{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T11:40:06Z","timestamp":1755776406255,"version":"3.44.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>This study aimed to evaluate oxidative DNA damage and its association with polymorphisms in DNA repair enzymes among patients with differentiated thyroid cancer (DTC) treated with high-dose radioactive iodine (RAI, \u2265100\u2009mCi). Relationships between DNA damage markers, gene variants, and clinical or tumor characteristics were also explored.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Seventy-nine patients with DTC and 59 age and sex matched controls from a Turkish population were included. Urinary 8-hydroxy-2\u2032-deoxyguanosine (8-oxoG), a marker of oxidative DNA damage, was measured by ELISA at baseline, 2 weeks, and 3 months post-RAI. Genotyping for hOGG1 Ser326Cys and APE1 Asp148Glu polymorphisms was performed on leukocyte-derived DNA using real-time PCR and melting curve analysis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Urinary 8-oxoG levels showed a non-significant upward trend over time (<jats:italic>p<\/jats:italic>\u2009=\u20090.252). The Cys\/Cys genotype of hOGG1 was more frequent in patients than controls (13 vs. 6%, <jats:italic>p<\/jats:italic>\u2009=\u20090.54), while the Ser\/Cys genotype was significantly less frequent in patients (36.7 vs. 57.6%; OR: 0.46, 95% CI: 0.22\u20130.94, <jats:italic>p<\/jats:italic>\u2009=\u20090.03). Cys allele frequencies were 0.32 in patients and 0.35 in controls. APE1 genotype and allele distributions did not differ significantly between groups. No associations were found between polymorphisms and 8-oxoG levels or clinical features, including DTC subtype, tumor stage, sex, smoking status, or age.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>This is the first study to jointly evaluate urinary 8-oxoG and hOGG1\/APE1 polymorphisms in Turkish DTC patients receiving RAI. No consistent associations were found with oxidative DNA damage or clinical characteristics. Larger studies are needed to validate these findings.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s12020-025-04288-7","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T09:27:43Z","timestamp":1748251663000},"page":"786-792","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oxidative DNA damage and DNA repair gene variants in differentiated thyroid cancer patients treated with radioactive iodine"],"prefix":"10.1007","volume":"89","author":[{"given":"Fevzi Necati","family":"Avsar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Semra Do\u011fru","family":"Abbaso\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evin","family":"Ademo\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuncay","family":"Sahutoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"issue":"no. 5","key":"4288_CR1","doi-asserted-by":"publisher","first-page":"723","DOI":"10.2967\/jnumed.118.211359","volume":"59","author":"M Tulchinsky","year":"2018","unstructured":"M. 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Meeting date: 26.11.2010; number: 10073).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics committee approval"}},{"value":"The patients were included in the study after their informed consent was obtained.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient consent"}},{"value":"The authors declare that they have no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}