar, S. Kushwaha, S. Chattopadhyay, N. Das, S. Pal, S.P. China, H. Kumar, A.K. Trivedi, R. Guha, N. Chattopadhyay, S. Sanyal, Long acting GLP-1 analog liraglutide ameliorates skeletal muscle atrophy in rodents. Metabolism: Clin. Exp. 103, 154044 (2020). https:\/\/doi.org\/10.1016\/j.metabol.2019.154044","journal-title":"Metabolism: Clin. Exp."}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-025-04251-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12020-025-04251-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-025-04251-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T14:51:28Z","timestamp":1757170288000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12020-025-04251-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,14]]},"references-count":43,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["4251"],"URL":"https:\/\/doi.org\/10.1007\/s12020-025-04251-6","relation":{},"ISSN":["1559-0100"],"issn-type":[{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,14]]},"assertion":[{"value":"7 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}