{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:55:57Z","timestamp":1787727357415,"version":"build-2784847793"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"DOI":"10.1007\/s12020-025-04331-7","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T14:15:29Z","timestamp":1752156929000},"page":"276-289","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Benefits of a 12 weeks-individually tailored physical activity program in patients with Cushing\u2019s disease in remission and controlled acromegaly"],"prefix":"10.1007","volume":"90","author":[{"given":"Luciana","family":"Martel-Duguech","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Bascu\u00f1ana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor Priego","family":"Corredor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriol","family":"Gonz\u00e1lez-Vi\u00f1uela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith Vinyals","family":"Rib\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toni Caparr\u00f3s","family":"Pons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Webb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3864-0105","authenticated-orcid":false,"given":"Elena","family":"Valassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,10]]},"reference":[{"issue":"12","key":"4331_CR1","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/S2213-8587(21)00235-7","volume":"9","author":"M Fleseriu","year":"2021","unstructured":"M. Fleseriu, R. Auchus, I. Bancos, A. Ben-Shlomo, J. Bertherat, N.R. Biermasz et al., Consensus on diagnosis and management of Cushing\u2019s disease: a guideline update. Lancet Diabetes Endocrinol. 9(12), 847\u2013875 (2021).","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"4","key":"4331_CR2","doi-asserted-by":"publisher","first-page":"e937","DOI":"10.1210\/clinem\/dgz096","volume":"105","author":"A Giustina","year":"2020","unstructured":"A. Giustina, A. Barkan, A. Beckers, N. Biermasz, B.M.K. Biller, C. Boguszewski et al., A consensus on the diagnosis and treatment of acromegaly comorbidities: an update. J. Clin. Endocrinol. Metab. 105(4), e937\u2013e946 (2020).","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"5","key":"4331_CR3","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s11102-017-0838-2","volume":"20","author":"FF Casanueva","year":"2017","unstructured":"F.F. Casanueva, A.L. Barkan, M. Buchfelder, A. Klibanski, E.R. Laws, J.S. Loeffler et al., Criteria for the definition of pituitary tumor centers of excellence (PTCOE): a pituitary society statement. Pituitary 20(5), 489\u2013498 (2017).","journal-title":"Pituitary"},{"issue":"7","key":"4331_CR4","doi-asserted-by":"publisher","first-page":"e220027","DOI":"10.1530\/EC-22-0027","volume":"11","author":"E Valassi","year":"2022","unstructured":"E. Valassi, I. Chiodini, R.A. Feelders, C.D. Andela, M. Abou-Hanna, S. Idres et al., Unmet needs in Cushing\u2019s syndrome: the patients\u2019 perspective. Endocr. Connect. 11(7), e220027 (2022).","journal-title":"Endocr. Connect."},{"key":"4331_CR5","doi-asserted-by":"publisher","first-page":"9014768","DOI":"10.1155\/2018\/9014768","volume":"2018","author":"I Kreitschmann-Andermahr","year":"2018","unstructured":"I. Kreitschmann-Andermahr, S. Siegel, C. Gammel, K. Campbell, L. Edwin, A. Grzywotz et al., Support needs of patients with Cushing\u2019s disease and Cushing\u2019s syndrome: results of a survey conducted in Germany and the USA. Int. J. Endocrinol. 2018, 9014768 (2018).","journal-title":"Int. J. Endocrinol."},{"issue":"5","key":"4331_CR6","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1007\/s11102-015-0636-7","volume":"18","author":"CD Andela","year":"2015","unstructured":"C.D. Andela, M. Scharloo, A.M. Pereira, A.A. Kaptein, N.R. Biermasz, Quality of life (QoL) impairments in patients with a pituitary adenoma: a systematic review of QoL studies. Pituitary 18(5), 752\u2013776 (2015).","journal-title":"Pituitary"},{"issue":"1","key":"4331_CR7","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1007\/s11102-014-0561-1","volume":"18","author":"CD Andela","year":"2015","unstructured":"C.D. Andela, N.D. Niemeijer, M. Scharloo, J. Tiemensma, S. Kanagasabapathy, A.M. Pereira et al., Towards a better quality of life (QoL) for patients with pituitary diseases: results from a focus group study exploring QoL. Pituitary 18(1), 86\u2013100 (2015).","journal-title":"Pituitary"},{"issue":"2","key":"4331_CR8","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1007\/s11102-019-01013-2","volume":"23","author":"EB Geer","year":"2019","unstructured":"E.B. Geer, J. Sisco, D.T. Adelman, W.H. Ludlam, A. Haviv, D. Gelbaum et al., Observed discordance between outcomes reported by acromegaly patients and their treating endocrinology medical provider.Pituitary 23(2), 140 (2019).","journal-title":"Pituitary"},{"issue":"3","key":"4331_CR9","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1530\/EJE-21-1071","volume":"186","author":"EB Geer","year":"2022","unstructured":"E.B. Geer, J.L. Kilgallon, K.J.P. Liebert, A. Kimball, L.B. Nachtigall, Virtual education programming for patients with acromegaly: a pilot study. Eur. J. Endocrinol. 186(3), 341\u2013349 (2022).","journal-title":"Eur. J. Endocrinol."},{"issue":"1","key":"4331_CR10","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1530\/EJE-21-0209","volume":"185","author":"L Martel-Duguech","year":"2021","unstructured":"L. Martel-Duguech, J. Alonso-P\u00e9rez, H. Bascu\u00f1ana, J. D\u00edaz-Manera, J. Llauger, C. Nu\u00f1ez-Peralta et al., Intramuscular fatty infiltration and physical function in controlled acromegaly. Eur. J. Endocrinol. 185(1), 167\u2013177 (2021).","journal-title":"Eur. J. Endocrinol."},{"issue":"5","key":"4331_CR11","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.1210\/clinem\/dgz329","volume":"105","author":"L Martel-Duguech","year":"2020","unstructured":"L. Martel-Duguech, A. Alonso-Jim\u00e9nez, H. Bascu\u00f1ana, J. D\u00edaz-Manera, J. Llauger, C. Nu\u00f1ez-Peralta et al., Thigh muscle fat infiltration is associated with impaired physical performance despite remission in Cushing\u2019s syndrome. J. Clin. Endocrinol. Metab. 105(5), 2039\u20132049 (2020).","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"5","key":"4331_CR12","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1111\/cen.14568","volume":"95","author":"L Martel-Duguech","year":"2021","unstructured":"L. Martel-Duguech, A. Alonso-Jimenez, H. Bascu\u00f1ana, J. D\u00edaz-Manera, J. Llauger, C. Nu\u00f1ez-Peralta et al., Prevalence of sarcopenia after remission of hypercortisolism and its impact on HRQoL. Clin. Endocrinol. 95(5), 735\u2013743 (2021).","journal-title":"Clin. Endocrinol."},{"issue":"8","key":"4331_CR13","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1159\/000511811","volume":"111","author":"M Cellini","year":"2021","unstructured":"M. Cellini, E. Biamonte, M. Mazza, N. Trenti, P. Ragucci, D. Milani et al., Vertebral fractures associated with spinal sagittal imbalance and quality of life in acromegaly: a radiographic study with EOS 2D\/3D technology. Neuroendocrinology 111(8), 775\u2013785 (2021).","journal-title":"Neuroendocrinology"},{"issue":"3","key":"4331_CR14","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1007\/s12020-022-03106-8","volume":"77","author":"B Cangiano","year":"2022","unstructured":"B. Cangiano, E. Giusti, C. Premoli, D. Soranna, G. Vitale, S. Grottoli et al., Psychological complications in patients with acromegaly: relationships with sex, arthropathy, and quality of life.Endocrine 77(3), 510 (2022).","journal-title":"Endocrine"},{"issue":"3","key":"4331_CR15","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.ghir.2010.02.003","volume":"20","author":"MJE Wassenaar","year":"2010","unstructured":"M.J.E. Wassenaar, N.R. Biermasz, M. Kloppenburg, A.A. van der Klaauw, J. Tiemensma, J.W.A. Smit et al., Clinical osteoarthritis predicts physical and psychological QoL in acromegaly patients. Growth Horm. IGF Res. 20(3), 226\u2013233 (2010).","journal-title":"Growth Horm. IGF Res."},{"issue":"5","key":"4331_CR16","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1530\/EJE-07-0838","volume":"158","author":"A Miller","year":"2008","unstructured":"A. Miller, H. Doll, J. David, J. Wass, Impact of musculoskeletal disease on quality of life in long-standing acromegaly. Eur. J. Endocrinol. 158(5), 587\u2013593 (2008).","journal-title":"Eur. J. Endocrinol."},{"issue":"2","key":"4331_CR17","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1023\/B:PITU.0000004798.27230.ed","volume":"6","author":"MD Johnson","year":"2003","unstructured":"M.D. Johnson, C.J. Woodburn, M. Lee Vance, Quality of life in patients with a pituitary adenoma. Pituitary 6(2), 81\u201387 (2003).","journal-title":"Pituitary"},{"issue":"3","key":"4331_CR18","first-page":"CD002759","volume":"2009","author":"CJ Liu","year":"2009","unstructured":"C.J. Liu, N.K. Latham, Progressive resistance strength training for improving physical function in older adults. Cochrane Database Syst. Rev. 2009(3), CD002759 (2009).","journal-title":"Cochrane Database Syst. Rev."},{"issue":"11","key":"4331_CR19","doi-asserted-by":"publisher","first-page":"2080","DOI":"10.1249\/MSS.0b013e31829a3b63","volume":"45","author":"B Strasser","year":"2013","unstructured":"B. Strasser, K. Steindorf, J. Wiskemann, C.M. Ulrich, Impact of resistance training in cancer survivors: a meta-analysis. Med. Sci. Sports Exerc. 45(11), 2080\u20132090 (2013).","journal-title":"Med. Sci. Sports Exerc."},{"issue":"5","key":"4331_CR20","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1152\/japplphysiol.90425.2008","volume":"105","author":"BH Goodpaster","year":"2008","unstructured":"B.H. Goodpaster, P. Chomentowski, B.K. Ward, A. Rossi, N.W. Glynn, M.J. Delmonico et al., Effects of physical activity on strength and skeletal muscle fat infiltration in older adults: a randomized controlled trial. J. Appl. Physiol. 105(5), 1498\u20131503 (2008).","journal-title":"J. Appl. Physiol."},{"issue":"2","key":"4331_CR21","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1002\/jbmr.3284","volume":"33","author":"SL Watson","year":"2018","unstructured":"S.L. Watson, B.K. Weeks, L.J. Weis, A.T. Harding, S.A. Horan, B.R. Beck, High-intensity resistance and impact training improves bone mineral density and physical function in postmenopausal women with osteopenia and osteoporosis: the LIFTMOR randomized controlled trial. J. Bone Miner. Res. 33(2), 211\u2013220 (2018).","journal-title":"J. Bone Miner. Res."},{"issue":"S4","key":"4331_CR22","doi-asserted-by":"publisher","first-page":"e13261","DOI":"10.1111\/obr.13261","volume":"22","author":"EV Carra\u00e7a","year":"2021","unstructured":"E.V. Carra\u00e7a, J. Encantado, F. Battista, K. Beaulieu, J.E. Blundell, L. Busetto et al., Effect of exercise training on psychological outcomes in adults with overweight or obesity: a systematic review and meta-analysis. Obes. Rev. 22(S4), e13261 (2021).","journal-title":"Obes. Rev."},{"issue":"2","key":"4331_CR23","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s12020-019-02011-x","volume":"66","author":"TRL Lima","year":"2019","unstructured":"T.R.L. Lima, L. Kasuki, M. Gadelha, A.J. Lopes, Physical exercise improves functional capacity and quality of life in patients with acromegaly: a 12-week follow-up study. Endocrine 66(2), 301\u2013309 (2019).","journal-title":"Endocrine"},{"issue":"5","key":"4331_CR24","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/s11102-019-00979-3","volume":"22","author":"O Haliloglu","year":"2019","unstructured":"O. Haliloglu, N. Topsakal, F. Camliguney, O. Polat Korkmaz, S. Sahin, B. Cotuk et al., Static and dynamic balances of patients with acromegaly and impact of exercise on balance. Pituitary 22(5), 497\u2013506 (2019).","journal-title":"Pituitary"},{"issue":"1","key":"4331_CR25","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1007\/s11102-013-0463-7","volume":"17","author":"E Hatipoglu","year":"2014","unstructured":"E. Hatipoglu, N. Topsakal, O.E. Atilgan, N. Alcalar, A.F. Camliguney, M. Niyazoglu et al., Impact of exercise on quality of life and body-self perception of patients with acromegaly. Pituitary 17(1), 38\u201343 (2014).","journal-title":"Pituitary"},{"issue":"7","key":"4331_CR26","doi-asserted-by":"publisher","first-page":"3141","DOI":"10.1210\/jc.2009-2670","volume":"95","author":"A Giustina","year":"2010","unstructured":"A. Giustina, P. Chanson, M.D. Bronstein, A. Klibanski, S. Lamberts, F.F. Casanueva et al., A consensus on criteria for cure of acromegaly. J. Clin. Endocrinol. Metab. 95(7), 3141\u20133148 (2010).","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"4","key":"4331_CR27","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1210\/jc.2007-2104","volume":"93","author":"O Alexopoulou","year":"2008","unstructured":"O. Alexopoulou, M. Bex, R. Abs, G. T\u2019Sjoen, B. Velkeniers, D. Maiter, Divergence between growth hormone and insulin-like growth factor-I concentrations in the follow-up of acromegaly. J. Clin. Endocrinol. Metab. 93(4), 1324\u20131330 (2008).","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"3","key":"4331_CR28","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.3390\/ijerph19031612","volume":"19","author":"M Batista","year":"2022","unstructured":"M. Batista, M. Leyton-Rom\u00e1n, R. Jim\u00e9nez-Castuera, Validity and reliability of the portuguese version of the healthy lifestyle questionnaire\u2014EVS III. Int. J. Environ. Res. Public. Health 19(3), 1612 (2022).","journal-title":"Int. J. Environ. Res. Public. Health"},{"issue":"2","key":"4331_CR29","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1249\/01.MSS.0000048831.15016.2A","volume":"35","author":"RJ Robertson","year":"2003","unstructured":"R.J. Robertson, F.L. Goss, J. Rutkowski, B. Lenz, C. Dixon, J. Timmer et al., Concurrent validation of the OMNI perceived exertion scale for resistance exercise. Med. Sci. Sports Exerc. 35(2), 333\u2013341 (2003).","journal-title":"Med. Sci. Sports Exerc."},{"issue":"5","key":"4331_CR30","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1097\/HCO.0000000000000097","volume":"29","author":"JL Reed","year":"2014","unstructured":"J.L. Reed, A.L. Pipe, The talk test: a useful tool for prescribing and monitoring exercise intensity. Curr. Opin. Cardiol. 29(5), 475\u2013480 (2014).","journal-title":"Curr. Opin. Cardiol."},{"issue":"1","key":"4331_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2165\/00007256-199826010-00001","volume":"26","author":"G Kentt\u00e4","year":"1998","unstructured":"G. Kentt\u00e4, P. Hassm\u00e9n, Overtraining and recovery. A conceptual model. Sports Med. 26(1), 1\u201316 (1998).","journal-title":"Sports Med."},{"issue":"5","key":"4331_CR32","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/S0022-3476(82)80286-2","volume":"101","author":"JZ Heckmatt","year":"1982","unstructured":"J.Z. Heckmatt, S. Leeman, V. Dubowitz, Ultrasound imaging in the diagnosis of muscle disease. J Pediatr. 101(5), 656\u2013660 (1982).","journal-title":"J Pediatr."},{"issue":"5","key":"4331_CR33","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1530\/EJE-07-0762","volume":"158","author":"SM Webb","year":"2008","unstructured":"S.M. Webb, X. Badia, M.J. Baarahona, A. Colao, C.J. Strasburger, A. Tabarin et al., Evaluation of health-related quality of life in patients with Cushing\u2019s syndrome with a new questionnaire. Eur. J. Endocrinol. 158(5), 623\u2013630 (2008).","journal-title":"Eur. J. Endocrinol."},{"key":"4331_CR34","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1477-7525-2-13","volume":"2","author":"X Badia","year":"2004","unstructured":"X. Badia, S.M. Webb, L. Prieto, N. Lara, Acromegaly quality of life questionnaire (AcroQoL). Health Qual. Life Outcomes 2, 13 (2004).","journal-title":"Health Qual. Life Outcomes"},{"issue":"3","key":"4331_CR35","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1097\/00005650-199603000-00003","volume":"34","author":"JE Ware","year":"1996","unstructured":"J.E. Ware, M. Kosinski, S.D. Keller, A 12-item short-form health survey: construction of scales and preliminary tests of reliability and validity. Med. Care 34(3), 220\u2013233 (1996).","journal-title":"Med. Care"},{"issue":"6","key":"4331_CR36","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1037\/0022-3514.54.6.1063","volume":"54","author":"D Watson","year":"1988","unstructured":"D. Watson, L.A. Clark, A. Tellegen, Development and validation of brief measures of positive and negative affect: the PANAS scales. J. Pers. Soc. Psychol. 54(6), 1063\u20131070 (1988).","journal-title":"J. Pers. Soc. Psychol."},{"issue":"9","key":"4331_CR37","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1046\/j.1525-1497.2001.016009606.x","volume":"16","author":"K Kroenke","year":"2001","unstructured":"K. Kroenke, R.L. Spitzer, J.B.W. Williams, The PHQ-9: validity of a brief depression severity measure. J. Gen. Intern. Med. 16(9), 606\u2013613 (2001).","journal-title":"J. Gen. Intern. Med."},{"issue":"10","key":"4331_CR38","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1001\/archinte.166.10.1092","volume":"166","author":"RL Spitzer","year":"2006","unstructured":"R.L. Spitzer, K. Kroenke, J.B.W. Williams, B. L\u00f6we, A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch. Intern. Med. 166(10), 1092\u20131097 (2006).","journal-title":"Arch. Intern. Med."},{"issue":"9","key":"4331_CR39","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1136\/jnnp.47.9.1009","volume":"47","author":"AA Khaleeli","year":"1984","unstructured":"A.A. Khaleeli, R.D. Levy, R.H.T. Edwards, G. Mcphail, K.R. Mills, J.M. Round et al., The neuromuscular features of acromegaly: a clinical and pathological study. J. Neurol. Neurosurg. Psychiatry 47(9), 1009\u20131015 (1984).","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"2","key":"4331_CR40","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1111\/j.1365-2265.1983.tb03198.x","volume":"18","author":"AA Khaleeli","year":"1983","unstructured":"A.A. Khaleeli, R.H. Edwards, K. Gohil, G. McPhail, M.J. Rennie, J. Round et al., Corticosteroid myopathy: a clinical and pathological study. Clin. Endocrinol. 18(2), 155\u2013166 (1983).","journal-title":"Clin. Endocrinol."},{"key":"4331_CR41","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/112_2013_17","volume":"166","author":"CA Goodman","year":"2014","unstructured":"C.A. Goodman, The role of mTORC1 in regulating protein synthesis and skeletal muscle mass in response to various mechanical stimuli. Rev. Physiol. Biochem. Pharmacol. 166, 43\u201395 (2014).","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"issue":"3","key":"4331_CR42","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1111\/j.1469-185X.2010.00161.x","volume":"86","author":"K Gundersen","year":"2011","unstructured":"K. Gundersen, Excitation-transcription coupling in skeletal muscle: the molecular pathways of exercise. Biol. Rev. 86(3), 564\u2013600 (2011).","journal-title":"Biol. Rev."},{"issue":"6","key":"4331_CR43","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1007\/s00421-006-0238-1","volume":"97","author":"M Toigo","year":"2006","unstructured":"M. Toigo, U. Boutellier, New fundamental resistance exercise determinants of molecular and cellular muscle adaptations. Eur. J. Appl. Physiol. 97(6), 643\u2013663 (2006).","journal-title":"Eur. J. Appl. Physiol."},{"issue":"3","key":"4331_CR44","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1249\/JES.0000000000000289","volume":"50","author":"SG Hong","year":"2022","unstructured":"S.G. Hong, J. Shin, M. Aldokhayyil, M.D. Brown, J.Y. Park, Mitochondrial and metabolic adaptations to exercise-induced fluid shear stress in endothelial cells. Exerc. Sport. Sci. Rev. 50(3), 145\u2013155 (2022).","journal-title":"Exerc. Sport. Sci. Rev."},{"issue":"2","key":"4331_CR45","doi-asserted-by":"publisher","first-page":"133","DOI":"10.2165\/00007256-200636020-00004","volume":"36","author":"DA Gabriel","year":"2006","unstructured":"D.A. Gabriel, G. Kamen, G. Frost, Neural adaptations to resistive exercise: mechanisms and recommendations for training practices. Sports Med. 36(2), 133\u2013149 (2006).","journal-title":"Sports Med."},{"issue":"1","key":"4331_CR46","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1111\/cen.12708","volume":"83","author":"E Hatipoglu","year":"2015","unstructured":"E. Hatipoglu, N. Topsakal, O. Erkut Atilgan, A.F. Camliguney, B. Ikitimur, S. Ugurlu et al., Physical and cardiovascular performance in cases with acromegaly after regular short-term exercise. Clin. Endocrinol. 83(1), 91\u201397 (2015).","journal-title":"Clin. Endocrinol."},{"issue":"12","key":"4331_CR47","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1007\/s40279-015-0385-9","volume":"45","author":"R Borde","year":"2015","unstructured":"R. Borde, T. Hortob\u00e1gyi, U. Granacher, Dose-response relationships of resistance training in healthy old adults: a systematic review and meta-analysis. Sports Med. 45(12), 1693\u20131720 (2015).","journal-title":"Sports Med."},{"issue":"4","key":"4331_CR48","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1093\/ageing\/afz046","volume":"48","author":"AJ Cruz-Jentoft","year":"2019","unstructured":"A.J. Cruz-Jentoft, G. Bahat, J. Bauer, Y. Boirie, O. Bruy\u00e8re, T. Cederholm et al., Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 48(4), 601 (2019).","journal-title":"Age Ageing"},{"issue":"8","key":"4331_CR49","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1007\/s40279-014-0176-8","volume":"44","author":"BS Cheema","year":"2014","unstructured":"B.S. Cheema, D. Chan, P. Fahey, E. Atlantis, Effect of progressive resistance training on measures of skeletal muscle hypertrophy, muscular strength and health-related quality of life in patients with chronic kidney disease: a systematic review and meta-analysis. Sports Med. 44(8), 1125\u20131138 (2014).","journal-title":"Sports Med."},{"issue":"3","key":"4331_CR50","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s40279-015-0418-4","volume":"46","author":"CR Straight","year":"2016","unstructured":"C.R. Straight, J.B. Lindheimer, A.O. Brady, R.K. Dishman, E.M. Evans, Effects of resistance training on lower-extremity muscle power in middle-aged and older adults: a systematic review and meta-analysis of randomized controlled trials. Sports Med. 46(3), 353\u2013364 (2016).","journal-title":"Sports Med."},{"issue":"6","key":"4331_CR51","doi-asserted-by":"publisher","first-page":"439","DOI":"10.2165\/00007256-200939060-00002","volume":"39","author":"A Guadalupe-Grau","year":"2009","unstructured":"A. Guadalupe-Grau, T. Fuentes, B. Guerra, J.A.L. Calbet, Exercise and bone mass in adults. Sports Med. 39(6), 439\u2013468 (2009).","journal-title":"Sports Med."},{"issue":"1","key":"4331_CR52","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s11695-009-0045-y","volume":"21","author":"S Stegen","year":"2011","unstructured":"S. Stegen, W. Derave, P. Calders, C. Van Laethem, P. Pattyn, Physical fitness in morbidly obese patients: effect of gastric bypass surgery and exercise training. Obes. Surg. 21(1), 61\u201370 (2011).","journal-title":"Obes. Surg."},{"issue":"8","key":"4331_CR53","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1515\/jpem-2017-0369","volume":"31","author":"NM Amer","year":"2018","unstructured":"N.M. Amer, M.J. Modesto, C.D. Dos Santos, O. Erichsen, L.P.G. Mascarenhas, S. Nesi-Fran\u00e7a et al., Resistance exercise alone improves muscle strength in growth hormone deficient males in the transition phase. J. Pediatr. Endocrinol. Metab. 31(8), 887\u2013894 (2018).","journal-title":"J. Pediatr. Endocrinol. Metab."},{"issue":"10","key":"4331_CR54","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1097\/00005768-200210000-00008","volume":"34","author":"CW Coelho","year":"2002","unstructured":"C.W. Coelho, C.R. Velloso, R.R. De Lima Oliveira Brasil, M. Vaisman, C.G.S. De Ara\u00fajo, Muscle power increases after resistance training in growth-hormone-deficient adults. Med. Sci. Sports Exerc. 34(10), 1577\u20131581 (2002).","journal-title":"Med. Sci. Sports Exerc."},{"issue":"12","key":"4331_CR55","doi-asserted-by":"publisher","first-page":"2454","DOI":"10.1002\/oby.21332","volume":"23","author":"TL Woodlief","year":"2015","unstructured":"T.L. Woodlief, E.A. Carnero, R.A. Standley, G. Distefano, S.J. Anthony, G.S. Dubis et al., Dose response of exercise training following roux-en-Y gastric bypass surgery: a randomized trial. Obesity 23(12), 2454\u20132461 (2015).","journal-title":"Obesity"},{"issue":"1","key":"4331_CR56","doi-asserted-by":"publisher","first-page":"rkad019","DOI":"10.1093\/rap\/rkad019","volume":"7","author":"S Kast","year":"2022","unstructured":"S. Kast, F. Jakob, M. Kohl, S. Von Stengel, K. Kerschan-Schindl, U. Lange et al., Exercise effects on glucocorticoid-induced bone loss in adults: a systematic review and meta-analysis. Rheumatol. Adv. Pract. 7(1), rkad019 (2022).","journal-title":"Rheumatol. Adv. Pract."},{"issue":"3","key":"4331_CR57","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1097\/01.TP.0000076471.25132.52","volume":"76","author":"MJ Mitchell","year":"2003","unstructured":"M.J. Mitchell, M.A. Baz, M.N. Fulton, C.F. Lisor, R.W. Braith, Resistance training prevents vertebral osteoporosis in lung transplant recipients. Transplantation 76(3), 557\u2013562 (2003).","journal-title":"Transplantation"},{"issue":"2","key":"4331_CR58","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1530\/eje.1.02214","volume":"155","author":"SM Webb","year":"2006","unstructured":"S.M. Webb, X. Badia, N.L. Surinach, R. Astorga, P. Benito, M. Catal\u00e1 et al., Validity and clinical applicability of the acromegaly quality of life questionnaire, AcroQoL: a 6-month prospective study. Eur. J. Endocrinol. 155(2), 269\u2013277 (2006).","journal-title":"Eur. J. Endocrinol."},{"issue":"6","key":"4331_CR59","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1530\/EJE-20-0652","volume":"183","author":"F Albarel","year":"2020","unstructured":"F. Albarel, I. Pellegrini, H. Rahabi, C. Baccou, L. Gonin, C. Rochette et al., Evaluation of an individualized education program in pituitary diseases: a pilot study. Eur. J. Endocrinol. 183(6), 551\u2013559 (2020).","journal-title":"Eur. J. Endocrinol."},{"issue":"1","key":"4331_CR60","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1530\/EJE-16-1015","volume":"177","author":"CD Andela","year":"2017","unstructured":"C.D. Andela, H. Repping-Wuts, N.M.M.L. Stikkelbroeck, M.C. Pronk, J. Tiemensma, A.R. Hermus et al., Enhanced self-efficacy after a self-management programme in pituitary disease: a randomized controlled trial. Eur. J. Endocrinol. 177(1), 59\u201372 (2017).","journal-title":"Eur. J. Endocrinol."}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-025-04331-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12020-025-04331-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-025-04331-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T05:03:11Z","timestamp":1758776591000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12020-025-04331-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,10]]},"references-count":60,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["4331"],"URL":"https:\/\/doi.org\/10.1007\/s12020-025-04331-7","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-6485925\/v1","asserted-by":"object"}]},"ISSN":["1559-0100"],"issn-type":[{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,10]]},"assertion":[{"value":"19 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}