{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T23:25:35Z","timestamp":1768519535509,"version":"3.49.0"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Turkish Society of Pediatric Endocrinology and Diabetes.","award":["2019\/12"],"award-info":[{"award-number":["2019\/12"]}]},{"name":"Turkish Society of Pediatric Endocrinology and Diabetes.","award":["2019\/12"],"award-info":[{"award-number":["2019\/12"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"DOI":"10.1007\/s12020-025-04382-w","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T19:41:49Z","timestamp":1754941309000},"page":"831-843","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Central precocious puberty in boys; diagnosis, treatment and follow-up: a nation-wide study"],"prefix":"10.1007","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5979-9206","authenticated-orcid":false,"given":"Sevinc","family":"Odabasi Gunes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4960-6092","authenticated-orcid":false,"given":"Merve","family":"Sakar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8215-0146","authenticated-orcid":false,"given":"Nursel","family":"Muratoglu Sahin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4116-5365","authenticated-orcid":false,"given":"Gulay","family":"Karaguzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7866-9228","authenticated-orcid":false,"given":"Emine Ayca","family":"Cimbek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4786-0780","authenticated-orcid":false,"given":"Feyza","family":"Darendeliler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8580-4504","authenticated-orcid":false,"given":"Ezgi","family":"Sarban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0802-3955","authenticated-orcid":false,"given":"Esra","family":"Doger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0774-6844","authenticated-orcid":false,"given":"Ganimet","family":"Oner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0921-2694","authenticated-orcid":false,"given":"Zeynep","family":"Siklar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1313-9426","authenticated-orcid":false,"given":"Gizem","family":"Senyazar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7374-229X","authenticated-orcid":false,"given":"Murat","family":"Aydin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9153-8409","authenticated-orcid":false,"given":"Behzat","family":"Ozkan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9079-4574","authenticated-orcid":false,"given":"Ozlem","family":"Sangun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3550-1425","authenticated-orcid":false,"given":"Mesut","family":"Parlak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8430-5519","authenticated-orcid":false,"given":"Onur","family":"Akin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9653-9347","authenticated-orcid":false,"given":"Kadriye Cansu","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1700-6778","authenticated-orcid":false,"given":"\u0130hsan","family":"Esen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1265-4952","authenticated-orcid":false,"given":"Aylin","family":"Kilinc Ugurlu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0614-4083","authenticated-orcid":false,"given":"Gulcan","family":"Seymen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8183-2188","authenticated-orcid":false,"given":"Semih","family":"Bolu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2037-7046","authenticated-orcid":false,"given":"Elif","family":"Sobu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1557-6040","authenticated-orcid":false,"given":"Servan","family":"Ozalkak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5746-6835","authenticated-orcid":false,"given":"Emine","family":"Demet Akbas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7888-7295","authenticated-orcid":false,"given":"Gonul","family":"Buyukyilmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6700-5346","authenticated-orcid":false,"given":"Beray","family":"Selver Eklioglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8144-8437","authenticated-orcid":false,"given":"Ahmet","family":"Ucar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0850-0360","authenticated-orcid":false,"given":"Pinar","family":"Kocaay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selma","family":"Tunc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6210-4807","authenticated-orcid":false,"given":"Serpil","family":"Bas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1468-6405","authenticated-orcid":false,"given":"\u0130smail","family":"Dundar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6586-7305","authenticated-orcid":false,"given":"Eda","family":"Celebi Bitkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7792-1727","authenticated-orcid":false,"given":"Ayca","family":"Torel Ergur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6064-9205","authenticated-orcid":false,"given":"Dilek","family":"Bingol Aydin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8313-5677","authenticated-orcid":false,"given":"Birgul","family":"Kirel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6987-0923","authenticated-orcid":false,"given":"Aysun","family":"Ata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9153-8580","authenticated-orcid":false,"given":"Muge","family":"Atar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8496-4696","authenticated-orcid":false,"given":"Mehmet","family":"Isakoca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8385-4049","authenticated-orcid":false,"given":"Emel Hatun","family":"Aytac Kaplan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7702-8296","authenticated-orcid":false,"given":"Tugba","family":"Kontbay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2935-3008","authenticated-orcid":false,"given":"Derya","family":"Tepe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7397-2837","authenticated-orcid":false,"given":"Oya","family":"Ercan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4289-9128","authenticated-orcid":false,"given":"Mehmet","family":"Boyraz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3443-0829","authenticated-orcid":false,"given":"Nesibe","family":"Akyurek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9809-0977","authenticated-orcid":false,"given":"Edip","family":"Unal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1706-8012","authenticated-orcid":false,"given":"Nurhan","family":"Ozcan Murat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9724-2369","authenticated-orcid":false,"given":"Serkan Bilge","family":"Koca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7335-1272","authenticated-orcid":false,"given":"Zumrut","family":"Kocabey Sutcu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8747-9867","authenticated-orcid":false,"given":"Feyza Nehir","family":"Oznur Muz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3974-2872","authenticated-orcid":false,"given":"Semra","family":"Cetinkaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"4382_CR1","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.bpobgyn.2017.11.004","volume":"48","author":"C Sultan","year":"2018","unstructured":"C. Sultan, L. Gaspari, L. Maimoun, N. Kalfa, F. Paris, Disorders of puberty. Best. Pract. Res. Clin. Obstet. Gynaecol. 48, 62\u201389 (2018). https:\/\/doi.org\/10.1016\/j.bpobgyn.2017.11.004.","journal-title":"Best. Pract. Res. Clin. Obstet. Gynaecol."},{"issue":"3","key":"4382_CR2","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S2213-8587(15)00380-0","volume":"4","author":"AC Latronica","year":"2016","unstructured":"A.C. Latronica, V.N. Brito, J.C. Carel, Causes, diagnosis, and treatment of central precocious puberty. Lancet Diabetes Endocrinol. 4(3), 265\u2013274 (2016). https:\/\/doi.org\/10.1016\/S2213-8587(15)00380-0.","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"520","key":"4382_CR3","doi-asserted-by":"publisher","first-page":"111094","DOI":"10.1016\/j.mce.2020.111094","volume":"15","author":"M Spaziani","year":"2021","unstructured":"M. Spaziani, C. Tarantino, N. Tahani, D. Gianfrilli, E. Sbardella, A. Lenzi, A.F. Radicioni, Hypothalamo-pituitary axis and puberty. Mol. Cell Endocrinol. 15(520), 111094 (2021). https:\/\/doi.org\/10.1016\/j.mce.2020.111094.","journal-title":"Mol. Cell Endocrinol."},{"issue":"5","key":"4382_CR4","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1159\/000377678","volume":"83","author":"A Alikasifo\u011flu","year":"2015","unstructured":"A. Alikasifo\u011flu, D. Vuralli, N.E. Gonc, A. Ozon, N. Kandemir, Changing etiological trends in male precocious puberty: evaluation of 100 cases with central precocious puberty over the last decade. Horm. Res. Paediatr. 83(5), 340\u2013344 (2015). https:\/\/doi.org\/10.1159\/000377678.","journal-title":"Horm. Res. Paediatr."},{"issue":"8","key":"4382_CR5","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1210\/clinem\/dgae035","volume":"109","author":"A Cassio","year":"2024","unstructured":"A. Cassio, G. Marescotti, T. Aversa, M. Salerno, G. Tornese, M. Stancampiano et al., Central precocious puberty in Italian boys: data from a Large Nationwide Cohort. J. Clin. Endocrinol. Metab. 109(8), 2061\u20132070 (2024). https:\/\/doi.org\/10.1210\/clinem\/dgae035.","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"4382_CR6","doi-asserted-by":"publisher","first-page":"ix","DOI":"10.1016\/j.ecl.2024.03.001","volume":"53","author":"R Rapport","year":"2024","unstructured":"R. Rapport, Precocious and delayed puberty revisited. Endocrinol. Metab. Clin. North. Am. 53(2), ix\u2013x (2024). https:\/\/doi.org\/10.1016\/j.ecl.2024.03.001.","journal-title":"Endocrinol. Metab. Clin. North. Am."},{"issue":"4","key":"4382_CR7","doi-asserted-by":"publisher","first-page":"e752","DOI":"10.1542\/peds.2008-1783","volume":"123","author":"JC Carel","year":"2009","unstructured":"J.C. Carel, E.A. Eugster, A. Rogol et al., Consensus statement on the use of gonadotropin-releasing hormone analogs in children. Pediatrics 123(4), e752\u2013e762 (2009). https:\/\/doi.org\/10.1542\/peds.2008-1783.","journal-title":"Pediatrics"},{"issue":"12","key":"4382_CR8","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1016\/S2352-4642(23)00237-7","volume":"7","author":"EL Zevin","year":"2023","unstructured":"E.L. Zevin, E.A. Eugster, Central precocious puberty: a review of diagnosis, treatment, and outcomes. Lancet Child. Adolesc. Health 7(12), 886\u2013896 (2023). https:\/\/doi.org\/10.1016\/S2352-4642(23)00237-7.","journal-title":"Lancet Child. Adolesc. Health"},{"key":"4382_CR9","unstructured":"M.J.Gonadotropins, in Diagnostics Of Endocrine Function in Children and Adolescents, ed. by M.B.Ranke (Karger, Basel, 2003), pp. 356\u2013371"},{"issue":"1","key":"4382_CR10","doi-asserted-by":"publisher","first-page":"12","DOI":"10.4274\/jcrpe.v3i1.03","volume":"3","author":"N Kandemir","year":"2011","unstructured":"N. Kandemir, H. Demirbilek, Z.A. Ozon, N. Gonc, A. Alikasifoglu, GnRH stimulation test in precocious puberty: single sample is adequate for diagnosis and dose adjustment. J. Clin. Pediatr. Endocrinol. 3(1), 12\u201317 (2011). https:\/\/doi.org\/10.4274\/jcrpe.v3i1.03.","journal-title":"J. Clin. Pediatr. Endocrinol."},{"issue":"4","key":"4382_CR11","doi-asserted-by":"publisher","first-page":"280","DOI":"10.4274\/jcrpe.2183","volume":"7","author":"O Neyzi","year":"2015","unstructured":"O. Neyzi, R. Bundak, G. G\u00f6kc\u0327ay et al., Reference values for weight, height, head circumference, and body mass index in Turkish children. J. Clin. Res. Pediatr. Endocrinol. 7(4), 280\u2013293 (2015). https:\/\/doi.org\/10.4274\/jcrpe.2183.","journal-title":"J. Clin. Res. Pediatr. Endocrinol."},{"issue":"239","key":"4382_CR12","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1136\/adc.45.239.13","volume":"45","author":"WA Marshall","year":"1970","unstructured":"W.A. Marshall, J.M. Tanner, Variations in the pattern of pubertal changes in boys. Arch. Dis. Child. 45(239), 13\u201323 (1970). https:\/\/doi.org\/10.1136\/adc.45.239.13.","journal-title":"Arch. Dis. Child."},{"issue":"1","key":"4382_CR13","first-page":"53","volume":"91","author":"WW Greulich","year":"1959","unstructured":"W.W. Greulich, S.I. Pyle, Radiographic atlas of skeletal development of the hand and wrist. Calif. Med. 91(1), 53 (1959).","journal-title":"Calif. Med."},{"issue":"4","key":"4382_CR14","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/s0022-3476(52)80205-7","volume":"40","author":"N Bayley","year":"1952","unstructured":"N. Bayley, S.R. Pinneau, Tables for predicting adult height from skeletal age: revised for use with the Greulich-Pyle hand standards. J. Pediatr. 40(4), 423\u2013441 (1952). https:\/\/doi.org\/10.1016\/s0022-3476(52)80205-7.","journal-title":"J. Pediatr."},{"issue":"1","key":"4382_CR15","doi-asserted-by":"publisher","first-page":"3","DOI":"10.4274\/jcrpe.galenos.2024.2024-6-6-S","volume":"17","author":"S Odaba\u015f\u0131 G\u00fcne\u015f","year":"2025","unstructured":"S. Odaba\u015f\u0131 G\u00fcne\u015f, H.N. Peltek Kendirci, E. \u00dcnal, A.D. Bulu\u015f, \u0130 D\u00fcndar, Z. \u015e\u0131klar, Clinical, biochemical and molecular characteristics of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. J. Clin. Res. Pediatr. 17(1), 3\u201311 (2025). https:\/\/doi.org\/10.4274\/jcrpe.galenos.2024.2024-6-6-S.","journal-title":"J. Clin. Res. Pediatr."},{"issue":"Suppl 1","key":"4382_CR16","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1515\/jpem.2000.13.s1.687","volume":"13","author":"V De Sanctis","year":"2000","unstructured":"V. De Sanctis, A. Corrias, V. Rizzo, S. Bertelloni, L. Urso, F. Galluzzi, A.M. Pasquino et al., Etiology of central precocious puberty in males: the results of the Italian study group for physiopathology of puberty. J. Ped Endocrinol. Metab. 13(Suppl 1), 687\u2013693 (2000). https:\/\/doi.org\/10.1515\/jpem.2000.13.s1.687.","journal-title":"J. Ped Endocrinol. Metab."},{"issue":"6","key":"4382_CR17","doi-asserted-by":"publisher","first-page":"e0199019","DOI":"10.1371\/journal.pone.0199019","volume":"13","author":"LS Topor","year":"2018","unstructured":"L.S. Topor, K. Bowerman, J.T. Machan, C.L. Gilbert, T. Kangarloo, N.D. Shaw, Central precocious puberty in Boston boys: a 10-year single center experience. PLoS ONE 13(6), e0199019 (2018). https:\/\/doi.org\/10.1371\/journal.pone.0199019.","journal-title":"PLoS ONE"},{"issue":"2","key":"4382_CR18","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1111\/cen.14462","volume":"95","author":"J Wang","year":"2021","unstructured":"J. Wang, S. Zhan, J. Yuan, R. Ullah, G. Dong, W. Wu, K. Huang, J. Fu, The incidence of brain lesions in central precocious puberty: the main cause for Chinese boys was idiopathic. Clin. Endocrinol. 95(2), 303\u2013307 (2021). https:\/\/doi.org\/10.1111\/cen.14462.","journal-title":"Clin. Endocrinol."},{"issue":"2","key":"4382_CR19","doi-asserted-by":"publisher","first-page":"75","DOI":"10.6065\/apem.2018.23.2.75","volume":"23","author":"J Lee","year":"2018","unstructured":"J. Lee, J. Kim, A. Yang, S.Y. Cho, D.K. Jin, Etiological trends in male central precocious puberty. Ann. Pediatr. Endocrinol. Metab. 23(2), 75\u201380 (2018). https:\/\/doi.org\/10.6065\/apem.2018.23.2.75.","journal-title":"Ann. Pediatr. Endocrinol. Metab."},{"issue":"4","key":"4382_CR20","doi-asserted-by":"publisher","first-page":"183","DOI":"10.6065\/apem.2013.18.4.183","volume":"18","author":"HK Choi","year":"2013","unstructured":"H.K. Choi, S.J. Chung, M.J. Kang, J.Y. Yoon, J.E. Lee, Y.A. Lee, C.H. Shin, S.W. Yang, Boys with precocious or early puberty: incidence of pathological brain magnetic resonance imaging findings and factors related to newly developed brain lesions. Ann. Pediatr. Endocrinol. Metab. 18(4), 183\u2013190 (2013). https:\/\/doi.org\/10.6065\/apem.2013.18.4.183.","journal-title":"Ann. Pediatr. Endocrinol. Metab."},{"key":"4382_CR21","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s13633-016-0027-5","volume":"2016","author":"PB Kaplowitz","year":"2016","unstructured":"P.B. Kaplowitz, Do 6-8 years old girls with central precocious puberty need routine brain imaging?. Int. J. Pediatr. Endocrinol. 2016, 9 (2016). https:\/\/doi.org\/10.1186\/s13633-016-0027-5.","journal-title":"Int. J. Pediatr. Endocrinol."},{"key":"4382_CR22","doi-asserted-by":"publisher","first-page":"4455","DOI":"10.1210\/jc.2014-2702","volume":"99","author":"S Pedicelli","year":"2014","unstructured":"S. Pedicelli, P. Alessio, G. Scire\u0300, M. Cappa, S. Cianfarani, Routine screening by brain magnetic resonance imaging is not indicated in every girl with onset of puberty between the ages of 6 and 8 years. J. Clin. Endocrinol. Metab. 99, 4455\u20134461 (2014). https:\/\/doi.org\/10.1210\/jc.2014-2702.","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"4382_CR23","doi-asserted-by":"publisher","first-page":"e29829","DOI":"10.1371\/journal.pone.0029829","volume":"7","author":"SS Mogensen","year":"2012","unstructured":"S.S. Mogensen, L. Aksglaede, A. Mouritsen, K. S\u00f8rensen, K.M. Main, P. Gideon, A. Juul, Pathological and incidental findings on brain MRI in a single-center study of 229 consecutive girls with early or precocious puberty. PLoS ONE 7(1), e29829 (2012). https:\/\/doi.org\/10.1371\/journal.pone.0029829.","journal-title":"PLoS ONE"},{"issue":"7","key":"4382_CR24","doi-asserted-by":"publisher","first-page":"e2557","DOI":"10.1210\/clinem\/dgab190","volume":"106","author":"D Helvac\u0131o\u011flu","year":"2021","unstructured":"D. Helvac\u0131o\u011flu, S. Demircio\u011flu, T. G\u00fcran, Z. Atay, A. Da\u011f\u00e7\u0131nar, D. Bezen, E. Karak\u0131l\u0131\u00e7\u00d6zturan, F. Darendeliler, A. Y\u00fcksel, F. Dursun, S. K\u0131l\u0131n\u00e7, S. Semiz, S. Abal\u0131, M. Y\u0131l\u0131dz, A. \u00d6nder, A. Bereket, Cranial MRI abnormalities and long-term follow-up of the lesions in 770 girls with central precocious puberty. J. Clin. Endocrinol. Metab. 106(7), e2557\u2013e2566 (2021). https:\/\/doi.org\/10.1210\/clinem\/dgab190.","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"4","key":"4382_CR25","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1067\/S0022-3476(03)00328-7","volume":"143","author":"M Chalumeau","year":"2003","unstructured":"M. Chalumeau, C.G. Hadjiathanasiou, S.M. Ng, A. Cassio, D. Mul, M. Cisternino, C.J. Partsch, C. Theodoridis, M. Didi, E. Cacciari, W. Oostdijk, A. Borghesi, W.G. Sippell, G. Breart, R. Brauner, Selecting girls with precocious puberty for brain imaging: validation of European evidence-based diagnosis rule. J. Pediatr. 143(4), 445\u2013450 (2003). https:\/\/doi.org\/10.1067\/S0022-3476(03)00328-7.","journal-title":"J. Pediatr."},{"issue":"3","key":"4382_CR26","doi-asserted-by":"publisher","first-page":"200","DOI":"10.6065\/apem.2244192.096","volume":"28","author":"YR Oh","year":"2023","unstructured":"Y.R. Oh, Y.J. Kim, K.E. Oh, G.H. Park, E. Kang, H.K. Nam, Y.J. Rhie, S. Oh, K.H. Lee, Brain magnetic resonance imaging (MRI) findings in central precocious puberty patients: is routine MRI necessary for newly diagnosed patients. Ann. Pediatr. Endocrinol. Metab. 28(3), 200\u2013205 (2023). https:\/\/doi.org\/10.6065\/apem.2244192.096.","journal-title":"Ann. Pediatr. Endocrinol. Metab."},{"key":"4382_CR27","doi-asserted-by":"publisher","first-page":"256","DOI":"10.3389\/fendo.2020.00256","volume":"11","author":"CF Chiu","year":"2020","unstructured":"C.F. Chiu, C.J. Wang, Y.P. Chen, F.S. Lo, Pathological and incidental findings in 403 taiwanese girls with central precocious puberty at initial diagnosis. Front. Endocrinol. 11, 256 (2020). https:\/\/doi.org\/10.3389\/fendo.2020.00256.","journal-title":"Front. Endocrinol."},{"issue":"7","key":"4382_CR28","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1515\/jpem-2018-0052","volume":"31","author":"S Cantas-Orsdemir","year":"2018","unstructured":"S. Cantas-Orsdemir, J.L. Garb, H.F. Allen, Prevalence of cranial MRI findings in girls with central precocious puberty: a systematic review and meta-analysis. J. Pediatr. Endocrinol. Metab. 31(7), 701\u2013710 (2018). https:\/\/doi.org\/10.1515\/jpem-2018-0052.","journal-title":"J. Pediatr. Endocrinol. Metab."},{"issue":"1","key":"4382_CR29","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s13633-015-0005-3","volume":"2015","author":"OJ Oatman","year":"2015","unstructured":"O.J. Oatman, D.R. McClellan, M.L. Olson, P. Garcia-Filion, Endocrine and pubertal disturbances in optic nerve hypoplasia, from infancy to adolescence. Int. J. Pediatr. Endocrinol. 2015(1), 8 (2015). https:\/\/doi.org\/10.1186\/s13633-015-0005-3.","journal-title":"Int. J. Pediatr. Endocrinol."},{"issue":"5","key":"4382_CR30","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1016\/s0022-3476(78)80142-5","volume":"92","author":"C Huseman","year":"1978","unstructured":"C. Huseman, R. Kelch, N. Hopwood, W. Zipf, Sexual precocity association with septo-optic dysplasia and hypothalamic hypopituitarism. J. Pediatr. 92(5), 748\u2013753 (1978). https:\/\/doi.org\/10.1016\/s0022-3476(78)80142-5.","journal-title":"J. Pediatr."},{"issue":"6","key":"4382_CR31","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.3171\/2011.6.JNS11506","volume":"115","author":"WN Al-Holou","year":"2011","unstructured":"W.N. Al-Holou, S.W. Terman, C. Kilburg, H.J.L. Garton, K.M. Muraszko, W.F. Chandler, M. \u0130brahim, O.C. Maher, Prevalence and natural history of pineal cysts in adults. J. Neurosurg. 115(6), 1106\u20131114 (2011). https:\/\/doi.org\/10.3171\/2011.6.JNS11506.","journal-title":"J. Neurosurg."},{"key":"4382_CR32","doi-asserted-by":"publisher","first-page":"1323947","DOI":"10.3389\/fendo.2024.1323947","volume":"15","author":"S Yuan","year":"2024","unstructured":"S. Yuan, Y. Lin, Y. Zhao, M. Du, S. Dong, Y. Chen, H. Wei, Pineal cysts may promote pubertal development in girls with central precocious puberty: a single-center study from China. Front. Endocrinol. 15, 1323947 (2024). https:\/\/doi.org\/10.3389\/fendo.2024.1323947.","journal-title":"Front. Endocrinol."},{"key":"4382_CR33","unstructured":"National Cancer Registration and Analysis Service. Children, teenagers and young adults UK cancer statistics report 2021, Public Health England http:\/\/www.ncin.org.uk\/cancer_type_and_topic_specific_work\/cancer_type_specific_work\/cancer_in_children_teenagers_and_young_adults\/ (2021)"},{"issue":"2","key":"4382_CR34","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1007\/s11102-019-00940-4","volume":"22","author":"P Souteiro","year":"2019","unstructured":"P. Souteiro, R. Maia, R. Santos-Silva, R. Figueiredo, C. Costa, S. Belo, C. Castro-Correia, D. Carvalho, M. Fontuoura, Pituitary incidentalomas in paediatric age are different from those described in adulthood. Pituitary 22(2), 124\u2013128 (2019). https:\/\/doi.org\/10.1007\/s11102-019-00940-4.","journal-title":"Pituitary"},{"issue":"5","key":"4382_CR35","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1007\/s004310051285","volume":"159","author":"L Adan","year":"2000","unstructured":"L. Adan, L. Bussie\u0300res, V. Dinand, M. Zerah, A. Pierre-Kahn, R. Brauner, Growth, puberty and hypothalamic-pituitary function in children with suprasellar arachnoid cyst. Eur. J. Pediatr. 159(5), 348\u2013355 (2000). https:\/\/doi.org\/10.1007\/s004310051285.","journal-title":"Eur. J. Pediatr."},{"issue":"2","key":"4382_CR36","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1111\/j.1365-2265.2006.02582.x","volume":"65","author":"C Trivin","year":"2006","unstructured":"C. Trivin, A.C. Couto-Silva, C. Sainte-Rose, Chemaitilly, C. Kalifa, F. Doz, M. Zerah, R. Brauner, Presentation and evolution of organic central precocious puberty according to the type of CNS lesion. Clin. Endocrinol. 65(2), 239\u2013245 (2006). https:\/\/doi.org\/10.1111\/j.1365-2265.2006.02582.x.","journal-title":"Clin. Endocrinol."},{"issue":"3","key":"4382_CR37","doi-asserted-by":"publisher","first-page":"164","DOI":"10.6065\/apem.2017.22.3.164","volume":"22","author":"JE Jung","year":"2017","unstructured":"J.E. Jung, J. Jin, M.K. Jung, A. Kwon, H.W. Chae, D.H. Kim et al., Clinical manifestations of Rathke\u2019s cleft cysts and their natural progression during 2 years in children and adolescents. Ann. Pediatr. Endocrinol. Metab. 22(3), 164\u2013169 (2017). https:\/\/doi.org\/10.6065\/apem.2017.22.3.164.","journal-title":"Ann. Pediatr. Endocrinol. Metab."},{"issue":"7","key":"4382_CR38","doi-asserted-by":"publisher","first-page":"759","DOI":"10.3345\/kjp.2010.53.7.759","volume":"53","author":"HH Lim","year":"2010","unstructured":"H.H. Lim, S.W. Yang, Risk factor for pituitary dysfunction in children and adolescents with Rathke\u2019s cleft cysts. Korean J. Pediatr. 53(7), 759\u2013765 (2010). https:\/\/doi.org\/10.3345\/kjp.2010.53.7.759.","journal-title":"Korean J. Pediatr."},{"issue":"2","key":"4382_CR39","doi-asserted-by":"publisher","first-page":"105","DOI":"10.6065\/apem.2142146.073","volume":"27","author":"QTV Hyunh","year":"2022","unstructured":"Q.T.V. Hyunh, B.T. Ho, N.Q.K. Le, T.H. Trinh, L.H.T. Lam, N.T.K. Nguyen, S.Y. Huang, Pathological brain lesions in girls with central precocious puberty at initial diagnosis in Southern Vietnam. Ann. Pediatr. Endocrinol. Metab. 27(2), 105\u2013112 (2022). https:\/\/doi.org\/10.6065\/apem.2142146.073.","journal-title":"Ann. Pediatr. Endocrinol. Metab."},{"issue":"9","key":"4382_CR40","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1001\/archpedi.155.9.1022","volume":"155","author":"ME Herman-Gidddens","year":"2001","unstructured":"M.E. Herman-Gidddens, L. Wang, G. Koch, Secondary sexual characteristics in boys: estimates from the national health and nutrition examination survey III, 1988\u20131994. Arch. Pediatr. Adolesc. Med. 155(9), 1022\u20131028 (2001). https:\/\/doi.org\/10.1001\/archpedi.155.9.1022.","journal-title":"Arch. Pediatr. Adolesc. Med."},{"issue":"4","key":"4382_CR41","doi-asserted-by":"publisher","first-page":"e195881","DOI":"10.1001\/jamapediatrics.2019.5881","volume":"174","author":"C Eckert-Lind","year":"2020","unstructured":"C. Eckert-Lind, A.S. Busch, J.H. Petersen, F.M. Biro, G. Butler, E.V. Br\u00e4uner, A. Juul, Worldwide secular trends in age at pubertal onset assessed by breast development among girls: a systematic review and meta- analysis. JAMA Pediatr. 174(4), e195881 (2020). https:\/\/doi.org\/10.1001\/jamapediatrics.2019.5881.","journal-title":"JAMA Pediatr."},{"issue":"6","key":"4382_CR42","doi-asserted-by":"publisher","first-page":"680","DOI":"10.3109\/03014460903049074","volume":"36","author":"M Roelants","year":"2009","unstructured":"M. Roelants, R. Hauspie, K. Hoppenbrouwers, References for growth and pubertal development from birth to 21 years in Flanders, Belgium. Ann. Hum. Biol. 36(6), 680\u2013694 (2009). https:\/\/doi.org\/10.3109\/03014460903049074.","journal-title":"Ann. Hum. Biol."},{"key":"4382_CR43","doi-asserted-by":"publisher","first-page":"04099","DOI":"10.7189\/jogh.14.04099","volume":"10","author":"D Shi","year":"2024","unstructured":"D. Shi, M. Ning, L. Yunfei, D. Jiajia, Z. Panliang, C. Shan, C. Ziyue, M. Jun, S. Yi, Association between BMI and age at menarche or spermarche among both sexes: findings from six successive national surveys in China. J. Glob. Health 10, 04099 (2024). https:\/\/doi.org\/10.7189\/jogh.14.04099.","journal-title":"J. Glob. Health"},{"issue":"1","key":"4382_CR44","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1542\/peds.2008-0146","volume":"123","author":"RL Rosenfield","year":"2009","unstructured":"R.L. Rosenfield, R.B. Lipton, M.L. Drum, Thelarche, pubarche, and menarche attainment in children with normal and elevated body mass index. Pediatrics 123(1), 84\u201388 (2009). https:\/\/doi.org\/10.1542\/peds.2008-0146.","journal-title":"Pediatrics"},{"issue":"1","key":"4382_CR45","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1097\/MED.0000000000000377","volume":"25","author":"LC Greenspan","year":"2018","unstructured":"L.C. Greenspan, M.M. Lee, Endocrine disrupters and pubertal timing. Curr. Opin. Endocrinol. Diabetes Obes. 25(1), 49\u201354 (2018). https:\/\/doi.org\/10.1097\/MED.0000000000000377.","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"4382_CR46","doi-asserted-by":"publisher","first-page":"1190445","DOI":"10.3389\/fendo.2023.1190445","volume":"14","author":"A K\u0131l\u0131nc Ugurlu","year":"2023","unstructured":"A. K\u0131l\u0131nc Ugurlu, A. Bideci, A.M. Demirel, G.T. Kaplano\u011flu, D. Dayan\u0131r, \u00d6 G\u00fclbahar, T.S. Devecibulut, E. D\u00f6\u011fer, M.O. \u00c7amurdan, Is blue light exposure a cause of precocious puberty in male rats?. Front. Endocrinol. 14, 1190445 (2023). https:\/\/doi.org\/10.3389\/fendo.2023.1190445.","journal-title":"Front. Endocrinol."},{"key":"4382_CR47","doi-asserted-by":"publisher","first-page":"1259172","DOI":"10.3389\/fendo.2023.1259172","volume":"14","author":"J Tang","year":"2023","unstructured":"J. Tang, T. Yu, Y. Jiang, P. Xue, H. Kong, C. Lin, C. Lin, S. Liu, Y. Tian, The association between sleep and early pubertal development in Chinese children: a school population-based cross- sectional study. Front. Endocrinol. 14, 1259172 (2023). https:\/\/doi.org\/10.3389\/fendo.2023.1259172.","journal-title":"Front. Endocrinol."},{"issue":"4","key":"4382_CR48","doi-asserted-by":"publisher","first-page":"392","DOI":"10.4274\/jcrpe.3091","volume":"8","author":"HS Lee","year":"2016","unstructured":"H.S. Lee, J.S. Yoon, J.S. Hwang, Luteinizing hormone secretion during gonadotropin-releasing hormone stimulation tests in obese girls with central precocious puberty. J. Clin. Res. Pediatr. Endocrinol. 8(4), 392\u2013398 (2016). https:\/\/doi.org\/10.4274\/jcrpe.3091.","journal-title":"J. Clin. Res. Pediatr. Endocrinol."},{"issue":"3","key":"4382_CR49","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1159\/000342342","volume":"97","author":"HS Lee","year":"2013","unstructured":"H.S. Lee, H.K. Park, J.H. Ko, Y.J. Kim, J.S. Hwang, Impact of body mass index on luteinizing hormone secretion in gonadotropin-releasing hormone stimulation tests of boys experiencing precocious puberty. Neuroendocrinology 97(3), 225\u2013231 (2013).","journal-title":"Neuroendocrinology"},{"issue":"10","key":"4382_CR50","doi-asserted-by":"publisher","first-page":"4522","DOI":"10.1159\/000342342","volume":"87","author":"N Abate","year":"2002","unstructured":"N. Abate, S.M. Haffner, A. Garg, R.M. Peshock, S.M. Grundy, Sex steroid hormones, upper body obesity, and insulin resistance. J. Clin. Endocrinol. Metab. 87(10), 4522\u20134527 (2002). https:\/\/doi.org\/10.1159\/000342342.","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"4382_CR51","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1080\/tam.5.2.98.102","volume":"5","author":"A Vermeulen","year":"2002","unstructured":"A. Vermeulen, J.M. Kaufman, S. Goemaere, I. Pottelberg, Estradiol in elderly men. Aging Male 5(2), 98\u2013102 (2002).","journal-title":"Aging Male"},{"issue":"5","key":"4382_CR52","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1172\/JCI107278","volume":"52","author":"RP Kelch","year":"1973","unstructured":"R.P. Kelch, Suppression of urinary and plasma follicle-stimulating hormone by exogenous estrogens in prepubertal and pubertal children. J. Clin. Invest. 52(5), 1122\u20131128 (1973). https:\/\/doi.org\/10.1172\/JCI107278.","journal-title":"J. Clin. Invest."},{"issue":"2","key":"4382_CR53","doi-asserted-by":"publisher","first-page":"e20150164","DOI":"10.1542\/peds.2015-0164","volume":"137","author":"JM Lee","year":"2016","unstructured":"J.M. Lee, R. Wasserman, N. Kaciroti, A. Gebremariam, J. Steffes, S. Dowshen, D. Harris, J. Serwint, D. Abney, L. Smitherman, E. Reiter, M.E. Herman-Giddens, Timing of puberty in overweight versus obese boys. Pediatrics 137(2), e20150164 (2016). https:\/\/doi.org\/10.1542\/peds.2015-0164.","journal-title":"Pediatrics"},{"issue":"5","key":"4382_CR54","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1159\/000535132","volume":"97","author":"L Hou","year":"2024","unstructured":"L. Hou, Y. Ying, W. Wu, F. Ye, C. Zhang, X. Luo, The effect of GnRHa treatment on body mass index in central precocious puberty: a systematic review and meta-analysis. Horm. Res. Paediatr. 97(5), 419\u2013432 (2024). https:\/\/doi.org\/10.1159\/000535132.","journal-title":"Horm. Res. Paediatr."},{"issue":"1","key":"4382_CR55","doi-asserted-by":"publisher","first-page":"27","DOI":"10.4068\/cmj.2012.48.1.27","volume":"48","author":"SJ Lee","year":"2012","unstructured":"S.J. Lee, E.M. Yang, J.Y. Seo, C.J. Kim, Effects of gonadotropin-releasinghormone agonist therapy on body mass index and height in girls with central precocious puberty. Chonnam Med. J. 48(1), 27\u201331 (2012). https:\/\/doi.org\/10.4068\/cmj.2012.48.1.27.","journal-title":"Chonnam Med. J."},{"issue":"12","key":"4382_CR56","doi-asserted-by":"publisher","first-page":"e0243212","DOI":"10.1371\/journal.pone.0243212","volume":"15","author":"YS Shim","year":"2020","unstructured":"Y.S. Shim, K.I. Lim, H.S. Lee, J.S. Hwang, Long-term outcomes after gonadotropin- releasing hormone agonist treatment in boys with central precocious puberty. PLoS ONE 15(12), e0243212 (2020). https:\/\/doi.org\/10.1371\/journal.pone.0243212.","journal-title":"PLoS ONE"},{"key":"4382_CR57","doi-asserted-by":"publisher","first-page":"1008474","DOI":"10.3389\/fendo.2022.1008474","volume":"13","author":"T Knific","year":"2022","unstructured":"T. Knific, M. Lazarevic, J. Zibert, N. Obolnar, N. Aleksovska, J. SuputOmladic, T. Battelino, M. Avbelj Stefanjia, Final adult height in children with central precocious puberty \u2013 a retrospective study. Front. Endocrinol. 13, 1008474 (2022). https:\/\/doi.org\/10.3389\/fendo.2022.1008474.","journal-title":"Front. Endocrinol."},{"issue":"5-6","key":"4382_CR58","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1159\/000346145","volume":"78","author":"B Wolters","year":"2012","unstructured":"B. Wolters, N. Lass, T. Reinehr, Treatment with gonadotropin-releasing hormone analogues: different impact on body weight in normal-weight and overweight children. Horm. Res. Paediatr. 78(5-6), 304\u2013311 (2012). https:\/\/doi.org\/10.1159\/000346145.","journal-title":"Horm. Res. Paediatr."},{"issue":"10","key":"4382_CR59","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1515\/jpem-2019-0105","volume":"32","author":"M Censani","year":"2019","unstructured":"M. Censani, A. Feuer, S. Orton, G. Askin, M. Vogiatzi, Changes in body mass index in children on gonadotropin-releasing hormone agonist therapy with precocious puberty, early puberty or short stature. J. Pediatr. Endocrinol. Metab. 32(10), 1065\u20131070 (2019). https:\/\/doi.org\/10.1515\/jpem-2019-0105.","journal-title":"J. Pediatr. Endocrinol. Metab."},{"issue":"6","key":"4382_CR60","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1515\/jpem-2017-0523","volume":"31","author":"KO Klein","year":"2018","unstructured":"K.O. Klein, S. Dragnic, A.M. Soliman, P. Bacher, Predictors of bone maturation, growth rate and adult height in children with central precocious puberty treated with depot leuprolide acetate. J. Pediatr. Endocrinol. Metab. 31(6), 655\u2013663 (2018). https:\/\/doi.org\/10.1515\/jpem-2017-0523.","journal-title":"J. Pediatr. Endocrinol. Metab."}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-025-04382-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12020-025-04382-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-025-04382-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T11:06:53Z","timestamp":1761736013000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12020-025-04382-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,11]]},"references-count":60,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["4382"],"URL":"https:\/\/doi.org\/10.1007\/s12020-025-04382-w","relation":{},"ISSN":["1559-0100"],"issn-type":[{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,11]]},"assertion":[{"value":"8 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}