{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:45:37Z","timestamp":1788864337374,"version":"build-2803163510"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"The Research Foundation of the Odense University Hospital Consultants Council"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>This single-center retrospective study investigates the incidence of hypoparathyroidism after bilateral thyroidectomy at a tertiary referral center over one decade, including risk factors, time to recovery, and reasons for belated treatment initiation in seemingly \u201clate onset\u201d hypoparathyroidism.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Patients who underwent total\/completion thyroidectomy from January 2011 to December 2020 were included. Potential risk factors for hypoparathyroidism were retrieved from the medical records. Hypoparathyroidism was defined as treatment with an activated vitamin D analogue (AVDA). The incidence was registered 0, 6, 12, and &gt;12 months postoperatively. Hospital records were cross-linked with the national prescription database to ensure complete follow-up.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The incidence of hypoparathyroidism increased from 10.1% upon hospital discharge to 11.4% after 6 months, 12.2% after 12 months, and 12.6% &gt;12 months (median follow-up 7.7 years). The cumulative recovery rate was 19.9% by 6 months, 23.6% by 12 months, and 29.8% &gt;12 months. As many as 23.3% of patients with persistent hypoparathyroidism did not start AVDA treatment within 6 months of surgery, and 12.0% started treatment beyond one year after surgery. In contrast, 9.3% of patients receiving AVDA by 12 months went into remission later on. Two variables emerged as independent risk factors for persistent hypoparathyroidism: re-operation for bleeding (OR 4.21; 95%CI 1.31\u201313.38) and surgery due to a diagnosis\/suspicion of thyroid cancer (OR 2.09; 95%CI 1.04\u20134.19).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>The incidence of postoperative hypoparathyroidism is high and calls for action. Importantly, reassessment of post-surgical parathyroid function should be done regularly in order to neither overlook \u201clate onset\u201d hypoparathyroidism, nor late remission.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s12020-025-04330-8","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T07:20:00Z","timestamp":1751268000000},"page":"290-302","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Late remission and \u201clate onset\u201d of hypoparathyroidism after total and completion thyroidectomy: a retrospective cohort study of 1060 patients from a tertiary referral center"],"prefix":"10.1007","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2771-6127","authenticated-orcid":false,"given":"Sanne H\u00f8xbroe","family":"Michaelsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6335-3303","authenticated-orcid":false,"given":"Oke","family":"Gerke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7639-6337","authenticated-orcid":false,"given":"Christian","family":"Godballe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6898-1752","authenticated-orcid":false,"given":"Steen Joop","family":"Bonnema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8078-1908","authenticated-orcid":false,"given":"Viveque Egsgaard","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"key":"4330_CR1","unstructured":"S. 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