{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T12:59:57Z","timestamp":1781614797525,"version":"3.54.5"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007051","name":"Uppsala University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007051","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The aim of this study was to assess the effects of acute Glucagon-like peptide-1 (GLP-1) receptor agonist administration on metabolic and endocrine responses to a standardized meal test in individuals who have undergone Roux-en-Y gastric bypass surgery (RYGB), and thus to uncover mechanisms that might be important in post-bariatric hypoglycemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a single-center, randomized crossover study, 10 patients without diabetes underwent two standardized high-carbohydrate meal tests with either saline (SAL) or exenatide (EXE) infusion, one year after RYGB. We assessed glucose, insulin, c-peptide, ACTH, cortisol, GH, adrenalin, noradrenalin, dopamine, glucagon, active GLP-1 and GIP. Gastric emptying rate was estimated with repeated paracetamol measurements. Heart rate variability was recorded as a marker of sympathetic nervous system activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Postprandial glucose levels dropped below baseline levels in all subjects. Cortisol levels were higher during EXE infusion. As expected, insulin and c-peptide levels were higher with EXE. No other significant differences were observed in the measured hormones. EXE did not affect gastric emptying rate. HRV showed a decreased RR-interval during EXE infusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>During a meal test, acute exenatide infusion led to elevated cortisol levels but did not protect against post-prandial drops in glucose levels. Taken together with previous research, this implicates that alleviation of post-prandial hypoglycemia after RYGB via GLP-1 receptor agonist treatment likely involves other mechanisms than acute effects on conventional counter-regulatory hormones.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s12020-025-04446-x","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:00:28Z","timestamp":1760104828000},"page":"1287-1296","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of acute GLP-1 analogue infusion on the glycemic and neurohormonal responses to meal test in non- hypoglycemic subjects after gastric bypass"],"prefix":"10.1007","volume":"90","author":[{"given":"Kristina E.","family":"Almby","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urban","family":"Wiklund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin H.","family":"Lundqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria J.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5428-8025","authenticated-orcid":false,"given":"Niclas","family":"Abrahamsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,10]]},"reference":[{"issue":"4","key":"4446_CR1","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1097\/01.sla.0000089851.41115.1b","volume":"238","author":"PR Schauer","year":"2003","unstructured":"P.R. 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